Publications:

---

An integrated model for predicting KRAS dependency.

Plos Computational Biology

Tsai, Yihsuan S YS; Chareddy, Yogitha S YS; Price, Brandon A BA; Parker, Joel S JS; Pecot, Chad V CV

Publication Date: 2023-05-04

Variant appearance in text: NRAS: A146V

PubMed Link: 37141389

Variant Present in the following documents:

• Main text
• pcbi.1011095.pdf

View BVdb publication page

---

Clinical Review of Mucosal Melanoma: The 11-Year Experience of a Referral Center.

Dermatology Practical & Conceptual

Spadafora, Marco M; Santandrea, Giacomo G; Lai, Michela M; Borsari, Stafania S; Kaleci, Shaniko S; Banzi, Chiara C; Mandato, Vincenzo Dario VD; Pellacani, Giovanni G; Piana, Simonetta S; Longo, Caterina C

Publication Date: 2023-01-01

Variant appearance in text: NRAS: A146V

PubMed Link: 36892398

Variant Present in the following documents:

• 2582dp1301a57.pdf

View BVdb publication page

---

Rosai-Dorfman Disease between Proliferation and Neoplasia.

Cancers

Elbaz Younes, Ismail I; Sokol, Lubomir L; Zhang, Ling L

Publication Date: 2022-10-27

Variant appearance in text: NRAS: A146V

PubMed Link: 36358690

Variant Present in the following documents:

• cancers-14-05271.pdf

View BVdb publication page

---

A phase I/II study of ivaltinostat combined with gemcitabine and erlotinib in patients with untreated locally advanced or metastatic pancreatic adenocarcinoma.

International Journal Of Cancer

Jo, Jung Hyun JH; Jung, Dawoon E DE; Lee, Hee Seung HS; Park, Soo Been SB; Chung, Moon Jae MJ; Park, Jeong Youp JY; Bang, Seungmin S; Park, Seung Woo SW; Cho, Sangsook S; Song, Si Young SY

Publication Date: 2022-11-01

Variant appearance in text: NRAS: A146V

PubMed Link: 35657348

Variant Present in the following documents:

• IJC-151-1565-s001.pdf

View BVdb publication page

---

JAK3 mutations and mitochondrial apoptosis resistance in T-cell acute lymphoblastic leukemia.

Leukemia

Bodaar, Kimberly K; Yamagata, Natsuko N; Barthe, Anais A; Landrigan, Jack J; Chonghaile, Triona Ni TN; Burns, Melissa M; Stevenson, Kristen E KE; Devidas, Meenakshi M; Loh, Mignon L ML; Hunger, Stephen P SP; Wood, Brent B; Silverman, Lewis B LB; Teachey, David T DT; Meijerink, Jules P JP; Letai, Anthony A; Gutierrez, Alejandro A

Publication Date: 2022-06

Variant appearance in text: NRAS: 437C>T; A146V

PubMed Link: 35411095

Variant Present in the following documents:

• NIHMS1792675-supplement-Supplementary_Table_2.xlsx, sheet 1

View BVdb publication page

---

Integrated genomic analyses identify high-risk factors and actionable targets in T-cell acute lymphoblastic leukemia.

Blood Science (Baltimore, Md.)

Zhu, Haichuan H; Dong, Bingjie B; Zhang, Yingchi Y; Wang, Mei M; Rao, Jianan J; Cui, Bowen B; Liu, Yu Y; Jiang, Qian Q; Wang, Weitao W; Yang, Lu L; Yu, Anqi A; Li, Zongru Z; Liu, Chao C; Zhang, Leping L; Huang, Xiaojun X; Zhu, Xiaofan X; Wu, Hong H

Publication Date: 2022-01

Variant appearance in text: NRAS: A146V

PubMed Link: 35399540

Variant Present in the following documents:

• bls-4-16-s004.pdf

View BVdb publication page

---

A full-proteome, interaction-specific characterization of mutational hotspots across human cancers.

Genome Research

Chen, Siwei S; Liu, Yuan Y; Zhang, Yingying Y; Wierbowski, Shayne D SD; Lipkin, Steven M SM; Wei, Xiaomu X; Yu, Haiyuan H

Publication Date: 2022-01

Variant appearance in text: NRAS: A146V

PubMed Link: 34963661

Variant Present in the following documents:

• supp_gr.275437.121_Supplementary_Table_1.xlsx, sheet 3

View BVdb publication page

---

Concordance of acquired mutations between metastatic lesions and liquid biopsy in metastatic colorectal cancer.

Future Science Oa

Taniguchi, Fumitaka F; Nyuya, Akihiro A; Toshima, Toshiaki T; Yasui, Kazuya K; Mori, Yoshiko Y; Okawaki, Makoto M; Kishimoto, Hiroyuki H; Umeda, Yuzo Y; Fujiwara, Toshiyoshi T; Tanioka, Hiroaki H; Yamaguchi, Yoshiyuki Y; Goel, Ajay A; Nagasaka, Takeshi T

Publication Date: 2021-12

Variant appearance in text: NRAS: A146V

PubMed Link: 34840814

Variant Present in the following documents:

• Main text
• fsoa-07-757-s2.xlsx, sheet 1
• fsoa-07-757-s3.xlsx, sheet 1

View BVdb publication page

---

Predictive and Prognostic Value of BRAF and NRAS Mutation of 159 Sentinel Lymph Node Cases in Melanoma-A Retrospective Single-Institute Study.

Cancers

Liszkay, Gabriella G; Mátrai, Zoltán Z; Czirbesz, Kata K; Jani, Nóra N; Bencze, Eszter E; Kenessey, István I

Publication Date: 2021-06-30

Variant appearance in text: NRAS: A146V

PubMed Link: 34209415

Variant Present in the following documents:

• Main text
• cancers-13-03302.pdf

View BVdb publication page

---

Mutation status and prognostic value of KRAS and NRAS mutations in Moroccan colon cancer patients: A first report.

Plos One

El Agy, Fatima F; El Bardai, Sanae S; El Otmani, Ihsane I; Benbrahim, Zineb Z; Karim, Ibn Majdoub Hassani MH; Mazaz, Khalid K; Benjelloun, El Bachir EB; Ousadden, Abdelmalek A; El Abkari, Mohammed M; Ibrahimi, Sidi Adil SA; Chbani, Laila L

Publication Date: 2021

Variant appearance in text: NRAS: 437C>T

PubMed Link: 33784337

Variant Present in the following documents:

• pone.0248522.pdf

View BVdb publication page

---

Assessment of RAS Dependency for BRAF Alterations Using Cancer Genomic Databases.

Jama Network Open

Zhao, Yiqing Y; Yu, Hanzhong H; Ida, Cris M CM; Halling, Kevin C KC; Kipp, Benjamin R BR; Geiersbach, Katherine K; Rumilla, Kandelaria M KM; Gupta, Sounak S; Lin, Ming-Tseh MT; Zheng, Gang G

Publication Date: 2021-01-04

Variant appearance in text: NRAS: A146V

PubMed Link: 33507258

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Integrated molecular drivers coordinate biological and clinical states in melanoma.

Nature Genetics

Conway, Jake R JR; Dietlein, Felix F; Taylor-Weiner, Amaro A; AlDubayan, Saud S; Vokes, Natalie N; Keenan, Tanya T; Reardon, Brendan B; He, Meng Xiao MX; Margolis, Claire A CA; Weirather, Jason L JL; Haq, Rizwan R; Schilling, Bastian B; Stephen Hodi, F F; Schadendorf, Dirk D; Liu, David D; Van Allen, Eliezer M EM

Publication Date: 2020-12

Variant appearance in text: NRAS: 437C>T; A146V

PubMed Link: 33230298

Variant Present in the following documents:

• NIHMS1637640-supplement-SuppData1.xlsx, sheet 1

View BVdb publication page

---

The evolution of relapse of adult T cell acute lymphoblastic leukemia.

Genome Biology

Sentís, Inés I; Gonzalez, Santiago S; Genescà, Eulalia E; García-Hernández, Violeta V; Muiños, Ferran F; Gonzalez, Celia C; López-Arribillaga, Erika E; Gonzalez, Jessica J; Fernandez-Ibarrondo, Lierni L; Mularoni, Loris L; Espinosa, Lluís L; Bellosillo, Beatriz B; Ribera, Josep-Maria JM; Bigas, Anna A; Gonzalez-Perez, Abel A; Lopez-Bigas, Nuria N

Publication Date: 2020-11-23

Variant appearance in text: NRAS: A146V

PubMed Link: 33225950

Variant Present in the following documents:

• 13059_2020_2192_MOESM1_ESM.xlsx, sheet 5

View BVdb publication page

---

Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations

Haematologica

Antić, Željko Ž; Yu, Jiangyan J; Van Reijmersdal, Simon V SV; Van Dijk, Anke A; Dekker, Linde L; Segerink, Wouter H WH; Sonneveld, Edwin E; Fiocco, Marta M; Pieters, Rob R; Hoogerbrugge, Peter M PM; Van Leeuwen, Frank N FN; Van Kessel, Ad Geurts AG; Waanders, Esme E; Kuiper, Roland P RP

Publication Date: 2021-12-01

Variant appearance in text: NRAS: A146V

PubMed Link: 33147938

Variant Present in the following documents:

• 2020_259226_ANTIC_SUPPL_TABLES.xlsx, sheet 3

View BVdb publication page

---

Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations

Haematologica

Antić, Željko Ž; Yu, Jiangyan J; Van Reijmersdal, Simon V SV; Van Dijk, Anke A; Dekker, Linde L; Segerink, Wouter H WH; Sonneveld, Edwin E; Fiocco, Marta M; Pieters, Rob R; Hoogerbrugge, Peter M PM; Van Leeuwen, Frank N FN; Van Kessel, Ad Geurts AG; Waanders, Esme E; Kuiper, Roland P RP

Publication Date: 2021-12-01

Variant appearance in text: NRAS: A146V

PubMed Link: 33147938

Variant Present in the following documents:

• 2020_259226_ANTIC_SUPPL_TABLES.xlsx, sheet 3

View BVdb publication page

---

Validation and clinical application of a targeted next-generation sequencing gene panel for solid and hematologic malignancies.

Peerj

Prieto-Potin, Iván I; Carvajal, Nerea N; Plaza-Sánchez, Jenifer J; Manso, Rebeca R; Aúz-Alexandre, Carmen Laura CL; Chamizo, Cristina C; Zazo, Sandra S; López-Sánchez, Almudena A; Rodríguez-Pinilla, Socorro María SM; Camacho, Laura L; Longarón, Raquel R; Bellosillo, Beatriz B; Somoza, Rosa R; Hernández-Losa, Javier J; Fernández-Soria, Víctor Manuel VM; Ramos-Ruiz, Ricardo R; Cristóbal, Ion I; García-Foncillas, Jesús J; Rojo, Federico F

Publication Date: 2020

Variant appearance in text: NRAS: 437C>T; A146V

PubMed Link: 33083132

Variant Present in the following documents:

• peerj-08-10069-s007.xlsx, sheet 1

View BVdb publication page

---

Tumor Location Is Associated With the Prevalence of Braf And Pik3ca Mutations in Patients with Wild-Type Ras Colorectal Cancer: A Prospective Multi-Center Cohort Study in Japan.

Translational Oncology

Taniguchi, Hiroya H; Uehara, Keisuke K; Nakayama, Goro G; Nakayama, Hiroshi H; Aiba, Toshisada T; Hattori, Norifumi N; Kataoka, Masato M; Nakano, Yasuyuki Y; Kawase, Yoshihisa Y; Okochi, Osamu O; Matsuoka, Hiroshi H; Utsunomiya, Setsuo S; Sakamoto, Eiji E; Mori, Yoshinori Y; Umeda, Shinichi S; Shikano, Toshio T; Komori, Koji K; Tajika, Masahiro M; Kadowaki, Shigenori S; Muro, Kei K; Yatabe, Yasushi Y

Publication Date: 2020-07

Variant appearance in text: NRAS: A146V

PubMed Link: 32428838

Variant Present in the following documents:

• main.pdf

View BVdb publication page

---

Prognostic implications of EGFR protein expression in sporadic colorectal tumors: Correlation with copy number status, mRNA levels and miRNA regulation.

Scientific Reports

Del Carmen, Sofía S; Corchete, Luís Antonio LA; Gervas, Ruth R; Rodriguez, Alba A; Garcia, María M; Álcazar, José Antonio JA; García, Jacinto J; Bengoechea, Oscar O; Muñoz-Bellvis, Luis L; Sayagués, José María JM; Abad, Mar M

Publication Date: 2020-03-13

Variant appearance in text: NRAS: A146V

PubMed Link: 32170146

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Analysis of Molecular Pretreated Tumor Profiles as Predictive Biomarkers of Therapeutic Response and Survival Outcomes after Neoadjuvant Therapy for Rectal Cancer in Moroccan Population.

Disease Markers

El Otmani, Ihsane I; El Agy, Fatima F; El Baradai, Sanae S; Bouguenouch, Laila L; Lahmidani, Nada N; El Abkari, Mohammed M; Benajah, Dafr Allah DA; Toughrai, Imane I; El Bouhaddouti, Hicham H; Mouaqit, Ouadii O; Ibn Majdoub Hassani, Karim K; Mazaz, Khalid K; Benjelloun, El Bachir EB; Ousadden, Abdelmalek A; El Rhazi, Karima K; Bouhafa, Touria T; Benbrahim, Zineb Z; Ouldim, Karim K; Ibrahimi, Sidi Adil SA; Ait Taleb, Khalid K; Chbani, Laila L

Publication Date: 2020

Variant appearance in text: NRAS: A146V

PubMed Link: 31998419

Variant Present in the following documents:

• DM2020-8459303.pdf

View BVdb publication page

---

Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia.

Plos One

Pouliot, Gayle P GP; Degar, James J; Hinze, Laura L; Kochupurakkal, Bose B; Vo, Chau D CD; Burns, Melissa A MA; Moreau, Lisa L; Ganesa, Chirag C; Roderick, Justine J; Peirs, Sofie S; Menten, Bjorn B; Loh, Mignon L ML; Hunger, Stephen P SP; Silverman, Lewis B LB; Harris, Marian H MH; Stevenson, Kristen E KE; Weinstock, David M DM; Weng, Andrew P AP; Van Vlierberghe, Pieter P; D'Andrea, Alan D AD; Gutierrez, Alejandro A

Publication Date: 2019

Variant appearance in text: NRAS: 437C>T; A146V

PubMed Link: 31721781

Variant Present in the following documents:

• pone.0221288.s010.xlsx, sheet 1

View BVdb publication page

---

Variation in nomenclature of somatic variants for selection of oncological therapies: Can we reach a consensus soon?

Human Mutation

Keppens, Cleo C; Tack, Véronique V; Dufraing, Kelly K; Rouleau, Etienne E; Ligtenberg, Marjolijn J L MJL; Schuuring, Ed E; Dequeker, Elisabeth M C EMC

Publication Date: 2020-01

Variant appearance in text: NRAS: 437C>T; Ala146Val

PubMed Link: 31553104

Variant Present in the following documents:

• HUMU-41-7.pdf

View BVdb publication page

---

Evaluation of KRAS, NRAS and BRAF hotspot mutations detection for patients with metastatic colorectal cancer using direct DNA pipetting in a fully-automated platform and Next-Generation Sequencing for laboratory workflow optimisation.

Plos One

Gilson, Pauline P; Franczak, Claire C; Dubouis, Ludovic L; Husson, Marie M; Rouyer, Marie M; Demange, Jessica J; Perceau, Marie M; Leroux, Agnès A; Merlin, Jean-Louis JL; Harlé, Alexandre A

Publication Date: 2019

Variant appearance in text: NRAS: 437C>T; A146V

PubMed Link: 31265477

Variant Present in the following documents:

• Main text
• pone.0219204.pdf

View BVdb publication page

---

KRAS, NRAS, and BRAF mutations are highly enriched in trisomy 12 chronic lymphocytic leukemia and are associated with shorter treatment-free survival.

Leukemia

Vendramini, Elena E; Bomben, Riccardo R; Pozzo, Federico F; Benedetti, Dania D; Bittolo, Tamara T; Rossi, Francesca Maria FM; Dal Bo, Michele M; Rabe, Kari G KG; Pozzato, Gabriele G; Zaja, Francesco F; Chiarenza, Annalisa A; Di Raimondo, Francesco F; Braggio, Esteban E; Parikh, Sameer A SA; Kay, Neil E NE; Shanafelt, Tait D TD; Del Poeta, Giovanni G; Gattei, Valter V; Zucchetto, Antonella A

Publication Date: 2019-08

Variant appearance in text: NRAS: 437C>T; A146V

PubMed Link: 30872781

Variant Present in the following documents:

• 41375_2019_444_MOESM1_ESM.pdf

View BVdb publication page

---

Competitive evolution of NSCLC tumor clones and the drug resistance mechanism of first-generation EGFR-TKIs in Chinese NSCLC patients.

Heliyon

Deng, Qinfang Q; Xie, Boxiong B; Wu, Leilei L; Ji, Xianxiu X; Li, Chao C; Feng, Li L; Fang, Qiyu Q; Bao, Yuchen Y; Li, Jialu J; Jin, Shengnan S; Ding, Chunming C; Li, Yixue Y; Zhou, Songwen S

Publication Date: 2018-12

Variant appearance in text: NRAS: A146V

PubMed Link: 30603682

Variant Present in the following documents:

• mmc2.xlsx, sheet 1

View BVdb publication page

---

Clinical relevance of circulating tumor DNA assessed through deep sequencing in patients with metastatic colorectal cancer.

Cancer Medicine

Osumi, Hiroki H; Shinozaki, Eiji E; Takeda, Yoshinori Y; Wakatsuki, Takeru T; Ichimura, Takashi T; Saiura, Akio A; Yamaguchi, Kensei K; Takahashi, Shunji S; Noda, Tetsuo T; Zembutsu, Hitoshi H

Publication Date: 2019-01

Variant appearance in text: NRAS: A146V

PubMed Link: 30575318

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Computational analysis reveals histotype-dependent molecular profile and actionable mutation effects across cancers.

Genome Medicine

Heim, Daniel D; Montavon, Grégoire G; Hufnagl, Peter P; Müller, Klaus-Robert KR; Klauschen, Frederick F

Publication Date: 2018-11-15

Variant appearance in text: NRAS: A146V

PubMed Link: 30442178

Variant Present in the following documents:

• 13073_2018_591_MOESM4_ESM.xlsx, sheet 1

View BVdb publication page

---

Clinical Validation of Newly Developed Multiplex Kit Using Luminex xMAP Technology for Detecting Simultaneous RAS and BRAF Mutations in Colorectal Cancer: Results of the RASKET-B Study.

Neoplasia (New York, N.Y.)

Taniguchi, Hiroya H; Okamoto, Wataru W; Muro, Kei K; Akagi, Kiwamu K; Hara, Hiroki H; Nishina, Tomohiro T; Kajiwara, Takeshi T; Denda, Tadamichi T; Hironaka, Shuichi S; Kudo, Toshihiro T; Satoh, Taroh T; Yamanaka, Takeharu T; Abe, Yukiko Y; Fukushima, Yoshiyuki Y; Yoshino, Takayuki T

Publication Date: 2018-12

Variant appearance in text: NRAS: A146V

PubMed Link: 30412858

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

---

PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia.

The Journal Of Experimental Medicine

Ariës, Ingrid M IM; Bodaar, Kimberly K; Karim, Salmaan A SA; Chonghaile, Triona Ni TN; Hinze, Laura L; Burns, Melissa A MA; Pfirrmann, Maren M; Degar, James J; Landrigan, Jack T JT; Balbach, Sebastian S; Peirs, Sofie S; Menten, Björn B; Isenhart, Randi R; Stevenson, Kristen E KE; Neuberg, Donna S DS; Devidas, Meenakshi M; Loh, Mignon L ML; Hunger, Stephen P SP; Teachey, David T DT; Rabin, Karen R KR; Winter, Stuart S SS; Dunsmore, Kimberly P KP; Wood, Brent L BL; Silverman, Lewis B LB; Sallan, Stephen E SE; Van Vlierberghe, Pieter P; Orkin, Stuart H SH; Knoechel, Birgit B; Letai, Anthony G AG; Gutierrez, Alejandro A

Publication Date: 2018-12-03

Variant appearance in text: NRAS: 437C>T; A146V

PubMed Link: 30404791

Variant Present in the following documents:

• JEM_20180570_TableS4.xlsx, sheet 1

View BVdb publication page

---

Spatio-temporal tumor heterogeneity in metastatic CRC tumors: a mutational-based approach.

Oncotarget

Del Carmen, Sofía S; Sayagués, José María JM; Bengoechea, Oscar O; Anduaga, María Fernanda MF; Alcazar, Jose Antonio JA; Gervas, Ruth R; García, Jacinto J; Orfao, Alberto A; Bellvis, Luis Muñoz LM; Sarasquete, María Eugenia ME; Del Mar Abad, María M

Publication Date: 2018-09-28

Variant appearance in text: NRAS: A146V

PubMed Link: 30344942

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Quality and practical aspects of pathological and molecular diagnostics in metastatic colorectal cancer (mCRC).

Contemporary Oncology (Poznan, Poland)

Tysarowski, Andrzej A; Nasierowska-Guttmejer, Anna A

Publication Date: 2018

Variant appearance in text: NRAS: 437C>T; Ala146Val

PubMed Link: 30150883

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Mutation burden and other molecular markers of prognosis in colorectal cancer treated with curative intent: results from the QUASAR 2 clinical trial and an Australian community-based series.

The Lancet. Gastroenterology & Hepatology

Domingo, Enric E; Camps, Carme C; Kaisaki, Pamela J PJ; Parsons, Marie J MJ; Mouradov, Dmitri D; Pentony, Melissa M MM; Makino, Seiko S; Palmieri, Michelle M; Ward, Robyn L RL; Hawkins, Nicholas J NJ; Gibbs, Peter P; Askautrud, Hanne H; Oukrif, Dahmane D; Wang, Haitao H; Wood, Joe J; Tomlinson, Evie E; Bark, Yasmine Y; Kaur, Kulvinder K; Johnstone, Elaine C EC; Palles, Claire C; Church, David N DN; Novelli, Marco M; Danielsen, Havard E HE; Sherlock, Jon J; Kerr, David D; Kerr, Rachel R; Sieber, Oliver O; Taylor, Jenny C JC; Tomlinson, Ian I

Publication Date: 2018-09

Variant appearance in text: NRAS: A146V

PubMed Link: 30042065

Variant Present in the following documents:

• mmc1.pdf

View BVdb publication page

---

Detailed overview on the mutations detected by and the sensitivity of the GeneReader NGS sequencing platform.

Data In Brief

Lüsebrink, Jessica J; Pieper, Monika M; Tillmann, Ramona-Liza RL; Brockmann, Michael M; Schildgen, Oliver O; Schildgen, Verena V

Publication Date: 2018-06

Variant appearance in text: NRAS: A146V

PubMed Link: 29904702

Variant Present in the following documents:

• main.pdf

View BVdb publication page

---

The Cellular p53 Inhibitor MDM2 and the Growth Factor Receptor FLT3 as Biomarkers for Treatment Responses to the MDM2-Inhibitor Idasanutlin and the MEK1 Inhibitor Cobimetinib in Acute Myeloid Leukemia.

Cancers

Seipel, Katja K; Marques, Miguel A T MAT; Sidler, Corinne C; Mueller, Beatrice U BU; Pabst, Thomas T

Publication Date: 2018-05-31

Variant appearance in text: NRAS: A146V

PubMed Link: 29857559

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One

Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS

Publication Date: 2018

Variant appearance in text: NRAS: A146V

PubMed Link: 29698444

Variant Present in the following documents:

• pone.0196434.s001.xlsx, sheet 1
• pone.0196434.s001.xlsx, sheet 3
• pone.0196434.s001.xlsx, sheet 2

View BVdb publication page

---

Testing for NRAS Mutations in Serous Borderline Ovarian Tumors and Low-Grade Serous Ovarian Carcinomas.

Disease Markers

Sadlecki, Pawel P; Grzanka, Dariusz D; Grabiec, Marek M

Publication Date: 2018

Variant appearance in text: NRAS: 437C>T; A146V

PubMed Link: 29682098

Variant Present in the following documents:

• Main text
• DM2018-1497879.pdf

View BVdb publication page

---

Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas.

Cell Reports

Way, Gregory P GP; Sanchez-Vega, Francisco F; La, Konnor K; Armenia, Joshua J; Chatila, Walid K WK; Luna, Augustin A; Sander, Chris C; Cherniack, Andrew D AD; Mina, Marco M; Ciriello, Giovanni G; Schultz, Nikolaus N; , ; Sanchez, Yolanda Y; Greene, Casey S CS

Publication Date: 2018-04-03

Variant appearance in text: NRAS: 437C>T

PubMed Link: 29617658

Variant Present in the following documents:

• NIHMS958974-supplement-5.xlsx, sheet 1
• NIHMS958974-supplement-6.xlsx, sheet 1

View BVdb publication page

---

Clinical performance evaluation of the Idylla NRAS-BRAF mutation test on retrospectively collected formalin-fixed paraffin-embedded colorectal cancer tissue.

Journal Of Clinical Pathology

Johnston, Louise L; Power, Michael M; Sloan, Philip P; Long, Anna A; Silmon, Angela A; Chaffey, Ben B; Lisgo, Andrea Jane AJ; Little, Liam L; Vercauteren, Ellen E; Steiniche, Torben T; Meyer, Tine T; Simpson, John J

Publication Date: 2018-04

Variant appearance in text: NRAS: 437C>T; Ala146Val

PubMed Link: 28899979

Variant Present in the following documents:

• Main text
• jclinpath-2017-204629.pdf

View BVdb publication page

---

Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications

Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ

Publication Date: 2017-05-11

Variant appearance in text: NRAS: A146V

PubMed Link: 28492226

Variant Present in the following documents:

• ncomms15086-s3.xlsx, sheet 1
• ncomms15086.pdf

View BVdb publication page

---

SP174, NRAS Q61R Mutant-Specific Antibody, Cross-Reacts With KRAS Q61R Mutant Protein in Colorectal Carcinoma.

Archives Of Pathology & Laboratory Medicine

Lasota, Jerzy J; Kowalik, Artur A; Felisiak-Golabek, Anna A; Inaguma, Shingo S; Wang, Zeng-Feng ZF; Pięciak, Liliana L; Zięba, Sebastian S; Pęksa, Rafał R; Kopczynski, Janusz J; Okoń, Krzysztof K; Waloszczyk, Piotr P; Gozdz, Stanislaw S; Biernat, Wojciech W; Miettinen, Markku M

Publication Date: 2017-04

Variant appearance in text: NRAS: A146V

PubMed Link: 28353383

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.

Nature Communications

Schütte, Moritz M; Risch, Thomas T; Abdavi-Azar, Nilofar N; Boehnke, Karsten K; Schumacher, Dirk D; Keil, Marlen M; Yildiriman, Reha R; Jandrasits, Christine C; Borodina, Tatiana T; Amstislavskiy, Vyacheslav V; Worth, Catherine L CL; Schweiger, Caroline C; Liebs, Sandra S; Lange, Martin M; Warnatz, Hans-Jörg HJ; Butcher, Lee M LM; Barrett, James E JE; Sultan, Marc M; Wierling, Christoph C; Golob-Schwarzl, Nicole N; Lax, Sigurd S; Uranitsch, Stefan S; Becker, Michael M; Welte, Yvonne Y; Regan, Joseph Lewis JL; Silvestrov, Maxine M; Kehler, Inge I; Fusi, Alberto A; Kessler, Thomas T; Herwig, Ralf R; Landegren, Ulf U; Wienke, Dirk D; Nilsson, Mats M; Velasco, Juan A JA; Garin-Chesa, Pilar P; Reinhard, Christoph C; Beck, Stephan S; Schäfer, Reinhold R; Regenbrecht, Christian R A CR; Henderson, David D; Lange, Bodo B; Haybaeck, Johannes J; Keilholz, Ulrich U; Hoffmann, Jens J; Lehrach, Hans H; Yaspo, Marie-Laure ML

Publication Date: 2017-02-10

Variant appearance in text: NRAS: A146V

PubMed Link: 28186126

Variant Present in the following documents:

• ncomms14262.pdf

View BVdb publication page

---

Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Genome Research

Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U

Publication Date: 2017-04

Variant appearance in text: NRAS: 437C>T; A146V

PubMed Link: 28179366

Variant Present in the following documents:

• supp_gr.213546.116_Supplemental_Table_S7.xlsx, sheet 1

View BVdb publication page

---

Validation and Application of a Custom-Designed Targeted Next-Generation Sequencing Panel for the Diagnostic Mutational Profiling of Solid Tumors.

Plos One

Froyen, Guy G; Broekmans, An A; Hillen, Femke F; Pat, Karin K; Achten, Ruth R; Mebis, Jeroen J; Rummens, Jean-Luc JL; Willemse, Johan J; Maes, Brigitte B

Publication Date: 2016

Variant appearance in text: NRAS: A146V

PubMed Link: 27101000

Variant Present in the following documents:

• Main text
• pone.0154038.pdf

View BVdb publication page

---

LowMACA: exploiting protein family analysis for the identification of rare driver mutations in cancer.

Bmc Bioinformatics

Melloni, Giorgio E M GE; de Pretis, Stefano S; Riva, Laura L; Pelizzola, Mattia M; Céol, Arnaud A; Costanza, Jole J; Müller, Heiko H; Zammataro, Luca L

Publication Date: 2016-02-09

Variant appearance in text: NRAS: A146V

PubMed Link: 26860319

Variant Present in the following documents:

• 12859_2016_935_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

---

Validation of targeted next-generation sequencing for RAS mutation detection in FFPE colorectal cancer tissues: comparison with Sanger sequencing and ARMS-Scorpion real-time PCR.

Bmj Open

Gao, Jie J; Wu, Huanwen H; Wang, Li L; Zhang, Hui H; Duan, Huanli H; Lu, Junliang J; Liang, Zhiyong Z

Publication Date: 2016-01-08

Variant appearance in text: NRAS: 437C>T

PubMed Link: 26747035

Variant Present in the following documents:

• bmjopen-2015-009532.pdf

View BVdb publication page

---

Clinical Validation of a Multiplex Kit for RAS Mutations in Colorectal Cancer: Results of the RASKET (RAS KEy Testing) Prospective, Multicenter Study.

Ebiomedicine

Yoshino, Takayuki T; Muro, Kei K; Yamaguchi, Kensei K; Nishina, Tomohiro T; Denda, Tadamichi T; Kudo, Toshihiro T; Okamoto, Wataru W; Taniguchi, Hiroya H; Akagi, Kiwamu K; Kajiwara, Takeshi T; Hironaka, Shuichi S; Satoh, Taroh T

Publication Date: 2015-04

Variant appearance in text: NRAS: A146V

PubMed Link: 26137573

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Extended RAS and BRAF Mutation Analysis Using Next-Generation Sequencing.

Plos One

Sakai, Kazuko K; Tsurutani, Junji J; Yamanaka, Takeharu T; Yoneshige, Azusa A; Ito, Akihiko A; Togashi, Yosuke Y; De Velasco, Marco A MA; Terashima, Masato M; Fujita, Yoshihiko Y; Tomida, Shuta S; Tamura, Takao T; Nakagawa, Kazuhiko K; Nishio, Kazuto K

Publication Date: 2015

Variant appearance in text: NRAS: A146V

PubMed Link: 25954997

Variant Present in the following documents:

• Main text
• pone.0121891.pdf

View BVdb publication page

---

Targeted ultra-deep sequencing reveals recurrent and mutually exclusive mutations of cancer genes in blastic plasmacytoid dendritic cell neoplasm.

Oncotarget

Stenzinger, Albrecht A; Endris, Volker V; Pfarr, Nicole N; Andrulis, Mindaugas M; Jöhrens, Korinna K; Klauschen, Frederick F; Siebolts, Udo U; Wolf, Thomas T; Koch, Philipp-Sebastian PS; Schulz, Miriam M; Hartschuh, Wolfgang W; Goerdt, Sergij S; Lennerz, Jochen K JK; Wickenhauser, Claudia C; Klapper, Wolfram W; Anagnostopoulos, Ioannis I; Weichert, Wilko W

Publication Date: 2014-08-15

Variant appearance in text: NRAS: Ala146Val

PubMed Link: 25115387

Variant Present in the following documents:

• Main text
• oncotarget-05-6404-s001.xlsx, sheet 1

View BVdb publication page

---

KRAS, NRAS and BRAF mutations in Greek and Romanian patients with colorectal cancer: a cohort study.

Bmj Open

Negru, Serban S; Papadopoulou, Eirini E; Apessos, Angela A; Stanculeanu, Dana Lucia DL; Ciuleanu, Eliade E; Volovat, Constantin C; Croitoru, Adina A; Kakolyris, Stylianos S; Aravantinos, Gerasimos G; Ziras, Nikolaos N; Athanasiadis, Elias E; Touroutoglou, Nikolaos N; Pavlidis, Nikolaos N; Kalofonos, Haralabos P HP; Nasioulas, George G

Publication Date: 2014-05-23

Variant appearance in text: NRAS: 437C>T; A146V

PubMed Link: 24859998

Variant Present in the following documents:

• Main text
• bmjopen-2013-004652.pdf
• bmjopen-2013-004652.draft_revisions.pdf

View BVdb publication page

---

Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes.

Bmc Cancer

Gelsi-Boyer, Véronique V; Trouplin, Virginie V; Adélaïde, José J; Aceto, Nicola N; Remy, Virginie V; Pinson, Stephane S; Houdayer, Claude C; Arnoulet, Christine C; Sainty, Danielle D; Bentires-Alj, Mohamed M; Olschwang, Sylviane S; Vey, Norbert N; Mozziconacci, Marie-Joëlle MJ; Birnbaum, Daniel D; Chaffanet, Max M

Publication Date: 2008-10-16

Variant appearance in text: NRAS: Ala146Val

PubMed Link: 18925961

Variant Present in the following documents:

• Main text
• 1471-2407-8-299.pdf

View BVdb publication page

---