Impaired expression of metallothioneins contributes to allergen-induced inflammation in patients with atopic dermatitis.
Nature Communications
Sirvent, Sofia S; Vallejo, Andres F AF; Corden, Emma E; Teo, Ying Y; Davies, James J; Clayton, Kalum K; Seaby, Eleanor G EG; Lai, Chester C; Ennis, Sarah S; Alyami, Rfeef R; Douilhet, Gemma G; Dean, Lareb S N LSN; Loxham, Matthew M; Horswill, Sarah S; Healy, Eugene E; Roberts, Graham G; Hall, Nigel J NJ; Friedmann, Peter S PS; Singh, Harinder H; Bennett, Clare L CL; Ardern-Jones, Michael R MR; Polak, Marta E ME
In silico analysis of the profilaggrin sequence indicates alterations in the stability, degradation route, and intracellular protein fate in filaggrin null mutation carriers.
Frontiers In Molecular Biosciences
Paul, Argho Aninda AA; Szulc, Natalia A NA; Kobiela, Adrian A; Brown, Sara J SJ; Pokrzywa, Wojciech W; Gutowska-Owsiak, Danuta D
Genetic Variants in Epidermal Differentiation Complex Genes as Predictive Biomarkers for Atopic Eczema, Allergic Sensitization, and Eczema-Associated Asthma in a 6-Year Follow-Up Case-Control Study in Children.
Journal Of Clinical Medicine
Dębińska, Anna A; Danielewicz, Hanna H; Sozańska, Barbara B
Genomic, transcriptomic, and metabolomic profiles of hiPSC-derived dopamine neurons from clinically discordant brothers with identical PRKN deletions.
Npj Parkinson'S Disease
Cukier, Holly N HN; Kim, Hyunjin H; Griswold, Anthony J AJ; Codreanu, Simona G SG; Prince, Lisa M LM; Sherrod, Stacy D SD; McLean, John A JA; Dykxhoorn, Derek M DM; Ess, Kevin C KC; Hedera, Peter P; Bowman, Aaron B AB; Neely, M Diana MD
Publication Date: 2022-06-29
Variant appearance in text: FLG: S3247X; rs150597413
Comparison of Epidermal Barrier Integrity in Adults with Classic Atopic Dermatitis, Atopic Prurigo and Non-Atopic Prurigo Nodularis.
Biology
Fölster-Holst, Regina R; Reimer, Rahel R; Neumann, Claudia C; Proksch, Erhardt E; Rodriguez, Elke E; Weidinger, Stephan S; Goldust, Mohamad M; Hanisch, Eckhard E; Dähnhardt-Pfeiffer, Stephan S; Freitag-Wolf, Sandra S
Moisturisers from birth in at-risk infants of atopic dermatitis - a pragmatic randomised controlled trial.
The Australasian Journal Of Dermatology
Ng, Pamela Si Min PSM; Wee, Lynette Wei Yi LWY; Ho, Valerie Pui Yoong VPY; Tan, Weixuan Colin WC; Bishnoi, Priya P; Alagappan, Uma U; Wong, Sharon Mun Yee SMY; Gan, Emily Yiping EY; Quek, Bin Huey BH; Shen, Liang L; Su, Bing B; Common, John Ea JE; Koh, Mark Jean Aan MJA
Increased Th22 cell numbers in a general pediatric population with filaggrin haploinsufficiency: The Generation R Study.
Pediatric Allergy And Immunology : Official Publication Of The European Society Of Pediatric Allergy And Immunology
Looman, Kirsten I M KIM; van Mierlo, Minke M F MMF; van Zelm, Menno C MC; Hu, Chen C; Duijts, Liesbeth L; de Jongste, Johan C JC; Nijsten, Tamar T; Pardo, Luba M LM; Kiefte-de Jong, Jessica C JC; Moll, Henriëtte A HA; Pasmans, Suzanne G M A SGMA
Publication Date: 2021-08
Variant appearance in text: FLG: S3247X; rs150597413
Four childhood atopic dermatitis subtypes identified from trajectory and severity of disease and internally validated in a large UK birth cohort.
The British Journal Of Dermatology
Mulick, A R AR; Mansfield, K E KE; Silverwood, R J RJ; Budu-Aggrey, A A; Roberts, A A; Custovic, A A; Pearce, N N; Irvine, A D AD; Smeeth, L L; Abuabara, K K; Langan, S M SM
Filaggrin Polymorphisms and the Uptake of Chemicals through the Skin-A Human Experimental Study.
Environmental Health Perspectives
Rietz Liljedahl, Emelie E; Johanson, Gunnar G; Korres de Paula, Helena H; Faniband, Moosa M; Assarsson, Eva E; Littorin, Margareta M; Engfeldt, Malin M; Lidén, Carola C; Julander, Anneli A; Wahlberg, Karin K; Lindh, Christian C; Broberg, Karin K
Genetic and Epigenetic Aspects of Atopic Dermatitis.
International Journal Of Molecular Sciences
Nedoszytko, Bogusław B; Reszka, Edyta E; Gutowska-Owsiak, Danuta D; Trzeciak, Magdalena M; Lange, Magdalena M; Jarczak, Justyna J; Niedoszytko, Marek M; Jablonska, Ewa E; Romantowski, Jan J; Strapagiel, Dominik D; Skokowski, Jarosław J; Siekierzycka, Anna A; Nowicki, Roman J RJ; Dobrucki, Iwona T IT; Zaryczańska, Anna A; Kalinowski, Leszek L
Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial.
Lancet (London, England)
Chalmers, Joanne R JR; Haines, Rachel H RH; Bradshaw, Lucy E LE; Montgomery, Alan A AA; Thomas, Kim S KS; Brown, Sara J SJ; Ridd, Matthew J MJ; Lawton, Sandra S; Simpson, Eric L EL; Cork, Michael J MJ; Sach, Tracey H TH; Flohr, Carsten C; Mitchell, Eleanor J EJ; Swinden, Richard R; Tarr, Stella S; Davies-Jones, Susan S; Jay, Nicola N; Kelleher, Maeve M MM; Perkin, Michael R MR; Boyle, Robert J RJ; Williams, Hywel C HC; ,
Progression of acute-to-chronic atopic dermatitis is associated with quantitative rather than qualitative changes in cytokine responses.
The Journal Of Allergy And Clinical Immunology
Tsoi, Lam C LC; Rodriguez, Elke E; Stölzl, Dora D; Wehkamp, Ulrike U; Sun, Jingru J; Gerdes, Sascha S; Sarkar, Mrinal K MK; Hübenthal, Matthias M; Zeng, Chang C; Uppala, Ranjitha R; Xing, Xianying X; Thielking, Frederieke F; Billi, Allison C AC; Swindell, William R WR; Shefler, Alanna A; Chen, Jiahan J; Patrick, Matthew T MT; Harms, Paul W PW; Kahlenberg, J Michelle JM; Perez White, Bethany E BE; Maverakis, Emanual E; Gudjonsson, Johann E JE; Weidinger, Stephan S
Effect of immunosuppressive treatment on biomarkers in adult atopic dermatitis patients.
Journal Of The European Academy Of Dermatology And Venereology : Jeadv
Roekevisch, E E; Szegedi, K K; Hack, D P DP; Schram, M E ME; Res, P C J M PCJM; Bos, J D JD; Leeflang, M M G MMG; Luiten, R M RM; Kezic, S S; Spuls, P I PI; Middelkamp-Hup, M A MA
Proteomic analysis of a filaggrin-deficient skin organoid model shows evidence of increased transcriptional-translational activity, keratinocyte-immune crosstalk and disordered axon guidance.
Wellcome Open Research
Elias, Martina S MS; Wright, Sheila C SC; Nicholson, William V WV; Morrison, Kimberley D KD; Prescott, Alan R AR; Ten Have, Sara S; Whitfield, Phillip D PD; Lamond, Angus I AI; Brown, Sara J SJ
Association of Filaggrin Loss-of-Function Variants With Race in Children With Atopic Dermatitis.
Jama Dermatology
Margolis, David J DJ; Mitra, Nandita N; Wubbenhorst, Bradley B; D'Andrea, Kurt K; Kraya, Adam A AA; Hoffstad, Ole O; Shah, Saloni S; Nathanson, Katherine L KL
Publication Date: 2019-11-01
Variant appearance in text: FLG: S3247*; rs150597413
Clinical onset of atopic eczema: Results from 2 nationally representative British birth cohorts followed through midlife.
The Journal Of Allergy And Clinical Immunology
Abuabara, Katrina K; Ye, Morgan M; McCulloch, Charles E CE; Sullivan, Alice A; Margolis, David J DJ; Strachan, David P DP; Paternoster, Lavinia L; Yew, Yik Weng YW; Williams, Hywel C HC; Langan, Sinéad M SM
Publication Date: 2019-09
Variant appearance in text: FLG: S3247X; rs150597413
Most associations of early-life environmental exposures and genetic risk factors poorly differentiate between eczema phenotypes: the Generation R Study.
The British Journal Of Dermatology
Hu, C C; Duijts, L L; Erler, N S NS; Elbert, N J NJ; Piketty, C C; Bourdès, V V; Blanchet-Réthoré, S S; de Jongste, J C JC; Pasmans, S G M A SGMA; Felix, J F JF; Nijsten, T T