Variant ID: 1-11856378-G-A

NM_005957.4(MTHFR):c.665C>T;(p.Ala222Val)

This variant was identified in 1122 publications




Publications:


Computational Prediction of Probable Single Nucleotide Polymorphism-Cancer Relationships.

Cancer Informatics
S Bakhtiari, S Sulaimany, M Talebi, K Kalhor
Publication Date: 2020

Variant appearance in text: rs1801133
PMID: 32728337
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MTHFR Gene Polymorphisms Prevalence and Cardiovascular Risk Factors Involved in Cardioembolic Stroke Type and Severity.

Brain Sciences
DS Chita, A Tudor, R Christodorescu, FN Buleu, R Sosdean, SM Deme, S Mercea, A Pop Moldovan, AM Pah, A Docu Axelerad, D Docu Axelerad, SR Dragan
Publication Date: 2020-07-24

Variant appearance in text: MTHFR: A222V; rs1801133
PMID: 32722170
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C677T Polymorphism in the MTHFR Gene Is Associated With Risperidone-Induced Weight Gain in Schizophrenia.

Frontiers In Psychiatry
J Liao, N Wang, M Ma, T Lu, H Yan, W Yue
Publication Date: 2020

Variant appearance in text: rs1801133
PMID: 32714219
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In Vitro Assessment of Fluoropyrimidine-Metabolizing Enzymes: Dihydropyrimidine Dehydrogenase, Dihydropyrimidinase, and β-Ureidopropionase.

Journal Of Clinical Medicine
E Hishinuma, E Gutiérrez Rico, M Hiratsuka
Publication Date: 2020-07-22

Variant appearance in text: MTHFR: A222V; rs1801133
PMID: 32707991
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Decisive evidence corroborates a null relationship between MTHFR C677T and chronic kidney disease: A case-control study and a meta-analysis.

Medicine
HL Chang, GR Chen, PJ Hsiao, CC Chiu, MC Tai, CC Kao, DJ Tsai, H Su, YH Chen, WT Chen, SL Su
Publication Date: 2020-07-17

Variant appearance in text: rs1801133
PMID: 32702845
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Polymorphisms within methotrexate pathway genes: Relationship between plasma methotrexate levels, toxicity experienced and outcome in pediatric acute lymphoblastic leukemia.

Iranian Journal Of Basic Medical Sciences
MA Esmaili, A Kazemi, M Faranoush, H Mellstedt, F Zaker, M Safa, N Mehrvar, MR Rezvany
Publication Date: 2020-06

Variant appearance in text: rs1801133
PMID: 32695297
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Association of ESR1 (rs2234693 and rs9340799), CETP (rs708272), MTHFR (rs1801133 and rs2274976) and MS (rs185087) polymorphisms with Coronary Artery Disease (CAD).

Bmc Cardiovascular Disorders
JK Raina, M Sharma, RK Panjaliya, V Dogra, A Bakaya, P Kumar
Publication Date: 2020-07-18

Variant appearance in text: rs1801133
PMID: 32682401
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Nutritional Epigenomics and Age-Related Disease.

Current Developments In Nutrition
SD Amenyah, M Ward, JJ Strain, H McNulty, CF Hughes, C Dollin, CP Walsh, DJ Lees-Murdock
Publication Date: 2020-07

Variant appearance in text: rs1801133
PMID: 32666030
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Genetic Polymorphisms Associated with Rheumatoid Arthritis Development and Antirheumatic Therapy Response.

International Journal Of Molecular Sciences
DS Mikhaylenko, MV Nemtsova, IV Bure, EB Kuznetsova, EA Alekseeva, VV Tarasov, AN Lukashev, MI Beloukhova, AA Deviatkin, AA Zamyatnin
Publication Date: 2020-07-11

Variant appearance in text: rs1801133
PMID: 32664585
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Methylenetetrahydrofolate reductase gene polymorphisms in the risk of polycystic ovary syndrome and ovarian cancer.

Bioscience Reports
Y Xiong, C Bian, X Lin, X Wang, K Xu, X Zhao
Publication Date: 2020-07-08

Variant appearance in text: rs1801133
PMID: 32639550
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Pharmacogenomics and Pharmacogenetics in Osteosarcoma: Translational Studies and Clinical Impact.

International Journal Of Molecular Sciences
CM Hattinger, MP Patrizio, S Luppi, M Serra
Publication Date: 2020-06-30

Variant appearance in text: rs1801133
PMID: 32629971
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Germline and Somatic Pharmacogenomics to Refine Rectal Cancer Patients Selection for Neo-Adjuvant Chemoradiotherapy.

Frontiers In Pharmacology
E De Mattia, R Roncato, E Palazzari, G Toffoli, E Cecchin
Publication Date: 2020

Variant appearance in text: MTHFR: Ala222Val; rs1801133
PMID: 32625092
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Polymorphisms of SLC19A1 80 G>A, MTHFR 677 C>T, and Tandem TS Repeats Influence Pharmacokinetics, Acute Liver Toxicity, and Vomiting in Children With Acute Lymphoblastic Leukemia Treated With High Doses of Methotrexate.

Frontiers In Pediatrics
M Cwiklinska, M Czogala, K Kwiecinska, A Madetko-Talowska, M Szafarz, K Pawinska, A Wieczorek, T Klekawka, M Rej, K Stepien, P Halubiec, A Lazarczyk, K Miklusiak, M Bik-Multanowski, W Balwierz, S Skoczen
Publication Date: 2020

Variant appearance in text: rs1801133
PMID: 32612964
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Characterization of pharmacogenetic markers related to Acute Lymphoblastic Leukemia toxicity in Amazonian native Americans population.

Scientific Reports
DC de Carvalho, AV Wanderley, AMR Dos Santos, FC Moreira, RBA de Sá, MR Fernandes, AAC Modesto, TP de Souza, A Cohen-Paes, LPC Leitão, JCG Rodrigues, ALDC da Silva, JF Guerreiro, S Santos, AS Khayat, PP de Assumpção, NPC Dos Santos
Publication Date: 2020-06-24

Variant appearance in text: rs1801133
PMID: 32581388
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Genetic risk factors for venous thromboembolism among infertile men with Klinefelter syndrome.

Journal Of Clinical & Translational Endocrinology
TM Hussein, D Abd Elmoaty Elneily, F Mohamed Abdelfattah Elsayed, LM El-Attar
Publication Date: 2020-06

Variant appearance in text: rs1801133
PMID: 32577403
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The Effect of Interactions between Folic Acid Supplementation and One Carbon Metabolism Gene Variants on Small-for-Gestational-Age Births in the Screening for Pregnancy Endpoints (SCOPE) Cohort Study.

Nutrients
RE Bulloch, CR Wall, LME McCowan, RS Taylor, CT Roberts, JMD Thompson
Publication Date: 2020-06-04

Variant appearance in text: rs1801133
PMID: 32512764
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Low folate intake and serum levels are associated with higher body mass index and abdominal fat accumulation: a case control study.

Nutrition Journal
MA Mlodzik-Czyzewska, AM Malinowska, A Chmurzynska
Publication Date: 2020-06-04

Variant appearance in text: rs1801133
PMID: 32498709
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Interactive effect of MTHFR C677T polymorphism and sex on symptoms and cognitive functions in Chinese patients with chronic schizophrenia.

Aging
J Gao, MH Xiu, DY Liu, CW Wei, X Zhang
Publication Date: 2020-06-04

Variant appearance in text: MTHFR: Ala222Val
PMID: 32497019
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Genetic basis for prediction of non-responders to dietary plant sterol intervention (GenePredict-PS): a study protocol for a double-blind, placebo-controlled, randomized two-period crossover study.

Trials
M Shamloo, MJ Granger, EA Trautwein, JD House, D MacKay
Publication Date: 2020-06-01

Variant appearance in text: rs1801133
PMID: 32487131
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Association of NUDT15*3 and FPGS 2572C>T Variants with the Risk of Early Hematologic Toxicity During 6-MP and Low-Dose Methotrexate-Based Maintenance Therapy in Indian Patients with Acute Lymphoblastic Leukemia.

Genes
S Kodidela, P Dorababu, DN Thakkar, B Dubashi, R Sundaram, N Muralidharan, RP Nidanapu, A Aribandi, SC Pradhan, CRS Uppugunduri
Publication Date: 2020-05-28

Variant appearance in text: rs1801133
PMID: 32481505
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Combination of Exercise and Vegetarian Diet: Relationship with High Density-Lipoprotein Cholesterol in Taiwanese Adults Based on MTHFR rs1801133 Polymorphism.

Nutrients
SL Chang, ON Nfor, CC Ho, KJ Lee, WY Lu, CC Lung, DM Tantoh, SY Hsu, MC Chou, YP Liaw
Publication Date: 2020-05-27

Variant appearance in text: rs1801133
PMID: 32471241
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Genetic and Physiological Factors Affecting Human Milk Production and Composition.

Nutrients
Y Golan, YG Assaraf
Publication Date: 2020-05-21

Variant appearance in text: rs1801133
PMID: 32455695
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Independent and Interactive Influences of Environmental UVR, Vitamin D Levels, and Folate Variant MTHFD1-rs2236225 on Homocysteine Levels.

Nutrients
P Jones, M Lucock, C Martin, R Thota, M Garg, Z Yates, CJ Scarlett, M Veysey, E Beckett
Publication Date: 2020-05-18

Variant appearance in text: rs1801133
PMID: 32443475
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Associations Between Gestational Diabetes Mellitus Risk and Folate Status in Early Pregnancy and MTHFR C677T Polymorphisms in Chinese Women.

Diabetes, Metabolic Syndrome And Obesity : Targets And Therapy
PJ Liu, Y Liu, L Ma, AM Yao, XY Chen, YX Hou, LP Wu, LY Xia
Publication Date: 2020

Variant appearance in text: rs1801133
PMID: 32440179
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Association of Homocysteine, Methionine, and MTHFR 677C>T Polymorphism With Rate of Cardiovascular Multimorbidity Development in Older Adults in Sweden.

Jama Network Open
A Calderón-Larrañaga, M Saadeh, B Hooshmand, H Refsum, AD Smith, A Marengoni, DL Vetrano
Publication Date: 2020-05-01

Variant appearance in text: rs1801133
PMID: 32432712
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Are gene polymorphisms related to adverse events of methotrexate in patients with rheumatoid arthritis? A retrospective cohort study based on an updated meta-analysis.

Therapeutic Advances In Chronic Disease
J Huang, H Fan, Q Qiu, K Liu, S Lv, J Li, H Yang, X Shu, Y Xu, X Lu, C Lu, Y Zhang, C Xiao
Publication Date: 2020

Variant appearance in text: rs1801133
PMID: 32426102
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A molecular-beacon-based asymmetric PCR assay for detecting polymorphisms related to folate metabolism.

Journal Of Clinical Laboratory Analysis
Q Peng, S Liao, Y He, L Liang, X Su, C Rao, W Li, S Li, X Lu
Publication Date: 2020-05-15

Variant appearance in text: rs1801133
PMID: 32410296
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The Identification of Admixture Patterns Could Refine Pharmacogenetic Counseling: Analysis of a Population-Based Sample in Mexico.

Frontiers In Pharmacology
JJ Martínez-Magaña, AD Genis-Mendoza, JA Villatoro Velázquez, B Camarena, R Martín Del Campo Sanchez, C Fleiz Bautista, M Bustos Gamiño, E Reséndiz, A Aguilar, ME Medina-Mora, H Nicolini
Publication Date: 2020

Variant appearance in text: MTHFR: A222V; rs1801133
PMID: 32390825
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Pharmacogenomics of Cognitive Dysfunction and Neuropsychiatric Disorders in Dementia.

International Journal Of Molecular Sciences
R Cacabelos
Publication Date: 2020-04-26

Variant appearance in text: rs1801133
PMID: 32357528
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Association between methylenetetrahydrofolate reductase gene rs1801131 A/C polymorphism and urinary tumors' susceptibility.

Hereditas
S Xu, L Zuo
Publication Date: 2020-04-27

Variant appearance in text: rs1801133
PMID: 32340630
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The Different Relationship between Homocysteine and Uric Acid Levels with Respect to the MTHFR C677T Polymorphism According to Gender in Patients with Cognitive Impairment.

Nutrients
HJ Kim, IW Sohn, YS Kim, JB Jun
Publication Date: 2020-04-19

Variant appearance in text: MTHFR: A222V
PMID: 32325916
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3'UTR polymorphism of Thymidylate Synthase gene increased the risk of persistence of pre-neoplastic cervical lesions.

Bmc Cancer
NNT Silva, ACS Santos, VM Nogueira, CM Carneiro, AA Lima
Publication Date: 2020-04-15

Variant appearance in text: rs1801133
PMID: 32295543
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Genomics and Therapeutic Vulnerabilities of Primary Bone Tumors.

Cells
K Scotlandi, CM Hattinger, E Pellegrini, M Gambarotti, M Serra
Publication Date: 2020-04-14

Variant appearance in text: rs1801133
PMID: 32295254
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miR-9-1 gene methylation and DNMT3B (rs2424913) polymorphism may contribute to periodontitis.

Journal Of Applied Oral Science : Revista Fob
MC Coêlho, IC Queiroz, JMC Viana Filho, SG Aquino, DC Persuhn, NFP Oliveira
Publication Date: 2020

Variant appearance in text: rs1801133
PMID: 32267380
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Intranasal perillyl alcohol therapy improves survival of patients with recurrent glioblastoma harboring mutant variant for MTHFR rs1801133 polymorphism.

Bmc Cancer
GM Faria, IDP Soares, M D'Alincourt Salazar, MR Amorim, BL Pessoa, CO da Fonseca, T Quirico-Santos
Publication Date: 2020-04-07

Variant appearance in text: rs1801133
PMID: 32264844
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Genetic Polymorphisms and Platinum-Based Chemotherapy-Induced Toxicities in Patients With Lung Cancer: A Systematic Review and Meta-Analysis.

Frontiers In Oncology
W Liu, Y Wang, J Luo, H Yuan, Z Luo
Publication Date: 2019

Variant appearance in text: rs1801133
PMID: 32257953
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Single Nucleotide Polymorphisms in 25-Hydroxyvitamin D3 1-Alpha-Hydroxylase (CYP27B1) Gene: The Risk of Malignant Tumors and Other Chronic Diseases.

Nutrients
M Latacz, J Snarska, E Kostyra, E Fiedorowicz, HF Savelkoul, R Grzybowski, A Cieślińska
Publication Date: 2020-03-18

Variant appearance in text: rs1801133
PMID: 32197412
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MTHFR Ala222Val polymorphism and clinical characteristics confer susceptibility to suicide attempt in chronic patients with schizophrenia.

Scientific Reports
JH Liu, C Zhu, K Zheng, W Tang, LL Gao, TH Trihn, H Emily Wu, DC Chen, M Hong Xiu, X Yang Zhang
Publication Date: 2020-03-19

Variant appearance in text: MTHFR: Ala222Val; rs1801133
PMID: 32193498
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SNPs  in folate pathway are associated with the risk of nonsyndromic cleft lip with or without cleft palate, a meta-analysis.

Bioscience Reports
Q Li, L Xu, X Jia, K Saleem, T Zaib, W Sun, S Fu
Publication Date: 2020-03-03

Variant appearance in text: rs1801133
PMID: 32124929
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The Insulin-like Growth Factor-1 (G>A) and 5,10-methylenetetrahydrofolate Reductase (C677T) Gene Variants and the Serum Levels of Insulin-like Growth Factor-1, Insulin, and Homeostasis Model Assessment in Patients with Acne Vulgaris.

Iranian Journal Of Pathology
S Zinati-Saeed, E Shakiba, Z Rahimi, M Akbari, F Najafi, F Bahrehmand, A Vaisi-Raygani, Z Rahimi, A Ebrahimi, M Rahimi
Publication Date: 2020

Variant appearance in text: rs1801133
PMID: 32095146
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Relationship of genetic factors with development of aortic dissection and aneurysm.

Turk Gogus Kalp Damar Cerrahisi Dergisi
R Özmen, A Tunçay, EF Şener, ÖN Emiroğulları
Publication Date: 2018-10

Variant appearance in text: rs1801133
PMID: 32082797
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Combined Effect of HPV and Several Gene SNPs in Laryngeal Cancer.

Medicina (Kaunas, Lithuania)
A Stumbrytė-Kaminskienė, Ž Gudlevičienė, D Dabkevičienė, I Mackevičienė
Publication Date: 2020-02-17

Variant appearance in text: rs1801133
PMID: 32079256
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Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses.

The Journal Of Headache And Pain
Y Zhao, R Zhu, T Xiao, X Liu
Publication Date: 2020-02-11

Variant appearance in text: rs1801133
PMID: 32046629
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Rare Variants of Putative Candidate Genes Associated With Sporadic Meniere's Disease in East Asian Population.

Frontiers In Neurology
EH Oh, JH Shin, HS Kim, JW Cho, SY Choi, KD Choi, JK Rhee, S Lee, C Lee, JH Choi
Publication Date: 2019

Variant appearance in text: rs1801133
PMID: 32038468
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Food Intervention with Folate Reduces TNF-α and Interleukin Levels in Overweight and Obese Women with the MTHFR C677T Polymorphism: A Randomized Trial.

Nutrients
JVC Lisboa, MR Ribeiro, RCP Luna, RPA Lima, RAFD Nascimento, MGCA Monteiro, KQF Lima, CPNDS Fechine, NFP Oliveira, DC Persuhn, RC Veras, MDCR Gonçalves, FELL Ferreira, RT Lima, ASD Silva, ADS Diniz, ATC Almeida, RM Moraes, EV Junior, MJC Costa
Publication Date: 2020-01-30

Variant appearance in text: MTHFR: Ala222Val; rs1801133
PMID: 32019154
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Methylenetetrahydrofolate reductase C677T (Ala>Val, rs1801133 C>T) polymorphism decreases the susceptibility of hepatocellular carcinoma: A meta-analysis involving 12,628 subjects.

Bioscience Reports
S Zhang, J Jiang, W Tang, L Liu
Publication Date: 2020-02-03

Variant appearance in text: rs1801133
PMID: 32010931
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Methylenetetrahydrofolate reductase C677T polymorphism is not associated with the risk of nonsyndromic cleft lip/palate: An updated meta-analysis.

Scientific Reports
MM Imani, N Golchin, M Safaei, F Rezaei, H Abbasi, M Sadeghi, P Lopez-Jornet, HR Mozaffari, R Sharifi
Publication Date: 2020-01-30

Variant appearance in text: rs1801133
PMID: 32001764
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Genetic Landscape of Nonobstructive Azoospermia and New Perspectives for the Clinic.

Journal Of Clinical Medicine
M Cerván-Martín, JA Castilla, RJ Palomino-Morales, FD Carmona
Publication Date: 2020-01-21

Variant appearance in text: rs1801133
PMID: 31973052
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Heterogeneity in the distribution of 159 drug-response related SNPs in world populations and their genetic relatedness.

Plos One
T Ahsan, NJ Urmi, AA Sajib
Publication Date: 2020

Variant appearance in text: rs1801133
PMID: 31971968
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Utility of genetic variants to predict prognosis in coronary artery disease patients receiving statin treatment.

International Journal Of Clinical And Experimental Pathology
L Zhu, X Ji, L Jiang, Y Zhu, Y Xu, Q Jiang, J Bao, J Ye, H Sheng, H Yu
Publication Date: 2017

Variant appearance in text: rs1801133
PMID: 31966745
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Genetic Polymorphisms of Pharmacogenes among the Genetically Isolated Circassian Subpopulation from Jordan.

Journal Of Personalized Medicine
LN Al-Eitan, DM Rababa'h, NM Hakooz, MA Alghamdi, RB Dajani
Publication Date: 2020-01-06

Variant appearance in text: rs1801133
PMID: 31935801
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Interaction of serum vitamin B12 and folate with MTHFR genotypes on risk of ischemic stroke.

Neurology
X Qin, JD Spence, J Li, Y Zhang, Y Li, N Sun, M Liang, Y Song, Y Zhang, B Wang, X Cheng, L Zhao, X Wang, X Xu, Y Huo
Publication Date: 2020-01-13

Variant appearance in text: rs1801133
PMID: 31932513
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Homocysteine and IgA nephropathy: observational and Mendelian randomization analyses.

Chinese Medical Journal
YM Zhang, XJ Zhou, SF Shi, LJ Liu, JC Lyu, H Zhang
Publication Date: 2020-01-06

Variant appearance in text: MTHFR: A222V; rs1801133
PMID: 31929371
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Genetic Variants Associated with Chronic Kidney Disease in a Spanish Population.

Scientific Reports
Z Corredor, MIDS Filho, L Rodríguez-Ribera, A Velázquez, A Hernández, C Catalano, K Hemminki, E Coll, I Silva, JM Diaz, J Ballarin, M Vallés Prats, J Calabia Martínez, A Försti, R Marcos, S Pastor
Publication Date: 2020-01-10

Variant appearance in text: rs1801133
PMID: 31924810
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Gene interactions observed with the HDL-c blood lipid, intakes of protein, sugar and biotin in relation to circulating homocysteine concentrations in a group of black South Africans.

Molecular Genetics And Metabolism Reports
JP du Plessis, A Melse-Boonstra, L Zandberg, C Nienaber-Rousseau
Publication Date: 2020-03

Variant appearance in text: MTHFR: Ala222Val; rs1801133
PMID: 31908954
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A nutrigenetic approach for investigating the relationship between vitamin B12 status and metabolic traits in Indonesian women.

Journal Of Diabetes And Metabolic Disorders
S Surendran, AS Aji, U Ariyasra, SR Sari, SG Malik, N Tasrif, FF Yani, JA Lovegrove, IR Sudji, NI Lipoeto, KS Vimaleswaran
Publication Date: 2019-12

Variant appearance in text: rs1801133
PMID: 31890664
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Assessment of candidate genes and genetic heterogeneity in human non syndromic orofacial clefts specifically non syndromic cleft lip with or without palate.

Heliyon
K Saleem, T Zaib, W Sun, S Fu
Publication Date: 2019-12

Variant appearance in text: rs1801133
PMID: 31886431
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Olfactory-Related Quality of Life in Multiple Chemical Sensitivity: A Genetic-Acquired Factors Model.

International Journal Of Molecular Sciences
A Micarelli, A Cormano, D Caccamo, M Alessandrini
Publication Date: 2019-12-25

Variant appearance in text: MTHFR: A222V; rs1801133
PMID: 31881664
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Interplay of an Obesity-Based Genetic Risk Score with Dietary and Endocrine Factors on Insulin Resistance.

Nutrients
O Ramos-Lopez, JI Riezu-Boj, FI Milagro, M Cuervo, L Goni, JA Martinez
Publication Date: 2019-12-21

Variant appearance in text: rs1801133
PMID: 31877696
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Association of genes ARID5B, CEBPE and folate pathway with acute lymphoblastic leukemia in a population from the Brazilian Amazon region.

Leukemia Research Reports
DC Carvalho, AV Wanderley, FAR Mello Junior, AMRD Santos, LPC Leitão, TP Souza, ANCL Castro, LL Magalhães, MR Fernandes, JAN Carvalho Junior, AS Khayat, S Santos, PP Assumpção, NPC Dos Santos
Publication Date: 2020

Variant appearance in text: MTHFR: Ala222Val; rs1801133
PMID: 31867206
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Contribution of MTR A2756G polymorphism and MTRR A66G polymorphism to the risk of idiopathic male infertility.

Medicine
ZJ Ren, YP Zhang, PW Ren, B Yang, S Deng, ZF Peng, LR Liu, W Wei, Q Dong
Publication Date: 2019-12

Variant appearance in text: rs1801133
PMID: 31860974
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Polymorphisms of the TNF Gene and Three Susceptibility Loci Are Associated with Crohn's Disease and Perianal Fistula Crohn's Disease: A Study among the Han Population from South China.

Medical Science Monitor : International Medical Journal Of Experimental And Clinical Research
M Zhang, X Wang, X Jiang, X Yang, C Wen, M Zhi, X Gao, P Hu, H Liu
Publication Date: 2019-12-17

Variant appearance in text: rs1801133
PMID: 31844038
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Systematic meta-analyses, field synopsis and global assessment of the evidence of genetic association studies in colorectal cancer.

Gut
Z Montazeri, X Li, C Nyiraneza, X Ma, M Timofeeva, V Svinti, X Meng, Y He, Y Bo, S Morgan, S Castellví-Bel, C Ruiz-Ponte, C Fernández-Rozadilla, Á Carracedo, A Castells, T Bishop, D Buchanan, MA Jenkins, TO Keku, A Lindblom, FJB van Duijnhoven, A Wu, SM Farrington, MG Dunlop, H Campbell, E Theodoratou, W Zheng, J Little
Publication Date: 2019-12-09

Variant appearance in text: rs1801133
PMID: 31818908
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Plasma Homocysteine and Polymorphisms of Genes Involved in Folate Metabolism Correlate with DNMT1 Gene Methylation Levels.

Metabolites
F Coppedè, A Stoccoro, P Tannorella, L Migliore
Publication Date: 2019-12-07

Variant appearance in text: rs1801133
PMID: 31817852
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Association of single nucleotide polymorphisms of MTHFR, TCN2, RNF213 with susceptibility to hypertension and blood pressure.

Bioscience Reports
S Liu, M Liu, Q Li, X Liu, Y Wang, M Mambiya, K Zhang, L Yang, Q Zhang, M Shang, F Zeng, F Nie, W Liu
Publication Date: 2019-12-09

Variant appearance in text: rs1801133
PMID: 31815282
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Predicting Longitudinal Outcomes of Alzheimer's Disease via a Tensor-Based Joint Classification and Regression Model.

Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing
L Brand, K Nichols, H Wang, H Huang, L Shen,
Publication Date: 2020

Variant appearance in text: rs1801133
PMID: 31797582
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Rs4846049 Polymorphism at the 3'-UTR of MTHFR Gene: Association with Susceptibility to Childhood Acute Lymphoblastic Leukemia.

Biomed Research International
X Li, S Zhang, F Yu
Publication Date: 2019

Variant appearance in text: rs1801133
PMID: 31737664
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The Role of Single-Nucleotide Polymorphisms in the Function of Candidate Tumor Suppressor ALDH1L1.

Frontiers In Genetics
SA Krupenko, DA Horita
Publication Date: 2019

Variant appearance in text: MTHFR: A222V
PMID: 31737034
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Heterogeneity in Metabolic Responses to Dietary Fructose.

Frontiers In Genetics
R Hou, C Panda, VS Voruganti
Publication Date: 2019

Variant appearance in text: rs1801133
PMID: 31737029
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Association between methylenetetrahydrofolate reductase tagging polymorphisms and susceptibility of hepatocellular carcinoma: a case-control study.

Bioscience Reports
S Zhang, J Lin, J Jiang, Y Chen, W Tang, L Liu
Publication Date: 2019-11-29

Variant appearance in text: rs1801133
PMID: 31694048
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Single Nucleotide Polymorphisms in PEMT and MTHFR Genes are Associated with Omega 3 and 6 Fatty Acid Levels in the Red Blood Cells of Children with Obesity.

Nutrients
V Serafim, A Chirita-Emandi, N Andreescu, DA Tiugan, P Tutac, C Paul, I Velea, A Mihailescu, CL Șerban, CG Zimbru, M Puiu, MD Niculescu
Publication Date: 2019-10-30

Variant appearance in text: rs1801133
PMID: 31671528
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Non-syndromic cleft palate: Association analysis on three gene polymorphisms of the folate pathway in Asian and Italian populations.

International Journal Of Immunopathology And Pharmacology
F Carinci, A Palmieri, L Scapoli, F Cura, F Borelli, PG Morselli, N Nouri, H Abdali, AB Gianni, A Russillo, R Docimo, M Martinelli
Publication Date: 2019

Variant appearance in text: rs1801133
PMID: 31663447
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Association between oral cleft and transcobalamin 2 polymorphism in a sample study from Nassiriya, Iraq.

International Journal Of Immunopathology And Pharmacology
F Carinci, A Palmieri, L Scapoli, F Cura, F Abenavoli, AB Giannì, A Russillo, R Docimo, M Martinelli
Publication Date: 2019

Variant appearance in text: rs1801133
PMID: 31663440
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Association of MTHFR C677T polymorphism and type 2 diabetes mellitus (T2DM) susceptibility.

Molecular Genetics & Genomic Medicine
Y Meng, X Liu, K Ma, L Zhang, M Lu, M Zhao, MX Guan, G Qin
Publication Date: 2019-12

Variant appearance in text: MTHFR: Ala222Val; rs1801133
PMID: 31663297
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MTHFR and F5 genetic variations have association with preeclampsia in Pakistani patients: a case control study.

Bmc Medical Genetics
FF Khidri, YM Waryah, FK Ali, H Shaikh, ID Ujjan, AM Waryah
Publication Date: 2019-10-23

Variant appearance in text: rs1801133
PMID: 31646966
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Serum folate levels in bipolar disorder: a systematic review and meta-analysis.

Bmc Psychiatry
YC Hsieh, LS Chou, CH Lin, HC Wu, DJ Li, PT Tseng
Publication Date: 2019-10-22

Variant appearance in text: MTHFR: Ala222Val
PMID: 31640634
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Gene Influence in the Effectiveness of Plant Sterols Treatment in Children: Pilot Interventional Study.

Nutrients
I San Mauro Martín, E Garicano Vilar, S Sanz Rojo, L Collado Yurrita, E Pérez Arruche, E Arce Delgado, JA Blumenfeld Olivares
Publication Date: 2019-10-21

Variant appearance in text: rs1801133
PMID: 31640222
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Polymorphisms of MTHFR and TYMS predict capecitabine-induced hand-foot syndrome in patients with metastatic breast cancer.

Cancer Communications (London, England)
S Lin, J Yue, X Guan, P Yuan, J Wang, Y Luo, Y Fan, R Cai, Q Li, S Chen, P Zhang, Q Li, F Ma, B Xu
Publication Date: 2019-10-11

Variant appearance in text: MTHFR: Ala222Val; rs1801133
PMID: 31601265
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Genetic biomarkers related to hemarthrosis, inflammation, and cartilage structure in pediatric patients with hemophilic arthropathy.

Molecular Genetics & Genomic Medicine
JJ López-Jiménez, R Ortega-Cervantes, H Luna-Záizar, AL Fletes-Rayas, CP Beltrán-Miranda, R Troyo-Sanromán, J Soto-Padilla, A Tlacuilo-Parra, AR Jaloma-Cruz
Publication Date: 2019-11

Variant appearance in text: MTHFR: 665C>T; rs1801133
PMID: 31566926
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Clinical and Genetic Factors Associated with Resistance to Treatment in Patients with Schizophrenia: A Case-Control Study.

International Journal Of Molecular Sciences
A Hajj, S Obeid, S Sahyoun, C Haddad, J Azar, L Rabbaa Khabbaz, S Hallit
Publication Date: 2019-09-25

Variant appearance in text: MTHFR: Ala222Val; rs1801133
PMID: 31557839
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Association of MTHFR 677C>T Polymorphism with Susceptibility to Ovarian and Cervical Cancers: A Systematic Review and Meta-Analysis.

Asian Pacific Journal Of Cancer Prevention : Apjcp
M Karimi-Zarchi, M Moghimi, H Abbasi, A Hadadan, E Salimi, M Morovati-Sharifabad, MJ Akbarian-Bafghi, M Zare-Shehneh, A Mosavi-Jarrahi, H Neamatzadeh
Publication Date: 2019-09-01

Variant appearance in text: rs1801133
PMID: 31554347
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Investigating the methylation status of DACT2 gene and its association with MTHFR C677T polymorphism in patients with colorectal cancer.

Molecular Biology Research Communications
A Jalilvand, MS Soltanpour
Publication Date: 2019-06

Variant appearance in text: rs1801133
PMID: 31531376
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Discovery of Novel Biomarkers of Therapeutic Responses in Han Chinese Pemetrexed-Based Treated Advanced NSCLC Patients.

Frontiers In Pharmacology
X Zhang, D Zhang, L Huang, G Li, L Chen, J Ma, M Li, M Wei, W Zhou, C Zhou, J Zhu, Z Wang, S Qin
Publication Date: 2019

Variant appearance in text: rs1801133
PMID: 31507426
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Association of the MTHFR 677C>T Polymorphism with Obesity and Biochemical Variables in a Young Population of Mexico.

Journal Of Medical Biochemistry
E Leal-Ugarte, V Peralta-Leal, JP Meza-Espinoza, J Durán-González, N Macías-Gómez, A Bocanegra-Alonso, JR Lara-Ramos
Publication Date: 2019-10

Variant appearance in text: MTHFR: A222V; rs1801133
PMID: 31496910
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Whole-exome sequencing insights into pulmonary artery sarcoma mimicking pulmonary embolism: a case report and review.

Oncotargets And Therapy
Y Wu, J Huang, Q Wang, M Zhang, Y Luo, X Wang, X Zhu, H Liu
Publication Date: 2019

Variant appearance in text: rs1801133
PMID: 31496726
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Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome.

Genomics, Proteomics & Bioinformatics
Z Du, L Ma, H Qu, W Chen, B Zhang, X Lu, W Zhai, X Sheng, Y Sun, W Li, M Lei, Q Qi, N Yuan, S Shi, J Zeng, J Wang, Y Yang, Q Liu, Y Hong, L Dong, Z Zhang, D Zou, Y Wang, S Song, F Liu, X Fang, H Chen, X Liu, J Xiao, C Zeng
Publication Date: 2019-06

Variant appearance in text: rs1801133
PMID: 31494266
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The schizophrenia genetics knowledgebase: a comprehensive update of findings from candidate gene studies.

Translational Psychiatry
C Liu, T Kanazawa, Y Tian, S Mohamed Saini, S Mancuso, MS Mostaid, A Takahashi, D Zhang, F Zhang, H Yu, H Doo Shin, H Sub Cheong, M Ikeda, M Kubo, N Iwata, SI Woo, W Yue, Y Kamatani, Y Shi, Z Li, I Everall, C Pantelis, C Bousman
Publication Date: 2019-08-27

Variant appearance in text: rs1801133
PMID: 31455759
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Maternal Haplotypes in DHFR Promoter and MTHFR Gene in Tuning Childhood Acute Lymphoblastic Leukemia Onset-Latency: Genetic/Epigenetic Mother/Child Dyad Study (GEMCDS).

Genes
V Tisato, P Muggeo, T Lupiano, G Longo, ML Serino, M Grassi, E Arcamone, P Secchiero, G Zauli, N Santoro, D Gemmati
Publication Date: 2019-08-22

Variant appearance in text: rs1801133
PMID: 31443485
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Suitability and safety of L-5-methyltetrahydrofolate as a folate source in infant formula: A randomized-controlled trial.

Plos One
B Troesch, J Demmelmair, M Gimpfl, C Hecht, G Lakovic, R Roehle, L Sipka, B Trisic, M Vusurovic, R Schoop, S Zdjelar, B Koletzko,
Publication Date: 2019

Variant appearance in text: rs1801133
PMID: 31425504
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Plausible relationship between homocysteine and obesity risk via MTHFR gene: a meta-analysis of 38,317 individuals implementing Mendelian randomization.

Diabetes, Metabolic Syndrome And Obesity : Targets And Therapy
L Fu, YN Li, D Luo, S Deng, YQ Hu
Publication Date: 2019

Variant appearance in text: rs1801133
PMID: 31413611
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Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000376583.3 c.788C>T p.Ala263Val missense_variant 5/12 -
ENST00000376585.1 c.788C>T p.Ala263Val missense_variant 6/13 -
ENST00000376590.3 c.665C>T p.Ala222Val missense_variant 5/12 -
ENST00000376592.1 c.665C>T p.Ala222Val missense_variant 4/11 -
NM_001330358.1 c.788C>T p.Ala263Val missense_variant 5/12 -
NM_005957.5 c.665C>T p.Ala222Val missense_variant 5/12 -