Publications:

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Clinically actionable cancer somatic variants (CACSV): a tumor interpreted dataset for analytical workflows.

Bmc Medical Genomics

Sobahy, Turki M TM; Tashkandi, Ghassan G; Bahussain, Donya D; Al-Harbi, Raneem R

Publication Date: 2022-04-25

Variant appearance in text: NRAS: 392A>G

PubMed Link: 35468810

Variant Present in the following documents:

• 12920_2022_1235_MOESM2_ESM.xlsx, sheet 1

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Molecular landscape of TP53 mutations in breast cancer and their utility for predicting the response to HER-targeted therapy in HER2 amplification-positive and HER2 mutation-positive amplification-negative patients.

Cancer Medicine

Liu, Binliang B; Yi, Zongbi Z; Guan, Yanfang Y; Ouyang, Quchang Q; Li, Chunxiao C; Guan, Xiuwen X; Lv, Dan D; Li, Lixi L; Zhai, Jingtong J; Qian, Haili H; Xu, Binghe B; Ma, Fei F; Zeng, Yixin Y

Publication Date: 2022-07

Variant appearance in text: NRAS: 392A>G; H131R

PubMed Link: 35393784

Variant Present in the following documents:

• CAM4-11-2767-s001.xlsx, sheet 1

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A full-proteome, interaction-specific characterization of mutational hotspots across human cancers.

Genome Research

Chen, Siwei S; Liu, Yuan Y; Zhang, Yingying Y; Wierbowski, Shayne D SD; Lipkin, Steven M SM; Wei, Xiaomu X; Yu, Haiyuan H

Publication Date: 2022-01

Variant appearance in text: NRAS: H131R

PubMed Link: 34963661

Variant Present in the following documents:

• supp_gr.275437.121_Supplementary_Table_1.xlsx, sheet 3

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Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications

Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q

Publication Date: 2021-01-04

Variant appearance in text: NRAS: 392A>G; H131R

PubMed Link: 33397889

Variant Present in the following documents:

• 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1

View BVdb publication page

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Integrated molecular drivers coordinate biological and clinical states in melanoma.

Nature Genetics

Conway, Jake R JR; Dietlein, Felix F; Taylor-Weiner, Amaro A; AlDubayan, Saud S; Vokes, Natalie N; Keenan, Tanya T; Reardon, Brendan B; He, Meng Xiao MX; Margolis, Claire A CA; Weirather, Jason L JL; Haq, Rizwan R; Schilling, Bastian B; Stephen Hodi, F F; Schadendorf, Dirk D; Liu, David D; Van Allen, Eliezer M EM

Publication Date: 2020-12

Variant appearance in text: NRAS: 392A>G; H131R

PubMed Link: 33230298

Variant Present in the following documents:

• NIHMS1637640-supplement-SuppData1.xlsx, sheet 1

View BVdb publication page

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Molecular landscape and efficacy of HER2-targeted therapy in patients with HER2-mutated metastatic breast cancer.

Npj Breast Cancer

Yi, Zongbi Z; Rong, Guohua G; Guan, Yanfang Y; Li, Jin J; Chang, Lianpeng L; Li, Hui H; Liu, Binliang B; Wang, Wenna W; Guan, Xiuwen X; Ouyang, Quchang Q; Li, Lixi L; Zhai, Jingtong J; Li, Chunxiao C; Li, Lifeng L; Xia, Xuefeng X; Yang, Ling L; Qian, Haili H; Yi, Xin X; Xu, Binghe B; Ma, Fei F

Publication Date: 2020

Variant appearance in text: NRAS: 392A>G; H131R

PubMed Link: 33145402

Variant Present in the following documents:

• 41523_2020_201_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Cetuximab, irinotecan and fluorouracile in fiRst-line treatment of immunologically-selected advanced colorectal cancer patients: the CIFRA study protocol.

Bmc Cancer

Ottaiano, Alessandro A; Scala, Stefania S; Normanno, Nicola N; Napolitano, Maria M; Capozzi, Monica M; Rachiglio, Anna Maria AM; Roma, Cristin C; Trotta, Anna Maria AM; D'Alterio, Crescenzo C; Portella, Luigi L; Romano, Carmela C; Cassata, Antonino A; Casaretti, Rossana R; Silvestro, Lucrezia L; Nappi, Anna A; Tafuto, Salvatore S; Avallone, Antonio A; De Stefano, Alfonso A; Tamburini, Mario M; Picone, Carmine C; Petrillo, Antonella A; Izzo, Francesco F; Palaia, Raffaele R; Albino, Vittorio V; Amore, Alfonso A; Belli, Andrea A; Pace, Ugo U; Di Marzo, Massimiliano M; Chiodini, Paolo P; Botti, Gerardo G; De Feo, Gianfranco G; Delrio, Paolo P; Nasti, Guglielmo G

Publication Date: 2019-09-09

Variant appearance in text: NRAS: H131R

PubMed Link: 31500586

Variant Present in the following documents:

• Main text
• 12885_2019_Article_6109.pdf

View BVdb publication page

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Combination of KIR2DS4 and FcγRIIa polymorphisms predicts the response to cetuximab in KRAS mutant metastatic colorectal cancer.

Scientific Reports

Borrero-Palacios, A A; Cebrián, A A; Gómez Del Pulgar, M T MT; García-Carbonero, R R; Garcia-Alfonso, P P; Aranda, E E; Elez, E E; López-López, R R; Cervantes, A A; Valladares, M M; Nadal, C C; Viéitez, J M JM; Guillén-Ponce, C C; Rodríguez, J J; Hernández, I I; García, J L JL; Vega-Bravo, R R; Puime-Otin, A A; Martínez-Useros, J J; Del Puerto-Nevado, L L; Rincón, R R; Rodríguez-Remírez, M M; Rojo, F F; García-Foncillas, J J

Publication Date: 2019-02-22

Variant appearance in text: NRAS: H131R

PubMed Link: 30796344

Variant Present in the following documents:

• Main text
• 41598_2019_Article_39291.pdf

View BVdb publication page

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Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One

Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS

Publication Date: 2018

Variant appearance in text: NRAS: H131R

PubMed Link: 29698444

Variant Present in the following documents:

• pone.0196434.s001.xlsx, sheet 1
• pone.0196434.s001.xlsx, sheet 3
• pone.0196434.s001.xlsx, sheet 2

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Rationale for combination of therapeutic antibodies targeting tumor cells and immune checkpoint receptors: Harnessing innate and adaptive immunity through IgG1 isotype immune effector stimulation.

Cancer Treatment Reviews

Ferris, Robert L RL; Lenz, Heinz-Josef HJ; Trotta, Anna Maria AM; García-Foncillas, Jesús J; Schulten, Jeltje J; Audhuy, François F; Merlano, Marco M; Milano, Gerard G

Publication Date: 2018-02

Variant appearance in text: NRAS: H131R

PubMed Link: 29223828

Variant Present in the following documents:

• Main text
• nihms-1623487.pdf

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Insights from animal models of bladder cancer: recent advances, challenges, and opportunities.

Oncotarget

John, Bincy Anu BA; Said, Neveen N

Publication Date: 2017-08-22

Variant appearance in text: NRAS: H131R

PubMed Link: 28915710

Variant Present in the following documents:

• Main text
• oncotarget-08-57766.pdf

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NF1-mutated melanoma tumors harbor distinct clinical and biological characteristics.

Molecular Oncology

Cirenajwis, Helena H; Lauss, Martin M; Ekedahl, Henrik H; Törngren, Therese T; Kvist, Anders A; Saal, Lao H LH; Olsson, Håkan H; Staaf, Johan J; Carneiro, Ana A; Ingvar, Christian C; Harbst, Katja K; Hayward, Nicholas K NK; Jönsson, Göran G

Publication Date: 2017-04

Variant appearance in text: NRAS: 392A>G; H131R

PubMed Link: 28267273

Variant Present in the following documents:

• MOL2-11-438-s003.xls, sheet 1

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Prognostic and predictive biomarkers in metastatic colorectal cancer anti-EGFR therapy.

World Journal Of Gastroenterology

Lo Nigro, Cristiana C; Ricci, Vincenzo V; Vivenza, Daniela D; Granetto, Cristina C; Fabozzi, Teresa T; Miraglio, Emanuela E; Merlano, Marco C MC

Publication Date: 2016-08-14

Variant appearance in text: NRAS: H131R

PubMed Link: 27570430

Variant Present in the following documents:

• Main text

View BVdb publication page

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A Landscape of Pharmacogenomic Interactions in Cancer.

Cell

Iorio, Francesco F; Knijnenburg, Theo A TA; Vis, Daniel J DJ; Bignell, Graham R GR; Menden, Michael P MP; Schubert, Michael M; Aben, Nanne N; Gonçalves, Emanuel E; Barthorpe, Syd S; Lightfoot, Howard H; Cokelaer, Thomas T; Greninger, Patricia P; van Dyk, Ewald E; Chang, Han H; de Silva, Heshani H; Heyn, Holger H; Deng, Xianming X; Egan, Regina K RK; Liu, Qingsong Q; Mironenko, Tatiana T; Mitropoulos, Xeni X; Richardson, Laura L; Wang, Jinhua J; Zhang, Tinghu T; Moran, Sebastian S; Sayols, Sergi S; Soleimani, Maryam M; Tamborero, David D; Lopez-Bigas, Nuria N; Ross-Macdonald, Petra P; Esteller, Manel M; Gray, Nathanael S NS; Haber, Daniel A DA; Stratton, Michael R MR; Benes, Cyril H CH; Wessels, Lodewyk F A LFA; Saez-Rodriguez, Julio J; McDermott, Ultan U; Garnett, Mathew J MJ

Publication Date: 2016-07-28

Variant appearance in text: NRAS: 392A>G; H131R

PubMed Link: 27397505

Variant Present in the following documents:

• mmc3.xlsx, sheet 3

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Evaluation of antibody-dependent cell-mediated cytotoxicity activity and cetuximab response in KRAS wild-type metastatic colorectal cancer patients.

World Journal Of Gastrointestinal Oncology

Lo Nigro, Cristiana C; Ricci, Vincenzo V; Vivenza, Daniela D; Monteverde, Martino M; Strola, Giuliana G; Lucio, Francesco F; Tonissi, Federica F; Miraglio, Emanuela E; Granetto, Cristina C; Fortunato, Mirella M; Merlano, Marco Carlo MC

Publication Date: 2016-02-15

Variant appearance in text: NRAS: H131R

PubMed Link: 26909137

Variant Present in the following documents:

• Main text

View BVdb publication page

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LowMACA: exploiting protein family analysis for the identification of rare driver mutations in cancer.

Bmc Bioinformatics

Melloni, Giorgio E M GE; de Pretis, Stefano S; Riva, Laura L; Pelizzola, Mattia M; Céol, Arnaud A; Costanza, Jole J; Müller, Heiko H; Zammataro, Luca L

Publication Date: 2016-02-09

Variant appearance in text: NRAS: H131R

PubMed Link: 26860319

Variant Present in the following documents:

• 12859_2016_935_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Recurrent inactivating RASA2 mutations in melanoma.

Nature Genetics

Arafeh, Rand R; Qutob, Nouar N; Emmanuel, Rafi R; Keren-Paz, Alona A; Madore, Jason J; Elkahloun, Abdel A; Wilmott, James S JS; Gartner, Jared J JJ; Di Pizio, Antonella A; Winograd-Katz, Sabina S; Sindiri, Sivasish S; Rotkopf, Ron R; Dutton-Regester, Ken K; Johansson, Peter P; Pritchard, Antonia L AL; Waddell, Nicola N; Hill, Victoria K VK; Lin, Jimmy C JC; Hevroni, Yael Y; Rosenberg, Steven A SA; Khan, Javed J; Ben-Dor, Shifra S; Niv, Masha Y MY; Ulitsky, Igor I; Mann, Graham J GJ; Scolyer, Richard A RA; Hayward, Nicholas K NK; Samuels, Yardena Y

Publication Date: 2015-12

Variant appearance in text: NRAS: 392A>G; H131R

PubMed Link: 26502337

Variant Present in the following documents:

• NIHMS65345-supplement-Supplementary_table_3.xlsx, sheet 1
• NIHMS65345-supplement-Supplementary_table_1.xlsx, sheet 1

View BVdb publication page

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A highly recurrent RPS27 5'UTR mutation in melanoma.

Oncotarget

Dutton-Regester, Ken K; Gartner, Jared J JJ; Emmanuel, Rafi R; Qutob, Nouar N; Davies, Michael A MA; Gershenwald, Jeffrey E JE; Robinson, William W; Robinson, Steven S; Rosenberg, Steven A SA; Scolyer, Richard A RA; Mann, Graham J GJ; Thompson, John F JF; Hayward, Nicholas K NK; Samuels, Yardena Y

Publication Date: 2014-05-30

Variant appearance in text: NRAS: 392A>G; H131R

PubMed Link: 24913145

Variant Present in the following documents:

• oncotarget-05-2912-s003.xlsx, sheet 1

View BVdb publication page

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FCGR2A and FCGR3A polymorphisms and clinical outcome in metastatic colorectal cancer patients treated with first-line 5-fluorouracil/folinic acid and oxaliplatin +/- cetuximab.

Bmc Cancer

Kjersem, Janne B JB; Skovlund, Eva E; Ikdahl, Tone T; Guren, Tormod T; Kersten, Christian C; Dalsgaard, Astrid M AM; Yilmaz, Mette K MK; Fokstuen, Tone T; Tveit, Kjell M KM; Kure, Elin H EH

Publication Date: 2014-05-19

Variant appearance in text: NRAS: H131R

PubMed Link: 24884501

Variant Present in the following documents:

• Main text
• 1471-2407-14-340.pdf

View BVdb publication page

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Genetic and immune factors underlying the efficacy of cetuximab and panitumumab in the treatment of patients with metastatic colorectal cancer.

Contemporary Oncology (Poznan, Poland)

Krawczyk, Paweł Adam PA; Kowalski, Dariusz M DM

Publication Date: 2014

Variant appearance in text: NRAS: H131R

PubMed Link: 24876815

Variant Present in the following documents:

• Main text

View BVdb publication page

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A meta-analysis of somatic mutations from next generation sequencing of 241 melanomas: a road map for the study of genes with potential clinical relevance.

Molecular Cancer Therapeutics

Xia, Junfeng J; Jia, Peilin P; Hutchinson, Katherine E KE; Dahlman, Kimberly B KB; Johnson, Douglas D; Sosman, Jeffrey J; Pao, William W; Zhao, Zhongming Z

Publication Date: 2014-07

Variant appearance in text: NRAS: 392A>G; H131R

PubMed Link: 24755198

Variant Present in the following documents:

• Main text

View BVdb publication page

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Integrating anti-EGFR therapies in metastatic colorectal cancer.

Journal Of Gastrointestinal Oncology

Haraldsdottir, Sigurdis S; Bekaii-Saab, Tanios T

Publication Date: 2013-09

Variant appearance in text: NRAS: H131R

PubMed Link: 23997940

Variant Present in the following documents:

• Main text

View BVdb publication page

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A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer.

Journal Of Hematology & Oncology

Mellor, James D JD; Brown, Michael P MP; Irving, Helen R HR; Zalcberg, John R JR; Dobrovic, Alexander A

Publication Date: 2013-01-04

Variant appearance in text: NRAS: His131Arg

PubMed Link: 23286345

Variant Present in the following documents:

• Main text
• 1756-8722-6-1.pdf

View BVdb publication page

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