Variant ID: 1-115256529-T-C

NM_002524.4(NRAS):c.182A>G;(p.Gln61Arg)

This variant was identified in 674 publications




Publications:


Comparison of BRAF Mutation Screening Strategies in a Large Real-Life Series of Advanced Melanoma Patients.

Journal Of Clinical Medicine
M Colombino, C Rozzo, P Paliogiannis, M Casula, A Manca, V Doneddu, MA Fedeli, MC Sini, G Palomba, M Pisano, PA Ascierto, C Caracò, A Lissia, A Cossu, G Palmieri
Publication Date: 2020-07-30

Variant appearance in text: NRAS: Q61R
PMID: 32751423
View BVdb publication page



Personalized Treatment Selection and Disease Monitoring Using Circulating Tumor DNA Profiling in Real-World Cancer Patient Management.

Diagnostics (Basel, Switzerland)
J Wehrle, U Philipp, M Jolic, M Follo, S Hussung, S Waldeck, M Deuter, M Rassner, J Braune, J Rawluk, C Greil, CF Waller, H Becker, J Duque-Afonso, AL Illert, RM Fritsch, F Meiss, J Duyster, N von Bubnoff, F Scherer
Publication Date: 2020-08-02

Variant appearance in text: NRAS: Q61R
PMID: 32748806
View BVdb publication page



Plasmacytoid Dendritic Cell Impairment in Metastatic Melanoma by Lactic Acidosis.

Cancers
M Monti, R Vescovi, F Consoli, D Farina, D Moratto, A Berruti, C Specchia, W Vermi
Publication Date: 2020-07-28

Variant appearance in text: NRAS: Q61R
PMID: 32731406
View BVdb publication page



Study of Ras Mutations' Prognostic Value in Metastatic Colorectal Cancer: STORIA Analysis.

Cancers
A Ottaiano, N Normanno, S Facchini, A Cassata, A Nappi, C Romano, L Silvestro, A De Stefano, AM Rachiglio, C Roma, MR Maiello, S Scala, P Delrio, F Tatangelo, A Di Mauro, G Botti, A Avallone, G Nasti
Publication Date: 2020-07-16

Variant appearance in text: NRAS: Q61R
PMID: 32708575
View BVdb publication page



Mutational spectrum and prognosis in NRAS-mutated acute myeloid leukemia.

Scientific Reports
S Wang, Z Wu, T Li, Y Li, W Wang, Q Hao, X Xie, D Wan, Z Jiang, C Wang, Y Liu
Publication Date: 2020-07-22

Variant appearance in text: NRAS: Q61R
PMID: 32699322
View BVdb publication page



The Current State of Molecular Testing in the BRAF-Mutated Melanoma Landscape.

Frontiers In Molecular Biosciences
I Vanni, ET Tanda, F Spagnolo, V Andreotti, W Bruno, P Ghiorzo
Publication Date: 2020

Variant appearance in text: NRAS: Q61R
PMID: 32695793
View BVdb publication page



Ovarian mesonephric-like adenocarcinoma arising in serous borderline tumor: a case report with complex morphological and molecular analysis.

Diagnostic Pathology
P Dundr, M Gregová, K Němejcová, M Bártů, N Hájková, J Hojný, I Stružinská, D Fischerová
Publication Date: 2020-07-21

Variant appearance in text: NRAS: Q61R
PMID: 32693840
View BVdb publication page



Circulating Tumour DNA Is an Independent Prognostic Biomarker for Survival in Metastatic BRAF or NRAS-Mutated Melanoma Patients.

Cancers
G Herbreteau, A Vallée, AC Knol, S Théoleyre, G Quéreux, C Frénard, E Varey, P Hofman, A Khammari, B Dréno, MG Denis
Publication Date: 2020-07-11

Variant appearance in text: NRAS: 182A>G; Q61R
PMID: 32664549
View BVdb publication page



Comprehensive Assessment of TERT mRNA Expression across a Large Cohort of Benign and Malignant Thyroid Tumours.

Cancers
A Pestana, R Batista, R Celestino, S Canberk, M Sobrinho-Simões, P Soares
Publication Date: 2020-07-09

Variant appearance in text: NRAS: Q61R
PMID: 32659948
View BVdb publication page



Mutation profile of primary subungual melanomas in Caucasians.

Oncotarget
A Borkowska, A Szumera-Ciećkiewicz, M Spałek, P Teterycz, A Czarnecka, A Kowalik, P Rutkowski
Publication Date: 2020-06-23

Variant appearance in text: NRAS: 182A>G; Q61R
PMID: 32637031
View BVdb publication page



BRAF inhibition in melanoma is associated with the dysregulation of histone methylation and histone methyltransferases.

Neoplasia (New York, N.Y.)
F Grigore, H Yang, ND Hanson, MW VanBrocklin, AL Sarver, JP Robinson
Publication Date: 2020-07-03

Variant appearance in text: NRAS: Q61R
PMID: 32629178
View BVdb publication page



Clinicopathological Characteristics and Mutation Spectrum of Colorectal Adenocarcinoma With Mucinous Component in a Chinese Cohort: Comparison With Classical Adenocarcinoma.

Frontiers In Oncology
J Chen, L Zhou, J Gao, T Lu, J Wang, H Wu, Z Liang
Publication Date: 2020

Variant appearance in text: NRAS: Q61R
PMID: 32582557
View BVdb publication page



Reassessing the role of high dose cytarabine and mitoxantrone in relapsed/refractory acute myeloid leukemia.

Oncotarget
J Canaani, M Nagar, G Heering, C Gefen, R Yerushalmi, N Shem-Tov, Y Volchek, D Merkel, A Avigdor, A Shimoni, N Amariglio, G Rechavi, A Nagler
Publication Date: 2020-06-09

Variant appearance in text: NRAS: Q61R
PMID: 32577167
View BVdb publication page



Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver.

Cell
M Rodríguez-Martínez, T Boissiére, MN Gonzalez, K Litchfield, R Mitter, J Walker, S Kjœr, M Ismail, J Downward, C Swanton, JQ Svejstrup
Publication Date: 2020-06-11

Variant appearance in text: NRAS: Q61R
PMID: 32531245
View BVdb publication page



Inflammatory Cytokines and ctDNA Are Biomarkers for Progression in Advanced-Stage Melanoma Patients Receiving Checkpoint Inhibitors.

Cancers
JG Pedersen, AT Madsen, KR Gammelgaard, N Aggerholm-Pedersen, BS Sørensen, TH Øllegaard, MR Jakobsen
Publication Date: 2020-05-30

Variant appearance in text: NRAS: Q61R
PMID: 32486146
View BVdb publication page



A novel NGS-based microsatellite instability (MSI) status classifier with 9 loci for colorectal cancer patients.

Journal Of Translational Medicine
K Zheng, H Wan, J Zhang, G Shan, N Chai, D Li, N Fang, L Liu, J Zhang, R Du, Q Wu, X Li, C Zhang
Publication Date: 2020-05-28

Variant appearance in text: NRAS: Q61R
PMID: 32466784
View BVdb publication page



17-Aminogeldanamycin Inhibits Constitutive Nuclear Factor-Kappa B (NF-κB) Activity in Patient-Derived Melanoma Cell Lines.

International Journal Of Molecular Sciences
ML Hartman, M Rogut, A Mielczarek-Lewandowska, M Wozniak, M Czyz
Publication Date: 2020-05-26

Variant appearance in text: NRAS: Q61R
PMID: 32466509
View BVdb publication page



New insights into classification and risk stratification of encapsulated thyroid tumors with a predominantly papillary architecture.

Journal Of Pathology And Translational Medicine
CK Jung, SY Park, JH Kim, K Kakudo
Publication Date: 2020-05

Variant appearance in text: NRAS: Q61R
PMID: 32460473
View BVdb publication page



Application of Next-Generation Sequencing for the Genomic Characterization of Patients with Smoldering Myeloma.

Cancers
M Manzoni, V Marchica, P Storti, B Ziccheddu, G Sammarelli, G Todaro, F Pelizzoni, S Salerio, L Notarfranchi, A Pompa, L Baldini, N Bolli, A Neri, N Giuliani, M Lionetti
Publication Date: 2020-05-23

Variant appearance in text: NRAS: Q61R
PMID: 32456143
View BVdb publication page



Metabolic Reprogramming in Metastatic Melanoma with Acquired Resistance to Targeted Therapies: Integrative Metabolomic and Proteomic Analysis.

Cancers
L Soumoy, C Schepkens, M Krayem, A Najem, V Tagliatti, GE Ghanem, S Saussez, JM Colet, F Journe
Publication Date: 2020-05-22

Variant appearance in text: NRAS: Q61R
PMID: 32455924
View BVdb publication page



Giant congenital melanocytic nevus of the scalp: from clinical-histological to molecular diagnosis.

Hereditas
Y Sun, Y Zou, L Wang, H Gu, Q Cen, H Chen, X Lin, R Cai
Publication Date: 2020-05-19

Variant appearance in text: NRAS: Q61R
PMID: 32430073
View BVdb publication page



Differential responsiveness to BRAF inhibitors of melanoma cell lines BRAF V600E-mutated.

Journal Of Translational Medicine
M Al Hashmi, KS Sastry, L Silcock, L Chouchane, V Mattei, N James, R Mathew, D Bedognetti, V De Giorgi, D Murtas, W Liu, A Chouchane, R Temanni, B Seliger, E Wang, FM Marincola, S Tomei
Publication Date: 2020-05-11

Variant appearance in text: NRAS: Q61R
PMID: 32393282
View BVdb publication page



Ultra-high throughput single-cell analysis of proteins and RNAs by split-pool synthesis.

Communications Biology
M O'Huallachain, FA Bava, M Shen, C Dallett, S Paladugu, N Samusik, S Yu, R Hussein, GR Hillman, S Higgins, M Lou, A Trejo, L Qin, YC Tai, SM Kinoshita, A Jager, D Lashkari, Y Goltsev, S Ozturk, GP Nolan
Publication Date: 2020-05-07

Variant appearance in text: NRAS: Q61R
PMID: 32382044
View BVdb publication page



RAS Mutational Status Detection in Tissue, Plasma, and Stool Samples for Colorectal Cancer.

Biomed Research International
L Zhu, Y Wang, Y Zhou, Q Dong, Y Liu, J Zhang
Publication Date: 2020

Variant appearance in text: NRAS: Q61R
PMID: 32351996
View BVdb publication page



Impact of the Italian Society of Anatomic Pathology and Diagnostic Cytology Classification of Thyroid Nodules in the Treatment of Indeterminate Follicular Lesions: Five-Year Results at a Single Center.

International Journal Of Endocrinology
M Pastoricchio, A Cubisino, A Lanzaro, M Troian, F Zanconati, S Bernardi, B Fabris, N de Manzini, C Dobrinja
Publication Date: 2020

Variant appearance in text: NRAS: Q61R
PMID: 32351561
View BVdb publication page



The role of AIP variants in pituitary adenomas and concomitant thyroid carcinomas in the Netherlands: a nationwide pathology registry (PALGA) study.

Endocrine
EC Coopmans, A Muhammad, AF Daly, WW de Herder, FJ van Kemenade, A Beckers, M de Haan, AJ van der Lely, E Korpershoek, SJCMM Neggers
Publication Date: 2020-04-24

Variant appearance in text: NRAS: Q61R
PMID: 32333269
View BVdb publication page



COX-2 as a potential biomarker and therapeutic target in melanoma.

Cancer Biology & Medicine
DV Tudor, I Bâldea, M Lupu, T Kacso, E Kutasi, A Hopârtean, R Stretea, A Gabriela Filip
Publication Date: 2020-02-15

Variant appearance in text: NRAS: Q61R
PMID: 32296574
View BVdb publication page



Spatially resolved analyses link genomic and immune diversity and reveal unfavorable neutrophil activation in melanoma.

Nature Communications
A Mitra, MC Andrews, W Roh, MP De Macedo, CW Hudgens, F Carapeto, S Singh, A Reuben, F Wang, X Mao, X Song, K Wani, S Tippen, KS Ng, A Schalck, DA Sakellariou-Thompson, E Chen, SM Reddy, CN Spencer, D Wiesnoski, LD Little, C Gumbs, ZA Cooper, EM Burton, P Hwu, MA Davies, J Zhang, C Bernatchez, N Navin, P Sharma, JP Allison, JA Wargo, C Yee, MT Tetzlaff, WJ Hwu, AJ Lazar, PA Futreal
Publication Date: 2020-04-15

Variant appearance in text: NRAS: Q61R
PMID: 32296058
View BVdb publication page



Amplicon-Based NGS Panels for Actionable Cancer Target Identification in Follicular Cell-Derived Thyroid Neoplasia.

Frontiers In Endocrinology
MB Madsen, K Kiss, F Cilius Nielsen, FN Bennedbæk, M Rossing
Publication Date: 2020

Variant appearance in text: NRAS: Q61R
PMID: 32265839
View BVdb publication page



Pre-analytical factors affecting the establishment of a single tube assay for multiparameter liquid biopsy detection in melanoma patients.

Molecular Oncology
S Schneegans, L Lück, K Besler, L Bluhm, JC Stadler, J Staub, R Greinert, B Volkmer, M Kubista, C Gebhardt, A Sartori, D Irwin, E Serkkola, T Af Hällström, E Lianidou, M Sprenger-Haussels, M Hussong, P Mohr, SW Schneider, J Shaffer, K Pantel, H Wikman
Publication Date: 2020-04-04

Variant appearance in text: NRAS: 182A>G; Q61R
PMID: 32246814
View BVdb publication page



Targeted chemotherapy overcomes drug resistance in melanoma.

Genes & Development
J Yue, R Vendramin, F Liu, O Lopez, MG Valencia, H Gomes Dos Santos, G Gaidosh, F Beckedorff, E Blumenthal, L Speroni, SD Nimer, JC Marine, R Shiekhattar
Publication Date: 2020-04-02

Variant appearance in text: NRAS: Q61R
PMID: 32241802
View BVdb publication page



Combinatorial Therapies in Thyroid Cancer: An Overview of Preclinical and Clinical Progresses.

Cells
G Laetitia, S Sven, J Fabrice
Publication Date: 2020-03-30

Variant appearance in text: NRAS: 182A>G
PMID: 32235612
View BVdb publication page



Comparison of Somatic Mutation Profiles Between Formalin-Fixed Paraffin Embedded Tissues and Plasma Cell-Free DNA from Ovarian Cancer Patients Before and After Surgery.

Bioresearch Open Access
M Jagelkova, K Zelinova, Z Laucekova, M Bobrovska, Z Dankova, M Grendar, K Dokus
Publication Date: 2020

Variant appearance in text: NRAS: 182A>G
PMID: 32219013
View BVdb publication page



Molecular subtypes in canine hemangiosarcoma reveal similarities with human angiosarcoma.

Plos One
G Wang, M Wu, AC Durham, E Radaelli, NJ Mason, X Xu, DB Roth
Publication Date: 2020

Variant appearance in text: NRAS: Q61R
PMID: 32210430
View BVdb publication page



RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML.

Blood Advances
AL Brown, P Arts, CL Carmichael, M Babic, J Dobbins, CE Chong, AW Schreiber, J Feng, K Phillips, PPS Wang, T Ha, CC Homan, SL King-Smith, L Rawlings, C Vakulin, A Dubowsky, J Burdett, S Moore, G McKavanagh, D Henry, A Wells, B Mercorella, M Nicola, J Suttle, E Wilkins, XC Li, J Michaud, P Brautigan, P Cannon, M Altree, L Jaensch, M Fine, C Butcher, RJ D'Andrea, ID Lewis, DK Hiwase, E Papaemmanuil, MS Horwitz, G Natsoulis, HY Rienhoff, N Patton, S Mapp, R Susman, S Morgan, J Cooney, M Currie, U Popat, T Bochtler, S Izraeli, K Bradstock, LA Godley, A Krämer, S Fröhling, AH Wei, C Forsyth, H Mar Fan, NK Poplawski, CN Hahn, HS Scott
Publication Date: 2020-03-24

Variant appearance in text: NRAS: Q61R
PMID: 32208489
View BVdb publication page



Prognostic implications of EGFR protein expression in sporadic colorectal tumors: Correlation with copy number status, mRNA levels and miRNA regulation.

Scientific Reports
S Del Carmen, LA Corchete, R Gervas, A Rodriguez, M Garcia, JA Álcazar, J García, O Bengoechea, L Muñoz-Bellvis, JM Sayagués, M Abad
Publication Date: 2020-03-13

Variant appearance in text: NRAS: Q61R
PMID: 32170146
View BVdb publication page



Immune-awakening revealed by peripheral T cell dynamics after one cycle of immunotherapy.

Nature Cancer
S Valpione, E Galvani, J Tweedy, PA Mundra, A Banyard, P Middlehurst, J Barry, S Mills, Z Salih, J Weightman, A Gupta, G Gremel, F Baenke, N Dhomen, PC Lorigan, R Marais
Publication Date: 2020-02

Variant appearance in text: NRAS: Q61R
PMID: 32110781
View BVdb publication page



Characterizations of Gene Alterations in Melanoma Patients from Chinese Population.

Biomed Research International
Y Luo, Z Zhang, J Liu, L Li, X Xu, X Yao, Z Dai, X Wang, S Yang, H Wu, J Bu, Y Wu, T Xiang, X Li
Publication Date: 2020

Variant appearance in text: NRAS: Q61R
PMID: 32083130
View BVdb publication page



Loss of both CDKN2A and CDKN2B allows for centrosome overduplication in melanoma.

The Journal Of Investigative Dermatology
S Patel, CJ Wilkinson, EV Sviderskaya
Publication Date: 2020-02-14

Variant appearance in text: NRAS: Q61R
PMID: 32067956
View BVdb publication page



The paradox of cancer genes in non-malignant conditions: implications for precision medicine.

Genome Medicine
JJ Adashek, S Kato, SM Lippman, R Kurzrock
Publication Date: 2020-02-17

Variant appearance in text: NRAS: Q61R
PMID: 32066498
View BVdb publication page



Malignant struma ovarii with a robust response to radioactive iodine.

Endocrinology, Diabetes & Metabolism Case Reports
ML Gild, L Heath, JY Paik, RJ Clifton-Bligh, BG Robinson
Publication Date: 2020-02-14

Variant appearance in text: NRAS: Q61R
PMID: 32061155
View BVdb publication page



The "ART" of Epigenetics in Melanoma: From histone "Alterations, to Resistance and Therapies".

Theranostics
T Strub, R Ballotti, C Bertolotto
Publication Date: 2020

Variant appearance in text: NRAS: Q61R
PMID: 32042336
View BVdb publication page



The Susceptibility of Human Melanoma Cells to Infection with the Leningrad-16 Vaccine Strain of Measles Virus.

Viruses
Y Ammour, O Ryabaya, Y Shchetinina, E Prokofeva, M Gavrilova, D Khochenkov, D Vorobyev, E Faizuloev, I Shohin, VV Zverev, O Svitich, T Nasedkina
Publication Date: 2020-02-04

Variant appearance in text: NRAS: 182A>G; Q61R
PMID: 32033013
View BVdb publication page



Kaposiform hemangioendothelioma: current knowledge and future perspectives.

Orphanet Journal Of Rare Diseases
Y Ji, S Chen, K Yang, C Xia, L Li
Publication Date: 2020-02-03

Variant appearance in text: NRAS: Q61R
PMID: 32014025
View BVdb publication page



Assessment of the clinical utility of four NGS panels in myeloid malignancies. Suggestions for NGS panel choice or design.

Plos One
A Aguilera-Diaz, I Vazquez, B Ariceta, A Mañú, Z Blasco-Iturri, S Palomino-Echeverría, MJ Larrayoz, R García-Sanz, MI Prieto-Conde, M Del Carmen Chillón, A Alfonso-Pierola, F Prosper, M Fernandez-Mercado, MJ Calasanz
Publication Date: 2020

Variant appearance in text: NRAS: 182A>G; Gln61Arg
PMID: 31978184
View BVdb publication page



Genetic mutations in lung enteric adenocarcinoma identified using next-generation sequencing.

International Journal Of Clinical And Experimental Pathology
L Lin, W Zhuang, W Wang, C Xu, R Chen, Y Guan, X Yi, Y Shao, Y Tai, Y Chen, M Wu, J Wei, G Chen
Publication Date: 2017

Variant appearance in text: NRAS: Q61R
PMID: 31966835
View BVdb publication page



Evaluation of KRAS, NRAS and BRAF mutations detection in plasma using an automated system for patients with metastatic colorectal cancer.

Plos One
C Franczak, A Witz, K Geoffroy, J Demange, M Rouyer, M Husson, V Massard, C Gavoille, A Lambert, P Gilson, N Gambier, J Scala-Bertola, JL Merlin, A Harlé
Publication Date: 2020

Variant appearance in text: NRAS: Gln61Arg
PMID: 31940389
View BVdb publication page



Diversity spectrum analysis identifies mutation-specific effects of cancer driver genes.

Communications Biology
X Dong, D Huang, X Yi, S Zhang, Z Wang, B Yan, P Chung Sham, K Chen, M Jun Li
Publication Date: 2020-01-07

Variant appearance in text: NRAS: Q61R
PMID: 31925297
View BVdb publication page



AXL and CAV-1 play a role for MTH1 inhibitor TH1579 sensitivity in cutaneous malignant melanoma.

Cell Death And Differentiation
I Das, H Gad, L Bräutigam, L Pudelko, R Tuominen, V Höiom, I Almlöf, V Rajagopal, J Hansson, T Helleday, S Egyházi Brage, U Warpman Berglund
Publication Date: 2020-01-09

Variant appearance in text: NRAS: Q61R
PMID: 31919461
View BVdb publication page



KRAS and NRAS mutational gene profile of metastatic colorectal cancer patients in Jordan.

Plos One
M Awidi, N Ababneh, M Shomaf, F Al Fararjeh, L Owaidi, M AlKhatib, B Al Tarawneh, A Awidi
Publication Date: 2019

Variant appearance in text: NRAS: Q61R
PMID: 31881025
View BVdb publication page



Inotuzumab ozogamicin as chemotherapy-sparing salvage in a 67-year-old man with primary refractory B-cell acute lymphoblastic leukemia with high-risk genomic features.

Leukemia Research Reports
X Yang, F Sen, MB Geyer
Publication Date: 2019

Variant appearance in text: NRAS: Q61R
PMID: 31867204
View BVdb publication page



A Review of Key Biological and Molecular Events Underpinning Transformation of Melanocytes to Primary and Metastatic Melanoma.

Cancers
LA Jackett, RA Scolyer
Publication Date: 2019-12-17

Variant appearance in text: NRAS: Q61R
PMID: 31861163
View BVdb publication page



New insights into intranuclear inclusions in thyroid carcinoma: Association with autophagy and with BRAFV600E mutation.

Plos One
S Schwertheim, S Theurer, H Jastrow, T Herold, S Ting, D Westerwick, S Bertram, CM Schaefer, J Kälsch, HA Baba, KW Schmid
Publication Date: 2019

Variant appearance in text: NRAS: Q61R
PMID: 31841566
View BVdb publication page



Identification of Circulating Genomic and Metabolic Biomarkers in Intrahepatic Cholangiocarcinoma.

Cancers
H Winter, PJ Kaisaki, J Harvey, E Giacopuzzi, MP Ferla, MM Pentony, SJL Knight, RA Sharma, JC Taylor, JSO McCullagh
Publication Date: 2019-11-28

Variant appearance in text: NRAS: 182A>G; Q61R
PMID: 31795195
View BVdb publication page



ctDNA detected by ddPCR reveals changes in tumour load in metastatic malignant melanoma treated with bevacizumab.

Scientific Reports
RB Forthun, R Hovland, C Schuster, H Puntervoll, HP Brodal, HM Namløs, LB Aasheim, LA Meza-Zepeda, BT Gjertsen, S Knappskog, O Straume
Publication Date: 2019-11-25

Variant appearance in text: NRAS: Q61R
PMID: 31767937
View BVdb publication page



VEGF-A and ICAM-1 Gene Polymorphisms as Predictors of Clinical Outcome to First-Line Bevacizumab-Based Treatment in Metastatic Colorectal Cancer.

International Journal Of Molecular Sciences
A Papachristos, P Kemos, T Katsila, E Panoilia, GP Patrinos, H Kalofonos, GB Sivolapenko
Publication Date: 2019-11-18

Variant appearance in text: rs11554290
PMID: 31752122
View BVdb publication page



Discovery of actionable genetic alterations with targeted panel sequencing in children with relapsed or refractory solid tumors.

Plos One
JW Lee, NKD Kim, SH Lee, HW Cho, Y Ma, HY Ju, KH Yoo, KW Sung, HH Koo, WY Park
Publication Date: 2019

Variant appearance in text: NRAS: Q61R
PMID: 31747416
View BVdb publication page



Quantitative monitoring of circulating tumor DNA in patients with advanced pancreatic cancer undergoing chemotherapy.

Cancer Science
M Sugimori, K Sugimori, H Tsuchiya, Y Suzuki, S Tsuyuki, Y Kaneta, A Hirotani, K Sanga, Y Tozuka, S Komiyama, T Sato, S Tezuka, Y Goda, K Irie, H Miwa, Y Miura, T Ishii, T Kaneko, M Nagahama, W Shibata, A Nozaki, S Maeda
Publication Date: 2019-11-19

Variant appearance in text: NRAS: Q61R
PMID: 31746520
View BVdb publication page



A comprehensive evaluation of pathogenic mutations in primary cutaneous melanomas, including the identification of novel loss-of-function variants.

Scientific Reports
I Ticha, J Hojny, R Michalkova, O Kodet, E Krkavcova, N Hajkova, K Nemejcova, M Bartu, R Jaksa, M Dura, M Kanwal, AS Martinikova, L Macurek, P Zemankova, Z Kleibl, P Dundr
Publication Date: 2019-11-19

Variant appearance in text: NRAS: Q61R
PMID: 31745173
View BVdb publication page



Rational combination therapy for melanoma with dinaciclib by targeting BAK-dependent cell death.

Molecular Cancer Therapeutics
X Xu, S Eshima, S Kato, DE Fisher, H Sakurai, Y Hayakawa, S Yokoyama
Publication Date: 2019-11-19

Variant appearance in text: NRAS: Q61R
PMID: 31744894
View BVdb publication page



A versatile ES cell-based melanoma mouse modeling platform.

Cancer Research
I Bok, O Vera, X Xu, N Jasani, K Nakamura, J Reff, A Nenci, JG Gonzalez, FA Karreth
Publication Date: 2019-11-19

Variant appearance in text: NRAS: Q61R
PMID: 31744817
View BVdb publication page



Targeting melanoma's MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors.

Nature Communications
MJ Sale, E Minihane, NR Monks, R Gilley, FM Richards, KP Schifferli, CL Andersen, EJ Davies, MA Vicente, E Ozono, A Markovets, JR Dry, L Drew, V Flemington, T Proia, DI Jodrell, PD Smith, SJ Cook
Publication Date: 2019-11-14

Variant appearance in text: NRAS: Q61R
PMID: 31727888
View BVdb publication page



Accurate detection of KRAS, NRAS and BRAF mutations in metastatic colorectal cancers by bridged nucleic acid-clamp real-time PCR.

Bmc Medical Genomics
Y Nagakubo, Y Hirotsu, K Amemiya, T Oyama, H Mochizuki, M Omata
Publication Date: 2019-11-11

Variant appearance in text: NRAS: Q61R
PMID: 31711486
View BVdb publication page



Cell cycle regulatory markers in melanoma: New strategies in diagnosis and treatment.

Medical Journal Of The Islamic Republic Of Iran
N Afrang, M Honardoost
Publication Date: 2019

Variant appearance in text: NRAS: Q61R
PMID: 31696090
View BVdb publication page



A Comparative Analysis of Individual RAS Mutations in Cancer Biology.

Frontiers In Oncology
C Muñoz-Maldonado, Y Zimmer, M Medová
Publication Date: 2019

Variant appearance in text: NRAS: Q61R
PMID: 31681616
View BVdb publication page



Revised criteria for diagnosis of NIFTP reveals a better correlation with tumor biological behavior.

Endocrine Connections
ACJ Paniza, TB Mendes, MDB Vianna, DMD Thomaz, P Chiappini, GA Colazza-Gama, SC Lindsey, MB de Carvalho, VAF Alves, O Curione, AU Bastos, JM Cerutti
Publication Date: 2019-10-01

Variant appearance in text: NRAS: Q61R
PMID: 31671409
View BVdb publication page



Whole-Exome Sequencing of Matched Primary and Metastatic Papillary Thyroid Cancer.

Thyroid : Official Journal Of The American Thyroid Association
T Masoodi, AK Siraj, S Siraj, S Azam, Z Qadri, WN Albalawy, SK Parvathareddy, SS Al-Sobhi, F Al-Dayel, FS Alkuraya, KS Al-Kuraya
Publication Date: 2019-12-04

Variant appearance in text: NRAS: Q61R
PMID: 31668133
View BVdb publication page



Inhibitors of HSP90 in melanoma.

Apoptosis : An International Journal On Programmed Cell Death
A Mielczarek-Lewandowska, ML Hartman, M Czyz
Publication Date: 2019-10-28

Variant appearance in text: NRAS: Q61R
PMID: 31659567
View BVdb publication page



The Oncogenic Signaling Pathways in BRAF-Mutant Melanoma Cells are Modulated by Naphthalene Diimide-Like G-Quadruplex Ligands.

Cells
M Recagni, M Tassinari, F Doria, G Cimino-Reale, N Zaffaroni, M Freccero, M Folini, SN Richter
Publication Date: 2019-10-18

Variant appearance in text: NRAS: Q61R
PMID: 31635389
View BVdb publication page



TYRP1 mRNA level is stable and MITF-M-independent in drug-naïve, vemurafenib- and trametinib-resistant BRAFV600E melanoma cells.

Archives Of Dermatological Research
ML Hartman, M Czyz
Publication Date: 2019-10-17

Variant appearance in text: NRAS: Q61R
PMID: 31624899
View BVdb publication page



The Antitumor Effect of Lipophilic Bisphosphonate BPH1222 in Melanoma Models: The Role of the PI3K/Akt Pathway and the Small G Protein Rheb.

International Journal Of Molecular Sciences
D Rittler, M Baranyi, E Molnár, T Garay, I Jalsovszky, IK Varga, L Hegedűs, C Aigner, J Tóvári, J Tímár, B Hegedűs
Publication Date: 2019-10-03

Variant appearance in text: NRAS: Q61R
PMID: 31623406
View BVdb publication page



CRISPR-Cas9 Knockdown and Induced Expression of CD133 Reveal Essential Roles in Melanoma Invasion and Metastasis.

Cancers
CM Simbulan-Rosenthal, R Dougherty, S Vakili, AM Ferraro, LW Kuo, R Alobaidi, L Aljehane, A Gaur, P Sykora, E Glasgow, S Agarwal, DS Rosenthal
Publication Date: 2019-10-03

Variant appearance in text: NRAS: Q61R
PMID: 31623313
View BVdb publication page



Limited Utility of Circulating Cell-Free DNA Integrity as a Diagnostic Tool for Differentiating Between Malignant and Benign Thyroid Nodules With Indeterminate Cytology (Bethesda Category III).

Frontiers In Oncology
S Thakur, A Tobey, B Daley, S Auh, M Walter, D Patel, N Nilubol, E Kebebew, A Patel, K Jensen, V Vasko, J Klubo-Gwiezdzinska
Publication Date: 2019

Variant appearance in text: NRAS: Q61R
PMID: 31620364
View BVdb publication page



Detection of ctDNA in the plasma of patients with papillary thyroid carcinoma.

Experimental And Therapeutic Medicine
H Li, J Zhao, J Zhang, C Wang, M Li, S Wu, Z Su, Q Pan
Publication Date: 2019-11

Variant appearance in text: NRAS: Q61R
PMID: 31602213
View BVdb publication page



In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site.

Leukemia
A Chaturvedi, R Goparaju, C Gupta, J Weder, T Klünemann, MM Araujo Cruz, A Kloos, K Goerlich, R Schottmann, B Othman, EA Struys, H Bähre, D Grote-Koska, K Brand, A Ganser, M Preller, M Heuser
Publication Date: 2019-10-04

Variant appearance in text: NRAS: Q61R
PMID: 31586149
View BVdb publication page



Investigating the role of immunotherapy in advanced/recurrent female genital tract melanoma: a preliminary experience.

Journal Of Gynecologic Oncology
A Indini, L Di Guardo, C Cimminiello, D Lorusso, F Raspagliesi, M Del Vecchio
Publication Date: 2019-11

Variant appearance in text: NRAS: Q61R
PMID: 31576688
View BVdb publication page



A genome-wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS-mutant melanoma.

Pigment Cell & Melanoma Research
A Nagler, DW Vredevoogd, M Alon, PF Cheng, S Trabish, S Kalaora, R Arafeh, V Goldin, MP Levesque, DS Peeper, Y Samuels
Publication Date: 2019-09-24

Variant appearance in text: NRAS: Q61R
PMID: 31549767
View BVdb publication page



Analytical Evaluation of an NGS Testing Method for Routine Molecular Diagnostics on Melanoma Formalin-Fixed, Paraffin-Embedded Tumor-Derived DNA.

Diagnostics (Basel, Switzerland)
I Mancini, L Simi, F Salvianti, F Castiglione, G Sonnati, P Pinzani
Publication Date: 2019-09-12

Variant appearance in text: NRAS: Gln61Arg
PMID: 31547467
View BVdb publication page



Clinical-pathological issues in thyroid pathology: study on the routine application of NIFTP diagnostic criteria.

Scientific Reports
V Canini, D Leni, AI Pincelli, M Scardilli, M Garancini, C Villa, C Di Bella, G Capitoli, R Cimini, BE Leone, F Pagni
Publication Date: 2019-09-12

Variant appearance in text: NRAS: q61r
PMID: 31515532
View BVdb publication page



Detection of NRAS mutation in cell-free DNA biological fluids from patients with kaposiform lymphangiomatosis.

Orphanet Journal Of Rare Diseases
M Ozeki, Y Aoki, A Nozawa, S Yasue, S Endo, Y Hori, K Matsuoka, T Niihori, R Funayama, M Shirota, K Nakayama, T Fukao
Publication Date: 2019-09-11

Variant appearance in text: NRAS: Q61R
PMID: 31511039
View BVdb publication page



Combining ERBB family and MET inhibitors is an effective therapeutic strategy in cutaneous malignant melanoma independent of BRAF/NRAS mutation status.

Cell Death & Disease
I Das, M Wilhelm, V Höiom, R Franco Marquez, F Costa Svedman, J Hansson, R Tuominen, S Egyhàzi Brage
Publication Date: 2019-09-10

Variant appearance in text: NRAS: Q61R
PMID: 31506424
View BVdb publication page



Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers.

Nature Medicine
AR Parikh, I Leshchiner, L Elagina, L Goyal, C Levovitz, G Siravegna, D Livitz, K Rhrissorrakrai, EE Martin, EE Van Seventer, M Hanna, K Slowik, F Utro, CJ Pinto, A Wong, BP Danysh, FF de la Cruz, IJ Fetter, B Nadres, HA Shahzade, JN Allen, LS Blaszkowsky, JW Clark, B Giantonio, JE Murphy, RD Nipp, E Roeland, DP Ryan, CD Weekes, EL Kwak, JE Faris, JY Wo, F Aguet, I Dey-Guha, M Hazar-Rethinam, D Dias-Santagata, DT Ting, AX Zhu, TS Hong, TR Golub, AJ Iafrate, VA Adalsteinsson, A Bardelli, L Parida, D Juric, G Getz, RB Corcoran
Publication Date: 2019-09

Variant appearance in text: NRAS: Q61R
PMID: 31501609
View BVdb publication page



Morpho-Molecular Assessment Indicates New Prognostic Aspects and Personalized Therapeutic Options in Sinonasal Melanoma.

Cancers
SN Freiberger, GB Morand, P Turko, U Wager, R Dummer, M Hüllner, D Holzmann, NJ Rupp, MP Levesque
Publication Date: 2019-09-07

Variant appearance in text: NRAS: Gln61Arg
PMID: 31500314
View BVdb publication page



Undetectable circulating tumor DNA (ctDNA) levels correlate with favorable outcome in metastatic melanoma patients treated with anti-PD1 therapy.

Journal Of Translational Medicine
T Seremet, Y Jansen, S Planken, H Njimi, M Delaunoy, H El Housni, G Awada, JK Schwarze, M Keyaerts, H Everaert, D Lienard, V Del Marmol, P Heimann, B Neyns
Publication Date: 2019-09-05

Variant appearance in text: NRAS: Q61R
PMID: 31488153
View BVdb publication page



The impact of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) on the diagnosis of thyroid nodules.

Gland Surgery
M Pusztaszeri, M Bongiovanni
Publication Date: 2019-08

Variant appearance in text: NRAS: Q61R
PMID: 31475095
View BVdb publication page



Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation.

Nature
J Niu, Y Sun, B Chen, B Zheng, GK Jarugumilli, SR Walker, AN Hata, M Mino-Kenudson, DA Frank, X Wu
Publication Date: 2019-09

Variant appearance in text: NRAS: Q61R
PMID: 31462771
View BVdb publication page



Differentiated Thyroid Carcinoma in Pediatric Age: Genetic and Clinical Scenario.

Frontiers In Endocrinology
F Galuppini, F Vianello, S Censi, S Barollo, L Bertazza, S Carducci, C Colato, J Manso, M Rugge, M Iacobone, S Watutantrige Fernando, G Pennelli, C Mian
Publication Date: 2019

Variant appearance in text: NRAS: Q61R
PMID: 31456750
View BVdb publication page



Targeted Treatment Options of Recurrent Radioactive Iodine Refractory Hürthle Cell Cancer.

Cancers
MD Aydemirli, W Corver, R Beuk, P Roepman, N Solleveld-Westerink, T van Wezel, E Kapiteijn, H Morreau
Publication Date: 2019-08-15

Variant appearance in text: NRAS: 182A>G; Gln61Arg
PMID: 31443247
View BVdb publication page



Abstracts : 31 st European Congress of Pathology.

Virchows Archiv : An International Journal Of Pathology
.
Publication Date: 2019-09

Variant appearance in text: NRAS: Q61R
PMID: 31440833
View BVdb publication page



Development, Implementation and Assessment of Molecular Diagnostics by Next Generation Sequencing in Personalized Treatment of Cancer: Experience of a Public Reference Healthcare Hospital.

Cancers
J Simarro, R Murria, G Pérez-Simó, M Llop, N Mancheño, D Ramos, I Juan, E Barragán, B Laiz, E Cases, E Ansótegui, J Gómez-Codina, J Aparicio, C Salvador, Ó Juan, S Palanca
Publication Date: 2019-08-16

Variant appearance in text: NRAS: Gln61Arg
PMID: 31426418
View BVdb publication page



An H-TERT Mutated Skin Metastasis as First Occurrence in a Case of Follicular Thyroid Carcinoma.

Frontiers In Endocrinology
E Monti, M Dono, E Gonella, B Spina, F Pitto, F Petrogalli, L Conte, E Ambrosetti, MN Minuto, GL Ansaldo, S Morbelli, S Zupo, M Giusti
Publication Date: 2019

Variant appearance in text: NRAS: Gln61Arg
PMID: 31417495
View BVdb publication page



Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000369535.4 c.182A>G p.Gln61Arg missense_variant 3/7 -
NM_002524.5 c.182A>G p.Gln61Arg missense_variant 3/7 -