IL6R c.1067-700C>T

Variant ID: 1-154426264-C-T

NM_000565.3(IL6R):c.1067-700C>T

This variant was identified in 121 publications

View GRCh38 version.




Publications:


Assessment of the Potential Role of Selected Single Nucleotide Polymorphisms (SNPs) of Genes Related to the Functioning of Regulatory T Cells in the Pathogenesis of Psoriasis.

International Journal Of Molecular Sciences
Purzycka-Bohdan, Dorota D; Nedoszytko, Bogusław B; Sobalska-Kwapis, Marta M; Zabłotna, Monika M; Żmijewski, Michał A MA; Wierzbicka, Justyna J; Gleń, Jolanta J; Strapagiel, Dominik D; Szczerkowska-Dobosz, Aneta A; Nowicki, Roman J RJ
Publication Date: 2023-03-23

Variant appearance in text: rs4129267
PubMed Link: 37047033
Variant Present in the following documents:
  • ijms-24-06061.pdf
View BVdb publication page



Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits.

Scientific Reports
Deming, Yuetiva Y; Xia, Jian J; Cai, Yefei Y; Lord, Jenny J; Del-Aguila, Jorge L JL; Fernandez, Maria Victoria MV; Carrell, David D; Black, Kathleen K; Budde, John J; Ma, ShengMei S; Saef, Benjamin B; Howells, Bill B; Bertelsen, Sarah S; Bailey, Matthew M; Ridge, Perry G PG; , ; Holtzman, David D; Morris, John C JC; Bales, Kelly K; Pickering, Eve H EH; Lee, Jin-Moo JM; Heitsch, Laura L; Kauwe, John J; Goate, Alison A; Piccio, Laura L; Cruchaga, Carlos C
Publication Date: 2016-01-04

Variant appearance in text: rs4129267
PubMed Link: 36647296
Variant Present in the following documents:
  • srep18092-s1.pdf
View BVdb publication page



Exploring the causality between ankylosing spondylitis and atrial fibrillation: A two-sample Mendelian randomization study.

Frontiers In Genetics
Chen, Shuhong S; Luo, Xiqing X; Zhao, Jiaoshi J; Liang, Zhenguo Z; Gu, Jieruo J
Publication Date: 2022

Variant appearance in text: rs4129267
PubMed Link: 36468019
Variant Present in the following documents:
  • Main text
  • fgene-13-951893.pdf
View BVdb publication page



Establishment and characterization of a new mantle cell lymphoma cell line with a NOTCH2 mutation, Arbo.

Ejhaem
Safa, Firas F; Rasmussen, Terri T; Lobelle-Rich, Patricia P; Collier, Stephanie S; Milligan, Nicholas N; Schmeig, John J; Schmid, Janet J; Wiewiorowski, Carol C; Totaro, Denise D; Brown, Theresa C TC; Satyavarapu, Ishwarya I; Badoo, Melody M; Ungerleider, Nathan N; Flemington, Erik K EK; Safah, Hana H; Saba, Nakhle S NS
Publication Date: 2022-11

Variant appearance in text: rs4129267
PubMed Link: 36467812
Variant Present in the following documents:
  • JHA2-3-1326-s001.xlsx, sheet 1
View BVdb publication page



Practical Significance of Biomarkers in Axial Spondyloarthritis: Updates on Diagnosis, Disease Activity, and Prognosis.

International Journal Of Molecular Sciences
Diaconu, Alexandra-Diana AD; Ceasovschih, Alexandr A; Șorodoc, Victorița V; Pomîrleanu, Cristina C; Lionte, Cătălina C; Șorodoc, Laurențiu L; Ancuța, Codrina C
Publication Date: 2022-09-30

Variant appearance in text: rs4129267
PubMed Link: 36232862
Variant Present in the following documents:
  • Main text
  • ijms-23-11561.pdf
View BVdb publication page



Fibrinogen in Alzheimer's Disease, Parkinson's Disease and Lewy Body Dementia: A Mendelian Randomization Study.

Frontiers In Aging Neuroscience
Zhang, Hanyu H; Zhou, Zengyuan Z
Publication Date: 2022

Variant appearance in text: rs4129267
PubMed Link: 35875802
Variant Present in the following documents:
  • Main text
  • fnagi-14-847583.pdf
View BVdb publication page



PiER: web-based facilities tailored for genetic target prioritisation harnessing human disease genetics, functional genomics and protein interactions.

Nucleic Acids Research
Fang, Hai H
Publication Date: 2022-05-24

Variant appearance in text: rs4129267
PubMed Link: 35610036
Variant Present in the following documents:
  • Main text
  • gkac379.pdf
View BVdb publication page



Cumulative Evidence for Associations Between Genetic Variants in Interleukin 6 Receptor Gene and Human Diseases and Phenotypes.

Frontiers In Immunology
Zhang, Min M; Bai, Ye Y; Wang, Yutong Y; Cui, Huijie H; Tang, Mingshuang M; Wang, Lanbing L; Wang, Xin X; Gu, Dongqing D
Publication Date: 2022

Variant appearance in text: rs4129267
PubMed Link: 35493452
Variant Present in the following documents:
  • Main text
  • fimmu-13-860703.pdf
View BVdb publication page



Genetic analysis of over half a million people characterises C-reactive protein loci.

Nature Communications
Said, Saredo S; Pazoki, Raha R; Karhunen, Ville V; Võsa, Urmo U; Ligthart, Symen S; Bodinier, Barbara B; Koskeridis, Fotios F; Welsh, Paul P; Alizadeh, Behrooz Z BZ; Chasman, Daniel I DI; Sattar, Naveed N; Chadeau-Hyam, Marc M; Evangelou, Evangelos E; Jarvelin, Marjo-Riitta MR; Elliott, Paul P; Tzoulaki, Ioanna I; Dehghan, Abbas A
Publication Date: 2022-04-22

Variant appearance in text: rs4129267
PubMed Link: 35459240
Variant Present in the following documents:
  • 41467_2022_29650_MOESM1_ESM.pdf
View BVdb publication page



Polymorphisms and Gene-Gene Interaction in AGER/IL6 Pathway Might Be Associated with Diabetic Ischemic Heart Disease.

Journal Of Personalized Medicine
Liu, Kuo K; Xie, Yunyi Y; Zhao, Qian Q; Peng, Wenjuan W; Guo, Chunyue C; Zhang, Jie J; Zhang, Ling L
Publication Date: 2022-03-04

Variant appearance in text: rs4129267
PubMed Link: 35330392
Variant Present in the following documents:
  • Main text
  • jpm-12-00392.pdf
View BVdb publication page



Genetically Determined Inflammatory Biomarkers and the Risk of Heart Failure: A Mendelian Randomization Study.

Frontiers In Cardiovascular Medicine
Li, Xintao X; Peng, Shi S; Guan, Bo B; Chen, Songwen S; Zhou, Genqing G; Wei, Yong Y; Gong, Chao C; Xu, Juan J; Lu, Xiaofeng X; Zhang, Xiaoyu X; Liu, Shaowen S
Publication Date: 2021

Variant appearance in text: rs4129267
PubMed Link: 34881299
Variant Present in the following documents:
  • Main text
  • fcvm-08-734400.pdf
View BVdb publication page



Vascular Smooth Muscle Cells in Aortic Aneurysm: From Genetics to Mechanisms.

Journal Of The American Heart Association
Lu, Haocheng H; Du, Wa W; Ren, Lu L; Hamblin, Milton H MH; Becker, Richard C RC; Chen, Y Eugene YE; Fan, Yanbo Y
Publication Date: 2021-12-21

Variant appearance in text: rs4129267
PubMed Link: 34796717
Variant Present in the following documents:
  • Main text
  • JAH3-10-e023601.pdf
View BVdb publication page



IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetes.

Jci Insight
Greenbaum, Carla J CJ; Serti, Elisavet E; Lambert, Katharina K; Weiner, Lia J LJ; Kanaparthi, Sai S; Lord, Sandra S; Gitelman, Stephen E SE; Wilson, Darrell M DM; Gaglia, Jason L JL; Griffin, Kurt J KJ; Russell, William E WE; Raskin, Philip P; Moran, Antoinette A; Willi, Steven M SM; Tsalikian, Eva E; DiMeglio, Linda A LA; Herold, Kevan C KC; Moore, Wayne V WV; Goland, Robin R; Harris, Mark M; Craig, Maria E ME; Schatz, Desmond A DA; Baidal, David A DA; Rodriguez, Henry H; Utzschneider, Kristina M KM; Nel, Hendrik J HJ; Soppe, Carol L CL; Boyle, Karen D KD; Cerosaletti, Karen K; Keyes-Elstein, Lynette L; Long, S Alice SA; Thomas, Ranjeny R; McNamara, James G JG; Buckner, Jane H JH; Sanda, Srinath S; ,
Publication Date: 2021-11-08

Variant appearance in text: rs4129267
PubMed Link: 34747368
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic Associations Between IL-6 and the Development of Autoimmune Arthritis Are Gender-Specific.

Frontiers In Immunology
Hong, Jianqiao J; Qu, Zihao Z; Ji, Xiaoxiao X; Li, Congsun C; Zhang, Geng G; Jin, Ciliang C; Wang, Jie J; Zhang, Yongxing Y; Shen, Yue Y; Meng, Jiahong J; Zhou, Chenhe C; Fang, Chaohua C; Wang, Wei W; Yan, Shigui S
Publication Date: 2021

Variant appearance in text: rs4129267
PubMed Link: 34539640
Variant Present in the following documents:
  • Main text
  • fimmu-12-707617.pdf
View BVdb publication page



Assessing the potential correlation of polymorphisms in the IL6R with relative IL6 elevation in severely ill COVID-19 patients'.

Cytokine
Smieszek, Sandra P SP; Przychodzen, Bartlomiej P BP; Polymeropoulos, Vasilios M VM; Polymeropoulos, Christos M CM; Polymeropoulos, Mihael H MH
Publication Date: 2021-12

Variant appearance in text: rs4129267
PubMed Link: 34353696
Variant Present in the following documents:
  • mmc2.xlsx, sheet 1
View BVdb publication page



Polygenic risk scores predict diabetes complications and their response to intensive blood pressure and glucose control.

Diabetologia
Tremblay, Johanne J; Haloui, Mounsif M; Attaoua, Redha R; Tahir, Ramzan R; Hishmih, Camil C; Harvey, François F; Marois-Blanchet, François-Christophe FC; Long, Carole C; Simon, Paul P; Santucci, Lara L; Hizel, Candan C; Chalmers, John J; Marre, Michel M; Harrap, Stephen S; Cífková, Renata R; Krajčoviechová, Alena A; Matthews, David R DR; Williams, Bryan B; Poulter, Neil N; Zoungas, Sophia S; Colagiuri, Stephen S; Mancia, Giuseppe G; Grobbee, Diederick E DE; Rodgers, Anthony A; Liu, Liusheng L; Agbessi, Mawussé M; Bruat, Vanessa V; Favé, Marie-Julie MJ; Harwood, Michelle P MP; Awadalla, Philip P; Woodward, Mark M; Hussin, Julie G JG; Hamet, Pavel P
Publication Date: 2021-09

Variant appearance in text: rs4129267
PubMed Link: 34226943
Variant Present in the following documents:
  • 125_2021_5491_MOESM1_ESM.pdf
View BVdb publication page



Genetic associations for two biological age measures point to distinct aging phenotypes.

Aging Cell
Kuo, Chia-Ling CL; Pilling, Luke C LC; Liu, Zuyun Z; Atkins, Janice L JL; Levine, Morgan E ME
Publication Date: 2021-06

Variant appearance in text: rs4129267
PubMed Link: 34038024
Variant Present in the following documents:
  • Main text
View BVdb publication page



Serum anti-inflammatory and inflammatory markers have no causal impact on telomere length: a Mendelian randomization study.

Archives Of Medical Science : Ams
Mazidi, Mohsen M; Shekoohi, Niloofar N; Katsiki, Niki N; Rakowski, Michal M; Mikhailidis, Dimitri P DP; Banach, Maciej M
Publication Date: 2021

Variant appearance in text: rs4129267
PubMed Link: 34025845
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetically determined elevated C-reactive protein associated with primary colorectal cancer risk: Mendelian randomization with lifestyle interactions.

American Journal Of Cancer Research
Jung, Su Yon SY; Yu, Herbert H; Pellegrini, Matteo M; Papp, Jeanette C JC; Sobel, Eric M EM; Zhang, Zuo-Feng ZF
Publication Date: 2021

Variant appearance in text: rs4129267
PubMed Link: 33948386
Variant Present in the following documents:
  • Main text
View BVdb publication page



Relationship of Soluble Interleukin-6 Receptors With Asthma: A Mendelian Randomization Study.

Frontiers In Medicine
Raita, Yoshihiko Y; Zhu, Zhaozhong Z; Camargo, Carlos A CA; Freishtat, Robert J RJ; Ngo, Debby D; Liang, Liming L; Hasegawa, Kohei K
Publication Date: 2021

Variant appearance in text: rs4129267
PubMed Link: 33912579
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic Variability in Molecular Pathways Implicated in Alzheimer's Disease: A Comprehensive Review.

Frontiers In Aging Neuroscience
Vogrinc, David D; Goričar, Katja K; Dolžan, Vita V
Publication Date: 2021

Variant appearance in text: rs4129267
PubMed Link: 33815092
Variant Present in the following documents:
  • Main text
  • fnagi-13-646901.pdf
View BVdb publication page



Genetics and Epigenetics in Asthma.

International Journal Of Molecular Sciences
Ntontsi, Polyxeni P; Photiades, Andreas A; Zervas, Eleftherios E; Xanthou, Georgina G; Samitas, Konstantinos K
Publication Date: 2021-02-27

Variant appearance in text: rs4129267
PubMed Link: 33673725
Variant Present in the following documents:
  • Main text
  • ijms-22-02412.pdf
View BVdb publication page



FRZB as a key molecule in abdominal aortic aneurysm progression affecting vascular integrity.

Bioscience Reports
Oh, Chang-Kyu CK; Ko, Yeji Y; Park, Jeong Jun JJ; Heo, Hye Jin HJ; Kang, Junho J; Kwon, Eun Jung EJ; Kang, Ji Wan JW; Lee, Yoonsung Y; Myung, Kyungjae K; Kang, Jin Mo JM; Ko, Dai Sik DS; Kim, Yun Hak YH
Publication Date: 2021-01-29

Variant appearance in text: rs4129267
PubMed Link: 33245093
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome-wide association study of high-sensitivity C-reactive protein, D-dimer, and interleukin-6 levels in multiethnic HIV+ cohorts.

Aids (London, England)
Sherman, Brad T BT; Hu, Xiaojun X; Singh, Kanal K; Haine, Lillian L; Rupert, Adam W AW; Neaton, James D JD; Lundgren, Jens D JD; Imamichi, Tomozumi T; Chang, Weizhong W; Lane, H Clifford HC; ,
Publication Date: 2021-02-02

Variant appearance in text: rs4129267
PubMed Link: 33095540
Variant Present in the following documents:
  • aids-35-193-s003.xlsx, sheet 1
View BVdb publication page



Dissecting the Association Between Inflammation, Metabolic Dysregulation, and Specific Depressive Symptoms: A Genetic Correlation and 2-Sample Mendelian Randomization Study.

Jama Psychiatry
Kappelmann, Nils N; Arloth, Janine J; Georgakis, Marios K MK; Czamara, Darina D; Rost, Nicolas N; Ligthart, Symen S; Khandaker, Golam M GM; Binder, Elisabeth B EB
Publication Date: 2021-02-01

Variant appearance in text: rs4129267
PubMed Link: 33079133
Variant Present in the following documents:
  • jamapsychiatry-e203436-s001.pdf
View BVdb publication page



Genetics and the axial spondyloarthritis spectrum.

Rheumatology (Oxford, England)
Brown, Matthew A MA; Xu, Huji H; Li, Zhixiu Z
Publication Date: 2020-10-01

Variant appearance in text: rs4129267
PubMed Link: 33053195
Variant Present in the following documents:
  • Main text
  • keaa464.pdf
View BVdb publication page



Multiomics dissection of molecular regulatory mechanisms underlying autoimmune-associated noncoding SNPs.

Jci Insight
Chen, Xiao-Feng XF; Guo, Ming-Rui MR; Duan, Yuan-Yuan YY; Jiang, Feng F; Wu, Hao H; Dong, Shan-Shan SS; Zhou, Xiao-Rong XR; Thynn, Hlaing Nwe HN; Liu, Cong-Cong CC; Zhang, Lin L; Guo, Yan Y; Yang, Tie-Lin TL
Publication Date: 2020-09-03

Variant appearance in text: rs4129267
PubMed Link: 32879140
Variant Present in the following documents:
  • jciinsight-5-136477-s105.xlsx, sheet 5
View BVdb publication page



Inflammasomes: a preclinical assessment of targeting in atherosclerosis.

Expert Opinion On Therapeutic Targets
Stitham, Jeremiah J; Rodriguez-Velez, Astrid A; Zhang, Xiangyu X; Jeong, Se-Jin SJ; Razani, Babak B
Publication Date: 2020-09

Variant appearance in text: rs4129267
PubMed Link: 32757967
Variant Present in the following documents:
  • Main text
View BVdb publication page



A general framework for integrative analysis of incomplete multiomics data.

Genetic Epidemiology
Lin, Dan-Yu DY; Zeng, Donglin D; Couper, David D
Publication Date: 2020-10

Variant appearance in text: rs4129267
PubMed Link: 32691502
Variant Present in the following documents:
  • Main text
View BVdb publication page



Prioritization of causal genes for coronary artery disease based on cumulative evidence from experimental and in silico studies.

Scientific Reports
Shadrina, Alexandra S AS; Shashkova, Tatiana I TI; Torgasheva, Anna A AA; Sharapov, Sodbo Z SZ; Klarić, Lucija L; Pakhomov, Eugene D ED; Alexeev, Dmitry G DG; Wilson, James F JF; Tsepilov, Yakov A YA; Joshi, Peter K PK; Aulchenko, Yurii S YS
Publication Date: 2020-06-26

Variant appearance in text: rs4129267
PubMed Link: 32591598
Variant Present in the following documents:
  • Main text
  • 41598_2020_67001_MOESM6_ESM.pdf
View BVdb publication page



Treatment options in type-2 low asthma.

The European Respiratory Journal
Hinks, Timothy S C TSC; Levine, Stewart J SJ; Brusselle, Guy G GG
Publication Date: 2021-01

Variant appearance in text: rs4129267
PubMed Link: 32586877
Variant Present in the following documents:
  • Main text
View BVdb publication page



Methylation Pattern of the SOCS3 and IL6R Promoters in Rheumatoid Arthritis.

International Journal Of Inflammation
Cieśla, Marek M; Kolarz, Bogdan B; Majdan, Maria M; Darmochwał-Kolarz, Dorota D
Publication Date: 2020

Variant appearance in text: rs4129267
PubMed Link: 32292581
Variant Present in the following documents:
  • Main text
View BVdb publication page



Circulating interleukins in relation to coronary artery disease, atrial fibrillation and ischemic stroke and its subtypes: A two-sample Mendelian randomization study.

International Journal Of Cardiology
Yuan, Shuai S; Lin, Ang A; He, Qi-Qiang QQ; Burgess, Stephen S; Larsson, Susanna C SC
Publication Date: 2020-08-15

Variant appearance in text: rs4129267
PubMed Link: 32223966
Variant Present in the following documents:
  • EMS133104-supplement-Supplementary_Information.pdf
View BVdb publication page



Allelic Heterogeneity at the CRP Locus Identified by Whole-Genome Sequencing in Multi-ancestry Cohorts.

American Journal Of Human Genetics
Raffield, Laura M LM; Iyengar, Apoorva K AK; Wang, Biqi B; Gaynor, Sheila M SM; Spracklen, Cassandra N CN; Zhong, Xue X; Kowalski, Madeline H MH; Salimi, Shabnam S; Polfus, Linda M LM; Benjamin, Emelia J EJ; Bis, Joshua C JC; Bowler, Russell R; Cade, Brian E BE; Choi, Won Jung WJ; Comellas, Alejandro P AP; Correa, Adolfo A; Cruz, Pedro P; Doddapaneni, Harsha H; Durda, Peter P; Gogarten, Stephanie M SM; Jain, Deepti D; Kim, Ryan W RW; Kral, Brian G BG; Lange, Leslie A LA; Larson, Martin G MG; Laurie, Cecelia C; Lee, Jiwon J; Lee, Seonwook S; Lewis, Joshua P JP; Metcalf, Ginger A GA; Mitchell, Braxton D BD; Momin, Zeineen Z; Muzny, Donna M DM; Pankratz, Nathan N; Park, Cheol Joo CJ; Rich, Stephen S SS; Rotter, Jerome I JI; Ryan, Kathleen K; Seo, Daekwan D; Tracy, Russell P RP; Viaud-Martinez, Karine A KA; Yanek, Lisa R LR; Zhao, Lue Ping LP; Lin, Xihong X; Li, Bingshan B; Li, Yun Y; Dupuis, Josée J; Reiner, Alexander P AP; Mohlke, Karen L KL; Auer, Paul L PL; , ; ,
Publication Date: 2020-01-02

Variant appearance in text: rs4129267
PubMed Link: 31883642
Variant Present in the following documents:
  • Main text
View BVdb publication page



Polygenic Susceptibility of Aortic Aneurysms Associates to the Diameter of the Aneurysm Sac: the Aneurysm-Express Biobank Cohort.

Scientific Reports
van Laarhoven, Constance J H C M CJHCM; van Setten, Jessica J; van Herwaarden, Joost A JA; Pasterkamp, Gerard G; de Kleijn, Dominique P V DPV; de Borst, Gert J GJ; van der Laan, Sander W SW
Publication Date: 2019-12-27

Variant appearance in text: rs4129267
PubMed Link: 31882626
Variant Present in the following documents:
  • Main text
  • 41598_2019_Article_56230.pdf
View BVdb publication page



Genetic Interleukin 6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis.

Circulation
Bick, Alexander G AG; Pirruccello, James P JP; Griffin, Gabriel K GK; Gupta, Namrata N; Gabriel, Stacey S; Saleheen, Danish D; Libby, Peter P; Kathiresan, Sekar S; Natarajan, Pradeep P
Publication Date: 2020-01-14

Variant appearance in text: rs4129267
PubMed Link: 31707836
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic analysis of hsCRP in American Indians: The Strong Heart Family Study.

Plos One
Best, Lyle G LG; Balakrishnan, Poojitha P; Cole, Shelley A SA; Haack, Karin K; Kocarnik, Jonathan M JM; Pankratz, Nathan N; Anderson, Matthew Z MZ; Franceschini, Nora N; Howard, Barbara V BV; Lee, Elisa T ET; North, Kari E KE; Umans, Jason G JG; Yracheta, Joseph M JM; Navas-Acien, Ana A; Voruganti, V Saroja VS
Publication Date: 2019

Variant appearance in text: rs4129267
PubMed Link: 31622379
Variant Present in the following documents:
  • Main text
View BVdb publication page



A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity.

Npj Genomic Medicine
Rosa, Mickael M; Chignon, Arnaud A; Li, Zhonglin Z; Boulanger, Marie-Chloé MC; Arsenault, Benoit J BJ; Bossé, Yohan Y; Thériault, Sébastien S; Mathieu, Patrick P
Publication Date: 2019

Variant appearance in text: rs4129267
PubMed Link: 31552141
Variant Present in the following documents:
  • Main text
  • 41525_2019_Article_97.pdf
View BVdb publication page



Severe exacerbations in moderate-to-severe asthmatics are associated with increased pro-inflammatory and type 1 mediators in sputum and serum.

Bmc Pulmonary Medicine
Ghebre, Michael A MA; Pang, Pee Hwee PH; Desai, Dhananjay D; Hargadon, Beverley B; Newby, Chris C; Woods, Joanne J; Rapley, Laura L; Cohen, Suzanne E SE; Herath, Athula A; Gaillard, Erol A EA; May, Richard D RD; Brightling, Chris E CE
Publication Date: 2019-08-08

Variant appearance in text: rs4129267
PubMed Link: 31395050
Variant Present in the following documents:
  • Main text
  • 12890_2019_Article_906.pdf
View BVdb publication page



Systemic inflammation and causal risk for Alzheimer's dementia: Possibilities and limitations of a Mendelian randomization approach.

Aging Medicine (Milton (N.S.W))
Tsui, Alex A; Davis, Daniel D
Publication Date: 2018-12

Variant appearance in text: rs4129267
PubMed Link: 31328178
Variant Present in the following documents:
  • Main text
View BVdb publication page



Effects of interleukin-6 receptor blockade on allergen-induced airway responses in mild asthmatics.

Clinical & Translational Immunology
Revez, Joana A JA; Bain, Lisa M LM; Watson, Rick M RM; Towers, Michelle M; Collins, Tina T; Killian, Kieran J KJ; O'Byrne, Paul M PM; Gauvreau, Gail M GM; Upham, John W JW; Ferreira, Manuel Ar MA
Publication Date: 2019

Variant appearance in text: rs4129267
PubMed Link: 31223480
Variant Present in the following documents:
  • Main text
View BVdb publication page



Targeting inflammatory pathways in axial spondyloarthritis.

Arthritis Research & Therapy
Furst, Daniel E DE; Louie, James S JS
Publication Date: 2019-06-04

Variant appearance in text: rs4129267
PubMed Link: 31164157
Variant Present in the following documents:
  • Main text
View BVdb publication page



Causal Factors for Knee, Hip, and Hand Osteoarthritis: A Mendelian Randomization Study in the UK Biobank.

Arthritis & Rheumatology (Hoboken, N.J.)
Funck-Brentano, Thomas T; Nethander, Maria M; Movérare-Skrtic, Sofia S; Richette, Pascal P; Ohlsson, Claes C
Publication Date: 2019-10

Variant appearance in text: rs4129267
PubMed Link: 31099188
Variant Present in the following documents:
  • ART-71-1634-s001.pdf
View BVdb publication page



Genetics of Thoracic and Abdominal Aortic Diseases.

Circulation Research
Pinard, Amélie A; Jones, Gregory T GT; Milewicz, Dianna M DM
Publication Date: 2019-02-15

Variant appearance in text: rs4129267
PubMed Link: 30763214
Variant Present in the following documents:
  • Main text
View BVdb publication page



Lessons Learned From GWAS of Asthma.

Allergy, Asthma & Immunology Research
Kim, Kyung Won KW; Ober, Carole C
Publication Date: 2019-03

Variant appearance in text: rs4129267
PubMed Link: 30661310
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic Landscape of Slovenians: Past Admixture and Natural Selection Pattern.

Frontiers In Genetics
Maisano Delser, Pierpaolo P; Ravnik-Glavač, Metka M; Gasparini, Paolo P; Glavač, Damjan D; Mezzavilla, Massimo M
Publication Date: 2018

Variant appearance in text: rs4129267
PubMed Link: 30510563
Variant Present in the following documents:
  • Main text
  • fgene-09-00551.pdf
View BVdb publication page



Mendelian randomization analysis of C-reactive protein on colorectal cancer risk.

International Journal Of Epidemiology
Wang, Xiaoliang X; Dai, James Y JY; Albanes, Demetrius D; Arndt, Volker V; Berndt, Sonja I SI; Bézieau, Stéphane S; Brenner, Hermann H; Buchanan, Daniel D DD; Butterbach, Katja K; Caan, Bette B; Casey, Graham G; Campbell, Peter T PT; Chan, Andrew T AT; Chen, Zhengyi Z; Chang-Claude, Jenny J; Cotterchio, Michelle M; Easton, Douglas F DF; Giles, Graham G GG; Giovannucci, Edward E; Grady, William M WM; Hoffmeister, Michael M; Hopper, John L JL; Hsu, Li L; Jenkins, Mark A MA; Joshi, Amit D AD; Lampe, Johanna W JW; Larsson, Susanna C SC; Lejbkowicz, Flavio F; Li, Li L; Lindblom, Annika A; Le Marchand, Loic L; Martin, Vicente V; Milne, Roger L RL; Moreno, Victor V; Newcomb, Polly A PA; Offitt, Kenneth K; Ogino, Shuji S; Pharoah, Paul D P PDP; Pinchev, Mila M; Potter, John D JD; Rennert, Hedy S HS; Rennert, Gad G; Saliba, Walid W; Schafmayer, Clemens C; Schoen, Robert E RE; Schrotz-King, Petra P; Slattery, Martha L ML; Song, Mingyang M; Stegmaier, Christa C; Weinstein, Stephanie J SJ; Wolk, Alicja A; Woods, Michael O MO; Wu, Anna H AH; Gruber, Stephen B SB; Peters, Ulrike U; White, Emily E
Publication Date: 2019-06-01

Variant appearance in text: rs4129267
PubMed Link: 30476131
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Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.

American Journal Of Human Genetics
Ligthart, Symen S; Vaez, Ahmad A; Võsa, Urmo U; Stathopoulou, Maria G MG; de Vries, Paul S PS; Prins, Bram P BP; Van der Most, Peter J PJ; Tanaka, Toshiko T; Naderi, Elnaz E; Rose, Lynda M LM; Wu, Ying Y; Karlsson, Robert R; Barbalic, Maja M; Lin, Honghuang H; Pool, René R; Zhu, Gu G; Macé, Aurélien A; Sidore, Carlo C; Trompet, Stella S; Mangino, Massimo M; Sabater-Lleal, Maria M; Kemp, John P JP; Abbasi, Ali A; Kacprowski, Tim T; Verweij, Niek N; Smith, Albert V AV; Huang, Tao T; Marzi, Carola C; Feitosa, Mary F MF; Lohman, Kurt K KK; Kleber, Marcus E ME; Milaneschi, Yuri Y; Mueller, Christian C; Huq, Mahmudul M; Vlachopoulou, Efthymia E; Lyytikäinen, Leo-Pekka LP; Oldmeadow, Christopher C; Deelen, Joris J; Perola, Markus M; Zhao, Jing Hua JH; Feenstra, Bjarke B; , ; Amini, Marzyeh M; , ; Lahti, Jari J; Schraut, Katharina E KE; Fornage, Myriam M; Suktitipat, Bhoom B; Chen, Wei-Min WM; Li, Xiaohui X; Nutile, Teresa T; Malerba, Giovanni G; Luan, Jian'an J; Bak, Tom T; Schork, Nicholas N; Del Greco M, Fabiola F; Thiering, Elisabeth E; Mahajan, Anubha A; Marioni, Riccardo E RE; Mihailov, Evelin E; Eriksson, Joel J; Ozel, Ayse Bilge AB; Zhang, Weihua W; Nethander, Maria M; Cheng, Yu-Ching YC; Aslibekyan, Stella S; Ang, Wei W; Gandin, Ilaria I; Yengo, Loïc L; Portas, Laura L; Kooperberg, Charles C; Hofer, Edith E; Rajan, Kumar B KB; Schurmann, Claudia C; den Hollander, Wouter W; Ahluwalia, Tarunveer S TS; Zhao, Jing J; Draisma, Harmen H M HHM; Ford, Ian I; Timpson, Nicholas N; Teumer, Alexander A; Huang, Hongyan H; Wahl, Simone S; Liu, YongMei Y; Huang, Jie J; Uh, Hae-Won HW; Geller, Frank F; Joshi, Peter K PK; Yanek, Lisa R LR; Trabetti, Elisabetta E; Lehne, Benjamin B; Vozzi, Diego D; Verbanck, Marie M; Biino, Ginevra G; Saba, Yasaman Y; Meulenbelt, Ingrid I; O'Connell, Jeff R JR; Laakso, Markku M; Giulianini, Franco F; Magnusson, Patrik K E PKE; Ballantyne, Christie M CM; Hottenga, Jouke Jan JJ; Montgomery, Grant W GW; Rivadineira, Fernando F; Rueedi, Rico R; Steri, Maristella M; Herzig, Karl-Heinz KH; Stott, David J DJ; Menni, Cristina C; Frånberg, Mattias M; St Pourcain, Beate B; Felix, Stephan B SB; Pers, Tune H TH; Bakker, Stephan J L SJL; Kraft, Peter P; Peters, Annette A; Vaidya, Dhananjay D; Delgado, Graciela G; Smit, Johannes H JH; Großmann, Vera V; Sinisalo, Juha J; Seppälä, Ilkka I; Williams, Stephen R SR; Holliday, Elizabeth G EG; Moed, Matthijs M; Langenberg, Claudia C; Räikkönen, Katri K; Ding, Jingzhong J; Campbell, Harry H; Sale, Michele M MM; Chen, Yii-Der I YI; James, Alan L AL; Ruggiero, Daniela D; Soranzo, Nicole N; Hartman, Catharina A CA; Smith, Erin N EN; Berenson, Gerald S GS; Fuchsberger, Christian C; Hernandez, Dena D; Tiesler, Carla M T CMT; Giedraitis, Vilmantas V; Liewald, David D; Fischer, Krista K; Mellström, Dan D; Larsson, Anders A; Wang, Yunmei Y; Scott, William R WR; Lorentzon, Matthias M; Beilby, John J; Ryan, Kathleen A KA; Pennell, Craig E CE; Vuckovic, Dragana D; Balkau, Beverly B; Concas, Maria Pina MP; Schmidt, Reinhold R; Mendes de Leon, Carlos F CF; Bottinger, Erwin P EP; Kloppenburg, Margreet M; Paternoster, Lavinia L; Boehnke, Michael M; Musk, A W AW; Willemsen, Gonneke G; Evans, David M DM; Madden, Pamela A F PAF; Kähönen, Mika M; Kutalik, Zoltán Z; Zoledziewska, Magdalena M; Karhunen, Ville V; Kritchevsky, Stephen B SB; Sattar, Naveed N; Lachance, Genevieve G; Clarke, Robert R; Harris, Tamara B TB; Raitakari, Olli T OT; Attia, John R JR; van Heemst, Diana D; Kajantie, Eero E; Sorice, Rossella R; Gambaro, Giovanni G; Scott, Robert A RA; Hicks, Andrew A AA; Ferrucci, Luigi L; Standl, Marie M; Lindgren, Cecilia M CM; Starr, John M JM; Karlsson, Magnus M; Lind, Lars L; Li, Jun Z JZ; Chambers, John C JC; Mori, Trevor A TA; de Geus, Eco J C N EJCN; Heath, Andrew C AC; Martin, Nicholas G NG; Auvinen, Juha J; Buckley, Brendan M BM; de Craen, Anton J M AJM; Waldenberger, Melanie M; Strauch, Konstantin K; Meitinger, Thomas T; Scott, Rodney J RJ; McEvoy, Mark M; Beekman, Marian M; Bombieri, Cristina C; Ridker, Paul M PM; Mohlke, Karen L KL; Pedersen, Nancy L NL; Morrison, Alanna C AC; Boomsma, Dorret I DI; Whitfield, John B JB; Strachan, David P DP; Hofman, Albert A; Vollenweider, Peter P; Cucca, Francesco F; Jarvelin, Marjo-Riitta MR; Jukema, J Wouter JW; Spector, Tim D TD; Hamsten, Anders A; Zeller, Tanja T; Uitterlinden, André G AG; Nauck, Matthias M; Gudnason, Vilmundur V; Qi, Lu L; Grallert, Harald H; Borecki, Ingrid B IB; Rotter, Jerome I JI; März, Winfried W; Wild, Philipp S PS; Lokki, Marja-Liisa ML; Boyle, Michael M; Salomaa, Veikko V; Melbye, Mads M; Eriksson, Johan G JG; Wilson, James F JF; Penninx, Brenda W J H BWJH; Becker, Diane M DM; Worrall, Bradford B BB; Gibson, Greg G; Krauss, Ronald M RM; Ciullo, Marina M; Zaza, Gianluigi G; Wareham, Nicholas J NJ; Oldehinkel, Albertine J AJ; Palmer, Lyle J LJ; Murray, Sarah S SS; Pramstaller, Peter P PP; Bandinelli, Stefania S; Heinrich, Joachim J; Ingelsson, Erik E; Deary, Ian J IJ; Mägi, Reedik R; Vandenput, Liesbeth L; van der Harst, Pim P; Desch, Karl C KC; Kooner, Jaspal S JS; Ohlsson, Claes C; Hayward, Caroline C; Lehtimäki, Terho T; Shuldiner, Alan R AR; Arnett, Donna K DK; Beilin, Lawrence J LJ; Robino, Antonietta A; Froguel, Philippe P; Pirastu, Mario M; Jess, Tine T; Koenig, Wolfgang W; Loos, Ruth J F RJF; Evans, Denis A DA; Schmidt, Helena H; Smith, George Davey GD; Slagboom, P Eline PE; Eiriksdottir, Gudny G; Morris, Andrew P AP; Psaty, Bruce M BM; Tracy, Russell P RP; Nolte, Ilja M IM; Boerwinkle, Eric E; Visvikis-Siest, Sophie S; Reiner, Alex P AP; Gross, Myron M; Bis, Joshua C JC; Franke, Lude L; Franco, Oscar H OH; Benjamin, Emelia J EJ; Chasman, Daniel I DI; Dupuis, Josée J; Snieder, Harold H; Dehghan, Abbas A; Alizadeh, Behrooz Z BZ
Publication Date: 2018-11-01

Variant appearance in text: rs4129267
PubMed Link: 30388399
Variant Present in the following documents:
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Recent advances in ankylosing spondylitis: understanding the disease and management.

F1000Research
Garcia-Montoya, Leticia L; Gul, Hanna H; Emery, Paul P
Publication Date: 2018

Variant appearance in text: rs4129267
PubMed Link: 30345001
Variant Present in the following documents:
  • Main text
  • f1000research-7-16283.pdf
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Association of Interleukin 6 Receptor Variant With Cardiovascular Disease Effects of Interleukin 6 Receptor Blocking Therapy: A Phenome-Wide Association Study.

Jama Cardiology
Cai, Tianxi T; Zhang, Yichi Y; Ho, Yuk-Lam YL; Link, Nicholas N; Sun, Jiehuan J; Huang, Jie J; Cai, Tianrun A TA; Damrauer, Scott S; Ahuja, Yuri Y; Honerlaw, Jacqueline J; Huang, Jie J; Costa, Lauren L; Schubert, Petra P; Hong, Chuan C; Gagnon, David D; Sun, Yan V YV; Gaziano, J Michael JM; Wilson, Peter P; Cho, Kelly K; Tsao, Philip P; O'Donnell, Christopher J CJ; Liao, Katherine P KP; ,
Publication Date: 2018-09-01

Variant appearance in text: rs4129267
PubMed Link: 30090940
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Discovery, fine-mapping, and conditional analyses of genetic variants associated with C-reactive protein in multiethnic populations using the Metabochip in the Population Architecture using Genomics and Epidemiology (PAGE) study.

Human Molecular Genetics
Kocarnik, Jonathan M JM; Richard, Melissa M; Graff, Misa M; Haessler, Jeffrey J; Bien, Stephanie S; Carlson, Chris C; Carty, Cara L CL; Reiner, Alexander P AP; Avery, Christy L CL; Ballantyne, Christie M CM; LaCroix, Andrea Z AZ; Assimes, Themistocles L TL; Barbalic, Maja M; Pankratz, Nathan N; Tang, Weihong W; Tao, Ran R; Chen, Dongquan D; Talavera, Gregory A GA; Daviglus, Martha L ML; Chirinos-Medina, Diana A DA; Pereira, Rocio R; Nishimura, Katie K; Bužková, Petra P; Best, Lyle G LG; Ambite, José Luis JL; Cheng, Iona I; Crawford, Dana C DC; Hindorff, Lucia A LA; Fornage, Myriam M; Heiss, Gerardo G; North, Kari E KE; Haiman, Christopher A CA; Peters, Ulrike U; Le Marchand, Loic L; Kooperberg, Charles C
Publication Date: 2018-08-15

Variant appearance in text: rs4129267
PubMed Link: 29878111
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A pilot study of single nucleotide polymorphisms in the interleukin-6 receptor and their effects on pre- and post-transplant serum mediator level and outcome after allogeneic stem cell transplantation.

Clinical And Experimental Immunology
Tvedt, T H A THA; Hovland, R R; Tsykunova, G G; Ahmed, A B AB; Gedde-Dahl, T T; Bruserud, Ø Ø
Publication Date: 2018-07

Variant appearance in text: rs4129267
PubMed Link: 29513361
Variant Present in the following documents:
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Lessons from ten years of genome-wide association studies of asthma.

Clinical & Translational Immunology
Vicente, Cristina T CT; Revez, Joana A JA; Ferreira, Manuel A R MAR
Publication Date: 2017-12

Variant appearance in text: rs4129267
PubMed Link: 29333270
Variant Present in the following documents:
  • Main text
  • cti201754a.pdf
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Exome-wide study of ankylosing spondylitis demonstrates additional shared genetic background with inflammatory bowel disease.

Npj Genomic Medicine
Robinson, Philip C PC; Leo, Paul J PJ; Pointon, Jennifer J JJ; Harris, Jessica J; Cremin, Katie K; Bradbury, Linda A LA; Stebbings, Simon S; Harrison, Andrew A AA; , ; , ; , ; , ; , ; , ; Duncan, Emma L EL; Evans, David M DM; Wordsworth, Paul B PB; Brown, Matthew A MA
Publication Date: 2016

Variant appearance in text: rs4129267
PubMed Link: 29263810
Variant Present in the following documents:
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Inflammatory Biomarkers and Risk of Schizophrenia: A 2-Sample Mendelian Randomization Study.

Jama Psychiatry
Hartwig, Fernando Pires FP; Borges, Maria Carolina MC; Horta, Bernardo Lessa BL; Bowden, Jack J; Davey Smith, George G
Publication Date: 2017-12-01

Variant appearance in text: rs4129267
PubMed Link: 29094161
Variant Present in the following documents:
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Associations between SNPs and immune-related circulating proteins in schizophrenia.

Scientific Reports
Chan, Man K MK; Cooper, Jason D JD; Heilmann-Heimbach, Stefanie S; Frank, Josef J; Witt, Stephanie H SH; Nöthen, Markus M MM; Steiner, Johann J; Rietschel, Marcella M; Bahn, Sabine S
Publication Date: 2017-10-03

Variant appearance in text: rs4129267
PubMed Link: 28974776
Variant Present in the following documents:
  • Main text
  • 41598_2017_Article_12986.pdf
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Exome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling.

Human Molecular Genetics
Dand, Nick N; Mucha, Sören S; Tsoi, Lam C LC; Mahil, Satveer K SK; Stuart, Philip E PE; Arnold, Andreas A; Baurecht, Hansjörg H; Burden, A David AD; Callis Duffin, Kristina K; Chandran, Vinod V; Curtis, Charles J CJ; Das, Sayantan S; Ellinghaus, David D; Ellinghaus, Eva E; Enerback, Charlotta C; Esko, Tõnu T; Gladman, Dafna D DD; Griffiths, Christopher E M CEM; Gudjonsson, Johann E JE; Hoffman, Per P; Homuth, Georg G; Hüffmeier, Ulrike U; Krueger, Gerald G GG; Laudes, Matthias M; Lee, Sang Hyuck SH; Lieb, Wolfgang W; Lim, Henry W HW; Löhr, Sabine S; Mrowietz, Ulrich U; Müller-Nurayid, Martina M; Nöthen, Markus M; Peters, Annette A; Rahman, Proton P; Reis, André A; Reynolds, Nick J NJ; Rodriguez, Elke E; Schmidt, Carsten O CO; Spain, Sarah L SL; Strauch, Konstantin K; Tejasvi, Trilokraj T; Voorhees, John J JJ; Warren, Richard B RB; Weichenthal, Michael M; Weidinger, Stephan S; Zawistowski, Matthew M; Nair, Rajan P RP; Capon, Francesca F; Smith, Catherine H CH; Trembath, Richard C RC; Abecasis, Goncalo R GR; Elder, James T JT; Franke, Andre A; Simpson, Michael A MA; Barker, Jonathan N JN
Publication Date: 2017-11-01

Variant appearance in text: rs4129267
PubMed Link: 28973304
Variant Present in the following documents:
  • dand_exomewideassociationstudy_hmg_2017_supplementaryexcel_ddx328.xlsx, sheet 2
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Inflammation and bone mineral density: A Mendelian randomization study.

Scientific Reports
Huang, Jian V JV; Schooling, C Mary CM
Publication Date: 2017-08-17

Variant appearance in text: rs4129267
PubMed Link: 28819125
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Coronary artery disease-associated genetic variants and biomarkers of inflammation.

Plos One
Christiansen, Morten Krogh MK; Larsen, Sanne Bøjet SB; Nyegaard, Mette M; Neergaard-Petersen, Søs S; Ajjan, Ramzi R; Würtz, Morten M; Grove, Erik Lerkevang EL; Hvas, Anne-Mette AM; Jensen, Henrik Kjærulf HK; Kristensen, Steen Dalby SD
Publication Date: 2017

Variant appearance in text: rs4129267
PubMed Link: 28686695
Variant Present in the following documents:
  • Main text
  • pone.0180365.pdf
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