Variant ID: 1-115256530-G-T

NM_002524.4(NRAS):c.181C>A;(p.Gln61Lys)

This variant was identified in 730 publications




Publications:


Comparison of BRAF Mutation Screening Strategies in a Large Real-Life Series of Advanced Melanoma Patients.

Journal Of Clinical Medicine
M Colombino, C Rozzo, P Paliogiannis, M Casula, A Manca, V Doneddu, MA Fedeli, MC Sini, G Palomba, M Pisano, PA Ascierto, C Caracò, A Lissia, A Cossu, G Palmieri
Publication Date: 2020-07-30

Variant appearance in text: NRAS: Q61K
PMID: 32751423
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Plasmacytoid Dendritic Cell Impairment in Metastatic Melanoma by Lactic Acidosis.

Cancers
M Monti, R Vescovi, F Consoli, D Farina, D Moratto, A Berruti, C Specchia, W Vermi
Publication Date: 2020-07-28

Variant appearance in text: NRAS: Q61K
PMID: 32731406
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Mutational spectrum and prognosis in NRAS-mutated acute myeloid leukemia.

Scientific Reports
S Wang, Z Wu, T Li, Y Li, W Wang, Q Hao, X Xie, D Wan, Z Jiang, C Wang, Y Liu
Publication Date: 2020-07-22

Variant appearance in text: NRAS: Q61K
PMID: 32699322
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The Current State of Molecular Testing in the BRAF-Mutated Melanoma Landscape.

Frontiers In Molecular Biosciences
I Vanni, ET Tanda, F Spagnolo, V Andreotti, W Bruno, P Ghiorzo
Publication Date: 2020

Variant appearance in text: NRAS: Q61K
PMID: 32695793
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Circulating Tumour DNA Is an Independent Prognostic Biomarker for Survival in Metastatic BRAF or NRAS-Mutated Melanoma Patients.

Cancers
G Herbreteau, A Vallée, AC Knol, S Théoleyre, G Quéreux, C Frénard, E Varey, P Hofman, A Khammari, B Dréno, MG Denis
Publication Date: 2020-07-11

Variant appearance in text: NRAS: 181C>A; Q61K
PMID: 32664549
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Mutation profile of primary subungual melanomas in Caucasians.

Oncotarget
A Borkowska, A Szumera-Ciećkiewicz, M Spałek, P Teterycz, A Czarnecka, A Kowalik, P Rutkowski
Publication Date: 2020-06-23

Variant appearance in text: NRAS: 181C>A; Q61K
PMID: 32637031
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KRAS, NRAS, and BRAF mutation prevalence, clinicopathological association, and their application in a predictive model in Mexican patients with metastatic colorectal cancer: A retrospective cohort study.

Plos One
HE Sanchez-Ibarra, X Jiang, EY Gallegos-Gonzalez, AC Cavazos-González, Y Chen, F Morcos, HA Barrera-Saldaña
Publication Date: 2020

Variant appearance in text: NRAS: Q61K
PMID: 32628708
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A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS.

Nature Communications
N Bery, A Miller, T Rabbitts
Publication Date: 2020-06-26

Variant appearance in text: NRAS: Q61K
PMID: 32591521
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The molecular pathogenesis of Trichilemmal carcinoma.

Bmc Cancer
JH Ha, C Lee, KS Lee, CS Pak, CH Sun, Y Koh, H Chang
Publication Date: 2020-06-03

Variant appearance in text: NRAS: Gln61Lys
PMID: 32493317
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Inflammatory Cytokines and ctDNA Are Biomarkers for Progression in Advanced-Stage Melanoma Patients Receiving Checkpoint Inhibitors.

Cancers
JG Pedersen, AT Madsen, KR Gammelgaard, N Aggerholm-Pedersen, BS Sørensen, TH Øllegaard, MR Jakobsen
Publication Date: 2020-05-30

Variant appearance in text: NRAS: Q61K
PMID: 32486146
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Epigenetics and metabolism at the crossroads of stress-induced plasticity, stemness and therapeutic resistance in cancer.

Theranostics
D Ravindran Menon, H Hammerlindl, J Torrano, H Schaider, M Fujita
Publication Date: 2020

Variant appearance in text: NRAS: Q61K
PMID: 32483452
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Application of Next-Generation Sequencing for the Genomic Characterization of Patients with Smoldering Myeloma.

Cancers
M Manzoni, V Marchica, P Storti, B Ziccheddu, G Sammarelli, G Todaro, F Pelizzoni, S Salerio, L Notarfranchi, A Pompa, L Baldini, N Bolli, A Neri, N Giuliani, M Lionetti
Publication Date: 2020-05-23

Variant appearance in text: NRAS: Q61K
PMID: 32456143
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From Tank to Treatment: Modeling Melanoma in Zebrafish.

Cells
WT Frantz, CJ Ceol
Publication Date: 2020-05-22

Variant appearance in text: NRAS: Q61K
PMID: 32455885
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Differential responsiveness to BRAF inhibitors of melanoma cell lines BRAF V600E-mutated.

Journal Of Translational Medicine
M Al Hashmi, KS Sastry, L Silcock, L Chouchane, V Mattei, N James, R Mathew, D Bedognetti, V De Giorgi, D Murtas, W Liu, A Chouchane, R Temanni, B Seliger, E Wang, FM Marincola, S Tomei
Publication Date: 2020-05-11

Variant appearance in text: NRAS: Q61K
PMID: 32393282
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RAS Mutational Status Detection in Tissue, Plasma, and Stool Samples for Colorectal Cancer.

Biomed Research International
L Zhu, Y Wang, Y Zhou, Q Dong, Y Liu, J Zhang
Publication Date: 2020

Variant appearance in text: NRAS: Q61K
PMID: 32351996
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Impact of the Italian Society of Anatomic Pathology and Diagnostic Cytology Classification of Thyroid Nodules in the Treatment of Indeterminate Follicular Lesions: Five-Year Results at a Single Center.

International Journal Of Endocrinology
M Pastoricchio, A Cubisino, A Lanzaro, M Troian, F Zanconati, S Bernardi, B Fabris, N de Manzini, C Dobrinja
Publication Date: 2020

Variant appearance in text: NRAS: Q61K
PMID: 32351561
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The role of AIP variants in pituitary adenomas and concomitant thyroid carcinomas in the Netherlands: a nationwide pathology registry (PALGA) study.

Endocrine
EC Coopmans, A Muhammad, AF Daly, WW de Herder, FJ van Kemenade, A Beckers, M de Haan, AJ van der Lely, E Korpershoek, SJCMM Neggers
Publication Date: 2020-04-24

Variant appearance in text: NRAS: Q61K
PMID: 32333269
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Inflammatory Responses during Tumour Initiation: From Zebrafish Transgenic Models of Cancer to Evidence from Mouse and Man.

Cells
A Elliot, H Myllymäki, Y Feng
Publication Date: 2020-04-20

Variant appearance in text: NRAS: Q61K
PMID: 32325966
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Comparison of commercially available whole-genome sequencing kits for variant detection in circulating cell-free DNA.

Scientific Reports
F Mauger, C Horgues, M Pierre-Jean, N Oussada, L Mesrob, JF Deleuze
Publication Date: 2020-04-10

Variant appearance in text: NRAS: Q61K
PMID: 32277101
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Combinatorial Therapies in Thyroid Cancer: An Overview of Preclinical and Clinical Progresses.

Cells
G Laetitia, S Sven, J Fabrice
Publication Date: 2020-03-30

Variant appearance in text: NRAS: Gln61Lys
PMID: 32235612
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Combined targeting of MEK and the glucocorticoid receptor for the treatment of RAS-mutant multiple myeloma.

Bmc Cancer
P Sriskandarajah, A De Haven Brandon, K MacLeod, NO Carragher, V Kirkin, M Kaiser, SR Whittaker
Publication Date: 2020-03-30

Variant appearance in text: NRAS: Q61K
PMID: 32228485
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Nanotechnology Strategies for the Analysis of Circulating Tumor DNA: A Review.

Medical Science Monitor : International Medical Journal Of Experimental And Clinical Research
X Chen, L Wang, J Lou
Publication Date: 2020-03-22

Variant appearance in text: NRAS: Q61K
PMID: 32200389
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Next-Generation Sequencing for Clinical Management of Multiple Myeloma: Ready for Prime Time?

Frontiers In Oncology
N Bolli, E Genuardi, B Ziccheddu, M Martello, S Oliva, C Terragna
Publication Date: 2020

Variant appearance in text: NRAS: Q61K
PMID: 32181154
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Prognostic implications of EGFR protein expression in sporadic colorectal tumors: Correlation with copy number status, mRNA levels and miRNA regulation.

Scientific Reports
S Del Carmen, LA Corchete, R Gervas, A Rodriguez, M Garcia, JA Álcazar, J García, O Bengoechea, L Muñoz-Bellvis, JM Sayagués, M Abad
Publication Date: 2020-03-13

Variant appearance in text: NRAS: Q61K
PMID: 32170146
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Genetic mutational analysis of pediatric acute lymphoblastic leukemia from a single center in China using exon sequencing.

Bmc Cancer
H Zhang, H Wang, X Qian, S Gao, J Xia, J Liu, Y Cheng, J Man, X Zhai
Publication Date: 2020-03-12

Variant appearance in text: NRAS: Q61K
PMID: 32164600
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Effect of Tumor Location on Clinicopathological and Molecular Markers in Colorectal Cancer in Eastern China Patients: An Analysis of 2,356 Cases.

Frontiers In Genetics
Y Song, L Wang, W Ran, G Li, Y Xiao, X Wang, L Zhang, X Xing
Publication Date: 2020

Variant appearance in text: NRAS: Q61K
PMID: 32161617
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Ras pathway mutation feature in the same individuals at diagnosis and relapse of childhood acute lymphoblastic leukemia.

Translational Pediatrics
HH Zhang, HS Wang, XW Qian, XH Zhu, H Miao, Y Yu, JH Meng, J Le, JY Jiang, P Cao, WJ Jiang, P Wang, Y Fu, J Li, MX Qian, XW Zhai
Publication Date: 2020-02

Variant appearance in text: NRAS: Q61K
PMID: 32154130
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Precision cell-free DNA extraction for liquid biopsy by integrated microfluidics.

Npj Precision Oncology
H Lee, C Park, W Na, KH Park, S Shin
Publication Date: 2020

Variant appearance in text: NRAS: Q61K
PMID: 32133418
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Loss of both CDKN2A and CDKN2B allows for centrosome overduplication in melanoma.

The Journal Of Investigative Dermatology
S Patel, CJ Wilkinson, EV Sviderskaya
Publication Date: 2020-02-14

Variant appearance in text: NRAS: Q61K
PMID: 32067956
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The paradox of cancer genes in non-malignant conditions: implications for precision medicine.

Genome Medicine
JJ Adashek, S Kato, SM Lippman, R Kurzrock
Publication Date: 2020-02-17

Variant appearance in text: NRAS: Q61K
PMID: 32066498
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Prebiotic-Induced Anti-tumor Immunity Attenuates Tumor Growth.

Cell Reports
Y Li, L Elmén, I Segota, Y Xian, R Tinoco, Y Feng, Y Fujita, RR Segura Muñoz, R Schmaltz, LM Bradley, A Ramer-Tait, R Zarecki, T Long, SN Peterson, ZA Ronai
Publication Date: 2020-02-11

Variant appearance in text: NRAS: Q61K
PMID: 32049008
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Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity.

International Journal Of Molecular Sciences
S Lee, J Rauch, W Kolch
Publication Date: 2020-02-07

Variant appearance in text: NRAS: Q61K
PMID: 32046099
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The "ART" of Epigenetics in Melanoma: From histone "Alterations, to Resistance and Therapies".

Theranostics
T Strub, R Ballotti, C Bertolotto
Publication Date: 2020

Variant appearance in text: NRAS: Q61K
PMID: 32042336
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Clinical significance of TP53, BIRC3, ATM and MAPK-ERK genes in chronic lymphocytic leukaemia: data from the randomised UK LRF CLL4 trial.

Leukemia
SJ Blakemore, R Clifford, H Parker, P Antoniou, E Stec-Dziedzic, M Larrayoz, Z Davis, L Kadalyayil, A Colins, P Robbe, D Vavoulis, J Forster, L Carr, R Morilla, M Else, D Bryant, H McCarthy, RJ Walewska, AJ Steele, J Chan, G Speight, T Stankovic, MS Cragg, D Catovsky, DG Oscier, MJJ Rose-Zerilli, A Schuh, JC Strefford
Publication Date: 2020-02-03

Variant appearance in text: NRAS: Q61K
PMID: 32015491
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Evaluation of KRAS, NRAS and BRAF mutations detection in plasma using an automated system for patients with metastatic colorectal cancer.

Plos One
C Franczak, A Witz, K Geoffroy, J Demange, M Rouyer, M Husson, V Massard, C Gavoille, A Lambert, P Gilson, N Gambier, J Scala-Bertola, JL Merlin, A Harlé
Publication Date: 2020

Variant appearance in text: NRAS: 181C>A; Gln61Lys
PMID: 31940389
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The ETS transcription factor ETV5 is a target of activated ALK in neuroblastoma contributing to increased tumour aggressiveness.

Scientific Reports
LM Mus, I Lambertz, S Claeys, C Kumps, W Van Loocke, C Van Neste, G Umapathy, M Vaapil, C Bartenhagen, G Laureys, O De Wever, D Bexell, M Fischer, B Hallberg, J Schulte, B De Wilde, K Durinck, G Denecker, K De Preter, F Speleman
Publication Date: 2020-01-14

Variant appearance in text: NRAS: Q61K
PMID: 31937834
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Dissecting Mechanisms of Melanoma Resistance to BRAF and MEK Inhibitors Revealed Genetic and Non-Genetic Patient- and Drug-Specific Alterations and Remarkable Phenotypic Plasticity.

Cells
ML Hartman, M Sztiller-Sikorska, A Gajos-Michniewicz, M Czyz
Publication Date: 2020-01-07

Variant appearance in text: NRAS: Q61K
PMID: 31936151
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STAT3 Relays a Differential Response to Melanoma-Associated NRAS Mutations.

Cancers
J Kim, D Novak, C Sachpekidis, J Utikal, L Larribère
Publication Date: 2020-01-02

Variant appearance in text: NRAS: Q61K
PMID: 31906480
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Spitz melanoma is a distinct subset of spitzoid melanoma.

Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc
SS Raghavan, S Peternel, TW Mully, JP North, LB Pincus, PE LeBoit, TH McCalmont, BC Bastian, I Yeh
Publication Date: 2020-01-03

Variant appearance in text: NRAS: Q61K
PMID: 31900433
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Inter-laboratory proficiency testing scheme for tumour next-generation sequencing in Ontario: a pilot study.

Current Oncology (Toronto, Ont.)
T Spence, N Stickle, C Yu, H Chow, H Feilotter, B Lo, E McCready, B Sadikovic, LL Siu, PL Bedard, TL Stockley
Publication Date: 2019-12

Variant appearance in text: NRAS: 181C>A; Gln61Lys
PMID: 31896942
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A Pilot Feasibility Study of Yttrium-90 Liver Radioembolization Followed by Durvalumab and Tremelimumab in Patients with Microsatellite Stable Colorectal Cancer Liver Metastases.

The Oncologist
C Wang, J Park, C Ouyang, JA Longmate, M Tajon, J Chao, D Lim, J Sandhu, HH Yin, R Pillai, MC Gozo, C Avalos, CA Egelston, PP Lee, M Fakih
Publication Date: 2019-12-19

Variant appearance in text: NRAS: Q61K
PMID: 31857446
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Mutation-derived Neoantigen-specific T-cell Responses in Multiple Myeloma.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
D Perumal, N Imai, A Laganà, J Finnigan, D Melnekoff, VV Leshchenko, A Solovyov, D Madduri, A Chari, HJ Cho, JT Dudley, JD Brody, S Jagannath, B Greenbaum, S Gnjatic, N Bhardwaj, S Parekh
Publication Date: 2019-12-19

Variant appearance in text: NRAS: Q61K
PMID: 31857430
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Engineering State-of-the-Art Plasmonic Nanomaterials for SERS-Based Clinical Liquid Biopsy Applications.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
J Wang, KM Koo, Y Wang, M Trau
Publication Date: 2019-12

Variant appearance in text: NRAS: Q61K
PMID: 31832306
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Non-Redundant and Overlapping Oncogenic Readouts of Non-Canonical and Novel Colorectal Cancer KRAS and NRAS Mutants.

Cells
KMM Alcantara, JRP Malapit, RTD Yu, JAMG Garrido, JPT Rigor, AKJ Angeles, EM Cutiongco-de la Paz, RL Garcia
Publication Date: 2019-12-03

Variant appearance in text: NRAS: Q61K
PMID: 31816869
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Molecular determinants of chaperone interactions on MHC-I for folding and antigen repertoire selection.

Proceedings Of The National Academy Of Sciences Of The United States Of America
AC McShan, CA Devlin, SA Overall, J Park, JS Toor, D Moschidi, D Flores-Solis, H Choi, S Tripathi, E Procko, NG Sgourakis
Publication Date: 2019-12-03

Variant appearance in text: NRAS: Q61K
PMID: 31796585
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ctDNA detected by ddPCR reveals changes in tumour load in metastatic malignant melanoma treated with bevacizumab.

Scientific Reports
RB Forthun, R Hovland, C Schuster, H Puntervoll, HP Brodal, HM Namløs, LB Aasheim, LA Meza-Zepeda, BT Gjertsen, S Knappskog, O Straume
Publication Date: 2019-11-25

Variant appearance in text: NRAS: Q61K
PMID: 31767937
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Dissection of major cancer gene variants in subsets of circulating tumor cells in advanced breast cancer.

Scientific Reports
S D'Oronzo, D Lovero, R Palmirotta, LS Stucci, M Tucci, C Felici, E Cascardi, C Giardina, P Cafforio, F Silvestris
Publication Date: 2019-11-21

Variant appearance in text: NRAS: Q61K
PMID: 31754145
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Genomic Profiling of Driver Gene Mutations in Chinese Patients With Non-Small Cell Lung Cancer.

Frontiers In Genetics
H Meng, X Guo, D Sun, Y Liang, J Lang, Y Han, Q Lu, Y Zhang, Y An, G Tian, D Yuan, S Xu, J Geng
Publication Date: 2019

Variant appearance in text: NRAS: Q61K
PMID: 31749831
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Discovery of actionable genetic alterations with targeted panel sequencing in children with relapsed or refractory solid tumors.

Plos One
JW Lee, NKD Kim, SH Lee, HW Cho, Y Ma, HY Ju, KH Yoo, KW Sung, HH Koo, WY Park
Publication Date: 2019

Variant appearance in text: NRAS: Q61K
PMID: 31747416
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A comprehensive evaluation of pathogenic mutations in primary cutaneous melanomas, including the identification of novel loss-of-function variants.

Scientific Reports
I Ticha, J Hojny, R Michalkova, O Kodet, E Krkavcova, N Hajkova, K Nemejcova, M Bartu, R Jaksa, M Dura, M Kanwal, AS Martinikova, L Macurek, P Zemankova, Z Kleibl, P Dundr
Publication Date: 2019-11-19

Variant appearance in text: NRAS: Q61K
PMID: 31745173
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Translational reprogramming marks adaptation to asparagine restriction in cancer.

Nature Cell Biology
G Pathria, JS Lee, E Hasnis, K Tandoc, DA Scott, S Verma, Y Feng, L Larue, AD Sahu, I Topisirovic, E Ruppin, ZA Ronai
Publication Date: 2019-12

Variant appearance in text: NRAS: Q61K
PMID: 31740775
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Targeting melanoma's MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors.

Nature Communications
MJ Sale, E Minihane, NR Monks, R Gilley, FM Richards, KP Schifferli, CL Andersen, EJ Davies, MA Vicente, E Ozono, A Markovets, JR Dry, L Drew, V Flemington, T Proia, DI Jodrell, PD Smith, SJ Cook
Publication Date: 2019-11-14

Variant appearance in text: NRAS: Q61K
PMID: 31727888
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Germline RUNX1 Intragenic Deletion: Implications for Accurate Diagnosis of FPD/AML.

Hemasphere
N Duployez, JE Martin, S Khalife-Hachem, R Benkhelil, V Saada, C Marzac, N Auger, A Marceau-Renaut, R Favier, P Ballerini, O Caron, A Baruchel, S de Botton, C Preudhomme, JB Micol, H Raslova, I Antony-Debré
Publication Date: 2019-06

Variant appearance in text: NRAS: Q61K
PMID: 31723833
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The Impact of PI3-kinase/RAS Pathway Cooperating Mutations in the Evolution of KMT2A-rearranged Leukemia.

Hemasphere
MT Esposito
Publication Date: 2019-06

Variant appearance in text: NRAS: Q61K
PMID: 31723831
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Persistence of HIV reservoir following successful haematopoietic stem cell transplant for juvenile myelomonocytic leukaemia in a child with perinatally acquired HIV.

Journal Of Virus Eradication
G Dobson, N Klein, P Veys, W Qasim, J Silva, IL Cheng, D Shingadia, G Tudor-Williams, SA Watters, H Lyall, A Rao, C Foster, A Bamford
Publication Date: 2019-09-18

Variant appearance in text: NRAS: Gln61Lys
PMID: 31700667
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Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design.

Cell Reports
JL Rokita, KS Rathi, MF Cardenas, KA Upton, J Jayaseelan, KL Cross, J Pfeil, LE Egolf, GP Way, A Farrel, NM Kendsersky, K Patel, KS Gaonkar, A Modi, ER Berko, G Lopez, Z Vaksman, C Mayoh, J Nance, K McCoy, M Haber, K Evans, H McCalmont, K Bendak, JW Böhm, GM Marshall, V Tyrrell, K Kalletla, FK Braun, L Qi, Y Du, H Zhang, HB Lindsay, S Zhao, J Shu, P Baxter, C Morton, D Kurmashev, S Zheng, Y Chen, J Bowen, AC Bryan, KM Leraas, SE Coppens, H Doddapaneni, Z Momin, W Zhang, GI Sacks, LS Hart, K Krytska, YP Mosse, GJ Gatto, Y Sanchez, CS Greene, SJ Diskin, OM Vaske, D Haussler, JM Gastier-Foster, EA Kolb, R Gorlick, XN Li, CP Reynolds, RT Kurmasheva, PJ Houghton, MA Smith, RB Lock, P Raman, DA Wheeler, JM Maris
Publication Date: 2019-11-05

Variant appearance in text: NRAS: Q61K
PMID: 31693904
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A Comparative Analysis of Individual RAS Mutations in Cancer Biology.

Frontiers In Oncology
C Muñoz-Maldonado, Y Zimmer, M Medová
Publication Date: 2019

Variant appearance in text: NRAS: Q61K
PMID: 31681616
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YAP1 Mediates Resistance to MEK1/2 Inhibition in Neuroblastomas with Hyperactivated RAS Signaling.

Cancer Research
GE Coggins, A Farrel, KS Rathi, CM Hayes, L Scolaro, JL Rokita, JM Maris
Publication Date: 2019-12-15

Variant appearance in text: NRAS: Q61K
PMID: 31672841
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Intra-Patient Heterogeneity of Circulating Tumor Cells and Circulating Tumor DNA in Blood of Melanoma Patients.

Cancers
K Gorges, L Wiltfang, TM Gorges, A Sartori, L Hildebrandt, L Keller, B Volkmer, S Peine, A Babayan, I Moll, SW Schneider, S Twarock, P Mohr, JW Fischer, K Pantel
Publication Date: 2019-10-29

Variant appearance in text: NRAS: Q61K
PMID: 31671846
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Revised criteria for diagnosis of NIFTP reveals a better correlation with tumor biological behavior.

Endocrine Connections
ACJ Paniza, TB Mendes, MDB Vianna, DMD Thomaz, P Chiappini, GA Colazza-Gama, SC Lindsey, MB de Carvalho, VAF Alves, O Curione, AU Bastos, JM Cerutti
Publication Date: 2019-10-01

Variant appearance in text: NRAS: Q61K
PMID: 31671409
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Whole-Exome Sequencing of Matched Primary and Metastatic Papillary Thyroid Cancer.

Thyroid : Official Journal Of The American Thyroid Association
T Masoodi, AK Siraj, S Siraj, S Azam, Z Qadri, WN Albalawy, SK Parvathareddy, SS Al-Sobhi, F Al-Dayel, FS Alkuraya, KS Al-Kuraya
Publication Date: 2019-12-04

Variant appearance in text: NRAS: Q61K
PMID: 31668133
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Combined quantitation of HMGA2 mRNA, microRNAs, and mitochondrial-DNA content enables the identification and typing of thyroid tumors in fine-needle aspiration smears.

Bmc Cancer
SE Titov, MK Ivanov, PS Demenkov, GA Katanyan, ES Kozorezova, AV Malek, YA Veryaskina, IF Zhimulev
Publication Date: 2019-10-28

Variant appearance in text: NRAS: Q61K
PMID: 31660895
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Rho-mediated signaling promotes BRAF inhibitor resistance in de-differentiated melanoma cells.

Oncogene
SA Misek, KM Appleton, TS Dexheimer, EM Lisabeth, RS Lo, SD Larsen, KA Gallo, RR Neubig
Publication Date: 2019-10-28

Variant appearance in text: NRAS: Q61K
PMID: 31659259
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The Oncogenic Signaling Pathways in BRAF-Mutant Melanoma Cells are Modulated by Naphthalene Diimide-Like G-Quadruplex Ligands.

Cells
M Recagni, M Tassinari, F Doria, G Cimino-Reale, N Zaffaroni, M Freccero, M Folini, SN Richter
Publication Date: 2019-10-18

Variant appearance in text: NRAS: Q61K
PMID: 31635389
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A Multi-institutional Study of Prevalence and Clinicopathologic Features of Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) in Korea.

Journal Of Pathology And Translational Medicine
JY Seo, JH Park, JY Pyo, YJ Cha, CK Jung, DE Song, JJ Kwak, SY Park, HY Na, JH Kim, JY Seok, HS Kim, SW Hong
Publication Date: 2019-11

Variant appearance in text: NRAS: 181C>A; Gln61Lys
PMID: 31634988
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The Antitumor Effect of Lipophilic Bisphosphonate BPH1222 in Melanoma Models: The Role of the PI3K/Akt Pathway and the Small G Protein Rheb.

International Journal Of Molecular Sciences
D Rittler, M Baranyi, E Molnár, T Garay, I Jalsovszky, IK Varga, L Hegedűs, C Aigner, J Tóvári, J Tímár, B Hegedűs
Publication Date: 2019-10-03

Variant appearance in text: NRAS: Q61K
PMID: 31623406
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CRISPR-Cas9 Knockdown and Induced Expression of CD133 Reveal Essential Roles in Melanoma Invasion and Metastasis.

Cancers
CM Simbulan-Rosenthal, R Dougherty, S Vakili, AM Ferraro, LW Kuo, R Alobaidi, L Aljehane, A Gaur, P Sykora, E Glasgow, S Agarwal, DS Rosenthal
Publication Date: 2019-10-03

Variant appearance in text: NRAS: Q61K
PMID: 31623313
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Genetic Landscape of Somatic Mutations in a Large Cohort of Sporadic Medullary Thyroid Carcinomas Studied by Next-Generation Targeted Sequencing.

Iscience
R Ciampi, C Romei, T Ramone, A Prete, A Tacito, V Cappagli, V Bottici, D Viola, L Torregrossa, C Ugolini, F Basolo, R Elisei
Publication Date: 2019-10-25

Variant appearance in text: NRAS: Q61K
PMID: 31605946
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Detection of Three Distinct Clonal Populations Using Circulating Cell Free DNA: A Cautionary Note on the Use of Liquid Biopsy.

Jco Precision Oncology
GM Riedlinger, N Jalloul, E Poplin, JM Mehnert, R Groisberg, H Khiabanian, S Ganesan
Publication Date: 2019

Variant appearance in text: NRAS: Q61K
PMID: 31588418
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Targeting CDC7 sensitizes resistance melanoma cells to BRAFV600E-specific inhibitor by blocking the CDC7/MCM2-7 pathway.

Scientific Reports
SA Gad, HEA Ali, R Gaballa, RM Abdelsalam, M Zerfaoui, HI Ali, SH Salama, SA Kenawy, E Kandil, ZY Abd Elmageed
Publication Date: 2019-10-02

Variant appearance in text: NRAS: Q61K
PMID: 31578454
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Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers.

Cell Reports
R Sulahian, JJ Kwon, KH Walsh, E Pailler, TL Bosse, M Thaker, D Almanza, JM Dempster, J Pan, F Piccioni, N Dumont, A Gonzalez, J Rennhack, B Nabet, JA Bachman, A Goodale, Y Lee, M Bagul, R Liao, A Navarro, TL Yuan, RWS Ng, S Raghavan, NS Gray, A Tsherniak, F Vazquez, DE Root, AJ Firestone, J Settleman, WC Hahn, AJ Aguirre
Publication Date: 2019-10-01

Variant appearance in text: NRAS: Q61K
PMID: 31577942
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Analytical and Clinical Validation of Expressed Variants and Fusions From the Whole Transcriptome of Thyroid FNA Samples.

Frontiers In Endocrinology
TE Angell, LJ Wirth, ME Cabanillas, ML Shindo, ES Cibas, JE Babiarz, Y Hao, SY Kim, PS Walsh, J Huang, RT Kloos, GC Kennedy, SG Waguespack
Publication Date: 2019

Variant appearance in text: NRAS: Q61K
PMID: 31572297
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Variation in nomenclature of somatic variants for selection of oncological therapies: Can we reach a consensus soon?

Human Mutation
C Keppens, V Tack, K Dufraing, E Rouleau, MJL Ligtenberg, E Schuuring, EMC Dequeker
Publication Date: 2019-09-25

Variant appearance in text: NRAS: 181C>A; Gln61Lys
PMID: 31553104
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A genome-wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS-mutant melanoma.

Pigment Cell & Melanoma Research
A Nagler, DW Vredevoogd, M Alon, PF Cheng, S Trabish, S Kalaora, R Arafeh, V Goldin, MP Levesque, DS Peeper, Y Samuels
Publication Date: 2019-09-24

Variant appearance in text: NRAS: Q61K
PMID: 31549767
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Thyroid Cancer in the Pediatric Population.

Genes
VA Paulson, ER Rudzinski, DS Hawkins
Publication Date: 2019-09-18

Variant appearance in text: NRAS: Q61K
PMID: 31540418
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BRAF Inhibitors in Thyroid Cancer: Clinical Impact, Mechanisms of Resistance and Future Perspectives.

Cancers
F Crispo, T Notarangelo, M Pietrafesa, G Lettini, G Storto, A Sgambato, F Maddalena, M Landriscina
Publication Date: 2019-09-18

Variant appearance in text: NRAS: Q61K
PMID: 31540406
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High-Throughput Assessment of Kinome-wide Activation States.

Cell Systems
T Schmidlin, DO Debets, CAGH van Gelder, KE Stecker, S Rontogianni, BL van den Eshof, K Kemper, EH Lips, M van den Biggelaar, DS Peeper, AJR Heck, M Altelaar
Publication Date: 2019-10-23

Variant appearance in text: NRAS: Q61K
PMID: 31521607
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Morpho-Molecular Assessment Indicates New Prognostic Aspects and Personalized Therapeutic Options in Sinonasal Melanoma.

Cancers
SN Freiberger, GB Morand, P Turko, U Wager, R Dummer, M Hüllner, D Holzmann, NJ Rupp, MP Levesque
Publication Date: 2019-09-07

Variant appearance in text: NRAS: Gln61Lys
PMID: 31500314
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Precision Oncology-The Quest for Evidence.

Journal Of Personalized Medicine
TG Soldatos, S Kaduthanam, DB Jackson
Publication Date: 2019-09-05

Variant appearance in text: NRAS: Q61K
PMID: 31492009
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Undetectable circulating tumor DNA (ctDNA) levels correlate with favorable outcome in metastatic melanoma patients treated with anti-PD1 therapy.

Journal Of Translational Medicine
T Seremet, Y Jansen, S Planken, H Njimi, M Delaunoy, H El Housni, G Awada, JK Schwarze, M Keyaerts, H Everaert, D Lienard, V Del Marmol, P Heimann, B Neyns
Publication Date: 2019-09-05

Variant appearance in text: NRAS: Q61K
PMID: 31488153
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Genetic variants and clinical significance of pediatric acute lymphoblastic leukemia.

Annals Of Translational Medicine
HH Zhang, HS Wang, XW Qian, CQ Fan, J Li, H Miao, XH Zhu, Y Yu, JH Meng, P Cao, J Le, JY Jiang, WJ Jiang, P Wang, XW Zhai
Publication Date: 2019-07

Variant appearance in text: NRAS: Q61K; rs121913254
PMID: 31475166
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Differentiated Thyroid Carcinoma in Pediatric Age: Genetic and Clinical Scenario.

Frontiers In Endocrinology
F Galuppini, F Vianello, S Censi, S Barollo, L Bertazza, S Carducci, C Colato, J Manso, M Rugge, M Iacobone, S Watutantrige Fernando, G Pennelli, C Mian
Publication Date: 2019

Variant appearance in text: NRAS: Q61K
PMID: 31456750
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High Frequency of KRAS Codon 146 and FBXW7 Mutations in Thai Patients with Stage II-III Colon Cancer.

Asian Pacific Journal Of Cancer Prevention : Apjcp
K Korphaisarn, A Pongpaibul, E Roothumnong, K Pongsuktavorn, L Thamlikitkul, T Anekpuritanang, N Poungvarin, W Thongnoppakhun, M Pithukpakorn
Publication Date: 2019-08-01

Variant appearance in text: NRAS: Q61K
PMID: 31450901
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Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients.

Nature Communications
IG Serebriiskii, C Connelly, G Frampton, J Newberg, M Cooke, V Miller, S Ali, JS Ross, E Handorf, S Arora, C Lieu, EA Golemis, JE Meyer
Publication Date: 2019-08-19

Variant appearance in text: NRAS: Q61K
PMID: 31427573
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Targeting Oncogenic BRAF: Past, Present, and Future.

Cancers
A Zaman, W Wu, TG Bivona
Publication Date: 2019-08-16

Variant appearance in text: NRAS: Q61K
PMID: 31426419
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Understanding the Mechanisms of Resistance in EGFR-Positive NSCLC: From Tissue to Liquid Biopsy to Guide Treatment Strategy.

International Journal Of Molecular Sciences
M Del Re, S Crucitta, G Gianfilippo, A Passaro, I Petrini, G Restante, A Michelucci, S Fogli, F de Marinis, C Porta, A Chella, R Danesi
Publication Date: 2019-08-14

Variant appearance in text: NRAS: Q61K
PMID: 31416192
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Prospective evaluation of two screening methods for molecular testing of metastatic melanoma: Diagnostic performance of BRAF V600E immunohistochemistry and of a NRAS-BRAF fully automated real-time PCR-based assay.

Plos One
A Vallée, M Denis-Musquer, G Herbreteau, S Théoleyre, C Bossard, MG Denis
Publication Date: 2019

Variant appearance in text: NRAS: Q61K
PMID: 31415669
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Analyses of molecular and histopathologic features and expression of PRAME by immunohistochemistry in mucosal melanomas.

Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc
A Toyama, L Siegel, AC Nelson, M Najmuddin, L Bu, R LaRue, C Henzler, E Caicedo-Granados, A Giubellino, F Li
Publication Date: 2019-12

Variant appearance in text: NRAS: Q61K
PMID: 31375769
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Dietary methionine influences therapy in mouse cancer models and alters human metabolism.

Nature
X Gao, SM Sanderson, Z Dai, MA Reid, DE Cooper, M Lu, JP Richie, A Ciccarella, A Calcagnotto, PG Mikhael, SJ Mentch, J Liu, G Ables, DG Kirsch, DS Hsu, SN Nichenametla, JW Locasale
Publication Date: 2019-08

Variant appearance in text: NRAS: Q61K
PMID: 31367041
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Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000369535.4 c.181C>A p.Gln61Lys missense_variant 3/7 -
NM_002524.5 c.181C>A p.Gln61Lys missense_variant 3/7 -