IL6R c.86-1657G>T

Variant ID: 1-154400015-G-T

NM_000565.3(IL6R):c.86-1657G>T

This variant was identified in 24 publications

View GRCh38 version.




Publications:


Assessment of the Potential Role of Selected Single Nucleotide Polymorphisms (SNPs) of Genes Related to the Functioning of Regulatory T Cells in the Pathogenesis of Psoriasis.

International Journal Of Molecular Sciences
Purzycka-Bohdan, Dorota D; Nedoszytko, Bogusław B; Sobalska-Kwapis, Marta M; Zabłotna, Monika M; Żmijewski, Michał A MA; Wierzbicka, Justyna J; Gleń, Jolanta J; Strapagiel, Dominik D; Szczerkowska-Dobosz, Aneta A; Nowicki, Roman J RJ
Publication Date: 2023-03-23

Variant appearance in text: rs4845618
PubMed Link: 37047033
Variant Present in the following documents:
  • Main text
  • ijms-24-06061.pdf
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Monocyte programming by cancer therapy.

Frontiers In Immunology
Patysheva, Marina M; Frolova, Anastasia A; Larionova, Irina I; Afanas'ev, Sergey S; Tarasova, Anna A; Cherdyntseva, Nadezhda N; Kzhyshkowska, Julia J
Publication Date: 2022

Variant appearance in text: rs4845618
PubMed Link: 36341366
Variant Present in the following documents:
  • Main text
  • fimmu-13-994319.pdf
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Integrative transcriptome-wide analysis of atopic dermatitis for drug repositioning.

Communications Biology
Song, Jaeseung J; Kim, Daeun D; Lee, Sora S; Jung, Junghyun J; Joo, Jong Wha J JWJ; Jang, Wonhee W
Publication Date: 2022-06-22

Variant appearance in text: rs4845618
PubMed Link: 35729261
Variant Present in the following documents:
  • Main text
  • 42003_2022_Article_3564.pdf
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Cumulative Evidence for Associations Between Genetic Variants in Interleukin 6 Receptor Gene and Human Diseases and Phenotypes.

Frontiers In Immunology
Zhang, Min M; Bai, Ye Y; Wang, Yutong Y; Cui, Huijie H; Tang, Mingshuang M; Wang, Lanbing L; Wang, Xin X; Gu, Dongqing D
Publication Date: 2022

Variant appearance in text: rs4845618
PubMed Link: 35493452
Variant Present in the following documents:
  • Main text
  • fimmu-13-860703.pdf
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Machine Learning Revealed Ferroptosis Features and a Novel Ferroptosis-Based Classification for Diagnosis in Acute Myocardial Infarction.

Frontiers In Genetics
Huang, Dan D; Zheng, Shiya S; Liu, Zhuyuan Z; Zhu, Kongbo K; Zhi, Hong H; Ma, Genshan G
Publication Date: 2022

Variant appearance in text: rs4845618
PubMed Link: 35145551
Variant Present in the following documents:
  • Main text
  • fgene-13-813438.pdf
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Genetic associations with immune-mediated outcomes after allogeneic hematopoietic cell transplantation.

Blood Advances
Martin, Paul J PJ; Levine, David M DM; Storer, Barry E BE; Sather, Cassandra L CL; Spellman, Stephen R SR; Hansen, John A JA
Publication Date: 2022-04-26

Variant appearance in text: rs4845618
PubMed Link: 34996099
Variant Present in the following documents:
  • advancesADV2021005620-suppl1.pdf
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Integrative Analysis of Transcriptome-Wide Association Study and mRNA Expression Profiles Identified Candidate Genes and Pathways Associated With Acute Myocardial Infarction.

Frontiers In Genetics
Chen, Guanzhong G; Liu, Liwei L; Li, Huanqiang H; Lun, Zhubin Z; Mai, Ziling Z; Lai, Wenguang W; Chen, Enzhao E; Zhou, Chunyun C; Yu, Sijia S; Yang, Junqing J; Chen, Shiqun S; Chen, Jiyan J; Liu, Yong Y
Publication Date: 2021

Variant appearance in text: rs4845618
PubMed Link: 33603775
Variant Present in the following documents:
  • Main text
  • fgene-12-616492.pdf
View BVdb publication page



Genetic Polymorphisms Associated with Rheumatoid Arthritis Development and Antirheumatic Therapy Response.

International Journal Of Molecular Sciences
Mikhaylenko, Dmitry S DS; Nemtsova, Marina V MV; Bure, Irina V IV; Kuznetsova, Ekaterina B EB; Alekseeva, Ekaterina A EA; Tarasov, Vadim V VV; Lukashev, Alexander N AN; Beloukhova, Marina I MI; Deviatkin, Andrei A AA; Zamyatnin, Andrey A AA
Publication Date: 2020-07-11

Variant appearance in text: rs4845618
PubMed Link: 32664585
Variant Present in the following documents:
  • Main text
  • ijms-21-04911.pdf
View BVdb publication page



Systemic inflammation and causal risk for Alzheimer's dementia: Possibilities and limitations of a Mendelian randomization approach.

Aging Medicine (Milton (N.S.W))
Tsui, Alex A; Davis, Daniel D
Publication Date: 2018-12

Variant appearance in text: rs4845618
PubMed Link: 31328178
Variant Present in the following documents:
  • Main text
  • AGM2-1-249.pdf
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Sex-Specific Genetic Susceptibility to Adverse Neurodevelopmental Outcome in Offspring of Pregnancies at Risk of Early Preterm Delivery.

American Journal Of Perinatology
Varner, Michael W MW; Costantine, Maged M MM; Jablonski, Kathleen A KA; Rouse, Dwight J DJ; Mercer, Brian M BM; Leveno, Kenneth J KJ; Reddy, Uma M UM; Buhimschi, Catalin C; Wapner, Ronald J RJ; Sorokin, Yoram Y; Thorp, John M JM; Ramin, Susan M SM; Malone, Fergal D FD; Carpenter, Marshall M; O'sullivan, Mary J MJ; Peaceman, Alan M AM; Dudley, Donald J DJ; Caritis, Steve N SN; ,
Publication Date: 2020-02

Variant appearance in text: rs4845618
PubMed Link: 30731481
Variant Present in the following documents:
  • Main text
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A pilot study of single nucleotide polymorphisms in the interleukin-6 receptor and their effects on pre- and post-transplant serum mediator level and outcome after allogeneic stem cell transplantation.

Clinical And Experimental Immunology
Tvedt, T H A THA; Hovland, R R; Tsykunova, G G; Ahmed, A B AB; Gedde-Dahl, T T; Bruserud, Ø Ø
Publication Date: 2018-07

Variant appearance in text: rs4845618
PubMed Link: 29513361
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic Variation, Magnesium Sulfate Exposure, and Adverse Neurodevelopmental Outcomes Following Preterm Birth.

American Journal Of Perinatology
Clark, Erin A S EAS; Weiner, Steven J SJ; Rouse, Dwight J DJ; Mercer, Brian M BM; Reddy, Uma M UM; Iams, Jay D JD; Wapner, Ronald J RJ; Sorokin, Yoram Y; Malone, Fergal D FD; O'Sullivan, Mary J MJ; Peaceman, Alan M AM; Hankins, Gary D V GDV; Dudley, Donald J DJ; Caritis, Steve N SN; ,
Publication Date: 2018-08

Variant appearance in text: rs4845618
PubMed Link: 29510423
Variant Present in the following documents:
  • Main text
View BVdb publication page



NALP3-Inflammasome-Related Gene Polymorphisms in Patients with Prehypertension and Coronary Atherosclerosis.

Biomed Research International
Zhao, Xin X; Gu, Chonghuai C; Yan, Chenghui C; Zhang, Xiaolin X; Li, Yi Y; Wang, Li L; Ren, Lili L; Zhang, Yan Y; Peng, Junyin J; Zhu, Zhiming Z; Han, Yaling Y
Publication Date: 2016

Variant appearance in text: rs4845618
PubMed Link: 27446957
Variant Present in the following documents:
  • Main text
  • BMRI2016-7395627.pdf
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Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis.

Arthritis Research & Therapy
Lopez-Lasanta, Maria M; Julià, Antonio A; Maymó, Joan J; Fernández-Gutierrez, Benjamín B; Ureña-Garnica, Inmaculada I; Blanco, Francisco J FJ; Cañete, Juan D JD; Alperi-López, Mercedes M; Olivè, Alex A; Corominas, Héctor H; Tornero, Jesus J; Erra, Alba A; Almirall, Miriam M; Palau, Nuria N; Ortiz, Ana A; Avila, Gabriela G; Rodriguez-Rodriguez, Luis L; Alonso, Arnald A; Tortosa, Raül R; Gonzalez-Alvaro, Isidoro I; Marsal, Sara S
Publication Date: 2015-09-04

Variant appearance in text: rs4845618
PubMed Link: 26336855
Variant Present in the following documents:
  • Main text
  • 13075_2015_Article_737.pdf
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Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation.

Plos Genetics
Kauwe, John S K JS; Bailey, Matthew H MH; Ridge, Perry G PG; Perry, Rachel R; Wadsworth, Mark E ME; Hoyt, Kaitlyn L KL; Staley, Lyndsay A LA; Karch, Celeste M CM; Harari, Oscar O; Cruchaga, Carlos C; Ainscough, Benjamin J BJ; Bales, Kelly K; Pickering, Eve H EH; Bertelsen, Sarah S; , ; Fagan, Anne M AM; Holtzman, David M DM; Morris, John C JC; Goate, Alison M AM
Publication Date: 2014-10

Variant appearance in text: rs4845618
PubMed Link: 25340798
Variant Present in the following documents:
  • pgen.1004758.s006.xlsx, sheet 1
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A 3'UTR polymorphism of IL-6R is associated with Chinese pediatric tuberculosis.

Biomed Research International
Shen, Chen C; Qi, Hui H; Sun, Lin L; Xiao, Jing J; Yin, Qing-qin QQ; Jiao, Wei-wei WW; Wu, Xi-rong XR; Tian, Jian-ling JL; Han, Rui R; Shen, A-dong AD
Publication Date: 2014

Variant appearance in text: rs4845618
PubMed Link: 24772425
Variant Present in the following documents:
  • Main text
  • BMRI2014-483759.pdf
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IL-6 pathway-driven investigation of response to IL-6 receptor inhibition in rheumatoid arthritis.

Bmj Open
Wang, Jianmei J; Platt, Adam A; Upmanyu, Ruchi R; Germer, Søren S; Lei, Guiyuan G; Rabe, Christina C; Benayed, Ryma R; Kenwright, Andrew A; Hemmings, Andrew A; Martin, Mitchell M; Harari, Olivier O
Publication Date: 2013-08-19

Variant appearance in text: rs4845618
PubMed Link: 23959753
Variant Present in the following documents:
  • Main text
View BVdb publication page



Exploring genome-wide - dietary heme iron intake interactions and the risk of type 2 diabetes.

Frontiers In Genetics
Pasquale, Louis R LR; Loomis, Stephanie J SJ; Aschard, Hugues H; Kang, Jae H JH; Cornelis, Marilyn C MC; Qi, Lu L; Kraft, Peter P; Hu, Frank B FB
Publication Date: 2013

Variant appearance in text: rs4845618
PubMed Link: 23386860
Variant Present in the following documents:
  • Main text
  • fgene-04-00007.pdf
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The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.

Lancet (London, England)
, ; Swerdlow, Daniel I DI; Holmes, Michael V MV; Kuchenbaecker, Karoline B KB; Engmann, Jorgen E L JE; Shah, Tina T; Sofat, Reecha R; Guo, Yiran Y; Chung, Christina C; Peasey, Anne A; Pfister, Roman R; Mooijaart, Simon P SP; Ireland, Helen A HA; Leusink, Maarten M; Langenberg, Claudia C; Li, Ka Wah KW; Palmen, Jutta J; Howard, Philip P; Cooper, Jackie A JA; Drenos, Fotios F; Hardy, John J; Nalls, Michael A MA; Li, Yun Rose YR; Lowe, Gordon G; Stewart, Marlene M; Bielinski, Suzette J SJ; Peto, Julian J; Timpson, Nicholas J NJ; Gallacher, John J; Dunlop, Malcolm M; Houlston, Richard R; Tomlinson, Ian I; Tzoulaki, Ioanna I; Luan, Jian'an J; Boer, Jolanda M A JM; Forouhi, Nita G NG; Onland-Moret, N Charlotte NC; van der Schouw, Yvonne T YT; Schnabel, Renate B RB; Hubacek, Jaroslav A JA; Kubinova, Ruzena R; Baceviciene, Migle M; Tamosiunas, Abdonas A; Pajak, Andrzej A; Topor-Madry, Roman R; Malyutina, Sofia S; Baldassarre, Damiano D; Sennblad, Bengt B; Tremoli, Elena E; de Faire, Ulf U; Ferrucci, Luigi L; Bandenelli, Stefania S; Tanaka, Toshiko T; Meschia, James F JF; Singleton, Andrew A; Navis, Gerjan G; Mateo Leach, Irene I; Bakker, Stephan J L SJ; Gansevoort, Ron T RT; Ford, Ian I; Epstein, Stephen E SE; Burnett, Mary Susan MS; Devaney, Joe M JM; Jukema, J Wouter JW; Westendorp, Rudi G J RG; Jan de Borst, Gert G; van der Graaf, Yolanda Y; de Jong, Pim A PA; Mailand-van der Zee, Anke-Hilse AH; Klungel, Olaf H OH; de Boer, Anthonius A; Doevendans, Pieter A PA; Stephens, Jeffrey W JW; Eaton, Charles B CB; Robinson, Jennifer G JG; Manson, JoAnn E JE; Fowkes, F Gerry FG; Frayling, Timonthy M TM; Price, Jackie F JF; Whincup, Peter H PH; Morris, Richard W RW; Lawlor, Debbie A DA; Smith, George Davey GD; Ben-Shlomo, Yoav Y; Redline, Susan S; Lange, Leslie A LA; Kumari, Meena M; Wareham, Nick J NJ; Verschuren, W M Monique WM; Benjamin, Emelia J EJ; Whittaker, John C JC; Hamsten, Anders A; Dudbridge, Frank F; Delaney, J A Chris JA; Wong, Andrew A; Kuh, Diana D; Hardy, Rebecca R; Castillo, Berta Almoguera BA; Connolly, John J JJ; van der Harst, Pim P; Brunner, Eric J EJ; Marmot, Michael G MG; Wassel, Christina L CL; Humphries, Steve E SE; Talmud, Philippa J PJ; Kivimaki, Mika M; Asselbergs, Folkert W FW; Voevoda, Mikhail M; Bobak, Martin M; Pikhart, Hynek H; Wilson, James G JG; Hakonarson, Hakon H; Reiner, Alex P AP; Keating, Brendan J BJ; Sattar, Naveed N; Hingorani, Aroon D AD; Casas, Juan Pablo JP
Publication Date: 2012-03-31

Variant appearance in text: rs4845618
PubMed Link: 22421340
Variant Present in the following documents:
  • mmc1.pdf
View BVdb publication page



Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults.

Experimental Gerontology
Walston, Jeremy D JD; Matteini, Amy M AM; Nievergelt, Caroline C; Lange, Leslie A LA; Fallin, Dani M DM; Barzilai, Nir N; Ziv, Elad E; Pawlikowska, Ludmila L; Kwok, Pui P; Cummings, Steve R SR; Kooperberg, Charles C; LaCroix, Andrea A; Tracy, Russell P RP; Atzmon, Gil G; Lange, Ethan M EM; Reiner, Alex P AP
Publication Date: 2009-05

Variant appearance in text: rs4845618
PubMed Link: 19249341
Variant Present in the following documents:
  • Main text
View BVdb publication page



Interleukin-6 receptor gene, plasma C-reactive protein, and diabetes risk in women.

Diabetes
Qi, Lu L; Rifai, Nader N; Hu, Frank B FB
Publication Date: 2009-01

Variant appearance in text: rs4845618
PubMed Link: 18852330
Variant Present in the following documents:
  • Main text
  • 275.pdf
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Genetic contributions to disparities in preterm birth.

Pediatric Research
Anum, Emmanuel A EA; Springel, Edward H EH; Shriver, Mark D MD; Strauss, Jerome F JF
Publication Date: 2009-01

Variant appearance in text: rs4845618
PubMed Link: 18787421
Variant Present in the following documents:
  • Main text
View BVdb publication page



Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma.

Melanoma Research
Gu, Fangyi F; Qureshi, Abrar A AA; Niu, Tianhua T; Kraft, Peter P; Guo, Qun Q; Hunter, David J DJ; Han, Jiali J
Publication Date: 2008-10

Variant appearance in text: rs4845618
PubMed Link: 18781131
Variant Present in the following documents:
  • Main text
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Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels.

American Journal Of Human Genetics
Reich, David D; Patterson, Nick N; Ramesh, Vijaya V; De Jager, Philip L PL; McDonald, Gavin J GJ; Tandon, Arti A; Choy, Edwin E; Hu, Donglei D; Tamraz, Bani B; Pawlikowska, Ludmila L; Wassel-Fyr, Christina C; Huntsman, Scott S; Waliszewska, Alicja A; Rossin, Elizabeth E; Li, Rongling R; Garcia, Melissa M; Reiner, Alexander A; Ferrell, Robert R; Cummings, Steve S; Kwok, Pui-Yan PY; Harris, Tamara T; Zmuda, Joseph M JM; Ziv, Elad E; ,
Publication Date: 2007-04

Variant appearance in text: rs4845618
PubMed Link: 17357077
Variant Present in the following documents:
  • Main text
View BVdb publication page