Variant ID: 1-11854476-T-G

NM_005957.4(MTHFR):c.1286A>C;(p.Glu429Ala)

This variant was identified in 618 publications




Publications:


Computational Prediction of Probable Single Nucleotide Polymorphism-Cancer Relationships.

Cancer Informatics
S Bakhtiari, S Sulaimany, M Talebi, K Kalhor
Publication Date: 2020

Variant appearance in text: rs1801131
PMID: 32728337
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C677T Polymorphism in the MTHFR Gene Is Associated With Risperidone-Induced Weight Gain in Schizophrenia.

Frontiers In Psychiatry
J Liao, N Wang, M Ma, T Lu, H Yan, W Yue
Publication Date: 2020

Variant appearance in text: rs1801131
PMID: 32714219
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In Vitro Assessment of Fluoropyrimidine-Metabolizing Enzymes: Dihydropyrimidine Dehydrogenase, Dihydropyrimidinase, and β-Ureidopropionase.

Journal Of Clinical Medicine
E Hishinuma, E Gutiérrez Rico, M Hiratsuka
Publication Date: 2020-07-22

Variant appearance in text: MTHFR: E429A; rs1801131
PMID: 32707991
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Polymorphisms within methotrexate pathway genes: Relationship between plasma methotrexate levels, toxicity experienced and outcome in pediatric acute lymphoblastic leukemia.

Iranian Journal Of Basic Medical Sciences
MA Esmaili, A Kazemi, M Faranoush, H Mellstedt, F Zaker, M Safa, N Mehrvar, MR Rezvany
Publication Date: 2020-06

Variant appearance in text: rs1801131
PMID: 32695297
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Genetic Polymorphisms Associated with Rheumatoid Arthritis Development and Antirheumatic Therapy Response.

International Journal Of Molecular Sciences
DS Mikhaylenko, MV Nemtsova, IV Bure, EB Kuznetsova, EA Alekseeva, VV Tarasov, AN Lukashev, MI Beloukhova, AA Deviatkin, AA Zamyatnin
Publication Date: 2020-07-11

Variant appearance in text: rs1801131
PMID: 32664585
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Methylenetetrahydrofolate reductase gene polymorphisms in the risk of polycystic ovary syndrome and ovarian cancer.

Bioscience Reports
Y Xiong, C Bian, X Lin, X Wang, K Xu, X Zhao
Publication Date: 2020-07-08

Variant appearance in text: rs1801131
PMID: 32639550
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Pharmacogenomics and Pharmacogenetics in Osteosarcoma: Translational Studies and Clinical Impact.

International Journal Of Molecular Sciences
CM Hattinger, MP Patrizio, S Luppi, M Serra
Publication Date: 2020-06-30

Variant appearance in text: rs1801131
PMID: 32629971
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Germline and Somatic Pharmacogenomics to Refine Rectal Cancer Patients Selection for Neo-Adjuvant Chemoradiotherapy.

Frontiers In Pharmacology
E De Mattia, R Roncato, E Palazzari, G Toffoli, E Cecchin
Publication Date: 2020

Variant appearance in text: MTHFR: Glu429Ala; rs1801131
PMID: 32625092
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Genetic risk factors for venous thromboembolism among infertile men with Klinefelter syndrome.

Journal Of Clinical & Translational Endocrinology
TM Hussein, D Abd Elmoaty Elneily, F Mohamed Abdelfattah Elsayed, LM El-Attar
Publication Date: 2020-06

Variant appearance in text: MTHFR: Glu429Ala; rs1801131
PMID: 32577403
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The Effect of Interactions between Folic Acid Supplementation and One Carbon Metabolism Gene Variants on Small-for-Gestational-Age Births in the Screening for Pregnancy Endpoints (SCOPE) Cohort Study.

Nutrients
RE Bulloch, CR Wall, LME McCowan, RS Taylor, CT Roberts, JMD Thompson
Publication Date: 2020-06-04

Variant appearance in text: rs1801131
PMID: 32512764
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Association of NUDT15*3 and FPGS 2572C>T Variants with the Risk of Early Hematologic Toxicity During 6-MP and Low-Dose Methotrexate-Based Maintenance Therapy in Indian Patients with Acute Lymphoblastic Leukemia.

Genes
S Kodidela, P Dorababu, DN Thakkar, B Dubashi, R Sundaram, N Muralidharan, RP Nidanapu, A Aribandi, SC Pradhan, CRS Uppugunduri
Publication Date: 2020-05-28

Variant appearance in text: rs1801131
PMID: 32481505
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Genetic and Physiological Factors Affecting Human Milk Production and Composition.

Nutrients
Y Golan, YG Assaraf
Publication Date: 2020-05-21

Variant appearance in text: rs1801131
PMID: 32455695
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Independent and Interactive Influences of Environmental UVR, Vitamin D Levels, and Folate Variant MTHFD1-rs2236225 on Homocysteine Levels.

Nutrients
P Jones, M Lucock, C Martin, R Thota, M Garg, Z Yates, CJ Scarlett, M Veysey, E Beckett
Publication Date: 2020-05-18

Variant appearance in text: rs1801131
PMID: 32443475
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Are gene polymorphisms related to adverse events of methotrexate in patients with rheumatoid arthritis? A retrospective cohort study based on an updated meta-analysis.

Therapeutic Advances In Chronic Disease
J Huang, H Fan, Q Qiu, K Liu, S Lv, J Li, H Yang, X Shu, Y Xu, X Lu, C Lu, Y Zhang, C Xiao
Publication Date: 2020

Variant appearance in text: rs1801131
PMID: 32426102
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A molecular-beacon-based asymmetric PCR assay for detecting polymorphisms related to folate metabolism.

Journal Of Clinical Laboratory Analysis
Q Peng, S Liao, Y He, L Liang, X Su, C Rao, W Li, S Li, X Lu
Publication Date: 2020-05-15

Variant appearance in text: rs1801131
PMID: 32410296
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Precision Medicine in Non Communicable Diseases.

International Journal Of Molecular And Cellular Medicine
M Hasanzad, N Sarhangi, HR Aghaei Meybodi, S Nikfar, F Khatami, B Larijani
Publication Date: 2019

Variant appearance in text: rs1801131
PMID: 32351905
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Toxicity and Pharmacogenomic Biomarkers in Breast Cancer Chemotherapy.

Frontiers In Pharmacology
ZN Al-Mahayri, GP Patrinos, BR Ali
Publication Date: 2020

Variant appearance in text: rs1801131
PMID: 32351390
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Genetic polymorphisms of pharmacogenomic VIP variants in the Dai population from Yunnan province.

Molecular Genetics & Genomic Medicine
Y Cheng, R Dai, W Chen, Q Li, C Zhang, T Yang
Publication Date: 2020-04-29

Variant appearance in text: rs1801131
PMID: 32347657
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Association between methylenetetrahydrofolate reductase gene rs1801131 A/C polymorphism and urinary tumors' susceptibility.

Hereditas
S Xu, L Zuo
Publication Date: 2020-04-27

Variant appearance in text: rs1801131
PMID: 32340630
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Intranasal perillyl alcohol therapy improves survival of patients with recurrent glioblastoma harboring mutant variant for MTHFR rs1801133 polymorphism.

Bmc Cancer
GM Faria, IDP Soares, M D'Alincourt Salazar, MR Amorim, BL Pessoa, CO da Fonseca, T Quirico-Santos
Publication Date: 2020-04-07

Variant appearance in text: rs1801131
PMID: 32264844
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Genetic Polymorphisms and Platinum-Based Chemotherapy-Induced Toxicities in Patients With Lung Cancer: A Systematic Review and Meta-Analysis.

Frontiers In Oncology
W Liu, Y Wang, J Luo, H Yuan, Z Luo
Publication Date: 2019

Variant appearance in text: rs1801131
PMID: 32257953
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Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses.

The Journal Of Headache And Pain
Y Zhao, R Zhu, T Xiao, X Liu
Publication Date: 2020-02-11

Variant appearance in text: rs1801131
PMID: 32046629
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Rare Variants of Putative Candidate Genes Associated With Sporadic Meniere's Disease in East Asian Population.

Frontiers In Neurology
EH Oh, JH Shin, HS Kim, JW Cho, SY Choi, KD Choi, JK Rhee, S Lee, C Lee, JH Choi
Publication Date: 2019

Variant appearance in text: rs1801131
PMID: 32038468
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Genetic Landscape of Nonobstructive Azoospermia and New Perspectives for the Clinic.

Journal Of Clinical Medicine
M Cerván-Martín, JA Castilla, RJ Palomino-Morales, FD Carmona
Publication Date: 2020-01-21

Variant appearance in text: rs1801131
PMID: 31973052
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Genetic Polymorphisms of Pharmacogenes among the Genetically Isolated Circassian Subpopulation from Jordan.

Journal Of Personalized Medicine
LN Al-Eitan, DM Rababa'h, NM Hakooz, MA Alghamdi, RB Dajani
Publication Date: 2020-01-06

Variant appearance in text: rs1801131
PMID: 31935801
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Olfactory-Related Quality of Life in Multiple Chemical Sensitivity: A Genetic-Acquired Factors Model.

International Journal Of Molecular Sciences
A Micarelli, A Cormano, D Caccamo, M Alessandrini
Publication Date: 2019-12-25

Variant appearance in text: MTHFR: E429A; rs1801131
PMID: 31881664
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Interplay of an Obesity-Based Genetic Risk Score with Dietary and Endocrine Factors on Insulin Resistance.

Nutrients
O Ramos-Lopez, JI Riezu-Boj, FI Milagro, M Cuervo, L Goni, JA Martinez
Publication Date: 2019-12-21

Variant appearance in text: rs1801131
PMID: 31877696
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Contribution of MTR A2756G polymorphism and MTRR A66G polymorphism to the risk of idiopathic male infertility.

Medicine
ZJ Ren, YP Zhang, PW Ren, B Yang, S Deng, ZF Peng, LR Liu, W Wei, Q Dong
Publication Date: 2019-12

Variant appearance in text: rs1801131
PMID: 31860974
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Systematic meta-analyses, field synopsis and global assessment of the evidence of genetic association studies in colorectal cancer.

Gut
Z Montazeri, X Li, C Nyiraneza, X Ma, M Timofeeva, V Svinti, X Meng, Y He, Y Bo, S Morgan, S Castellví-Bel, C Ruiz-Ponte, C Fernández-Rozadilla, Á Carracedo, A Castells, T Bishop, D Buchanan, MA Jenkins, TO Keku, A Lindblom, FJB van Duijnhoven, A Wu, SM Farrington, MG Dunlop, H Campbell, E Theodoratou, W Zheng, J Little
Publication Date: 2019-12-09

Variant appearance in text: rs1801131
PMID: 31818908
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Plasma Homocysteine and Polymorphisms of Genes Involved in Folate Metabolism Correlate with DNMT1 Gene Methylation Levels.

Metabolites
F Coppedè, A Stoccoro, P Tannorella, L Migliore
Publication Date: 2019-12-07

Variant appearance in text: rs1801131
PMID: 31817852
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Association of single nucleotide polymorphisms of MTHFR, TCN2, RNF213 with susceptibility to hypertension and blood pressure.

Bioscience Reports
S Liu, M Liu, Q Li, X Liu, Y Wang, M Mambiya, K Zhang, L Yang, Q Zhang, M Shang, F Zeng, F Nie, W Liu
Publication Date: 2019-12-09

Variant appearance in text: rs1801131
PMID: 31815282
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Rs4846049 Polymorphism at the 3'-UTR of MTHFR Gene: Association with Susceptibility to Childhood Acute Lymphoblastic Leukemia.

Biomed Research International
X Li, S Zhang, F Yu
Publication Date: 2019

Variant appearance in text: rs1801131
PMID: 31737664
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The Role of Single-Nucleotide Polymorphisms in the Function of Candidate Tumor Suppressor ALDH1L1.

Frontiers In Genetics
SA Krupenko, DA Horita
Publication Date: 2019

Variant appearance in text: MTHFR: E429A
PMID: 31737034
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Methotrexate an Old Drug with New Tricks.

International Journal Of Molecular Sciences
Y Bedoui, X Guillot, J Sélambarom, P Guiraud, C Giry, MC Jaffar-Bandjee, S Ralandison, P Gasque
Publication Date: 2019-10-10

Variant appearance in text: rs1801131
PMID: 31658782
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MTHFR and F5 genetic variations have association with preeclampsia in Pakistani patients: a case control study.

Bmc Medical Genetics
FF Khidri, YM Waryah, FK Ali, H Shaikh, ID Ujjan, AM Waryah
Publication Date: 2019-10-23

Variant appearance in text: rs1801131
PMID: 31646966
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Serum folate levels in bipolar disorder: a systematic review and meta-analysis.

Bmc Psychiatry
YC Hsieh, LS Chou, CH Lin, HC Wu, DJ Li, PT Tseng
Publication Date: 2019-10-22

Variant appearance in text: MTHFR: Glu429Ala
PMID: 31640634
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Polymorphisms of MTHFR and TYMS predict capecitabine-induced hand-foot syndrome in patients with metastatic breast cancer.

Cancer Communications (London, England)
S Lin, J Yue, X Guan, P Yuan, J Wang, Y Luo, Y Fan, R Cai, Q Li, S Chen, P Zhang, Q Li, F Ma, B Xu
Publication Date: 2019-10-11

Variant appearance in text: MTHFR: Glu429Ala; rs1801131
PMID: 31601265
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Genetic biomarkers related to hemarthrosis, inflammation, and cartilage structure in pediatric patients with hemophilic arthropathy.

Molecular Genetics & Genomic Medicine
JJ López-Jiménez, R Ortega-Cervantes, H Luna-Záizar, AL Fletes-Rayas, CP Beltrán-Miranda, R Troyo-Sanromán, J Soto-Padilla, A Tlacuilo-Parra, AR Jaloma-Cruz
Publication Date: 2019-11

Variant appearance in text: MTHFR: 1286A>C; rs1801131
PMID: 31566926
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Genetic Markers Associated with Power Athlete Status.

Journal Of Human Kinetics
A Maciejewska-Skrendo, P Cięszczyk, J Chycki, M Sawczuk, W Smółka
Publication Date: 2019-08

Variant appearance in text: rs1801131
PMID: 31531130
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Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome.

Genomics, Proteomics & Bioinformatics
Z Du, L Ma, H Qu, W Chen, B Zhang, X Lu, W Zhai, X Sheng, Y Sun, W Li, M Lei, Q Qi, N Yuan, S Shi, J Zeng, J Wang, Y Yang, Q Liu, Y Hong, L Dong, Z Zhang, D Zou, Y Wang, S Song, F Liu, X Fang, H Chen, X Liu, J Xiao, C Zeng
Publication Date: 2019-06

Variant appearance in text: rs1801131
PMID: 31494266
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Maternal Haplotypes in DHFR Promoter and MTHFR Gene in Tuning Childhood Acute Lymphoblastic Leukemia Onset-Latency: Genetic/Epigenetic Mother/Child Dyad Study (GEMCDS).

Genes
V Tisato, P Muggeo, T Lupiano, G Longo, ML Serino, M Grassi, E Arcamone, P Secchiero, G Zauli, N Santoro, D Gemmati
Publication Date: 2019-08-22

Variant appearance in text: MTHFR: E429A; rs1801131
PMID: 31443485
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Suitability and safety of L-5-methyltetrahydrofolate as a folate source in infant formula: A randomized-controlled trial.

Plos One
B Troesch, J Demmelmair, M Gimpfl, C Hecht, G Lakovic, R Roehle, L Sipka, B Trisic, M Vusurovic, R Schoop, S Zdjelar, B Koletzko,
Publication Date: 2019

Variant appearance in text: rs1801131
PMID: 31425504
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Sex-Related Differences in Impact on Safety of Pharmacogenetic Profile for Colon Cancer Patients Treated with FOLFOX-4 or XELOX Adjuvant Chemotherapy.

Scientific Reports
A Ruzzo, F Graziano, F Galli, F Galli, E Rulli, S Lonardi, M Ronzoni, B Massidda, V Zagonel, N Pella, C Mucciarini, R Labianca, MT Ionta, I Bagaloni, E Veltri, P Sozzi, S Barni, V Ricci, L Foltran, M Nicolini, E Biondi, A Bramati, D Turci, S Lazzarelli, C Verusio, F Bergamo, A Sobrero, L Frontini, M Magnani
Publication Date: 2019-08-08

Variant appearance in text: MTHFR: Glu429Ala; rs1801131
PMID: 31395900
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Association of Polymorphisms in Genes Involved in One-Carbon Metabolism with MTHFR Methylation Levels.

International Journal Of Molecular Sciences
F Coppedè, A Stoccoro, P Tannorella, R Gallo, V Nicolì, L Migliore
Publication Date: 2019-07-31

Variant appearance in text: rs1801131
PMID: 31370354
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Genetic polymorphisms analysis of pharmacogenomic VIP variants in Bai ethnic group from China.

Molecular Genetics & Genomic Medicine
W Chen, H Ding, Y Cheng, Q Li, R Dai, X Yang, C Zhang
Publication Date: 2019-09

Variant appearance in text: rs1801131
PMID: 31361092
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Methylenetetrahydrofolate reductase polymorphisms and colorectal cancer prognosis: A meta-analysis.

The Journal Of Gene Medicine
XL Chen, YM Wang, F Zhao, Z Chen, X Yang, C Sun, Y Gao, TG Yang, G Tian, YM Chen, SL Zhu, XB Lin, FB Liu
Publication Date: 2019-09

Variant appearance in text: rs1801131
PMID: 31330573
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Central Venous Access Devices (CVAD) in Pediatric Oncology Patients-A Single-Center Retrospective Study Over More Than 9 Years.

Frontiers In Pediatrics
O Beck, O Muensterer, S Hofmann, H Rossmann, A Poplawski, J Faber, J Gödeke
Publication Date: 2019

Variant appearance in text: MTHFR: 1286A>C; Glu429Ala; rs1801131
PMID: 31294007
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Polymorphisms of methalenetetrahydrofolate reductase in recurrent pregnancy loss: an overview of systematic reviews and meta-analyses.

Journal Of Assisted Reproduction And Genetics
B Du, X Shi, C Yin, X Feng
Publication Date: 2019-07

Variant appearance in text: rs1801131
PMID: 31254142
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Associations between Maternal and Fetal Inherited Thrombophilias, Placental Characteristics Associated with Vascular Malperfusion, and Fetal Growth.

Th Open : Companion Journal To Thrombosis And Haemostasis
AA Freedman, CJ Hogue, DJ Dudley, RM Silver, BJ Stoll, H Pinar, RL Goldenberg, C Drews-Botsch
Publication Date: 2017-06

Variant appearance in text: rs1801131
PMID: 31249910
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Association of Methylenetetrahydrofolate Reductase, Vitamin D Receptor, and Interleukin-16 Gene Polymorphisms With Renal Cell Carcinoma Risk.

Technology In Cancer Research & Treatment
T Zhou, H Li, WJ Xie, Z Zhong, H Zhong, ZJ Lin
Publication Date: 2019-01-01

Variant appearance in text: rs1801131
PMID: 31242814
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Nutrition and Female Fertility: An Interdependent Correlation.

Frontiers In Endocrinology
E Silvestris, D Lovero, R Palmirotta
Publication Date: 2019

Variant appearance in text: MTHFR: Glu429Ala; rs1801131
PMID: 31231310
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Population study of thrombophilic markers and pharmacogenetic markers of warfarin prevalence in Bosnia and Herzegovina.

Croatian Medical Journal
A Ašić, R Salazar, N Storm, S Doğan, W Höppner, D Marjanović, D Primorac
Publication Date: 2019-06-13

Variant appearance in text: MTHFR: 1286A>C
PMID: 31187948
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Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Growth and Remodeling.

Comprehensive Physiology
S Rajendran, X Shen, J Glawe, GK Kolluru, CG Kevil
Publication Date: 2019-06-12

Variant appearance in text: rs1801131
PMID: 31187898
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Ethnogeographic prevalence and implications of the 677C>T and 1298A>C MTHFR polymorphisms in US primary care populations.

Biomarkers In Medicine
JS Graydon, K Claudio, S Baker, M Kocherla, M Ferreira, A Roche-Lima, J Rodríguez-Maldonado, J Duconge, G Ruaño
Publication Date: 2019-06

Variant appearance in text: MTHFR: Glu429Ala; rs1801131
PMID: 31157538
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Genetic impact of methylenetetrahydrofolate reductase (MTHFR) polymorphism on the susceptibility to colorectal polyps: a meta-analysis.

Bmc Medical Genetics
M Sun, J Zhong, L Zhang, S Shi
Publication Date: 2019-05-30

Variant appearance in text: rs1801131
PMID: 31146742
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A case report of a severe fluoropyrimidine-related toxicity due to an uncommon DPYD variant.

Medicine
V De Falco, MI Natalicchio, S Napolitano, N Coppola, G Conzo, E Martinelli, N Zanaletti, P Vitale, EF Giunta, MT Vietri, PP Vitiello, D Ciardiello, A Marinaccio, F De Vita, F Ciardiello, T Troiani
Publication Date: 2019-05

Variant appearance in text: rs1801131
PMID: 31124962
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Lack of association between methylenetetrahydrofolate reductase gene variants & essential tremor in Han Chinese.

The Indian Journal Of Medical Research
D He, L Yuan, Z Song, X Deng, Y Chen, H Lu, H Deng
Publication Date: 2019-01

Variant appearance in text: MTHFR: 1286A>C; E429A; rs1801131
PMID: 31115378
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Polymorphisms of ADME-related genes and their implications for drug safety and efficacy in Amazonian Amerindians.

Scientific Reports
JCG Rodrigues, MR Fernandes, JF Guerreiro, ALDC da Silva, Â Ribeiro-Dos-Santos, S Santos, NPCD Santos
Publication Date: 2019-05-10

Variant appearance in text: rs1801131
PMID: 31076604
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Getting to precision psychopharmacology: Combining clinical and genetic information to predict fat gain from aripiprazole.

Journal Of Psychiatric Research
H Oughli, EJ Lenze, AE Locke, MD Yingling, Y Zhong, JP Miller, CF Reynolds, BH Mulsant, JW Newcomer, TR Peterson, DJ Müller, GE Nicol
Publication Date: 2019-07

Variant appearance in text: rs1801131
PMID: 31039482
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Systems Approach to Identify Common Genes and Pathways Associated with Response to Selective Serotonin Reuptake Inhibitors and Major Depression Risk.

International Journal Of Molecular Sciences
A Srivastava, P Singh, H Gupta, H Kaur, N Kanojia, D Guin, M Sood, RK Chadda, J Yadav, D Vohora, L Saso, R Kukreti
Publication Date: 2019-04-23

Variant appearance in text: rs1801131
PMID: 31018568
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The MTHFR 677C>T polymorphism is associated with unmetabolized folic acid in breast milk in a cohort of Canadian women.

The American Journal Of Clinical Nutrition
R Page, A Wong, TE Arbuckle, AJ MacFarlane
Publication Date: 2019-08-01

Variant appearance in text: rs1801131
PMID: 31005971
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Goeckerman Therapy of Psoriasis: Genotoxicity, Dietary Micronutrients, Homocysteine, and MTHFR Gene Polymorphisms.

International Journal Of Molecular Sciences
M Beranek, A Malkova, Z Fiala, J Kremlacek, K Hamakova, L Zaloudkova, P Borsky, T Adamus, V Palicka, L Borska
Publication Date: 2019-04-17

Variant appearance in text: rs1801131
PMID: 30999684
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Genetic analysis of pharmacogenomic VIP variants in the Blang population from Yunnan Province of China.

Molecular Genetics & Genomic Medicine
C Zhang, W Guo, Y Cheng, Q Li, X Yang, R Dai, L Zhu, W Chen
Publication Date: 2019-05

Variant appearance in text: rs1801131
PMID: 30955239
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Plasma B-vitamins and one-carbon metabolites and the risk of breast cancer in younger women.

Breast Cancer Research And Treatment
SC Houghton, AH Eliassen, SM Zhang, J Selhub, BA Rosner, WC Willett, SE Hankinson
Publication Date: 2019-07

Variant appearance in text: rs1801131
PMID: 30955184
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Folate/homocysteine metabolism and lung cancer risk among smokers.

Plos One
A Stanisławska-Sachadyn, J Borzyszkowska, M Krzemiński, A Janowicz, R Dziadziuszko, J Jassem, W Rzyman, J Limon
Publication Date: 2019

Variant appearance in text: MTHFR: 1286A>C; rs1801131
PMID: 30939165
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Polymorphism of MTHFR 1298A>C in relation to adverse pregnancy outcomes in Chinese populations.

Molecular Genetics & Genomic Medicine
H Mo, M Rao, G Wang, YX Long, HW Wang, L Tang
Publication Date: 2019-05

Variant appearance in text: rs1801131
PMID: 30900398
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Homocysteine Metabolism in Children and Adolescents: Influence of Age on Plasma Biomarkers and Correspondent Genotype Interactions.

Nutrients
H Caldeira-Araújo, R Ramos, C Florindo, I Rivera, R Castro, I Tavares de Almeida
Publication Date: 2019-03-16

Variant appearance in text: MTHFR: E429A
PMID: 30884849
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Association study between genetic polymorphisms in folate metabolism and gastric cancer susceptibility in Chinese Han population: A case-control study.

Molecular Genetics & Genomic Medicine
L Wei, F Niu, J Wu, F Chen, H Yang, J Li, T Jin, Y Wu
Publication Date: 2019-05

Variant appearance in text: rs1801131
PMID: 30884202
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Correlation between MTHFR polymorphisms and glaucoma: A meta-analysis.

Molecular Genetics & Genomic Medicine
L Zhang, B Chen
Publication Date: 2019-04

Variant appearance in text: rs1801131
PMID: 30851082
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Disturbed homocysteine metabolism is associated with cancer.

Experimental & Molecular Medicine
T Hasan, R Arora, AK Bansal, R Bhattacharya, GS Sharma, LR Singh
Publication Date: 2019-02-21

Variant appearance in text: MTHFR: Glu429Ala
PMID: 30804341
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Cumulative evidence for association between genetic polymorphisms and esophageal cancer susceptibility: A review with evidence from meta-analysis and genome-wide association studies.

Cancer Medicine
J Tian, C Liu, G Liu, C Zuo, H Chen
Publication Date: 2019-03

Variant appearance in text: rs1801131
PMID: 30793520
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Common Variations in Prothrombotic Genes and Susceptibility to Ischemic Stroke in Young Patients: A Case-Control Study in Southeast Iran.

Medicina (Kaunas, Lithuania)
SM Hashemi, N Ramroodi, H Amiri Fard, S Talebian, M Haghighi Rohani, M Rezaei, M Noora, S Salimi
Publication Date: 2019-02-13

Variant appearance in text: rs1801131
PMID: 30781868
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Sex-Specific Genetic Susceptibility To Adverse Neurodevelopmental Outcome in Offspring of Pregnancies at Risk of Early Preterm Delivery.

American Journal Of Perinatology
MW Varner, MM Costantine, KA Jablonski, DJ Rouse, BM Mercer, KJ Leveno, UM Reddy, C Buhimschi, RJ Wapner, Y Sorokin, JM Thorp, SM Ramin, FD Malone, M Carpenter, MJ O'sullivan, AM Peaceman, DJ Dudley, SN Caritis,
Publication Date: 2019-02-07

Variant appearance in text: rs1801131
PMID: 30731481
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TRIM4 is associated with neural tube defects based on genome-wide DNA methylation analysis.

Clinical Epigenetics
H Zhang, Y Guo, H Gu, X Wei, W Ma, D Liu, K Yu, W Luo, L Ma, Y Liu, J Xue, J Huang, Y Wang, S Jia, N Dong, H Wang, Z Yuan
Publication Date: 2019-02-01

Variant appearance in text: rs1801131
PMID: 30709423
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The MTHFR promoter hypermethylation pattern associated with the A1298C polymorphism influences lipid parameters and glycemic control in diabetic patients.

Diabetology & Metabolic Syndrome
H Santana Bezerra, C Severo de Assis, MK Dos Santos Nunes, I Wanderley de Queiroga Evangelista, J Modesto Filho, CN Alves Pegado Gomes, RA Ferreira do Nascimento, RC Pordeus Luna, MJ de Carvalho Costa, NFP de Oliveira, D Camati Persuhn
Publication Date: 2019

Variant appearance in text: MTHFR: Glu429Ala; rs1801131
PMID: 30675189
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Genotyping of Single Nucleotide Polymorphisms Using Allele-Specific qPCR Producing Amplicons of Small Sizes Directly from Crude Serum Isolated from Capillary Blood by a Hand-Powered Paper Centrifuge.

Diagnostics (Basel, Switzerland)
GB Barra, TH Santa Rita, DP Jardim, PG Mesquita, CS Nobre, RH Jácomo, LF Abdalla Nery
Publication Date: 2019-01-11

Variant appearance in text: rs1801131
PMID: 30641881
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Pharmacogenetic Correlates of Antipsychotic-Induced Weight Gain in the Chinese Population.

Neuroscience Bulletin
C Luo, J Liu, X Wang, X Mao, H Zhou, Z Liu
Publication Date: 2019-06

Variant appearance in text: rs1801131
PMID: 30607769
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MTHFR variant is associated with high-dose methotrexate-induced toxicity in the Chinese osteosarcoma patients.

Journal Of Bone Oncology
L Xu, L Wang, B Xue, S Wang
Publication Date: 2018-11

Variant appearance in text: rs1801131
PMID: 30591868
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Polymorphisms in folic acid metabolism genes do not associate with cancer cachexia in Japanese gastrointestinal patients.

Nagoya Journal Of Medical Science
T Morishita, A Hishida, Y Okugawa, Y Morimoto, Y Shirai, K Okamoto, S Momokita, A Ogawa, K Tanaka, R Nishikawa, Y Toiyama, Y Inoue, H Sakurai, H Urata, M Tanaka, C Miki
Publication Date: 2018-11

Variant appearance in text: rs1801131
PMID: 30587867
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Association of Single Nucleotide Polymorphisms (SNPs) in Genes Encoding for Folate Metabolising Enzymes with Glioma and Meningioma in Indian Population

Asian Pacific Journal Of Cancer Prevention : Apjcp
R Kumawat, SH Gowda, E Debnath, S Rashid, R Niwas, Y Gupta, AD Upadaya, A Suri, PS Chandra, DK Gupta, R Lakshmy, C Sarkar, S Sinha, K Chosdol
Publication Date: 2018-12-25

Variant appearance in text: rs1801131
PMID: 30583664
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Association between MTHFR 677C>T Polymorphism and Vitamin B12 Deficiency: A Case-control Study.

Journal Of Medical Biochemistry
KM Al-Batayneh, MSA Zoubi, M Shehab, B Al-Trad, K Bodoor, WA Khateeb, AAA Aljabali, MA Hamad, G Eaton
Publication Date: 2018-04

Variant appearance in text: MTHFR: 1286A>C; rs1801131
PMID: 30581350
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Machine Learning Models for Genetic Risk Assessment of Infants with Non-syndromic Orofacial Cleft.

Genomics, Proteomics & Bioinformatics
SJ Zhang, P Meng, J Zhang, P Jia, J Lin, X Wang, F Chen, X Wei
Publication Date: 2018-10

Variant appearance in text: rs1801131
PMID: 30578914
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Additional value of a combined genetic risk score to standard cardiovascular stratification.

Genetics And Molecular Biology
A Pereira, MI Mendonca, S Borges, AC Sousa, S Freitas, E Henriques, M Rodrigues, AI Freitas, G Guerra, C Freitas, D Pereira, A Brehm, RPD Reis
Publication Date: 2018

Variant appearance in text: rs1801131
PMID: 30571812
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Does L-Methylfolate Supplement Methylphenidate Pharmacotherapy in Attention-Deficit/Hyperactivity Disorder?: Evidence of Lack of Benefit From a Double-Blind, Placebo-Controlled, Randomized Clinical Trial.

Journal Of Clinical Psychopharmacology
C Surman, A Ceranoglu, C Vaudreuil, B Albright, M Uchida, A Yule, A Spencer, H Boland, R Grossman, L Rhodewalt, M Fitzgerald, J Biederman
Publication Date: 2019

Variant appearance in text: rs1801131
PMID: 30566416
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DPYD, TYMS and MTHFR Genes Polymorphism Frequencies in a Series of Turkish Colorectal Cancer Patients.

Journal Of Personalized Medicine
A Amirfallah, GC Kocal, OU Unal, H Ellidokuz, I Oztop, Y Basbinar
Publication Date: 2018-12-13

Variant appearance in text: MTHFR: E429A; rs1801131
PMID: 30551678
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Genetic Polymorphisms of TYMS, MTHFR, ATIC, MTR, and MTRR Are Related to the Outcome of Methotrexate Therapy for Rheumatoid Arthritis in a Chinese Population.

Frontiers In Pharmacology
S Lv, H Fan, J Li, H Yang, J Huang, X Shu, L Zhang, Y Xu, X Li, J Zuo, C Xiao
Publication Date: 2018

Variant appearance in text: rs1801131
PMID: 30546311
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Assessment of coding region variants in Kuwaiti population: implications for medical genetics and population genomics.

Scientific Reports
SE John, D Antony, M Eaaswarkhanth, P Hebbar, AM Channanath, D Thomas, S Devarajan, J Tuomilehto, F Al-Mulla, O Alsmadi, TA Thanaraj
Publication Date: 2018-11-08

Variant appearance in text: MTHFR: Glu429Ala; rs1801131
PMID: 30409984
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Methylenetetrahydrofolate reductase and psychiatric diseases.

Translational Psychiatry
L Wan, Y Li, Z Zhang, Z Sun, Y He, R Li
Publication Date: 2018-11-05

Variant appearance in text: rs1801131
PMID: 30397195
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Frequencies of poor metabolizer alleles of 12 pharmacogenomic actionable genes in Punjabi Sikhs of Indian Origin.

Scientific Reports
DK Sanghera, C Bejar, B Sapkota, GS Wander, S Ralhan
Publication Date: 2018-10-24

Variant appearance in text: MTHFR: E429A; rs1801131
PMID: 30356105
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The 677C→T variant of MTHFR is the major genetic modifier of biomarkers of folate status in a young, healthy Irish population.

The American Journal Of Clinical Nutrition
B Shane, F Pangilinan, JL Mills, R Fan, T Gong, CD Cropp, Y Kim, PM Ueland, JE Bailey-Wilson, AF Wilson, LC Brody, AM Molloy
Publication Date: 2018-12-01

Variant appearance in text: rs1801131
PMID: 30339177
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A Clinical-Genetic Score to Identify Surgically Resected Colorectal Cancer Patients Benefiting From an Adjuvant Fluoropyrimidine-Based Therapy.

Frontiers In Pharmacology
E De Mattia, E Dreussi, M Montico, S Gagno, C Zanusso, L Quartuccio, S De Vita, M Guardascione, A Buonadonna, M D'Andrea, N Pella, A Favaretto, E Mini, S Nobili, L Romanato, E Cecchin, G Toffoli
Publication Date: 2018

Variant appearance in text: rs1801131
PMID: 30337874
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Single nucleotide polymorphisms and sporadic colorectal cancer susceptibility: a field synopsis and meta-analysis.

Cancer Cell International
J Wen, Q Xu, Y Yuan
Publication Date: 2018

Variant appearance in text: rs1801131
PMID: 30337837
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A single-nucleotide polymorphism (rs1805087) in the methionine synthase (METH) gene increases the risk of prostate cancer.

Aging
X Zhang, J Tang, N Shen, K Ren
Publication Date: 2018-10-18

Variant appearance in text: rs1801131
PMID: 30337500
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The roles of MTRR and MTHFR gene polymorphisms in congenital heart diseases: a meta-analysis.

Bioscience Reports
A Xu, W Wang, X Jiang
Publication Date: 2018-12-21

Variant appearance in text: rs1801131
PMID: 30333252
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Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000376583.3 c.1409A>C p.Glu470Ala missense_variant 8/12 -
ENST00000376585.1 c.1409A>C p.Glu470Ala missense_variant 9/13 -
ENST00000376590.3 c.1286A>C p.Glu429Ala missense_variant 8/12 -
ENST00000376592.1 c.1286A>C p.Glu429Ala missense_variant 7/11 -
NM_001330358.1 c.1409A>C p.Glu470Ala missense_variant 8/12 -
NM_005957.5 c.1286A>C p.Glu429Ala missense_variant 8/12 -