IL6R c.85+3859T>G

Variant ID: 1-154382049-T-G

NM_000565.3(IL6R):c.85+3859T>G

This variant was identified in 17 publications

View GRCh38 version.




Publications:


Sex-specific association between inflammation and endothelial function relevant gene and vulnerable carotid plaque.

Frontiers In Physiology
Li, Jie J; Zhang, Ping P; Yi, Xingyang X; Luo, Hua H; Yu, Ming M; Chen, Hong H; Wang, Chun C
Publication Date: 2022

Variant appearance in text: rs1386821
PubMed Link: 36060677
Variant Present in the following documents:
  • Main text
  • fphys-13-977578.pdf
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Inflammation and Endothelial Function Relevant Genetic Polymorphisms and Carotid Plaque in Chinese Population.

Journal Of Atherosclerosis And Thrombosis
Yi, Xingyang X; Zhu, Ling L; Sui, Guo G; Li, Jie J; Luo, Hua H; Yu, Ming M; Wang, Chun C; Chen, Xiaorong X; Wei, Wei W; Bao, Shaozhi S
Publication Date: 2020-09-01

Variant appearance in text: rs1386821
PubMed Link: 31956237
Variant Present in the following documents:
  • Main text
  • jat-27-978.pdf
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A pilot study of single nucleotide polymorphisms in the interleukin-6 receptor and their effects on pre- and post-transplant serum mediator level and outcome after allogeneic stem cell transplantation.

Clinical And Experimental Immunology
Tvedt, T H A THA; Hovland, R R; Tsykunova, G G; Ahmed, A B AB; Gedde-Dahl, T T; Bruserud, Ø Ø
Publication Date: 2018-07

Variant appearance in text: rs1386821
PubMed Link: 29513361
Variant Present in the following documents:
  • Main text
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A study of genes encoding cytokines (IL6, IL10, TNF), cytokine receptors (IL6R, IL6ST), and glucocorticoid receptor (NR3C1) and susceptibility to bronchopulmonary dysplasia.

Bmc Medical Genetics
Huusko, Johanna M JM; Karjalainen, Minna K MK; Mahlman, Mari M; Haataja, Ritva R; Kari, M Anneli MA; Andersson, Sture S; Toldi, Gergely G; Tammela, Outi O; Rämet, Mika M; Lavoie, Pascal M PM; Hallman, Mikko M; ,
Publication Date: 2014-11-01

Variant appearance in text: rs1386821
PubMed Link: 25409741
Variant Present in the following documents:
  • Main text
  • 12881_2014_Article_120.pdf
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Genetic variants in interleukin genes are associated with breast cancer risk and survival in a genetically admixed population: the Breast Cancer Health Disparities Study.

Carcinogenesis
Slattery, Martha L ML; Herrick, Jennifer S JS; Torres-Mejia, Gabriella G; John, Esther M EM; Giuliano, Anna R AR; Hines, Lisa M LM; Stern, Mariana C MC; Baumgartner, Kathy B KB; Presson, Angela P AP; Wolff, Roger K RK
Publication Date: 2014-08

Variant appearance in text: rs1386821
PubMed Link: 24670917
Variant Present in the following documents:
  • Main text
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The inflammatory gene pathway is not a major contributor to polycystic ovary snydrome.

The Journal Of Clinical Endocrinology And Metabolism
Bhatt, Surabhi S; Mutharasan, Priscilla P; Garcia, Obed A OA; Jafari, Nadereh N; Legro, Richard S RS; Dunaif, Andrea A; Urbanek, Margrit M
Publication Date: 2014-03

Variant appearance in text: rs1386821
PubMed Link: 24423322
Variant Present in the following documents:
  • Main text
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IL-6 pathway-driven investigation of response to IL-6 receptor inhibition in rheumatoid arthritis.

Bmj Open
Wang, Jianmei J; Platt, Adam A; Upmanyu, Ruchi R; Germer, Søren S; Lei, Guiyuan G; Rabe, Christina C; Benayed, Ryma R; Kenwright, Andrew A; Hemmings, Andrew A; Martin, Mitchell M; Harari, Olivier O
Publication Date: 2013-08-19

Variant appearance in text: rs1386821
PubMed Link: 23959753
Variant Present in the following documents:
  • Main text
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A new regulatory variant in the interleukin-6 receptor gene associates with asthma risk.

Genes And Immunity
Revez, J A JA; Bain, L L; Chapman, B B; Powell, J E JE; Jansen, R R; Duffy, D L DL; Tung, J Y JY; , ; Penninx, B W BW; Visscher, P M PM; De Geus, E J C EJ; Boomsma, D I DI; Hinds, D A DA; Martin, N G NG; Montgomery, G W GW; Ferreira, M A R MA
Publication Date: 2013-10

Variant appearance in text: rs1386821
PubMed Link: 23945879
Variant Present in the following documents:
  • Main text
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Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases.

Plos Genetics
Ferreira, Ricardo C RC; Freitag, Daniel F DF; Cutler, Antony J AJ; Howson, Joanna M M JM; Rainbow, Daniel B DB; Smyth, Deborah J DJ; Kaptoge, Stephen S; Clarke, Pamela P; Boreham, Charlotte C; Coulson, Richard M RM; Pekalski, Marcin L ML; Chen, Wei-Min WM; Onengut-Gumuscu, Suna S; Rich, Stephen S SS; Butterworth, Adam S AS; Malarstig, Anders A; Danesh, John J; Todd, John A JA
Publication Date: 2013-04

Variant appearance in text: rs1386821
PubMed Link: 23593036
Variant Present in the following documents:
  • Main text
  • pgen.1003444.pdf
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Interleukin genes and associations with colon and rectal cancer risk and overall survival.

International Journal Of Cancer
Bondurant, Kristina L KL; Lundgreen, Abbie A; Herrick, Jennifer S JS; Kadlubar, Susan S; Wolff, Roger K RK; Slattery, Martha L ML
Publication Date: 2013-02-15

Variant appearance in text: rs1386821
PubMed Link: 22674296
Variant Present in the following documents:
  • Main text
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The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.

Lancet (London, England)
, ; Swerdlow, Daniel I DI; Holmes, Michael V MV; Kuchenbaecker, Karoline B KB; Engmann, Jorgen E L JE; Shah, Tina T; Sofat, Reecha R; Guo, Yiran Y; Chung, Christina C; Peasey, Anne A; Pfister, Roman R; Mooijaart, Simon P SP; Ireland, Helen A HA; Leusink, Maarten M; Langenberg, Claudia C; Li, Ka Wah KW; Palmen, Jutta J; Howard, Philip P; Cooper, Jackie A JA; Drenos, Fotios F; Hardy, John J; Nalls, Michael A MA; Li, Yun Rose YR; Lowe, Gordon G; Stewart, Marlene M; Bielinski, Suzette J SJ; Peto, Julian J; Timpson, Nicholas J NJ; Gallacher, John J; Dunlop, Malcolm M; Houlston, Richard R; Tomlinson, Ian I; Tzoulaki, Ioanna I; Luan, Jian'an J; Boer, Jolanda M A JM; Forouhi, Nita G NG; Onland-Moret, N Charlotte NC; van der Schouw, Yvonne T YT; Schnabel, Renate B RB; Hubacek, Jaroslav A JA; Kubinova, Ruzena R; Baceviciene, Migle M; Tamosiunas, Abdonas A; Pajak, Andrzej A; Topor-Madry, Roman R; Malyutina, Sofia S; Baldassarre, Damiano D; Sennblad, Bengt B; Tremoli, Elena E; de Faire, Ulf U; Ferrucci, Luigi L; Bandenelli, Stefania S; Tanaka, Toshiko T; Meschia, James F JF; Singleton, Andrew A; Navis, Gerjan G; Mateo Leach, Irene I; Bakker, Stephan J L SJ; Gansevoort, Ron T RT; Ford, Ian I; Epstein, Stephen E SE; Burnett, Mary Susan MS; Devaney, Joe M JM; Jukema, J Wouter JW; Westendorp, Rudi G J RG; Jan de Borst, Gert G; van der Graaf, Yolanda Y; de Jong, Pim A PA; Mailand-van der Zee, Anke-Hilse AH; Klungel, Olaf H OH; de Boer, Anthonius A; Doevendans, Pieter A PA; Stephens, Jeffrey W JW; Eaton, Charles B CB; Robinson, Jennifer G JG; Manson, JoAnn E JE; Fowkes, F Gerry FG; Frayling, Timonthy M TM; Price, Jackie F JF; Whincup, Peter H PH; Morris, Richard W RW; Lawlor, Debbie A DA; Smith, George Davey GD; Ben-Shlomo, Yoav Y; Redline, Susan S; Lange, Leslie A LA; Kumari, Meena M; Wareham, Nick J NJ; Verschuren, W M Monique WM; Benjamin, Emelia J EJ; Whittaker, John C JC; Hamsten, Anders A; Dudbridge, Frank F; Delaney, J A Chris JA; Wong, Andrew A; Kuh, Diana D; Hardy, Rebecca R; Castillo, Berta Almoguera BA; Connolly, John J JJ; van der Harst, Pim P; Brunner, Eric J EJ; Marmot, Michael G MG; Wassel, Christina L CL; Humphries, Steve E SE; Talmud, Philippa J PJ; Kivimaki, Mika M; Asselbergs, Folkert W FW; Voevoda, Mikhail M; Bobak, Martin M; Pikhart, Hynek H; Wilson, James G JG; Hakonarson, Hakon H; Reiner, Alex P AP; Keating, Brendan J BJ; Sattar, Naveed N; Hingorani, Aroon D AD; Casas, Juan Pablo JP
Publication Date: 2012-03-31

Variant appearance in text: rs1386821
PubMed Link: 22421340
Variant Present in the following documents:
  • mmc1.pdf
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HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes.

American Journal Of Epidemiology
Edwards, Todd L TL; Velez Edwards, Digna R DR; Villegas, Raquel R; Cohen, Sarah S SS; Buchowski, Maciej S MS; Fowke, Jay H JH; Schlundt, David D; Long, Jirong J; Long, Ji Rong JR; Cai, Qiuyin Q; Zheng, Wei W; Shu, Xiao-Ou XO; Hargreaves, Margaret K MK; Smith, Jeffrey J; Jeffrey, Smith S; Williams, Scott M SM; Signorello, Lisa B LB; Blot, William J WJ; Matthews, Charles E CE
Publication Date: 2012-01-01

Variant appearance in text: rs1386821
PubMed Link: 22106445
Variant Present in the following documents:
  • Main text
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Genetic variation in proinflammatory cytokines IL6, IL6R, TNF-region, and TNFRSF1A and risk of breast cancer.

Breast Cancer Research And Treatment
Madeleine, Margaret M MM; Johnson, Lisa G LG; Malkki, Mari M; Resler, Alexa J AJ; Petersdorf, Effie W EW; McKnight, Barbara B; Malone, Kathleen E KE
Publication Date: 2011-10

Variant appearance in text: rs1386821
PubMed Link: 21523452
Variant Present in the following documents:
  • Main text
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Carotid plaque and candidate genes related to inflammation and endothelial function in Hispanics from northern Manhattan.

Stroke
Gardener, Hannah H; Beecham, Ashley A; Cabral, Digna D; Yanuck, Danielle D; Slifer, Susan S; Wang, Liyong L; Blanton, Susan H SH; Sacco, Ralph L RL; Juo, Suh-Hang Hank SH; Rundek, Tatjana T
Publication Date: 2011-04

Variant appearance in text: rs1386821
PubMed Link: 21393601
Variant Present in the following documents:
  • Main text
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A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects.

Genes And Immunity
Rafiq, S S; Frayling, T M TM; Murray, A A; Hurst, A A; Stevens, K K; Weedon, M N MN; Henley, W W; Ferrucci, L L; Bandinelli, S S; Corsi, A-M AM; Guralnik, J M JM; Melzer, D D
Publication Date: 2007-10

Variant appearance in text: rs1386821
PubMed Link: 17671508
Variant Present in the following documents:
  • Main text
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Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels.

American Journal Of Human Genetics
Reich, David D; Patterson, Nick N; Ramesh, Vijaya V; De Jager, Philip L PL; McDonald, Gavin J GJ; Tandon, Arti A; Choy, Edwin E; Hu, Donglei D; Tamraz, Bani B; Pawlikowska, Ludmila L; Wassel-Fyr, Christina C; Huntsman, Scott S; Waliszewska, Alicja A; Rossin, Elizabeth E; Li, Rongling R; Garcia, Melissa M; Reiner, Alexander A; Ferrell, Robert R; Cummings, Steve S; Kwok, Pui-Yan PY; Harris, Tamara T; Zmuda, Joseph M JM; Ziv, Elad E; ,
Publication Date: 2007-04

Variant appearance in text: rs1386821
PubMed Link: 17357077
Variant Present in the following documents:
  • Main text
View BVdb publication page