MTHFR c.587-1495A>T

Variant ID: 1-11857951-T-A

NM_005957.4(MTHFR):c.587-1495A>T

This variant was identified in 14 publications

View GRCh38 version.




Publications:


The Roles of MTRR and MTHFR Gene Polymorphisms in Colorectal Cancer Survival.

Nutrients
Wang, Yu Y; Du, Meizhi M; Vallis, Jillian J; Shariati, Matin M; Parfrey, Patrick S PS; Mclaughlin, John R JR; Wang, Peizhong Peter PP; Zhu, Yun Y
Publication Date: 2022-11-01

Variant appearance in text: rs4846052
PubMed Link: 36364857
Variant Present in the following documents:
  • Main text
  • nutrients-14-04594.pdf
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Association of methylenetetrahydrofolate reductase gene polymorphisms and maternal folic acid use with the risk of congenital heart disease.

Frontiers In Pediatrics
Zhong, Taowei T; Song, Xinli X; Liu, Yiping Y; Sun, Mengting M; Zhang, Senmao S; Chen, Letao L; Diao, Jingyi J; Li, Jinqi J; Li, Yihuan Y; Shu, Jing J; Wei, Jianhui J; Zhu, Ping P; Wang, Tingting T; Qin, Jiabi J
Publication Date: 2022

Variant appearance in text: rs4846052
PubMed Link: 36160803
Variant Present in the following documents:
  • Main text
  • fped-10-939119.pdf
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Association analysis of maternal MTHFR gene polymorphisms and the occurrence of congenital heart disease in offspring.

Bmc Cardiovascular Disorders
Sun, Mengting M; Wang, Tingting T; Huang, Peng P; Diao, Jingyi J; Zhang, Senmao S; Li, Jinqi J; Luo, Liu L; Li, Yihuan Y; Chen, Letao L; Liu, Yiping Y; Wei, Jianhui J; Song, Xinli X; Sheng, Xiaoqi X; Qin, Jiabi J
Publication Date: 2021-06-14

Variant appearance in text: rs4846052
PubMed Link: 34126931
Variant Present in the following documents:
  • Main text
  • 12872_2021_Article_2117.pdf
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Single Nucleotide Polymorphisms in PEMT and MTHFR Genes are Associated with Omega 3 and 6 Fatty Acid Levels in the Red Blood Cells of Children with Obesity.

Nutrients
Serafim, Vlad V; Chirita-Emandi, Adela A; Andreescu, Nicoleta N; Tiugan, Diana-Andreea DA; Tutac, Paul P; Paul, Corina C; Velea, Iulian I; Mihailescu, Alexandra A; Șerban, Costela Lăcrimioara CL; Zimbru, Cristian G CG; Puiu, Maria M; Niculescu, Mihai Dinu MD
Publication Date: 2019-10-30

Variant appearance in text: rs4846052
PubMed Link: 31671528
Variant Present in the following documents:
  • Main text
  • nutrients-11-02600.pdf
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The 677C→T variant of MTHFR is the major genetic modifier of biomarkers of folate status in a young, healthy Irish population.

The American Journal Of Clinical Nutrition
Shane, Barry B; Pangilinan, Faith F; Mills, James L JL; Fan, Ruzong R; Gong, Tingting T; Cropp, Cheryl D CD; Kim, Yoonhee Y; Ueland, Per M PM; Bailey-Wilson, Joan E JE; Wilson, Alexander F AF; Brody, Lawrence C LC; Molloy, Anne M AM
Publication Date: 2018-12-01

Variant appearance in text: rs4846052
PubMed Link: 30339177
Variant Present in the following documents:
  • Main text
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DNA methylation mapping identifies gene regulatory effects in patients with systemic lupus erythematosus.

Annals Of The Rheumatic Diseases
Imgenberg-Kreuz, Juliana J; Carlsson Almlöf, Jonas J; Leonard, Dag D; Alexsson, Andrei A; Nordmark, Gunnel G; Eloranta, Maija-Leena ML; Rantapää-Dahlqvist, Solbritt S; Bengtsson, Anders A AA; Jönsen, Andreas A; Padyukov, Leonid L; Gunnarsson, Iva I; Svenungsson, Elisabet E; Sjöwall, Christopher C; Rönnblom, Lars L; Syvänen, Ann-Christine AC; Sandling, Johanna K JK
Publication Date: 2018-05

Variant appearance in text: rs4846052
PubMed Link: 29437559
Variant Present in the following documents:
  • annrheumdis-2017-212379supp016.pdf
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Polymorphisms and Pharmacogenomics for the Clinical Efficacy of Methotrexate in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-analysis.

Scientific Reports
Qiu, Qi Q; Huang, Jing J; Shu, Xiaoming X; Fan, Huizheng H; Zhou, Youwen Y; Xiao, Cheng C
Publication Date: 2017-03-07

Variant appearance in text: rs4846052
PubMed Link: 28266606
Variant Present in the following documents:
  • Main text
  • srep44015.pdf
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Interaction between arsenic exposure from drinking water and genetic polymorphisms on cardiovascular disease in Bangladesh: a prospective case-cohort study.

Environmental Health Perspectives
Wu, Fen F; Jasmine, Farzana F; Kibriya, Muhammad G MG; Liu, Mengling M; Cheng, Xin X; Parvez, Faruque F; Islam, Tariqul T; Ahmed, Alauddin A; Rakibuz-Zaman, Muhammad M; Jiang, Jieying J; Roy, Shantanu S; Paul-Brutus, Rachelle R; Slavkovich, Vesna V; Islam, Tariqul T; Levy, Diane D; VanderWeele, Tyler J TJ; Pierce, Brandon L BL; Graziano, Joseph H JH; Ahsan, Habibul H; Chen, Yu Y
Publication Date: 2015-05

Variant appearance in text: rs4846052
PubMed Link: 25575156
Variant Present in the following documents:
  • ehp.1307883.s001.508.pdf
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Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis.

Faseb Journal : Official Publication Of The Federation Of American Societies For Experimental Biology
Corbin, Karen D KD; Abdelmalek, Manal F MF; Spencer, Melanie D MD; da Costa, Kerry-Ann KA; Galanko, Joseph A JA; Sha, Wei W; Suzuki, Ayako A; Guy, Cynthia D CD; Cardona, Diana M DM; Torquati, Alfonso A; Diehl, Anna Mae AM; Zeisel, Steven H SH
Publication Date: 2013-04

Variant appearance in text: rs4846052
PubMed Link: 23292069
Variant Present in the following documents:
  • Main text
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The Genetic Diversity and Structure of Linkage Disequilibrium of the MTHFR Gene in Populations of Northern Eurasia.

Acta Naturae
Trifonova, E A EA; Eremina, E R ER; Urnov, F D FD; Stepanov, V A VA
Publication Date: 2012-01

Variant appearance in text: rs4846052
PubMed Link: 22708063
Variant Present in the following documents:
  • Main text
  • AN20758251-12-053.pdf
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Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia.

Cancer Causes & Control : Ccc
Metayer, Catherine C; Scélo, Ghislaine G; Chokkalingam, Anand P AP; Barcellos, Lisa F LF; Aldrich, Melinda C MC; Chang, Jeffrey S JS; Guha, Neela N; Urayama, Kevin Y KY; Hansen, Helen M HM; Block, Gladys G; Kiley, Vincent V; Wiencke, John K JK; Wiemels, Joseph L JL; Buffler, Patricia A PA
Publication Date: 2011-09

Variant appearance in text: rs4846052
PubMed Link: 21748308
Variant Present in the following documents:
  • Main text
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Folate pathway and nonsyndromic cleft lip and palate.

Birth Defects Research. Part A, Clinical And Molecular Teratology
Blanton, Susan H SH; Henry, Robin R RR; Yuan, Quiping Q; Mulliken, John B JB; Stal, Samuel S; Finnell, Richard H RH; Hecht, Jacqueline T JT
Publication Date: 2011-01

Variant appearance in text: rs4846052
PubMed Link: 21254359
Variant Present in the following documents:
  • Main text
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SNP-SNP interactions dominate the genetic architecture of candidate genes associated with left ventricular mass in African-Americans of the GENOA study.

Bmc Medical Genetics
Meyers, Kristin J KJ; Chu, Jian J; Mosley, Thomas H TH; Kardia, Sharon L R SL
Publication Date: 2010-11-10

Variant appearance in text: rs4846052
PubMed Link: 21067599
Variant Present in the following documents:
  • Main text
  • 1471-2350-11-160.pdf
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118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.

Bmc Medical Genetics
Shaw, Gary M GM; Lu, Wei W; Zhu, Huiping H; Yang, Wei W; Briggs, Farren B S FB; Carmichael, Suzan L SL; Barcellos, Lisa F LF; Lammer, Edward J EJ; Finnell, Richard H RH
Publication Date: 2009-06-03

Variant appearance in text: rs4846052
PubMed Link: 19493349
Variant Present in the following documents:
  • Main text
  • 1471-2350-10-49.pdf
View BVdb publication page