Transmembrane protease serine 2 (TMPRSS2) rs75603675, comorbidity, and sex are the primary predictors of COVID-19 severity.
Life Science Alliance
Villapalos-García, Gonzalo G; Zubiaur, Pablo P; Rivas-Durán, Rebeca R; Campos-Norte, Pilar P; Arévalo-Román, Cristina C; Fernández-Rico, Marta M; García-Fraile Fraile, Lucio L; Fernández-Campos, Paula P; Soria-Chacartegui, Paula P; Fernández de Córdoba-Oñate, Sara S; Delgado-Wicke, Pablo P; Fernández-Ruiz, Elena E; González-Álvaro, Isidoro I; Sanz, Jesús J; Abad-Santos, Francisco F; de Los Santos, Ignacio I
Inflammation and Brain Structure in Schizophrenia and Other Neuropsychiatric Disorders: A Mendelian Randomization Study.
Jama Psychiatry
Williams, John A JA; Burgess, Stephen S; Suckling, John J; Lalousis, Paris Alexandros PA; Batool, Fatima F; Griffiths, Sian Lowri SL; Palmer, Edward E; Karwath, Andreas A; Barsky, Andrey A; Gkoutos, Georgios V GV; Wood, Stephen S; Barnes, Nicholas M NM; David, Anthony S AS; Donohoe, Gary G; Neill, Joanna C JC; Deakin, Bill B; Khandaker, Golam M GM; Upthegrove, Rachel R; ,
Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study.
Human Molecular Genetics
Portilla-Fernandez, Eliana E; Klarin, Derek D; Hwang, Shih-Jen SJ; Biggs, Mary L ML; Bis, Joshua C JC; Weiss, Stefan S; Rospleszcz, Susanne S; Natarajan, Pradeep P; Hoffmann, Udo U; Rogers, Ian S IS; Truong, Quynh A QA; Völker, Uwe U; Dörr, Marcus M; Bülow, Robin R; Criqui, Michael H MH; Allison, Matthew M; Ganesh, Santhi K SK; Yao, Jie J; Waldenberger, Melanie M; Bamberg, Fabian F; Rice, Kenneth M KM; Essers, Jeroen J; Kapteijn, Daniek M C DMC; van der Laan, Sander W SW; de Knegt, Rob J RJ; Ghanbari, Mohsen M; Felix, Janine F JF; Ikram, M Arfan MA; Kavousi, Maryam M; Uitterlinden, Andre G AG; Roks, Anton J M AJM; Danser, A H Jan AHJ; Tsao, Philip S PS; Damrauer, Scott M SM; Guo, Xiuqing X; Rotter, Jerome I JI; Psaty, Bruce M BM; Kathiresan, Sekar S; Völzke, Henry H; Peters, Annette A; Johnson, Craig C; Strauch, Konstantin K; Meitinger, Thomas T; O'Donnell, Christopher J CJ; Dehghan, Abbas A; ,
Association between Biomarkers of Oxidative Stress and Inflammation with Cardiac Necrosis and Heart Failure in Non-ST Segment Elevation Myocardial Infarction Patients and Various Degrees of Kidney Function.
Oxidative Medicine And Cellular Longevity
Roumeliotis, Stefanos S; Veljkovic, Andrej A; Georgianos, Panagiotis I PI; Lazarevic, Gordana G; Perisic, Zoran Z; Hadzi-Djokic, Jovan J; Liakopoulos, Vassilios V; Kocic, Gordana G
Mendelian randomisation and experimental medicine approaches to interleukin-6 as a drug target in pulmonary arterial hypertension.
The European Respiratory Journal
Toshner, Mark M; Church, Colin C; Harbaum, Lars L; Rhodes, Christopher C; Villar Moreschi, Sofia S SS; Liley, James J; Jones, Rowena R; Arora, Amit A; Batai, Ken K; Desai, Ankit A AA; Coghlan, John G JG; Gibbs, J Simon R JSR; Gor, Dee D; Gräf, Stefan S; Harlow, Louise L; Hernandez-Sanchez, Jules J; Howard, Luke S LS; Humbert, Marc M; Karnes, Jason J; Kiely, David G DG; Kittles, Rick R; Knightbridge, Emily E; Lam, Brian B; Lutz, Katie A KA; Nichols, William C WC; Pauciulo, Michael W MW; Pepke-Zaba, Joanna J; Suntharalingam, Jay J; Soubrier, Florent F; Trembath, Richard C RC; Schwantes-An, Tae-Hwi L TL; Wort, S John SJ; Wilkins, Martin R MR; Gaine, Sean S; Morrell, Nicholas W NW; Corris, Paul A PA; ,
Inflammation and cardiovascular disease: From mechanisms to therapeutics.
American Journal Of Preventive Cardiology
Alfaddagh, Abdulhamied A; Martin, Seth S SS; Leucker, Thorsten M TM; Michos, Erin D ED; Blaha, Michael J MJ; Lowenstein, Charles J CJ; Jones, Steven R SR; Toth, Peter P PP
Genome-wide association study of high-sensitivity C-reactive protein, D-dimer, and interleukin-6 levels in multiethnic HIV+ cohorts.
Aids (London, England)
Sherman, Brad T BT; Hu, Xiaojun X; Singh, Kanal K; Haine, Lillian L; Rupert, Adam W AW; Neaton, James D JD; Lundgren, Jens D JD; Imamichi, Tomozumi T; Chang, Weizhong W; Lane, H Clifford HC; ,
Dissecting the Association Between Inflammation, Metabolic Dysregulation, and Specific Depressive Symptoms: A Genetic Correlation and 2-Sample Mendelian Randomization Study.
Jama Psychiatry
Kappelmann, Nils N; Arloth, Janine J; Georgakis, Marios K MK; Czamara, Darina D; Rost, Nicolas N; Ligthart, Symen S; Khandaker, Golam M GM; Binder, Elisabeth B EB
Vascular consequences of inflammation: a position statement from the ESH Working Group on Vascular Structure and Function and the ARTERY Society.
Journal Of Hypertension
Zanoli, Luca L; Briet, Marie M; Empana, Jean P JP; Cunha, Pedro G PG; Mäki-Petäjä, Kaisa M KM; Protogerou, Athanase D AD; Tedgui, Alain A; Touyz, Rhian M RM; Schiffrin, Ernesto L EL; Spronck, Bart B; Bouchard, Philippe P; Vlachopoulos, Charalambos C; Bruno, Rosa M RM; Boutouyrie, Pierre P; ,
Investigating evidence for a causal association between inflammation and self-harm: A multivariable Mendelian Randomisation study.
Brain, Behavior, And Immunity
Russell, Abigail Emma AE; Ford, Tamsin T; Gunnell, David D; Heron, Jon J; Joinson, Carol C; Moran, Paul P; Relton, Caroline C; Suderman, Matthew M; Hemani, Gibran G; Mars, Becky B
Circulating interleukins in relation to coronary artery disease, atrial fibrillation and ischemic stroke and its subtypes: A two-sample Mendelian randomization study.
International Journal Of Cardiology
Yuan, Shuai S; Lin, Ang A; He, Qi-Qiang QQ; Burgess, Stephen S; Larsson, Susanna C SC
Distinctive mutational spectrum and karyotype disruption in long-term cisplatin-treated urothelial carcinoma cell lines.
Scientific Reports
Skowron, Margaretha A MA; Petzsch, Patrick P; Hardt, Karin K; Wagner, Nicholas N; Beier, Manfred M; Stepanow, Stefanie S; Drechsler, Matthias M; Rieder, Harald H; Köhrer, Karl K; Niegisch, Günter G; Hoffmann, Michèle J MJ; Schulz, Wolfgang A WA
Shared mechanisms between coronary heart disease and depression: findings from a large UK general population-based cohort.
Molecular Psychiatry
Khandaker, Golam M GM; Zuber, Verena V; Rees, Jessica M B JMB; Carvalho, Livia L; Mason, Amy M AM; Foley, Christopher N CN; Gkatzionis, Apostolos A; Jones, Peter B PB; Burgess, Stephen S
Association between a Genetic Risk Score Based on Single Nucleotide Polymorphisms of Coronary Artery Disease-Related Genes and Left Main Coronary Artery Disease.
Biomed Research International
Xu, Zhengxi Z; Liu, Hanning H; Sun, Cheng C; Si, Ke K; Zhao, Yan Y; Zheng, Zhe Z
Interleukin-6 Receptor Signaling and Abdominal Aortic Aneurysm Growth Rates.
Circulation. Genomic And Precision Medicine
Paige, Ellie E; Clément, Marc M; Lareyre, Fabien F; Sweeting, Michael M; Raffort, Juliette J; Grenier, Céline C; Finigan, Alison A; Harrison, James J; Peters, James E JE; Sun, Benjamin B BB; Butterworth, Adam S AS; Harrison, Seamus C SC; Bown, Matthew J MJ; Lindholt, Jes S JS; Badger, Stephen A SA; Kullo, Iftikhar J IJ; Powell, Janet J; Norman, Paul E PE; Scott, D Julian A DJA; Bailey, Marc A MA; Rose-John, Stefan S; Danesh, John J; Freitag, Daniel F DF; Paul, Dirk S DS; Mallat, Ziad Z
Circulating Interleukin-6 is a biomarker for coronary atherosclerosis in nonalcoholic fatty liver disease: Results from the Multi-Ethnic Study of Atherosclerosis.
International Journal Of Cardiology
Simon, Tracey G TG; Trejo, Maria Esther Perez MEP; McClelland, Robyn R; Bradley, Ryan R; Blaha, Michael J MJ; Zeb, Irfan I; Corey, Kathleen E KE; Budoff, Matthew J MJ; Chung, Raymond T RT
Association between interleukin-6/6R gene polymorphisms and coronary artery disease in Russian population: influence of interleukin-6/6R gene polymorphisms on inflammatory markers.
Journal Of Inflammation Research
Mitrokhin, Vadim V; Nikitin, Alexey A; Brovkina, Olga O; Khodyrev, Dmitry D; Zotov, Alexander A; Vachrushev, Nikita N; Dragunov, Dmitry D; Shim, Andrey A; Mladenov, Mitko M; Kamkin, Andre A
Connecting genetic risk to disease end points through the human blood plasma proteome.
Nature Communications
Suhre, Karsten K; Arnold, Matthias M; Bhagwat, Aditya Mukund AM; Cotton, Richard J RJ; Engelke, Rudolf R; Raffler, Johannes J; Sarwath, Hina H; Thareja, Gaurav G; Wahl, Annika A; DeLisle, Robert Kirk RK; Gold, Larry L; Pezer, Marija M; Lauc, Gordan G; El-Din Selim, Mohammed A MA; Mook-Kanamori, Dennis O DO; Al-Dous, Eman K EK; Mohamoud, Yasmin A YA; Malek, Joel J; Strauch, Konstantin K; Grallert, Harald H; Peters, Annette A; Kastenmüller, Gabi G; Gieger, Christian C; Graumann, Johannes J
Ten-year alcohol consumption typologies and trajectories of C-reactive protein, interleukin-6 and interleukin-1 receptor antagonist over the following 12 years: a prospective cohort study.
Polymorphisms in the IL-6 and IL-6R receptor genes as new diagnostic biomarkers of acute appendicitis: a study on two candidate genes in pediatric patients with acute appendicitis.
Italian Journal Of Pediatrics
Sarsu, Sevgi Büyükbeşe SB; Yılmaz, Şenay Görücü ŞG; Bayram, Ali A; Denk, Affan A; Kargun, Kürşat K; Sungur, Mehmet Ali MA
Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation.
Plos Genetics
Kauwe, John S K JS; Bailey, Matthew H MH; Ridge, Perry G PG; Perry, Rachel R; Wadsworth, Mark E ME; Hoyt, Kaitlyn L KL; Staley, Lyndsay A LA; Karch, Celeste M CM; Harari, Oscar O; Cruchaga, Carlos C; Ainscough, Benjamin J BJ; Bales, Kelly K; Pickering, Eve H EH; Bertelsen, Sarah S; , ; Fagan, Anne M AM; Holtzman, David M DM; Morris, John C JC; Goate, Alison M AM