Publications:

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Impact of pharmacogenetics on aspirin resistance: a systematic review.

Arquivos De Neuro-Psiquiatria

Silva, Gustavo Figueiredo da GFD; Lopes, Bruno Mattei BM; Moser, Vinicius V; Ferreira, Leslie Ecker LE

Publication Date: 2023-01

Variant appearance in text: rs12566888

PubMed Link: 36918009

Variant Present in the following documents:

• Main text
• 10-1055-s-0042-1758445.pdf

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The 4G/5G polymorphism of plasminogen activator inhibitor type 1 is a predictor of allergic cough.

Frontiers In Genetics

Tang, Rui R; Lyu, Xiaohong X; Li, Hong H; Sun, Jinlyu J

Publication Date: 2023

Variant appearance in text: rs12566888

PubMed Link: 36911417

Variant Present in the following documents:

• Main text
• fgene-14-1139813.pdf

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DNA Polymorphisms in Pregnant Women with Sticky Platelet Syndrome.

Journal Of Clinical Medicine

Stančiaková, Lucia L; Žolková, Jana J; Vadelová, Ľubica Ľ; Hornáková, Andrea A; Kolková, Zuzana Z; Vážan, Martin M; Dobrotová, Miroslava M; Hollý, Pavol P; Jedináková, Zuzana Z; Grendár, Marián M; Bolek, Tomáš T; Samoš, Matej M; Biringer, Kamil K; Danko, Ján J; Burjanivová, Tatiana T; Lasabová, Zora Z; Kubisz, Peter P; Staško, Ján J

Publication Date: 2022-11-03

Variant appearance in text: rs12566888

PubMed Link: 36362759

Variant Present in the following documents:

• Main text
• jcm-11-06532.pdf

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Association of colorectal cancer with genetic and epigenetic variation in PEAR1-A population-based cohort study.

Plos One

Yang, Wen-Yi WY; Izzi, Benedetta B; Bress, Adam P AP; Thijs, Lutgarde L; Citterio, Lorena L; Wei, Fang-Fei FF; Salvi, Erika E; Delli Carpini, Simona S; Manunta, Paolo P; Cusi, Daniele D; Hoylaerts, Marc F MF; Luttun, Aernout A; Verhamme, Peter P; Hardikar, Sheetal S; Nawrot, Tim S TS; Staessen, Jan A JA; Zhang, Zhen-Yu ZY

Publication Date: 2022

Variant appearance in text: rs12566888

PubMed Link: 35390065

Variant Present in the following documents:

• Main text
• pone.0266481.pdf

View BVdb publication page

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Primary Thrombophilia XVI: A Look at the Genotype of the Sticky Platelet Syndrome Phenotype.

Clinical And Applied Thrombosis/Hemostasis : Official Journal Of The International Academy Of Clinical And Applied Thrombosis/Hemostasis

García-Villaseñor, Elizabeth E; Bojalil-Álvarez, Lorena L; Murrieta-Álvarez, Iván I; Cantero-Fortiz, Yahveth Y; Ruiz-Delgado, Guillermo J GJ; Ruiz-Argüelles, Guillermo J GJ

Publication Date: 2021

Variant appearance in text: rs12566888

PubMed Link: 34617458

Variant Present in the following documents:

• Main text

View BVdb publication page

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Primary Thrombophilia XVI: A Look at the Genotype of the Sticky Platelet Syndrome Phenotype.

Clinical And Applied Thrombosis/Hemostasis : Official Journal Of The International Academy Of Clinical And Applied Thrombosis/Hemostasis

García-Villaseñor, Elizabeth E; Bojalil-Álvarez, Lorena L; Murrieta-Álvarez, Iván I; Cantero-Fortiz, Yahveth Y; Ruiz-Delgado, Guillermo J GJ; Ruiz-Argüelles, Guillermo J GJ

Publication Date: 2021

Variant appearance in text: rs12566888

PubMed Link: 34617458

Variant Present in the following documents:

• Main text

View BVdb publication page

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G protein-coupled receptor kinase 5 regulates thrombin signaling in platelets via PAR-1.

Blood Advances

Downes, Kate K; Zhao, Xuefei X; Gleadall, Nicholas S NS; McKinney, Harriet H; Kempster, Carly C; Batista, Joana J; Thomas, Patrick L PL; Cooper, Matthew M; Michael, James V JV; Kreuzhuber, Roman R; Wedderburn, Katherine K; Waller, Kathryn K; Varney, Bianca B; Verdier, Hippolyte H; Kriek, Neline N; Ashford, Sofie E SE; Stirrups, Kathleen E KE; Dunster, Joanne L JL; McKenzie, Steven E SE; Ouwehand, Willem H WH; Gibbins, Jonathan M JM; Yang, Jing J; Astle, William J WJ; Ma, Peisong P

Publication Date: 2022-04-12

Variant appearance in text: rs12566888

PubMed Link: 34581777

Variant Present in the following documents:

• Main text
• advancesADV2021005453.pdf

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Biomarkers for Antiplatelet Therapies in Acute Ischemic Stroke: A Clinical Review.

Frontiers In Neurology

Alhazzani, Adel A; Venkatachalapathy, Poongothai P; Padhilahouse, Sruthi S; Sellappan, Mohan M; Munisamy, Murali M; Sekaran, Mangaiyarkarasi M; Kumar, Amit A

Publication Date: 2021

Variant appearance in text: rs12566888

PubMed Link: 34177775

Variant Present in the following documents:

• Main text
• fneur-12-667234.pdf

View BVdb publication page

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Genome sequencing unveils a regulatory landscape of platelet reactivity.

Nature Communications

Keramati, Ali R AR; Chen, Ming-Huei MH; Rodriguez, Benjamin A T BAT; Yanek, Lisa R LR; Bhan, Arunoday A; Gaynor, Brady J BJ; Ryan, Kathleen K; Brody, Jennifer A JA; Zhong, Xue X; Wei, Qiang Q; , ; Kammers, Kai K; Kanchan, Kanika K; Iyer, Kruthika K; Kowalski, Madeline H MH; Pitsillides, Achilleas N AN; Cupples, L Adrienne LA; Li, Bingshan B; Schlaeger, Thorsten M TM; Shuldiner, Alan R AR; O'Connell, Jeffrey R JR; Ruczinski, Ingo I; Mitchell, Braxton D BD; Faraday, Nauder N; Taub, Margaret A MA; Becker, Lewis C LC; Lewis, Joshua P JP; Mathias, Rasika A RA; Johnson, Andrew D AD

Publication Date: 2021-06-15

Variant appearance in text: rs12566888

PubMed Link: 34131117

Variant Present in the following documents:

• 41467_2021_23470_MOESM1_ESM.pdf

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Spontaneous intermuscular hematoma in a patient receiving ticagrelor and aspirin: A case report.

Biomedical Reports

Yoon, Byung Woo BW; Hong, Ji Yeon JY

Publication Date: 2021-02

Variant appearance in text: rs12566888

PubMed Link: 33408862

Variant Present in the following documents:

• Main text
• br-14-02-01404.pdf

View BVdb publication page

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Transcriptional profile of platelets and iPSC-derived megakaryocytes from whole-genome and RNA sequencing.

Blood

Kammers, Kai K; Taub, Margaret A MA; Rodriguez, Benjamin B; Yanek, Lisa R LR; Ruczinski, Ingo I; Martin, Joshua J; Kanchan, Kanika K; Battle, Alexis A; Cheng, Linzhao L; Wang, Zack Z ZZ; Johnson, Andrew D AD; Leek, Jeffrey T JT; Faraday, Nauder N; Becker, Lewis C LC; Mathias, Rasika A RA

Publication Date: 2021-02-18

Variant appearance in text: rs12566888

PubMed Link: 33094331

Variant Present in the following documents:

• Main text

View BVdb publication page

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Polymorphisms in GP6, PEAR1A, MRVI1, PIK3CG, JMJD1C, and SHH Genes in Patients with Unstable Angina.

International Journal Of Environmental Research And Public Health

Rudzik, Rafał R; Dziedziejko, Violetta V; Rać, Monika Ewa ME; Sawczuk, Marek M; Maciejewska-Skrendo, Agnieszka A; Safranow, Krzysztof K; Pawlik, Andrzej A

Publication Date: 2020-10-15

Variant appearance in text: rs12566888

PubMed Link: 33076381

Variant Present in the following documents:

• Main text
• ijerph-17-07506.pdf

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Genetic Variation in PEAR1, Cardiovascular Outcomes and Effects of Aspirin in a Healthy Elderly Population.

Clinical Pharmacology And Therapeutics

Lewis, Joshua P JP; Riaz, Moeen M; Xie, Sophia S; Polekhina, Galina G; Wolfe, Rory R; Nelson, Mark M; Tonkin, Andrew M AM; Reid, Christopher M CM; Murray, Anne M AM; McNeil, John J JJ; Shuldiner, Alan R AR; Lacaze, Paul P

Publication Date: 2020-12

Variant appearance in text: rs12566888

PubMed Link: 32562573

Variant Present in the following documents:

• Main text

View BVdb publication page

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Variation of PEAR1 DNA methylation influences platelet and leukocyte function.

Clinical Epigenetics

Izzi, Benedetta B; Gianfagna, Francesco F; Yang, Wen-Yi WY; Cludts, Katrien K; De Curtis, Amalia A; Verhamme, Peter P; Di Castelnuovo, Augusto A; Cerletti, Chiara C; Donati, Maria Benedetta MB; de Gaetano, Giovanni G; Staessen, Jan A JA; Hoylaerts, Marc F MF; Iacoviello, Licia L; ,

Publication Date: 2019-10-29

Variant appearance in text: rs12566888

PubMed Link: 31665082

Variant Present in the following documents:

• Main text
• 13148_2019_Article_744.pdf

View BVdb publication page

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A machine-compiled database of genome-wide association studies.

Nature Communications

Kuleshov, Volodymyr V; Ding, Jialin J; Vo, Christopher C; Hancock, Braden B; Ratner, Alexander A; Li, Yang Y; Ré, Christopher C; Batzoglou, Serafim S; Snyder, Michael M

Publication Date: 2019-07-26

Variant appearance in text: rs12566888

PubMed Link: 31350405

Variant Present in the following documents:

• Main text
• 41467_2019_Article_11026.pdf

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Pharmacogenomic considerations for antiplatelet agents: the era of precision medicine in stroke prevention and neurointerventional practice.

Cold Spring Harbor Molecular Case Studies

Bonney, Phillip A PA; Yim, Benjamin B; Brinjikji, Waleed W; Walcott, Brian P BP

Publication Date: 2019-04

Variant appearance in text: rs12566888

PubMed Link: 30936195

Variant Present in the following documents:

• Main text
• MCS003731Bon.pdf

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Variants of PEAR1 Are Associated With Outcome in Patients With ACS and Stable CAD Undergoing PCI.

Frontiers In Pharmacology

Stimpfle, Fabian F; Bauer, Maike M; Rath, Dominik D; Schaeffeler, Elke E; Schwab, Matthias M; Gawaz, Meinrad M; Winter, Stefan S; Geisler, Tobias T

Publication Date: 2018

Variant appearance in text: rs12566888

PubMed Link: 29867494

Variant Present in the following documents:

• Main text

View BVdb publication page

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Association of Genetic Variability in Selected Genes in Patients With Deep Vein Thrombosis and Platelet Hyperaggregability.

Clinical And Applied Thrombosis/Hemostasis : Official Journal Of The International Academy Of Clinical And Applied Thrombosis/Hemostasis

Sokol, Juraj J; Skerenova, Maria M; Ivankova, Jela J; Simurda, Tomas T; Stasko, Jan J

Publication Date: 2018-10

Variant appearance in text: rs12566888

PubMed Link: 29865896

Variant Present in the following documents:

• Main text
• 10.1177_1076029618779136.pdf

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Cell-Specific PEAR1 Methylation Studies Reveal a Locus that Coordinates Expression of Multiple Genes.

International Journal Of Molecular Sciences

Izzi, Benedetta B; Noro, Fabrizia F; Cludts, Katrien K; Freson, Kathleen K; Hoylaerts, Marc F MF

Publication Date: 2018-04-03

Variant appearance in text: rs12566888

PubMed Link: 29614055

Variant Present in the following documents:

• Main text

View BVdb publication page

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Targeted deep sequencing of the PEAR1 locus for platelet aggregation in European and African American families.

Platelets

Keramati, Ali R AR; Yanek, Lisa R LR; Iyer, Kruthika K; Taub, Margaret A MA; Ruczinski, Ingo I; Becker, Diane M DM; Becker, Lewis C LC; Faraday, Nauder N; Mathias, Rasika A RA

Publication Date: 2019

Variant appearance in text: rs12566888

PubMed Link: 29553866

Variant Present in the following documents:

• Main text

View BVdb publication page

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Strong selection during the last millennium for African ancestry in the admixed population of Madagascar.

Nature Communications

Pierron, Denis D; Heiske, Margit M; Razafindrazaka, Harilanto H; Pereda-Loth, Veronica V; Sanchez, Jazmin J; Alva, Omar O; Arachiche, Amal A; Boland, Anne A; Olaso, Robert R; Deleuze, Jean-Francois JF; Ricaut, Francois-Xavier FX; Rakotoarisoa, Jean-Aimé JA; Radimilahy, Chantal C; Stoneking, Mark M; Letellier, Thierry T

Publication Date: 2018-03-02

Variant appearance in text: rs12566888

PubMed Link: 29500350

Variant Present in the following documents:

• Main text

View BVdb publication page

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Ticagrelor - toward more efficient platelet inhibition and beyond.

Therapeutics And Clinical Risk Management

Kubisa, Michał J MJ; Jezewski, Mateusz P MP; Gasecka, Aleksandra A; Siller-Matula, Jolanta M JM; Postuła, Marek M

Publication Date: 2018

Variant appearance in text: rs12566888

PubMed Link: 29398917

Variant Present in the following documents:

• Main text
• tcrm-14-129.pdf

View BVdb publication page

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Exome-chip meta-analysis identifies association between variation in ANKRD26 and platelet aggregation.

Platelets

Chen, Ming-Huei MH; Yanek, Lisa R LR; Backman, Joshua D JD; Eicher, John D JD; Huffman, Jennifer E JE; Ben-Shlomo, Yoav Y; Beswick, Andrew D AD; Yerges-Armstrong, Laura M LM; Shuldiner, Alan R AR; O'Connell, Jeffrey R JR; Mathias, Rasika A RA; Becker, Diane M DM; Becker, Lewis C LC; Lewis, Joshua P JP; Johnson, Andrew D AD; Faraday, Nauder N

Publication Date: 2019

Variant appearance in text: rs12566888

PubMed Link: 29185836

Variant Present in the following documents:

• Main text

View BVdb publication page

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PEAR1 is not a major susceptibility gene for cardiovascular disease in a Flemish population.

Bmc Medical Genetics

Yang, Wen-Yi WY; Petit, Thibault T; Cauwenberghs, Nicholas N; Zhang, Zhen-Yu ZY; Sheng, Chang-Sheng CS; Thijs, Lutgarde L; Salvi, Erika E; Izzi, Benedetta B; Vandenbriele, Christophe C; Wei, Fang-Fei FF; Gu, Yu-Mei YM; Jacobs, Lotte L; Citterio, Lorena L; Delli Carpini, Simona S; Barlassina, Cristina C; Cusi, Daniele D; Hoylaerts, Marc F MF; Verhamme, Peter P; Kuznetsova, Tatiana T; Staessen, Jan A JA

Publication Date: 2017-04-27

Variant appearance in text: rs12566888

PubMed Link: 28449647

Variant Present in the following documents:

• Main text
• 12881_2017_Article_411.pdf

View BVdb publication page

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PEAR1 gene polymorphism in a Chinese pedigree with pulmonary thromboembolism.

Medicine

Fu, Yingyun Y; Sun, Silong S; Liang, Jie J; Liu, Shengguo S; Jiang, Yiqi Y; Xu, Lan L; Mei, Junpu J

Publication Date: 2016-12

Variant appearance in text: rs12566888

PubMed Link: 28002340

Variant Present in the following documents:

• Main text
• medi-95-e5687.pdf

View BVdb publication page

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Associations of MDR1, TBXA2R, PLA2G7, and PEAR1 genetic polymorphisms with the platelet activity in Chinese ischemic stroke patients receiving aspirin therapy.

Acta Pharmacologica Sinica

Peng, Ling-Ling LL; Zhao, Yuan-Qi YQ; Zhou, Zi-Yi ZY; Jin, Jing J; Zhao, Min M; Chen, Xin-Meng XM; Chen, Ling-Yan LY; Cai, Ye-Feng YF; Li, Jia-Li JL; Huang, Min M

Publication Date: 2016-11

Variant appearance in text: rs12566888

PubMed Link: 27641736

Variant Present in the following documents:

• Main text

View BVdb publication page

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Pairing megakaryopoiesis methylation with PEAR1.

Blood

Johnson, Andrew D AD

Publication Date: 2016-08-18

Variant appearance in text: rs12566888

PubMed Link: 27539998

Variant Present in the following documents:

• Main text

View BVdb publication page

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Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals.

American Journal Of Human Genetics

Eicher, John D JD; Chami, Nathalie N; Kacprowski, Tim T; Nomura, Akihiro A; Chen, Ming-Huei MH; Yanek, Lisa R LR; Tajuddin, Salman M SM; Schick, Ursula M UM; Slater, Andrew J AJ; Pankratz, Nathan N; Polfus, Linda L; Schurmann, Claudia C; Giri, Ayush A; Brody, Jennifer A JA; Lange, Leslie A LA; Manichaikul, Ani A; Hill, W David WD; Pazoki, Raha R; Elliot, Paul P; Evangelou, Evangelos E; Tzoulaki, Ioanna I; Gao, He H; Vergnaud, Anne-Claire AC; Mathias, Rasika A RA; Becker, Diane M DM; Becker, Lewis C LC; Burt, Amber A; Crosslin, David R DR; Lyytikäinen, Leo-Pekka LP; Nikus, Kjell K; Hernesniemi, Jussi J; Kähönen, Mika M; Raitoharju, Emma E; Mononen, Nina N; Raitakari, Olli T OT; Lehtimäki, Terho T; Cushman, Mary M; Zakai, Neil A NA; Nickerson, Deborah A DA; Raffield, Laura M LM; Quarells, Rakale R; Willer, Cristen J CJ; Peloso, Gina M GM; Abecasis, Goncalo R GR; Liu, Dajiang J DJ; , ; Deloukas, Panos P; Samani, Nilesh J NJ; Schunkert, Heribert H; Erdmann, Jeanette J; , ; , ; Fornage, Myriam M; Richard, Melissa M; Tardif, Jean-Claude JC; Rioux, John D JD; Dube, Marie-Pierre MP; de Denus, Simon S; Lu, Yingchang Y; Bottinger, Erwin P EP; Loos, Ruth J F RJ; Smith, Albert Vernon AV; Harris, Tamara B TB; Launer, Lenore J LJ; Gudnason, Vilmundur V; Velez Edwards, Digna R DR; Torstenson, Eric S ES; Liu, Yongmei Y; Tracy, Russell P RP; Rotter, Jerome I JI; Rich, Stephen S SS; Highland, Heather M HM; Boerwinkle, Eric E; Li, Jin J; Lange, Ethan E; Wilson, James G JG; Mihailov, Evelin E; Mägi, Reedik R; Hirschhorn, Joel J; Metspalu, Andres A; Esko, Tõnu T; Vacchi-Suzzi, Caterina C; Nalls, Mike A MA; Zonderman, Alan B AB; Evans, Michele K MK; Engström, Gunnar G; Orho-Melander, Marju M; Melander, Olle O; O'Donoghue, Michelle L ML; Waterworth, Dawn M DM; Wallentin, Lars L; White, Harvey D HD; Floyd, James S JS; Bartz, Traci M TM; Rice, Kenneth M KM; Psaty, Bruce M BM; Starr, J M JM; Liewald, David C M DC; Hayward, Caroline C; Deary, Ian J IJ; Greinacher, Andreas A; Völker, Uwe U; Thiele, Thomas T; Völzke, Henry H; van Rooij, Frank J A FJ; Uitterlinden, André G AG; Franco, Oscar H OH; Dehghan, Abbas A; Edwards, Todd L TL; Ganesh, Santhi K SK; Kathiresan, Sekar S; Faraday, Nauder N; Auer, Paul L PL; Reiner, Alex P AP; Lettre, Guillaume G; Johnson, Andrew D AD

Publication Date: 2016-07-07

Variant appearance in text: rs12566888

PubMed Link: 27346686

Variant Present in the following documents:

• Main text

View BVdb publication page

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Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression.

Blood

Faraday, Nauder N; Yanek, Lisa R LR; Yang, Xiao Ping XP; Mathias, Rasika R; Herrera-Galeano, J Enrique JE; Suktitipat, Bhoom B; Qayyum, Rehan R; Johnson, Andrew D AD; Chen, Ming-Huei MH; Tofler, Geoffrey H GH; Ruczinski, Ingo I; Friedman, Alan D AD; Gylfason, Arnaldur A; Thorsteinsdottir, Unnur U; Bray, Paul F PF; O'Donnell, Christopher J CJ; Becker, Diane M DM; Becker, Lewis C LC

Publication Date: 2011-09-22

Variant appearance in text: rs12566888

PubMed Link: 21791418

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.

Nature Genetics

Johnson, Andrew D AD; Yanek, Lisa R LR; Chen, Ming-Huei MH; Faraday, Nauder N; Larson, Martin G MG; Tofler, Geoffrey G; Lin, Shiow J SJ; Kraja, Aldi T AT; Province, Michael A MA; Yang, Qiong Q; Becker, Diane M DM; O'Donnell, Christopher J CJ; Becker, Lewis C LC

Publication Date: 2010-07

Variant appearance in text: rs12566888

PubMed Link: 20526338

Variant Present in the following documents:

• Main text
• nihms204741.pdf
• NIHMS204741-supplement-1.pdf

View BVdb publication page

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