Clinical Value of IL6R Gene Variants as Predictive Biomarkers for Toxicity to Tocilizumab in Patients with Rheumatoid Arthritis.
Journal Of Personalized Medicine
Sainz, Luis L; Riera, Pau P; Moya, Patricia P; Bernal, Sara S; Casademont, Jordi J; Díaz-Torné, Cesar C; Millán, Ana Milena AM; Park, Hye Sang HS; Lasa, Adriana A; Corominas, Héctor H
Role of IL6R Genetic Variants in Predicting Response to Tocilizumab in Patients with Rheumatoid Arthritis.
Pharmaceutics
Sainz, Luis L; Riera, Pau P; Moya, Patricia P; Bernal, Sara S; Casademont, Jordi J; Díaz-Torné, Cesar C; Millán, Ana Milena AM; Park, Hye Sang HS; Lasa, Adriana A; Corominas, Héctor H
Transmembrane protease serine 2 (TMPRSS2) rs75603675, comorbidity, and sex are the primary predictors of COVID-19 severity.
Life Science Alliance
Villapalos-García, Gonzalo G; Zubiaur, Pablo P; Rivas-Durán, Rebeca R; Campos-Norte, Pilar P; Arévalo-Román, Cristina C; Fernández-Rico, Marta M; García-Fraile Fraile, Lucio L; Fernández-Campos, Paula P; Soria-Chacartegui, Paula P; Fernández de Córdoba-Oñate, Sara S; Delgado-Wicke, Pablo P; Fernández-Ruiz, Elena E; González-Álvaro, Isidoro I; Sanz, Jesús J; Abad-Santos, Francisco F; de Los Santos, Ignacio I
Characterization of Rheumatoid Arthritis Risk-Associated SNPs and Identification of Novel Therapeutic Sites Using an In-Silico Approach.
Biology
Akhtar, Mehran M; Ali, Yasir Y; Islam, Zia-Ul ZU; Arshad, Maria M; Rauf, Mamoona M; Ali, Muhammad M; Maodaa, Saleh N SN; Al-Farraj, Saleh A SA; El-Serehy, Hamed A HA; Jalil, Fazal F
Genome-wide association study of circulating interleukin 6 levels identifies novel loci.
Human Molecular Genetics
Ahluwalia, Tarunveer S TS; Prins, Bram P BP; Abdollahi, Mohammadreza M; Armstrong, Nicola J NJ; Aslibekyan, Stella S; Bain, Lisa L; Jefferis, Barbara B; Baumert, Jens J; Beekman, Marian M; Ben-Shlomo, Yoav Y; Bis, Joshua C JC; Mitchell, Braxton D BD; de Geus, Eco E; Delgado, Graciela E GE; Marek, Diana D; Eriksson, Joel J; Kajantie, Eero E; Kanoni, Stavroula S; Kemp, John P JP; Lu, Chen C; Marioni, Riccardo E RE; McLachlan, Stela S; Milaneschi, Yuri Y; Nolte, Ilja M IM; Petrelis, Alexandros M AM; Porcu, Eleonora E; Sabater-Lleal, Maria M; Naderi, Elnaz E; Seppälä, Ilkka I; Shah, Tina T; Singhal, Gaurav G; Standl, Marie M; Teumer, Alexander A; Thalamuthu, Anbupalam A; Thiering, Elisabeth E; Trompet, Stella S; Ballantyne, Christie M CM; Benjamin, Emelia J EJ; Casas, Juan P JP; Toben, Catherine C; Dedoussis, George G; Deelen, Joris J; Durda, Peter P; Engmann, Jorgen J; Feitosa, Mary F MF; Grallert, Harald H; Hammarstedt, Ann A; Harris, Sarah E SE; Homuth, Georg G; Hottenga, Jouke-Jan JJ; Jalkanen, Sirpa S; Jamshidi, Yalda Y; Jawahar, Magdalene C MC; Jess, Tine T; Kivimaki, Mika M; Kleber, Marcus E ME; Lahti, Jari J; Liu, Yongmei Y; Marques-Vidal, Pedro P; Mellström, Dan D; Mooijaart, Simon P SP; Müller-Nurasyid, Martina M; Penninx, Brenda B; Revez, Joana A JA; Rossing, Peter P; Räikkönen, Katri K; Sattar, Naveed N; Scharnagl, Hubert H; Sennblad, Bengt B; Silveira, Angela A; Pourcain, Beate St BS; Timpson, Nicholas J NJ; Trollor, Julian J; , ; van Dongen, Jenny J; Van Heemst, Diana D; Visvikis-Siest, Sophie S; Vollenweider, Peter P; Völker, Uwe U; Waldenberger, Melanie M; Willemsen, Gonneke G; Zabaneh, Delilah D; Morris, Richard W RW; Arnett, Donna K DK; Baune, Bernhard T BT; Boomsma, Dorret I DI; Chang, Yen-Pei C YC; Deary, Ian J IJ; Deloukas, Panos P; Eriksson, Johan G JG; Evans, David M DM; Ferreira, Manuel A MA; Gaunt, Tom T; Gudnason, Vilmundur V; Hamsten, Anders A; Heinrich, Joachim J; Hingorani, Aroon A; Humphries, Steve E SE; Jukema, J Wouter JW; Koenig, Wolfgang W; Kumari, Meena M; Kutalik, Zoltan Z; Lawlor, Deborah A DA; Lehtimäki, Terho T; März, Winfried W; Mather, Karen A KA; Naitza, Silvia S; Nauck, Matthias M; Ohlsson, Claes C; Price, Jackie F JF; Raitakari, Olli O; Rice, Ken K; Sachdev, Perminder S PS; Slagboom, Eline E; Sørensen, Thorkild I A TIA; Spector, Tim T; Stacey, David D; Stathopoulou, Maria G MG; Tanaka, Toshiko T; Wannamethee, S Goya SG; Whincup, Peter P; Rotter, Jerome I JI; Dehghan, Abbas A; Boerwinkle, Eric E; Psaty, Bruce M BM; Snieder, Harold H; Alizadeh, Behrooz Z BZ
Genetic Polymorphisms Associated with Rheumatoid Arthritis Development and Antirheumatic Therapy Response.
International Journal Of Molecular Sciences
Mikhaylenko, Dmitry S DS; Nemtsova, Marina V MV; Bure, Irina V IV; Kuznetsova, Ekaterina B EB; Alekseeva, Ekaterina A EA; Tarasov, Vadim V VV; Lukashev, Alexander N AN; Beloukhova, Marina I MI; Deviatkin, Andrei A AA; Zamyatnin, Andrey A AA
A pilot study of single nucleotide polymorphisms in the interleukin-6 receptor and their effects on pre- and post-transplant serum mediator level and outcome after allogeneic stem cell transplantation.
Clinical And Experimental Immunology
Tvedt, T H A THA; Hovland, R R; Tsykunova, G G; Ahmed, A B AB; Gedde-Dahl, T T; Bruserud, Ø Ø
Interleukin-6 Receptor Polymorphisms Contribute to the Neurological Status of Korean Patients with Ischemic Stroke.
Journal Of Korean Medical Science
Kim, Dong Hwan DH; Yoo, Seung Don SD; Chon, Jinmann J; Yun, Dong Hwan DH; Kim, Hee-Sang HS; Park, Hae Jeong HJ; Kim, Su Kang SK; Chung, Joo-Ho JH; Kang, Jin Kyu JK; Lee, Seung Ah SA
Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases.
Plos Genetics
Ferreira, Ricardo C RC; Freitag, Daniel F DF; Cutler, Antony J AJ; Howson, Joanna M M JM; Rainbow, Daniel B DB; Smyth, Deborah J DJ; Kaptoge, Stephen S; Clarke, Pamela P; Boreham, Charlotte C; Coulson, Richard M RM; Pekalski, Marcin L ML; Chen, Wei-Min WM; Onengut-Gumuscu, Suna S; Rich, Stephen S SS; Butterworth, Adam S AS; Malarstig, Anders A; Danesh, John J; Todd, John A JA
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.
Lancet (London, England)
, ; Swerdlow, Daniel I DI; Holmes, Michael V MV; Kuchenbaecker, Karoline B KB; Engmann, Jorgen E L JE; Shah, Tina T; Sofat, Reecha R; Guo, Yiran Y; Chung, Christina C; Peasey, Anne A; Pfister, Roman R; Mooijaart, Simon P SP; Ireland, Helen A HA; Leusink, Maarten M; Langenberg, Claudia C; Li, Ka Wah KW; Palmen, Jutta J; Howard, Philip P; Cooper, Jackie A JA; Drenos, Fotios F; Hardy, John J; Nalls, Michael A MA; Li, Yun Rose YR; Lowe, Gordon G; Stewart, Marlene M; Bielinski, Suzette J SJ; Peto, Julian J; Timpson, Nicholas J NJ; Gallacher, John J; Dunlop, Malcolm M; Houlston, Richard R; Tomlinson, Ian I; Tzoulaki, Ioanna I; Luan, Jian'an J; Boer, Jolanda M A JM; Forouhi, Nita G NG; Onland-Moret, N Charlotte NC; van der Schouw, Yvonne T YT; Schnabel, Renate B RB; Hubacek, Jaroslav A JA; Kubinova, Ruzena R; Baceviciene, Migle M; Tamosiunas, Abdonas A; Pajak, Andrzej A; Topor-Madry, Roman R; Malyutina, Sofia S; Baldassarre, Damiano D; Sennblad, Bengt B; Tremoli, Elena E; de Faire, Ulf U; Ferrucci, Luigi L; Bandenelli, Stefania S; Tanaka, Toshiko T; Meschia, James F JF; Singleton, Andrew A; Navis, Gerjan G; Mateo Leach, Irene I; Bakker, Stephan J L SJ; Gansevoort, Ron T RT; Ford, Ian I; Epstein, Stephen E SE; Burnett, Mary Susan MS; Devaney, Joe M JM; Jukema, J Wouter JW; Westendorp, Rudi G J RG; Jan de Borst, Gert G; van der Graaf, Yolanda Y; de Jong, Pim A PA; Mailand-van der Zee, Anke-Hilse AH; Klungel, Olaf H OH; de Boer, Anthonius A; Doevendans, Pieter A PA; Stephens, Jeffrey W JW; Eaton, Charles B CB; Robinson, Jennifer G JG; Manson, JoAnn E JE; Fowkes, F Gerry FG; Frayling, Timonthy M TM; Price, Jackie F JF; Whincup, Peter H PH; Morris, Richard W RW; Lawlor, Debbie A DA; Smith, George Davey GD; Ben-Shlomo, Yoav Y; Redline, Susan S; Lange, Leslie A LA; Kumari, Meena M; Wareham, Nick J NJ; Verschuren, W M Monique WM; Benjamin, Emelia J EJ; Whittaker, John C JC; Hamsten, Anders A; Dudbridge, Frank F; Delaney, J A Chris JA; Wong, Andrew A; Kuh, Diana D; Hardy, Rebecca R; Castillo, Berta Almoguera BA; Connolly, John J JJ; van der Harst, Pim P; Brunner, Eric J EJ; Marmot, Michael G MG; Wassel, Christina L CL; Humphries, Steve E SE; Talmud, Philippa J PJ; Kivimaki, Mika M; Asselbergs, Folkert W FW; Voevoda, Mikhail M; Bobak, Martin M; Pikhart, Hynek H; Wilson, James G JG; Hakonarson, Hakon H; Reiner, Alex P AP; Keating, Brendan J BJ; Sattar, Naveed N; Hingorani, Aroon D AD; Casas, Juan Pablo JP
Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels.
American Journal Of Human Genetics
Reich, David D; Patterson, Nick N; Ramesh, Vijaya V; De Jager, Philip L PL; McDonald, Gavin J GJ; Tandon, Arti A; Choy, Edwin E; Hu, Donglei D; Tamraz, Bani B; Pawlikowska, Ludmila L; Wassel-Fyr, Christina C; Huntsman, Scott S; Waliszewska, Alicja A; Rossin, Elizabeth E; Li, Rongling R; Garcia, Melissa M; Reiner, Alexander A; Ferrell, Robert R; Cummings, Steve S; Kwok, Pui-Yan PY; Harris, Tamara T; Zmuda, Joseph M JM; Ziv, Elad E; ,