Publications:

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Clinical Value of IL6R Gene Variants as Predictive Biomarkers for Toxicity to Tocilizumab in Patients with Rheumatoid Arthritis.

Journal Of Personalized Medicine

Sainz, Luis L; Riera, Pau P; Moya, Patricia P; Bernal, Sara S; Casademont, Jordi J; Díaz-Torné, Cesar C; Millán, Ana Milena AM; Park, Hye Sang HS; Lasa, Adriana A; Corominas, Héctor H

Publication Date: 2022-12-28

Variant appearance in text: rs11265618

PubMed Link: 36675722

Variant Present in the following documents:

• Main text
• jpm-13-00061.pdf

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Considerations into pharmacogenomics of COVID-19 pharmacotherapy: Hope, hype and reality.

Pulmonary Pharmacology & Therapeutics

Al-Taie, Anmar A; Büyük, Ayşe Şeyma AŞ; Sardas, Semra S

Publication Date: 2022-12

Variant appearance in text: rs11265618

PubMed Link: 36265833

Variant Present in the following documents:

• main.pdf

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Role of IL6R Genetic Variants in Predicting Response to Tocilizumab in Patients with Rheumatoid Arthritis.

Pharmaceutics

Sainz, Luis L; Riera, Pau P; Moya, Patricia P; Bernal, Sara S; Casademont, Jordi J; Díaz-Torné, Cesar C; Millán, Ana Milena AM; Park, Hye Sang HS; Lasa, Adriana A; Corominas, Héctor H

Publication Date: 2022-09-14

Variant appearance in text: rs11265618

PubMed Link: 36145690

Variant Present in the following documents:

• Main text
• pharmaceutics-14-01942.pdf

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Pharmacogenomics of Monoclonal Antibodies for the Treatment of Rheumatoid Arthritis.

Journal Of Personalized Medicine

Lim, Sung Ho SH; Kim, Khangyoo K; Choi, Chang-Ik CI

Publication Date: 2022-07-31

Variant appearance in text: rs11265618

PubMed Link: 36013214

Variant Present in the following documents:

• Main text
• jpm-12-01265.pdf

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Genetic Biomarkers as Predictors of Response to Tocilizumab in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.

Genes

Janahiraman, Sivakami S; Too, Chun Lai CL; Lee, Kai Wei KW; Shahril, Nor Shuhaila NS; Leong, Chee Onn CO

Publication Date: 2022-07-20

Variant appearance in text: rs11265618

PubMed Link: 35886067

Variant Present in the following documents:

• genes-13-01284.pdf

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Will the Use of Pharmacogenetics Improve Treatment Efficiency in COVID-19?

Pharmaceuticals (Basel, Switzerland)

Franczyk, Beata B; Rysz, Jacek J; Miłoński, Jarosław J; Konecki, Tomasz T; Rysz-Górzyńska, Magdalena M; Gluba-Brzózka, Anna A

Publication Date: 2022-06-13

Variant appearance in text: rs11265618

PubMed Link: 35745658

Variant Present in the following documents:

• Main text
• pharmaceuticals-15-00739.pdf

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Transmembrane protease serine 2 (TMPRSS2) rs75603675, comorbidity, and sex are the primary predictors of COVID-19 severity.

Life Science Alliance

Villapalos-García, Gonzalo G; Zubiaur, Pablo P; Rivas-Durán, Rebeca R; Campos-Norte, Pilar P; Arévalo-Román, Cristina C; Fernández-Rico, Marta M; García-Fraile Fraile, Lucio L; Fernández-Campos, Paula P; Soria-Chacartegui, Paula P; Fernández de Córdoba-Oñate, Sara S; Delgado-Wicke, Pablo P; Fernández-Ruiz, Elena E; González-Álvaro, Isidoro I; Sanz, Jesús J; Abad-Santos, Francisco F; de Los Santos, Ignacio I

Publication Date: 2022-10

Variant appearance in text: rs11265618

PubMed Link: 35636966

Variant Present in the following documents:

• Main text
• LSA-2022-01396.pdf

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Single nucleotide polymorphisms located in TNFA, IL1RN, IL6R, and IL6 genes are associated with COVID-19 risk and severity in an Iranian population.

Cell Biology International

Rokni, Mohsen M; Sarhadi, Mohammad M; Heidari Nia, Milad M; Mohamed Khosroshahi, Leila L; Asghari, Somaye S; Sargazi, Saman S; Mirinejad, Shekoufeh S; Saravani, Ramin R

Publication Date: 2022-07

Variant appearance in text: rs11265618

PubMed Link: 35521908

Variant Present in the following documents:

• Main text
• CBIN-46-1109.pdf

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Assessing the potential correlation of polymorphisms in the IL6R with relative IL6 elevation in severely ill COVID-19 patients'.

Cytokine

Smieszek, Sandra P SP; Przychodzen, Bartlomiej P BP; Polymeropoulos, Vasilios M VM; Polymeropoulos, Christos M CM; Polymeropoulos, Mihael H MH

Publication Date: 2021-12

Variant appearance in text: rs11265618

PubMed Link: 34353696

Variant Present in the following documents:

• mmc2.xlsx, sheet 1

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Genome-wide association study of circulating interleukin 6 levels identifies novel loci.

Human Molecular Genetics

Ahluwalia, Tarunveer S TS; Prins, Bram P BP; Abdollahi, Mohammadreza M; Armstrong, Nicola J NJ; Aslibekyan, Stella S; Bain, Lisa L; Jefferis, Barbara B; Baumert, Jens J; Beekman, Marian M; Ben-Shlomo, Yoav Y; Bis, Joshua C JC; Mitchell, Braxton D BD; de Geus, Eco E; Delgado, Graciela E GE; Marek, Diana D; Eriksson, Joel J; Kajantie, Eero E; Kanoni, Stavroula S; Kemp, John P JP; Lu, Chen C; Marioni, Riccardo E RE; McLachlan, Stela S; Milaneschi, Yuri Y; Nolte, Ilja M IM; Petrelis, Alexandros M AM; Porcu, Eleonora E; Sabater-Lleal, Maria M; Naderi, Elnaz E; Seppälä, Ilkka I; Shah, Tina T; Singhal, Gaurav G; Standl, Marie M; Teumer, Alexander A; Thalamuthu, Anbupalam A; Thiering, Elisabeth E; Trompet, Stella S; Ballantyne, Christie M CM; Benjamin, Emelia J EJ; Casas, Juan P JP; Toben, Catherine C; Dedoussis, George G; Deelen, Joris J; Durda, Peter P; Engmann, Jorgen J; Feitosa, Mary F MF; Grallert, Harald H; Hammarstedt, Ann A; Harris, Sarah E SE; Homuth, Georg G; Hottenga, Jouke-Jan JJ; Jalkanen, Sirpa S; Jamshidi, Yalda Y; Jawahar, Magdalene C MC; Jess, Tine T; Kivimaki, Mika M; Kleber, Marcus E ME; Lahti, Jari J; Liu, Yongmei Y; Marques-Vidal, Pedro P; Mellström, Dan D; Mooijaart, Simon P SP; Müller-Nurasyid, Martina M; Penninx, Brenda B; Revez, Joana A JA; Rossing, Peter P; Räikkönen, Katri K; Sattar, Naveed N; Scharnagl, Hubert H; Sennblad, Bengt B; Silveira, Angela A; Pourcain, Beate St BS; Timpson, Nicholas J NJ; Trollor, Julian J; , ; van Dongen, Jenny J; Van Heemst, Diana D; Visvikis-Siest, Sophie S; Vollenweider, Peter P; Völker, Uwe U; Waldenberger, Melanie M; Willemsen, Gonneke G; Zabaneh, Delilah D; Morris, Richard W RW; Arnett, Donna K DK; Baune, Bernhard T BT; Boomsma, Dorret I DI; Chang, Yen-Pei C YC; Deary, Ian J IJ; Deloukas, Panos P; Eriksson, Johan G JG; Evans, David M DM; Ferreira, Manuel A MA; Gaunt, Tom T; Gudnason, Vilmundur V; Hamsten, Anders A; Heinrich, Joachim J; Hingorani, Aroon A; Humphries, Steve E SE; Jukema, J Wouter JW; Koenig, Wolfgang W; Kumari, Meena M; Kutalik, Zoltan Z; Lawlor, Deborah A DA; Lehtimäki, Terho T; März, Winfried W; Mather, Karen A KA; Naitza, Silvia S; Nauck, Matthias M; Ohlsson, Claes C; Price, Jackie F JF; Raitakari, Olli O; Rice, Ken K; Sachdev, Perminder S PS; Slagboom, Eline E; Sørensen, Thorkild I A TIA; Spector, Tim T; Stacey, David D; Stathopoulou, Maria G MG; Tanaka, Toshiko T; Wannamethee, S Goya SG; Whincup, Peter P; Rotter, Jerome I JI; Dehghan, Abbas A; Boerwinkle, Eric E; Psaty, Bruce M BM; Snieder, Harold H; Alizadeh, Behrooz Z BZ

Publication Date: 2021-04-27

Variant appearance in text: rs11265618

PubMed Link: 33517400

Variant Present in the following documents:

• Main text

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Computational Functional Genomics-Based AmpliSeq™ Panel for Next-Generation Sequencing of Key Genes of Pain.

International Journal Of Molecular Sciences

Kringel, Dario D; Malkusch, Sebastian S; Kalso, Eija E; Lötsch, Jörn J

Publication Date: 2021-01-16

Variant appearance in text: rs11265618

PubMed Link: 33467215

Variant Present in the following documents:

• Main text
• ijms-22-00878.pdf

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Pharmacogenomics and Pharmacogenetics: In Silico Prediction of Drug Effects in Treatments for Novel Coronavirus SARS-CoV2 Disease.

Pharmacogenomics And Personalized Medicine

Cafiero, Concetta C; Re, Agnese A; Micera, Alessandra A; Palmirotta, Raffaele R; Monaco, Delio D; Romano, Francesca F; Fabrizio, Claudia C; Di Francia, Raffaele R; Cacciamani, Andrea A; Surico, Pier Luigi PL; D'Amato, Gerardo G; Pisconti, Salvatore S

Publication Date: 2020

Variant appearance in text: rs11265618

PubMed Link: 33116761

Variant Present in the following documents:

• Main text
• pgpm-13-463.pdf

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Important Pharmacogenetic Information for Drugs Prescribed During the SARS-CoV-2 Infection (COVID-19).

Clinical And Translational Science

Zubiaur, Pablo P; Koller, Dora D; Saiz-Rodríguez, Miriam M; Navares-Gómez, Marcos M; Abad-Santos, Francisco F

Publication Date: 2020-11

Variant appearance in text: rs11265618

PubMed Link: 32936528

Variant Present in the following documents:

• Main text
• CTS-13-1023.pdf

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Polymorphisms Involved in Response to Biological Agents Used in Rheumatoid Arthritis.

Biomolecules

Pallio, Giovanni G; Mannino, Federica F; Irrera, Natasha N; Eid, Ali H AH; Squadrito, Francesco F; Bitto, Alessandra A

Publication Date: 2020-08-19

Variant appearance in text: rs11265618

PubMed Link: 32825059

Variant Present in the following documents:

• Main text
• biomolecules-10-01203.pdf

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Genetic Polymorphisms Associated with Rheumatoid Arthritis Development and Antirheumatic Therapy Response.

International Journal Of Molecular Sciences

Mikhaylenko, Dmitry S DS; Nemtsova, Marina V MV; Bure, Irina V IV; Kuznetsova, Ekaterina B EB; Alekseeva, Ekaterina A EA; Tarasov, Vadim V VV; Lukashev, Alexander N AN; Beloukhova, Marina I MI; Deviatkin, Andrei A AA; Zamyatnin, Andrey A AA

Publication Date: 2020-07-11

Variant appearance in text: rs11265618

PubMed Link: 32664585

Variant Present in the following documents:

• Main text

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Genetic variants in interleukin genes are associated with breast cancer risk and survival in a genetically admixed population: the Breast Cancer Health Disparities Study.

Carcinogenesis

Slattery, Martha L ML; Herrick, Jennifer S JS; Torres-Mejia, Gabriella G; John, Esther M EM; Giuliano, Anna R AR; Hines, Lisa M LM; Stern, Mariana C MC; Baumgartner, Kathy B KB; Presson, Angela P AP; Wolff, Roger K RK

Publication Date: 2014-08

Variant appearance in text: rs11265618

PubMed Link: 24670917

Variant Present in the following documents:

• Main text

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IL-6 pathway-driven investigation of response to IL-6 receptor inhibition in rheumatoid arthritis.

Bmj Open

Wang, Jianmei J; Platt, Adam A; Upmanyu, Ruchi R; Germer, Søren S; Lei, Guiyuan G; Rabe, Christina C; Benayed, Ryma R; Kenwright, Andrew A; Hemmings, Andrew A; Martin, Mitchell M; Harari, Olivier O

Publication Date: 2013-08-19

Variant appearance in text: rs11265618

PubMed Link: 23959753

Variant Present in the following documents:

• Main text

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Exploring genome-wide - dietary heme iron intake interactions and the risk of type 2 diabetes.

Frontiers In Genetics

Pasquale, Louis R LR; Loomis, Stephanie J SJ; Aschard, Hugues H; Kang, Jae H JH; Cornelis, Marilyn C MC; Qi, Lu L; Kraft, Peter P; Hu, Frank B FB

Publication Date: 2013

Variant appearance in text: rs11265618

PubMed Link: 23386860

Variant Present in the following documents:

• Main text
• fgene-04-00007.pdf

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Interleukin genes and associations with colon and rectal cancer risk and overall survival.

International Journal Of Cancer

Bondurant, Kristina L KL; Lundgreen, Abbie A; Herrick, Jennifer S JS; Kadlubar, Susan S; Wolff, Roger K RK; Slattery, Martha L ML

Publication Date: 2013-02-15

Variant appearance in text: rs11265618

PubMed Link: 22674296

Variant Present in the following documents:

• Main text

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Interaction between interleukin-1 receptor 2 and Toll-like receptor 4, and cervical cytokines.

Journal Of Reproductive Immunology

Ryckman, Kelli K KK; Williams, Scott M SM; Krohn, Marijane A MA; Simhan, Hyagriv N HN

Publication Date: 2011-08

Variant appearance in text: rs11265618

PubMed Link: 21704385

Variant Present in the following documents:

• Main text

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A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects.

Genes And Immunity

Rafiq, S S; Frayling, T M TM; Murray, A A; Hurst, A A; Stevens, K K; Weedon, M N MN; Henley, W W; Ferrucci, L L; Bandinelli, S S; Corsi, A-M AM; Guralnik, J M JM; Melzer, D D

Publication Date: 2007-10

Variant appearance in text: rs11265618

PubMed Link: 17671508

Variant Present in the following documents:

• Main text

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Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels.

American Journal Of Human Genetics

Reich, David D; Patterson, Nick N; Ramesh, Vijaya V; De Jager, Philip L PL; McDonald, Gavin J GJ; Tandon, Arti A; Choy, Edwin E; Hu, Donglei D; Tamraz, Bani B; Pawlikowska, Ludmila L; Wassel-Fyr, Christina C; Huntsman, Scott S; Waliszewska, Alicja A; Rossin, Elizabeth E; Li, Rongling R; Garcia, Melissa M; Reiner, Alexander A; Ferrell, Robert R; Cummings, Steve S; Kwok, Pui-Yan PY; Harris, Tamara T; Zmuda, Joseph M JM; Ziv, Elad E; ,

Publication Date: 2007-04

Variant appearance in text: rs11265618

PubMed Link: 17357077

Variant Present in the following documents:

• Main text

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