Clinical Value of IL6R Gene Variants as Predictive Biomarkers for Toxicity to Tocilizumab in Patients with Rheumatoid Arthritis.
Journal Of Personalized Medicine
Sainz, Luis L; Riera, Pau P; Moya, Patricia P; Bernal, Sara S; Casademont, Jordi J; Díaz-Torné, Cesar C; Millán, Ana Milena AM; Park, Hye Sang HS; Lasa, Adriana A; Corominas, Héctor H
Role of IL6R Genetic Variants in Predicting Response to Tocilizumab in Patients with Rheumatoid Arthritis.
Pharmaceutics
Sainz, Luis L; Riera, Pau P; Moya, Patricia P; Bernal, Sara S; Casademont, Jordi J; Díaz-Torné, Cesar C; Millán, Ana Milena AM; Park, Hye Sang HS; Lasa, Adriana A; Corominas, Héctor H
Single nucleotide polymorphisms located in TNFA, IL1RN, IL6R, and IL6 genes are associated with COVID-19 risk and severity in an Iranian population.
Cell Biology International
Rokni, Mohsen M; Sarhadi, Mohammad M; Heidari Nia, Milad M; Mohamed Khosroshahi, Leila L; Asghari, Somaye S; Sargazi, Saman S; Mirinejad, Shekoufeh S; Saravani, Ramin R
Causal risk and protective factors in rheumatoid arthritis: A genetic update.
Journal Of Translational Autoimmunity
Arleevskaya, M M; Takha, E E; Petrov, S S; Kazarian, G G; Novikov, A A; Larionova, R R; Valeeva, A A; Shuralev, E E; Mukminov, M M; Bost, C C; Renaudineau, Y Y
Genome-wide association study of circulating interleukin 6 levels identifies novel loci.
Human Molecular Genetics
Ahluwalia, Tarunveer S TS; Prins, Bram P BP; Abdollahi, Mohammadreza M; Armstrong, Nicola J NJ; Aslibekyan, Stella S; Bain, Lisa L; Jefferis, Barbara B; Baumert, Jens J; Beekman, Marian M; Ben-Shlomo, Yoav Y; Bis, Joshua C JC; Mitchell, Braxton D BD; de Geus, Eco E; Delgado, Graciela E GE; Marek, Diana D; Eriksson, Joel J; Kajantie, Eero E; Kanoni, Stavroula S; Kemp, John P JP; Lu, Chen C; Marioni, Riccardo E RE; McLachlan, Stela S; Milaneschi, Yuri Y; Nolte, Ilja M IM; Petrelis, Alexandros M AM; Porcu, Eleonora E; Sabater-Lleal, Maria M; Naderi, Elnaz E; Seppälä, Ilkka I; Shah, Tina T; Singhal, Gaurav G; Standl, Marie M; Teumer, Alexander A; Thalamuthu, Anbupalam A; Thiering, Elisabeth E; Trompet, Stella S; Ballantyne, Christie M CM; Benjamin, Emelia J EJ; Casas, Juan P JP; Toben, Catherine C; Dedoussis, George G; Deelen, Joris J; Durda, Peter P; Engmann, Jorgen J; Feitosa, Mary F MF; Grallert, Harald H; Hammarstedt, Ann A; Harris, Sarah E SE; Homuth, Georg G; Hottenga, Jouke-Jan JJ; Jalkanen, Sirpa S; Jamshidi, Yalda Y; Jawahar, Magdalene C MC; Jess, Tine T; Kivimaki, Mika M; Kleber, Marcus E ME; Lahti, Jari J; Liu, Yongmei Y; Marques-Vidal, Pedro P; Mellström, Dan D; Mooijaart, Simon P SP; Müller-Nurasyid, Martina M; Penninx, Brenda B; Revez, Joana A JA; Rossing, Peter P; Räikkönen, Katri K; Sattar, Naveed N; Scharnagl, Hubert H; Sennblad, Bengt B; Silveira, Angela A; Pourcain, Beate St BS; Timpson, Nicholas J NJ; Trollor, Julian J; , ; van Dongen, Jenny J; Van Heemst, Diana D; Visvikis-Siest, Sophie S; Vollenweider, Peter P; Völker, Uwe U; Waldenberger, Melanie M; Willemsen, Gonneke G; Zabaneh, Delilah D; Morris, Richard W RW; Arnett, Donna K DK; Baune, Bernhard T BT; Boomsma, Dorret I DI; Chang, Yen-Pei C YC; Deary, Ian J IJ; Deloukas, Panos P; Eriksson, Johan G JG; Evans, David M DM; Ferreira, Manuel A MA; Gaunt, Tom T; Gudnason, Vilmundur V; Hamsten, Anders A; Heinrich, Joachim J; Hingorani, Aroon A; Humphries, Steve E SE; Jukema, J Wouter JW; Koenig, Wolfgang W; Kumari, Meena M; Kutalik, Zoltan Z; Lawlor, Deborah A DA; Lehtimäki, Terho T; März, Winfried W; Mather, Karen A KA; Naitza, Silvia S; Nauck, Matthias M; Ohlsson, Claes C; Price, Jackie F JF; Raitakari, Olli O; Rice, Ken K; Sachdev, Perminder S PS; Slagboom, Eline E; Sørensen, Thorkild I A TIA; Spector, Tim T; Stacey, David D; Stathopoulou, Maria G MG; Tanaka, Toshiko T; Wannamethee, S Goya SG; Whincup, Peter P; Rotter, Jerome I JI; Dehghan, Abbas A; Boerwinkle, Eric E; Psaty, Bruce M BM; Snieder, Harold H; Alizadeh, Behrooz Z BZ
Genetics of 35 blood and urine biomarkers in the UK Biobank.
Nature Genetics
Sinnott-Armstrong, Nasa N; Tanigawa, Yosuke Y; Amar, David D; Mars, Nina N; Benner, Christian C; Aguirre, Matthew M; Venkataraman, Guhan Ram GR; Wainberg, Michael M; Ollila, Hanna M HM; Kiiskinen, Tuomo T; Havulinna, Aki S AS; Pirruccello, James P JP; Qian, Junyang J; Shcherbina, Anna A; , ; Rodriguez, Fatima F; Assimes, Themistocles L TL; Agarwala, Vineeta V; Tibshirani, Robert R; Hastie, Trevor T; Ripatti, Samuli S; Pritchard, Jonathan K JK; Daly, Mark J MJ; Rivas, Manuel A MA
Publication Date: 2021-02
Variant appearance in text: IL6R: 85+2913A>G; rs12083537
Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease.
Nature Communications
Nielsen, Jonas B JB; Rom, Oren O; Surakka, Ida I; Graham, Sarah E SE; Zhou, Wei W; Roychowdhury, Tanmoy T; Fritsche, Lars G LG; Gagliano Taliun, Sarah A SA; Sidore, Carlo C; Liu, Yuhao Y; Gabrielsen, Maiken E ME; Skogholt, Anne Heidi AH; Wolford, Brooke B; Overton, William W; Zhao, Ying Y; Chen, Jin J; Zhang, He H; Hornsby, Whitney E WE; Acheampong, Akua A; Grooms, Austen A; Schaefer, Amanda A; Zajac, Gregory J M GJM; Villacorta, Luis L; Zhang, Jifeng J; Brumpton, Ben B; Løset, Mari M; Rai, Vivek V; Lundegaard, Pia R PR; Olesen, Morten S MS; Taylor, Kent D KD; Palmer, Nicholette D ND; Chen, Yii-Der YD; Choi, Seung H SH; Lubitz, Steven A SA; Ellinor, Patrick T PT; Barnes, Kathleen C KC; Daya, Michelle M; Rafaels, Nicholas N; Weiss, Scott T ST; Lasky-Su, Jessica J; Tracy, Russell P RP; Vasan, Ramachandran S RS; Cupples, L Adrienne LA; Mathias, Rasika A RA; Yanek, Lisa R LR; Becker, Lewis C LC; Peyser, Patricia A PA; Bielak, Lawrence F LF; Smith, Jennifer A JA; Aslibekyan, Stella S; Hidalgo, Bertha A BA; Arnett, Donna K DK; Irvin, Marguerite R MR; Wilson, James G JG; Musani, Solomon K SK; Correa, Adolfo A; Rich, Stephen S SS; Guo, Xiuqing X; Rotter, Jerome I JI; Konkle, Barbara A BA; Johnsen, Jill M JM; Ashley-Koch, Allison E AE; Telen, Marilyn J MJ; Sheehan, Vivien A VA; Blangero, John J; Curran, Joanne E JE; Peralta, Juan M JM; Montgomery, Courtney C; Sheu, Wayne H-H WH; Chung, Ren-Hua RH; Schwander, Karen K; Nouraie, Seyed M SM; Gordeuk, Victor R VR; Zhang, Yingze Y; Kooperberg, Charles C; Reiner, Alexander P AP; Jackson, Rebecca D RD; Bleecker, Eugene R ER; Meyers, Deborah A DA; Li, Xingnan X; Das, Sayantan S; Yu, Ketian K; LeFaive, Jonathon J; Smith, Albert A; Blackwell, Tom T; Taliun, Daniel D; Zollner, Sebastian S; Forer, Lukas L; Schoenherr, Sebastian S; Fuchsberger, Christian C; Pandit, Anita A; Zawistowski, Matthew M; Kheterpal, Sachin S; Brummett, Chad M CM; Natarajan, Pradeep P; Schlessinger, David D; Lee, Seunggeun S; Kang, Hyun Min HM; Cucca, Francesco F; Holmen, Oddgeir L OL; Åsvold, Bjørn O BO; Boehnke, Michael M; Kathiresan, Sekar S; Abecasis, Goncalo R GR; Chen, Y Eugene YE; Willer, Cristen J CJ; Hveem, Kristian K
Dissecting the Association Between Inflammation, Metabolic Dysregulation, and Specific Depressive Symptoms: A Genetic Correlation and 2-Sample Mendelian Randomization Study.
Jama Psychiatry
Kappelmann, Nils N; Arloth, Janine J; Georgakis, Marios K MK; Czamara, Darina D; Rost, Nicolas N; Ligthart, Symen S; Khandaker, Golam M GM; Binder, Elisabeth B EB
Genetic Polymorphisms Associated with Rheumatoid Arthritis Development and Antirheumatic Therapy Response.
International Journal Of Molecular Sciences
Mikhaylenko, Dmitry S DS; Nemtsova, Marina V MV; Bure, Irina V IV; Kuznetsova, Ekaterina B EB; Alekseeva, Ekaterina A EA; Tarasov, Vadim V VV; Lukashev, Alexander N AN; Beloukhova, Marina I MI; Deviatkin, Andrei A AA; Zamyatnin, Andrey A AA
Investigating evidence for a causal association between inflammation and self-harm: A multivariable Mendelian Randomisation study.
Brain, Behavior, And Immunity
Russell, Abigail Emma AE; Ford, Tamsin T; Gunnell, David D; Heron, Jon J; Joinson, Carol C; Moran, Paul P; Relton, Caroline C; Suderman, Matthew M; Hemani, Gibran G; Mars, Becky B
A pilot study of single nucleotide polymorphisms in the interleukin-6 receptor and their effects on pre- and post-transplant serum mediator level and outcome after allogeneic stem cell transplantation.
Clinical And Experimental Immunology
Tvedt, T H A THA; Hovland, R R; Tsykunova, G G; Ahmed, A B AB; Gedde-Dahl, T T; Bruserud, Ø Ø
Identification of STOML2 as a putative novel asthma risk gene associated with IL6R.
Allergy
Revez, J A JA; Matheson, M C MC; Hui, J J; Baltic, S S; , ; James, A A; Upham, J W JW; Dharmage, S S; Thompson, P J PJ; Martin, N G NG; Hopper, J L JL; Ferreira, M A R MA
Analysis of the role of interleukin 6 receptor haplotypes in the regulation of circulating levels of inflammatory biomarkers and risk of coronary heart disease.
Plos One
Gigante, Bruna B; Strawbridge, Rona J RJ; Velasquez, Ilais Moreno IM; Golabkesh, Zahra Z; Silveira, Angela A; Goel, Anuj A; Baldassarre, Damiano D; Veglia, Fabrizio F; Tremoli, Elena E; Clarke, Robert R; Watkins, Hugh H; Hamsten, Anders A; Humphries, Steve E SE; de Faire, Ulf U
Interleukin polymorphisms associated with overall survival, disease-free survival, and recurrence in non-small cell lung cancer patients.
Molecular Carcinogenesis
Woods, Nicholas T NT; Monteiro, Alvaro N AN; Thompson, Zachary J ZJ; Amankwah, Ernest K EK; Naas, Nina N; Haura, Eric B EB; Beg, Amer A AA; Schabath, Matthew B MB
A new regulatory variant in the interleukin-6 receptor gene associates with asthma risk.
Genes And Immunity
Revez, J A JA; Bain, L L; Chapman, B B; Powell, J E JE; Jansen, R R; Duffy, D L DL; Tung, J Y JY; , ; Penninx, B W BW; Visscher, P M PM; De Geus, E J C EJ; Boomsma, D I DI; Hinds, D A DA; Martin, N G NG; Montgomery, G W GW; Ferreira, M A R MA
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.
Lancet (London, England)
, ; Swerdlow, Daniel I DI; Holmes, Michael V MV; Kuchenbaecker, Karoline B KB; Engmann, Jorgen E L JE; Shah, Tina T; Sofat, Reecha R; Guo, Yiran Y; Chung, Christina C; Peasey, Anne A; Pfister, Roman R; Mooijaart, Simon P SP; Ireland, Helen A HA; Leusink, Maarten M; Langenberg, Claudia C; Li, Ka Wah KW; Palmen, Jutta J; Howard, Philip P; Cooper, Jackie A JA; Drenos, Fotios F; Hardy, John J; Nalls, Michael A MA; Li, Yun Rose YR; Lowe, Gordon G; Stewart, Marlene M; Bielinski, Suzette J SJ; Peto, Julian J; Timpson, Nicholas J NJ; Gallacher, John J; Dunlop, Malcolm M; Houlston, Richard R; Tomlinson, Ian I; Tzoulaki, Ioanna I; Luan, Jian'an J; Boer, Jolanda M A JM; Forouhi, Nita G NG; Onland-Moret, N Charlotte NC; van der Schouw, Yvonne T YT; Schnabel, Renate B RB; Hubacek, Jaroslav A JA; Kubinova, Ruzena R; Baceviciene, Migle M; Tamosiunas, Abdonas A; Pajak, Andrzej A; Topor-Madry, Roman R; Malyutina, Sofia S; Baldassarre, Damiano D; Sennblad, Bengt B; Tremoli, Elena E; de Faire, Ulf U; Ferrucci, Luigi L; Bandenelli, Stefania S; Tanaka, Toshiko T; Meschia, James F JF; Singleton, Andrew A; Navis, Gerjan G; Mateo Leach, Irene I; Bakker, Stephan J L SJ; Gansevoort, Ron T RT; Ford, Ian I; Epstein, Stephen E SE; Burnett, Mary Susan MS; Devaney, Joe M JM; Jukema, J Wouter JW; Westendorp, Rudi G J RG; Jan de Borst, Gert G; van der Graaf, Yolanda Y; de Jong, Pim A PA; Mailand-van der Zee, Anke-Hilse AH; Klungel, Olaf H OH; de Boer, Anthonius A; Doevendans, Pieter A PA; Stephens, Jeffrey W JW; Eaton, Charles B CB; Robinson, Jennifer G JG; Manson, JoAnn E JE; Fowkes, F Gerry FG; Frayling, Timonthy M TM; Price, Jackie F JF; Whincup, Peter H PH; Morris, Richard W RW; Lawlor, Debbie A DA; Smith, George Davey GD; Ben-Shlomo, Yoav Y; Redline, Susan S; Lange, Leslie A LA; Kumari, Meena M; Wareham, Nick J NJ; Verschuren, W M Monique WM; Benjamin, Emelia J EJ; Whittaker, John C JC; Hamsten, Anders A; Dudbridge, Frank F; Delaney, J A Chris JA; Wong, Andrew A; Kuh, Diana D; Hardy, Rebecca R; Castillo, Berta Almoguera BA; Connolly, John J JJ; van der Harst, Pim P; Brunner, Eric J EJ; Marmot, Michael G MG; Wassel, Christina L CL; Humphries, Steve E SE; Talmud, Philippa J PJ; Kivimaki, Mika M; Asselbergs, Folkert W FW; Voevoda, Mikhail M; Bobak, Martin M; Pikhart, Hynek H; Wilson, James G JG; Hakonarson, Hakon H; Reiner, Alex P AP; Keating, Brendan J BJ; Sattar, Naveed N; Hingorani, Aroon D AD; Casas, Juan Pablo JP
HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes.
American Journal Of Epidemiology
Edwards, Todd L TL; Velez Edwards, Digna R DR; Villegas, Raquel R; Cohen, Sarah S SS; Buchowski, Maciej S MS; Fowke, Jay H JH; Schlundt, David D; Long, Jirong J; Long, Ji Rong JR; Cai, Qiuyin Q; Zheng, Wei W; Shu, Xiao-Ou XO; Hargreaves, Margaret K MK; Smith, Jeffrey J; Jeffrey, Smith S; Williams, Scott M SM; Signorello, Lisa B LB; Blot, William J WJ; Matthews, Charles E CE
A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects.
Genes And Immunity
Rafiq, S S; Frayling, T M TM; Murray, A A; Hurst, A A; Stevens, K K; Weedon, M N MN; Henley, W W; Ferrucci, L L; Bandinelli, S S; Corsi, A-M AM; Guralnik, J M JM; Melzer, D D