Single Nucleotide Polymorphisms in Amlodipine-Associated Genes and Their Correlation with Blood Pressure Control among South African Adults with Hypertension.
Genes
Masilela, Charity C; Adeniyi, Oladele Vincent OV; Benjeddou, Mongi M
Genetic and Molecular Aspects of Drug-Induced QT Interval Prolongation.
International Journal Of Molecular Sciences
Baracaldo-Santamaría, Daniela D; Llinás-Caballero, Kevin K; Corso-Ramirez, Julián Miguel JM; Restrepo, Carlos Martín CM; Dominguez-Dominguez, Camilo Alberto CA; Fonseca-Mendoza, Dora Janeth DJ; Calderon-Ospina, Carlos Alberto CA
KCNQ1 and Long QT Syndrome in 1/45 Amish: The Road From Identification to Implementation of Culturally Appropriate Precision Medicine.
Circulation. Genomic And Precision Medicine
Streeten, Elizabeth A EA; See, Vincent Y VY; Jeng, Linda B J LBJ; Maloney, Kristin A KA; Lynch, Megan M; Glazer, Andrew M AM; Yang, Tao T; Roden, Dan D; Pollin, Toni I TI; Daue, Melanie M; Ryan, Kathleen A KA; Van Hout, Cristopher C; Gosalia, Nehal N; Gonzaga-Jauregui, Claudia C; Economides, Aris A; Perry, James A JA; O'Connell, Jeffrey J; Beitelshees, Amber A; Palmer, Kathleen K; Mitchell, Braxton D BD; Shuldiner, Alan R AR; ,
Pharmacogenetics of hypoglycemia associated with sulfonylurea therapy in usual clinical care.
The Pharmacogenomics Journal
Mitchell, Sabrina L SL; Leon, Daniel A Carranza DAC; Chaugai, Sandip S; Kawai, Vivian K VK; Levinson, Rebecca T RT; Wei, Wei-Qi WQ; Stein, C Michael CM
ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals.
Circulation. Genomic And Precision Medicine
Bihlmeyer, Nathan A NA; Brody, Jennifer A JA; Smith, Albert Vernon AV; Warren, Helen R HR; Lin, Honghuang H; Isaacs, Aaron A; Liu, Ching-Ti CT; Marten, Jonathan J; Radmanesh, Farid F; Hall, Leanne M LM; Grarup, Niels N; Mei, Hao H; Müller-Nurasyid, Martina M; Huffman, Jennifer E JE; Verweij, Niek N; Guo, Xiuqing X; Yao, Jie J; Li-Gao, Ruifang R; van den Berg, Marten M; Weiss, Stefan S; Prins, Bram P BP; van Setten, Jessica J; Haessler, Jeffrey J; Lyytikäinen, Leo-Pekka LP; Li, Man M; Alonso, Alvaro A; Soliman, Elsayed Z EZ; Bis, Joshua C JC; Austin, Tom T; Chen, Yii-Der Ida YI; Psaty, Bruce M BM; Harrris, Tamara B TB; Launer, Lenore J LJ; Padmanabhan, Sandosh S; Dominiczak, Anna A; Huang, Paul L PL; Xie, Zhijun Z; Ellinor, Patrick T PT; Kors, Jan A JA; Campbell, Archie A; Murray, Alison D AD; Nelson, Christopher P CP; Tobin, Martin D MD; Bork-Jensen, Jette J; Hansen, Torben T; Pedersen, Oluf O; Linneberg, Allan A; Sinner, Moritz F MF; Peters, Annette A; Waldenberger, Melanie M; Meitinger, Thomas T; Perz, Siegfried S; Kolcic, Ivana I; Rudan, Igor I; de Boer, Rudolf A RA; van der Meer, Peter P; Lin, Henry J HJ; Taylor, Kent D KD; de Mutsert, Renée R; Trompet, Stella S; Jukema, J Wouter JW; Maan, Arie C AC; Stricker, Bruno H C BHC; Rivadeneira, Fernando F; Uitterlinden, André A; Völker, Uwe U; Homuth, Georg G; Völzke, Henry H; Felix, Stephan B SB; Mangino, Massimo M; Spector, Timothy D TD; Bots, Michiel L ML; Perez, Marco M; Raitakari, Olli T OT; Kähönen, Mika M; Mononen, Nina N; Gudnason, Vilmundur V; Munroe, Patricia B PB; Lubitz, Steven A SA; van Duijn, Cornelia M CM; Newton-Cheh, Christopher H CH; Hayward, Caroline C; Rosand, Jonathan J; Samani, Nilesh J NJ; Kanters, Jørgen K JK; Wilson, James G JG; Kääb, Stefan S; Polasek, Ozren O; van der Harst, Pim P; Heckbert, Susan R SR; Rotter, Jerome I JI; Mook-Kanamori, Dennis O DO; Eijgelsheim, Mark M; Dörr, Marcus M; Jamshidi, Yalda Y; Asselbergs, Folkert W FW; Kooperberg, Charles C; Lehtimäki, Terho T; Arking, Dan E DE; Sotoodehnia, Nona N
GWAS of the electrocardiographic QT interval in Hispanics/Latinos generalizes previously identified loci and identifies population-specific signals.
Scientific Reports
Méndez-Giráldez, Raúl R; Gogarten, Stephanie M SM; Below, Jennifer E JE; Yao, Jie J; Seyerle, Amanda A AA; Highland, Heather M HM; Kooperberg, Charles C; Soliman, Elsayed Z EZ; Rotter, Jerome I JI; Kerr, Kathleen F KF; Ryckman, Kelli K KK; Taylor, Kent D KD; Petty, Lauren E LE; Shah, Sanjiv J SJ; Conomos, Matthew P MP; Sotoodehnia, Nona N; Cheng, Susan S; Heckbert, Susan R SR; Sofer, Tamar T; Guo, Xiuqing X; Whitsel, Eric A EA; Lin, Henry J HJ; Hanis, Craig L CL; Laurie, Cathy C CC; Avery, Christy L CL
Sex is a moderator of the association between NOS1AP sequence variants and QTc in two long QT syndrome founder populations: a pedigree-based measured genotype association analysis.
Bmc Medical Genetics
Winbo, Annika A; Stattin, Eva-Lena EL; Westin, Ida Maria IM; Norberg, Anna A; Persson, Johan J; Jensen, Steen M SM; Rydberg, Annika A
A Common Polymorphism of the Human Cardiac Sodium Channel Alpha Subunit (SCN5A) Gene Is Associated with Sudden Cardiac Death in Chronic Ischemic Heart Disease.
Plos One
Marcsa, Boglárka B; Dénes, Réka R; Vörös, Krisztina K; Rácz, Gergely G; Sasvári-Székely, Mária M; Rónai, Zsolt Z; Törő, Klára K; Keszler, Gergely G
Analysis for Genetic Modifiers of Disease Severity in Patients With Long-QT Syndrome Type 2.
Circulation. Cardiovascular Genetics
Kolder, Iris C R M ICRM; Tanck, Michael W T MWT; Postema, Pieter G PG; Barc, Julien J; Sinner, Moritz F MF; Zumhagen, Sven S; Husemann, Anja A; Stallmeyer, Birgit B; Koopmann, Tamara T TT; Hofman, Nynke N; Pfeufer, Arne A; Lichtner, Peter P; Meitinger, Thomas T; Beckmann, Britt M BM; Myerburg, Robert J RJ; Bishopric, Nanette H NH; Roden, Dan M DM; Kääb, Stefan S; Wilde, Arthur A M AAM; Schott, Jean-Jacques JJ; Schulze-Bahr, Eric E; Bezzina, Connie R CR
Pharmacogenetic effects of 'candidate gene complexes' on stroke in the GenHAT study.
Pharmacogenetics And Genomics
Sørensen, Izel F IF; Vazquez, Ana I AI; Irvin, Marguerite R MR; Sørensen, Peter P; Davis, Barry R BR; Ford, Charles E CE; Boerwinkle, Eric E; Eckfeldt, John H JH; Arnett, Donna K DK
Evidence of heterogeneity by race/ethnicity in genetic determinants of QT interval.
Epidemiology (Cambridge, Mass.)
Seyerle, Amanda A AA; Young, Alicia M AM; Jeff, Janina M JM; Melton, Phillip E PE; Jorgensen, Neal W NW; Lin, Yi Y; Carty, Cara L CL; Deelman, Ewa E; Heckbert, Susan R SR; Hindorff, Lucia A LA; Jackson, Rebecca D RD; Martin, Lisa W LW; Okin, Peter M PM; Perez, Marco V MV; Psaty, Bruce M BM; Soliman, Elsayed Z EZ; Whitsel, Eric A EA; North, Kari E KE; Laston, Sandra S; Kooperberg, Charles C; Avery, Christy L CL
Screening for 392 polymorphisms in 141 pharmacogenes.
Biomedical Reports
Kim, Jason Yongha JY; Cheong, Hyun Sub HS; Park, Tae-Joon TJ; Shin, Hee Jung HJ; Seo, Doo Won DW; Na, Han Sung HS; Chung, Myeon Woo MW; Shin, Hyoung Doo HD
The pharmacogenetics of type 2 diabetes: a systematic review.
Diabetes Care
Maruthur, Nisa M NM; Gribble, Matthew O MO; Bennett, Wendy L WL; Bolen, Shari S; Wilson, Lisa M LM; Balakrishnan, Poojitha P; Sahu, Anita A; Bass, Eric E; Kao, W H Linda WH; Clark, Jeanne M JM
Almanac 2011: Cardiac Arrhythmias and Pacing. The National Society Journals Present Selected Research that has Driven Recent Advances in Clinical Cardiology.
Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.
Annals Of Human Genetics
Jeff, Janina M JM; Ritchie, Marylyn D MD; Denny, Joshua C JC; Kho, Abel N AN; Ramirez, Andrea H AH; Crosslin, David D; Armstrong, Loren L; Basford, Melissa A MA; Wolf, Wendy A WA; Pacheco, Jennifer A JA; Chisholm, Rex L RL; Roden, Dan M DM; Hayes, M Geoffrey MG; Crawford, Dana C DC
Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval.
The Pharmacogenomics Journal
Avery, C L CL; Sitlani, C M CM; Arking, D E DE; Arnett, D K DK; Bis, J C JC; Boerwinkle, E E; Buckley, B M BM; Ida Chen, Y-D YD; de Craen, A J M AJ; Eijgelsheim, M M; Enquobahrie, D D; Evans, D S DS; Ford, I I; Garcia, M E ME; Gudnason, V V; Harris, T B TB; Heckbert, S R SR; Hochner, H H; Hofman, A A; Hsueh, W-C WC; Isaacs, A A; Jukema, J W JW; Knekt, P P; Kors, J A JA; Krijthe, B P BP; Kristiansson, K K; Laaksonen, M M; Liu, Y Y; Li, X X; Macfarlane, P W PW; Newton-Cheh, C C; Nieminen, M S MS; Oostra, B A BA; Peloso, G M GM; Porthan, K K; Rice, K K; Rivadeneira, F F FF; Rotter, J I JI; Salomaa, V V; Sattar, N N; Siscovick, D S DS; Slagboom, P E PE; Smith, A V AV; Sotoodehnia, N N; Stott, D J DJ; Stricker, B H BH; Stürmer, T T; Trompet, S S; Uitterlinden, A G AG; van Duijn, C C; Westendorp, R G J RG; Witteman, J C JC; Whitsel, E A EA; Psaty, B M BM
Lack of interaction of beta-cell-function-associated variants with hypertension on change in fasting glucose and diabetes risk: the Framingham Offspring Study.
Journal Of Hypertension
de Miguel-Yanes, Jose M JM; Porneala, Bianca B; Pencina, Michael J MJ; Fox, Caroline S CS; Florez, Jose C JC; Siscovick, David S DS; Dupuis, Josée J; Meigs, James B JB
Associations between NOS1AP single nucleotide polymorphisms (SNPs) and QT interval duration in four racial/ethnic groups in the Multi-Ethnic Study of Atherosclerosis (MESA).
Annals Of Noninvasive Electrocardiology : The Official Journal Of The International Society For Holter And Noninvasive Electrocardiology, Inc
Shah, Sidharth A SA; Herrington, David M DM; Howard, Timothy D TD; Divers, Jasmin J; Arnett, Donna K DK; Burke, Greg L GL; Kao, Weng Hong WH; Guo, Xiuqing X; Siscovick, David S DS; Chakravarti, Aravinda A; Lima, Joao A JA; Psaty, Bruce M BM; Tomaselli, Gordon F GF; Rich, Stephen S SS; Bowden, Donald W DW; Post, Wendy W
Fine-mapping and initial characterization of QT interval loci in African Americans.
Plos Genetics
Avery, Christy L CL; Sethupathy, Praveen P; Buyske, Steven S; He, Qianchuan Q; Lin, Dan-Yu DY; Arking, Dan E DE; Carty, Cara L CL; Duggan, David D; Fesinmeyer, Megan D MD; Hindorff, Lucia A LA; Jeff, Janina M JM; Klein, Liviu L; Patton, Kristen K KK; Peters, Ulrike U; Shohet, Ralph V RV; Sotoodehnia, Nona N; Young, Alicia M AM; Kooperberg, Charles C; Haiman, Christopher A CA; Mohlke, Karen L KL; Whitsel, Eric A EA; North, Kari E KE
A common variant near the KCNJ2 gene is associated with T-peak to T-end interval.
Heart Rhythm
Marjamaa, Annukka A; Oikarinen, Lasse L; Porthan, Kimmo K; Ripatti, Samuli S; Peloso, Gina G; Noseworthy, Peter A PA; Viitasalo, Matti M; Nieminen, Markku S MS; Toivonen, Lauri L; Kontula, Kimmo K; Peltonen, Leena L; Havulinna, Aki S AS; Jula, Antti A; O'Donnell, Christopher J CJ; Newton-Cheh, Christopher C; Perola, Markus M; Salomaa, Veikko V
Torsades de pointes following acute myocardial infarction: evidence for a deadly link with a common genetic variant.
Heart Rhythm
Crotti, Lia L; Hu, Dan D; Barajas-Martinez, Hector H; De Ferrari, Gaetano M GM; Oliva, Antonio A; Insolia, Roberto R; Pollevick, Guido D GD; Dagradi, Federica F; Guerchicoff, Alejandra A; Greco, Federica F; Schwartz, Peter J PJ; Viskin, Sami S; Antzelevitch, Charles C
Relationship of common candidate gene variants to electrocardiographic T-wave peak to T-wave end interval and T-wave morphology parameters.
Heart Rhythm
Porthan, Kimmo K; Marjamaa, Annukka A; Viitasalo, Matti M; Väänänen, Heikki H; Jula, Antti A; Toivonen, Lauri L; Nieminen, Markku S MS; Newton-Cheh, Christopher C; Salomaa, Veikko V; Kontula, Kimmo K; Oikarinen, Lasse L
A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.
Circulation. Cardiovascular Genetics
Marroni, Fabio F; Pfeufer, Arne A; Aulchenko, Yurii S YS; Franklin, Christopher S CS; Isaacs, Aaron A; Pichler, Irene I; Wild, Sarah H SH; Oostra, Ben A BA; Wright, Alan F AF; Campbell, Harry H; Witteman, Jacqueline C JC; Kääb, Stefan S; Hicks, Andrew A AA; Gyllensten, Ulf U; Rudan, Igor I; Meitinger, Thomas T; Pattaro, Cristian C; van Duijn, Cornelia M CM; Wilson, James F JF; Pramstaller, Peter P PP; ,
NOS1AP variant associated with incidence of type 2 diabetes in calcium channel blocker users in the Atherosclerosis Risk in Communities (ARIC) study.
Diabetologia
Chu, A Y AY; Coresh, J J; Arking, D E DE; Pankow, J S JS; Tomaselli, G F GF; Chakravarti, A A; Post, W S WS; Spooner, P H PH; Boerwinkle, E E; Kao, W H L WH
NOS1AP is a genetic modifier of the long-QT syndrome.
Circulation
Crotti, Lia L; Monti, Maria Cristina MC; Insolia, Roberto R; Peljto, Anna A; Goosen, Althea A; Brink, Paul A PA; Greenberg, David A DA; Schwartz, Peter J PJ; George, Alfred L AL
Genetic variation in NOS1AP is associated with sudden cardiac death: evidence from the Rotterdam Study.
Human Molecular Genetics
Eijgelsheim, Mark M; Newton-Cheh, Christopher C; Aarnoudse, Adrianus L H J AL; van Noord, Charlotte C; Witteman, Jacqueline C M JC; Hofman, Albert A; Uitterlinden, André G AG; Stricker, Bruno H C BH
Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies.
Plos One
Nolte, Ilja M IM; Wallace, Chris C; Newhouse, Stephen J SJ; Waggott, Daryl D; Fu, Jingyuan J; Soranzo, Nicole N; Gwilliam, Rhian R; Deloukas, Panos P; Savelieva, Irina I; Zheng, Dongling D; Dalageorgou, Chrysoula C; Farrall, Martin M; Samani, Nilesh J NJ; Connell, John J; Brown, Morris M; Dominiczak, Anna A; Lathrop, Mark M; Zeggini, Eleftheria E; Wain, Louise V LV; , ; , ; Newton-Cheh, Christopher C; Eijgelsheim, Mark M; Rice, Kenneth K; de Bakker, Paul I W PI; , ; Pfeufer, Arne A; Sanna, Serena S; Arking, Dan E DE; , ; Asselbergs, Folkert W FW; Spector, Tim D TD; Carter, Nicholas D ND; Jeffery, Steve S; Tobin, Martin M; Caulfield, Mark M; Snieder, Harold H; Paterson, Andrew D AD; Munroe, Patricia B PB; Jamshidi, Yalda Y
Linkage disequilibrium mapping of the replicated type 2 diabetes linkage signal on chromosome 1q.
Diabetes
Prokopenko, Inga I; Zeggini, Eleftheria E; Hanson, Robert L RL; Mitchell, Braxton D BD; Rayner, N William NW; Akan, Pelin P; Baier, Leslie L; Das, Swapan K SK; Elliott, Katherine S KS; Fu, Mao M; Frayling, Timothy M TM; Groves, Christopher J CJ; Gwilliam, Rhian R; Scott, Laura J LJ; Voight, Benjamin F BF; Hattersley, Andrew T AT; Hu, Cheng C; Morris, Andrew D AD; Ng, Maggie M; Palmer, Colin N A CN; Tello-Ruiz, Marcela M; Vaxillaire, Martine M; Wang, Cong-Rong CR; Stein, Lincoln L; Chan, Juliana J; Jia, Weiping W; Froguel, Philippe P; Elbein, Steven C SC; Deloukas, Panos P; Bogardus, Clifton C; Shuldiner, Alan R AR; McCarthy, Mark I MI; ,
Common variants at ten loci modulate the QT interval duration in the QTSCD Study.
Nature Genetics
Pfeufer, Arne A; Sanna, Serena S; Arking, Dan E DE; Müller, Martina M; Gateva, Vesela V; Fuchsberger, Christian C; Ehret, Georg B GB; Orrú, Marco M; Pattaro, Cristian C; Köttgen, Anna A; Perz, Siegfried S; Usala, Gianluca G; Barbalic, Maja M; Li, Man M; Pütz, Benno B; Scuteri, Angelo A; Prineas, Ronald J RJ; Sinner, Moritz F MF; Gieger, Christian C; Najjar, Samer S SS; Kao, W H Linda WH; Mühleisen, Thomas W TW; Dei, Mariano M; Happle, Christine C; Möhlenkamp, Stefan S; Crisponi, Laura L; Erbel, Raimund R; Jöckel, Karl-Heinz KH; Naitza, Silvia S; Steinbeck, Gerhard G; Marroni, Fabio F; Hicks, Andrew A AA; Lakatta, Edward E; Müller-Myhsok, Bertram B; Pramstaller, Peter P PP; Wichmann, H-Erich HE; Schlessinger, David D; Boerwinkle, Eric E; Meitinger, Thomas T; Uda, Manuela M; Coresh, Josef J; Kääb, Stefan S; Abecasis, Gonçalo R GR; Chakravarti, Aravinda A
Common variants at ten loci influence QT interval duration in the QTGEN Study.
Nature Genetics
Newton-Cheh, Christopher C; Eijgelsheim, Mark M; Rice, Kenneth M KM; de Bakker, Paul I W PI; Yin, Xiaoyan X; Estrada, Karol K; Bis, Joshua C JC; Marciante, Kristin K; Rivadeneira, Fernando F; Noseworthy, Peter A PA; Sotoodehnia, Nona N; Smith, Nicholas L NL; Rotter, Jerome I JI; Kors, Jan A JA; Witteman, Jacqueline C M JC; Hofman, Albert A; Heckbert, Susan R SR; O'Donnell, Christopher J CJ; Uitterlinden, André G AG; Psaty, Bruce M BM; Lumley, Thomas T; Larson, Martin G MG; Stricker, Bruno H Ch BH
Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations.
Circulation
Kao, W H Linda WH; Arking, Dan E DE; Post, Wendy W; Rea, Thomas D TD; Sotoodehnia, Nona N; Prineas, Ronald J RJ; Bishe, Bryan B; Doan, Betty Q BQ; Boerwinkle, Eric E; Psaty, Bruce M BM; Tomaselli, Gordon F GF; Coresh, Josef J; Siscovick, David S DS; Marbán, Eduardo E; Spooner, Peter M PM; Burke, Gregory L GL; Chakravarti, Aravinda A
A common NOS1AP genetic polymorphism is associated with increased cardiovascular mortality in users of dihydropyridine calcium channel blockers.
British Journal Of Clinical Pharmacology
Becker, Matthijs L ML; Visser, Loes E LE; Newton-Cheh, Christopher C; Hofman, Albert A; Uitterlinden, André G AG; Witteman, Jacqueline C M JC; Stricker, Bruno H Ch BH
Common candidate gene variants are associated with QT interval duration in the general population.
Journal Of Internal Medicine
Marjamaa, A A; Newton-Cheh, C C; Porthan, K K; Reunanen, A A; Lahermo, P P; Väänänen, H H; Jula, A A; Karanko, H H; Swan, H H; Toivonen, L L; Nieminen, M S MS; Viitasalo, M M; Peltonen, L L; Oikarinen, L L; Palotie, A A; Kontula, K K; Salomaa, V V