Publications:

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Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics

Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P

Publication Date: 2023-02-23

Variant appearance in text: FMO3: 182A>G; Asn61Ser

PubMed Link: 36823319

Variant Present in the following documents:

• 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6

View BVdb publication page

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Targeting Trimethylamine N-Oxide: A New Therapeutic Strategy for Alleviating Atherosclerosis.

Frontiers In Cardiovascular Medicine

Jing, Lele L; Zhang, Honghong H; Xiang, Qiannan Q; Shen, Liang L; Guo, Xiaoxia X; Zhai, Changlin C; Hu, Huilin H

Publication Date: 2022

Variant appearance in text: FMO3: N61S

PubMed Link: 35770223

Variant Present in the following documents:

• fcvm-09-864600.pdf

View BVdb publication page

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Proteomics-Based Identification of Interaction Partners of the Xenobiotic Detoxification Enzyme FMO3 Reveals Involvement in Urea Cycle.

Toxics

Yang, Zhao Z; Stemmer, Paul M PM; Petriello, Michael C MC

Publication Date: 2022-01-28

Variant appearance in text: FMO3: N61S

PubMed Link: 35202247

Variant Present in the following documents:

• toxics-10-00060.pdf

View BVdb publication page

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Comprehensive analysis of important pharmacogenes in Koreans using the DMET™ platform.

Translational And Clinical Pharmacology

Kim, Byungwook B; Yoon, Deok Yong DY; Lee, SeungHwan S; Jang, In-Jin IJ; Yu, Kyung-Sang KS; Cho, Joo-Youn JY; Oh, Jaeseong J

Publication Date: 2021-09

Variant appearance in text: FMO3: 182A>G; N61S; rs72549322

PubMed Link: 34621706

Variant Present in the following documents:

• tcp-29-135-s001.xls, sheet 1

View BVdb publication page

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The prevalence, genetic complexity and population-specific founder effects of human autosomal recessive disorders.

Npj Genomic Medicine

Xiao, Qingyang Q; Lauschke, Volker M VM

Publication Date: 2021-06-02

Variant appearance in text: FMO3: 182A>G; Asn61Ser; rs72549322

PubMed Link: 34078906

Variant Present in the following documents:

• 41525_2021_203_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Population Pharmacokinetic and Pharmacogenetic Analysis of Mitotane in Patients with Adrenocortical Carcinoma: Towards Individualized Dosing.

Clinical Pharmacokinetics

Yin, Anyue A; Ettaieb, Madeleine H T MHT; Swen, Jesse J JJ; van Deun, Liselotte L; Kerkhofs, Thomas M A TMA; van der Straaten, Robert J H M RJHM; Corssmit, Eleonora P M EPM; Gelderblom, Hans H; Kerstens, Michiel N MN; Feelders, Richard A RA; Eekhoff, Marelise M; Timmers, Henri J L M HJLM; D'Avolio, Antonio A; Cusato, Jessica J; Guchelaar, Henk-Jan HJ; Haak, Harm R HR; Moes, Dirk Jan A R DJAR

Publication Date: 2021-01

Variant appearance in text: FMO3: 182A>G; N61S; rs72549322

PubMed Link: 32607875

Variant Present in the following documents:

• 40262_2020_913_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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Drug metabolite synthesis by immobilized human FMO3 and whole cell catalysts.

Microbial Cell Factories

Gao, Chongliang C; Zheng, Tingjie T

Publication Date: 2019-08-12

Variant appearance in text: FMO3: N61S

PubMed Link: 31405378

Variant Present in the following documents:

• 12934_2019_Article_1189.pdf

View BVdb publication page

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Association of FMO3 Variants with Blood Pressure in the Atherosclerosis Risk in Communities Study.

International Journal Of Hypertension

Bryant, Tyler S TS; Duggal, Priya P; Yu, Bing B; Morrison, Alanna C AC; Shafi, Tariq T; Ehret, Georg G; Franceschini, Nora N; Boerwinkle, Eric E; Coresh, Josef J; Tin, Adrienne A

Publication Date: 2019

Variant appearance in text: FMO3: N61S; rs72549322

PubMed Link: 30906589

Variant Present in the following documents:

• Main text
• IJHY2019-2137629.pdf

View BVdb publication page

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Nicotine-N'-Oxidation by Flavin Monooxygenase Enzymes.

Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology

Perez-Paramo, Yadira X YX; Chen, Gang G; Ashmore, Joseph H JH; Watson, Christy J W CJW; Nasrin, Shamema S; Adams-Haduch, Jennifer J; Wang, Renwei R; Gao, Yu-Tang YT; Koh, Woon-Puay WP; Yuan, Jian-Min JM; Lazarus, Philip P

Publication Date: 2019-02

Variant appearance in text: FMO3: N61S; rs72549322

PubMed Link: 30381441

Variant Present in the following documents:

• Main text

View BVdb publication page

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An optimized prediction framework to assess the functional impact of pharmacogenetic variants.

The Pharmacogenomics Journal

Zhou, Yitian Y; Mkrtchian, Souren S; Kumondai, Masaki M; Hiratsuka, Masahiro M; Lauschke, Volker M VM

Publication Date: 2019-04

Variant appearance in text: FMO3: N61S; rs72549322

PubMed Link: 30206299

Variant Present in the following documents:

• 41397_2018_44_MOESM5_ESM.xlsx, sheet 1

View BVdb publication page

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Genetic variation in human drug-related genes.

Genome Medicine

Schärfe, Charlotta Pauline Irmgard CPI; Tremmel, Roman R; Schwab, Matthias M; Kohlbacher, Oliver O; Marks, Debora Susan DS

Publication Date: 2017-12-22

Variant appearance in text: rs72549322

PubMed Link: 29273096

Variant Present in the following documents:

• 13073_2017_502_MOESM2_ESM.xlsx, sheet 2

View BVdb publication page

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Inactivation mechanism of N61S mutant of human FMO3 towards trimethylamine.

Scientific Reports

Gao, Chongliang C; Catucci, Gianluca G; Castrignanò, Silvia S; Gilardi, Gianfranco G; Sadeghi, Sheila J SJ

Publication Date: 2017-11-07

Variant appearance in text: FMO3: N61S

PubMed Link: 29116146

Variant Present in the following documents:

• Main text
• 41598_2017_Article_15224.pdf

View BVdb publication page

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Sources of discordance among germ-line variant classifications in ClinVar.

Genetics In Medicine : Official Journal Of The American College Of Medical Genetics

Yang, Shan S; Lincoln, Stephen E SE; Kobayashi, Yuya Y; Nykamp, Keith K; Nussbaum, Robert L RL; Topper, Scott S

Publication Date: 2017-10

Variant appearance in text: FMO3: 182A>G; Asn61Ser

PubMed Link: 28569743

Variant Present in the following documents:

• gim201760x7.xlsx, sheet 2

View BVdb publication page

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Genetic analysis of impaired trimethylamine metabolism using whole exome sequencing.

Bmc Medical Genetics

Guo, Yiran Y; Hwang, Liang-Dar LD; Li, Jiankang J; Eades, Jason J; Yu, Chung Wen CW; Mansfield, Corrine C; Burdick-Will, Alexis A; Chang, Xiao X; Chen, Yulan Y; Duke, Fujiko F FF; Zhang, Jianguo J; Fakharzadeh, Steven S; Fennessey, Paul P; Keating, Brendan J BJ; Jiang, Hui H; Hakonarson, Hakon H; Reed, Danielle R DR; Preti, George G

Publication Date: 2017-02-15

Variant appearance in text: FMO3: 182A>G; Asn61Ser; rs72549322

PubMed Link: 28196478

Variant Present in the following documents:

View BVdb publication page

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Characterization of ADME gene variation in 21 populations by exome sequencing.

Pharmacogenetics And Genomics

Hovelson, Daniel H DH; Xue, Zhengyu Z; Zawistowski, Matthew M; Ehm, Margaret G MG; Harris, Elizabeth C EC; Stocker, Sophie L SL; Gross, Annette S AS; Jang, In-Jin IJ; Ieiri, Ichiro I; Lee, Jong-Eun JE; Cardon, Lon R LR; Chissoe, Stephanie L SL; Abecasis, Gonçalo G; Nelson, Matthew R MR

Publication Date: 2017-03

Variant appearance in text: FMO3: 182A>G; N61S; rs72549322

PubMed Link: 27984508

Variant Present in the following documents:

• fpc-27-089-s005.xlsx, sheet 2

View BVdb publication page

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GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics

Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J

Publication Date: 2015-07-25

Variant appearance in text: FMO3: N61S

PubMed Link: 26206375

Variant Present in the following documents:

• 12859_2015_673_MOESM1_ESM.xls, sheet 1
• 12859_2015_673_MOESM2_ESM.xls, sheet 1

View BVdb publication page

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The Affymetrix DMET Plus platform reveals unique distribution of ADME-related variants in ethnic Arabs.

Disease Markers

Wakil, Salma M SM; Nguyen, Cao C; Muiya, Nzioka P NP; Andres, Editha E; Lykowska-Tarnowska, Agnieszka A; Baz, Batoul B; Tahir, Asma I AI; Meyer, Brian F BF; Morahan, Grant G; Dzimiri, Nduna N

Publication Date: 2015

Variant appearance in text: rs72549322

PubMed Link: 25802476

Variant Present in the following documents:

• 542543.f1.xlsx, sheet 1

View BVdb publication page

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The RPTEC/TERT1 cell line models key renal cell responses to the environmental toxicants, benzo[a]pyrene and cadmium.

Toxicology Reports

Simon, B R BR; Wilson, M J MJ; Wickliffe, J K JK

Publication Date: 2014

Variant appearance in text: rs72549322

PubMed Link: 25126521

Variant Present in the following documents:

• mmc1.xls, sheet 1

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Joint functions of protein residues and NADP(H) in oxygen activation by flavin-containing monooxygenase.

The Journal Of Biological Chemistry

Orru, Roberto R; Pazmiño, Daniel E Torres DE; Fraaije, Marco W MW; Mattevi, Andrea A

Publication Date: 2010-11-05

Variant appearance in text: FMO3: N61S

PubMed Link: 20807767

Variant Present in the following documents:

• Main text

View BVdb publication page

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Revealing the moonlighting role of NADP in the structure of a flavin-containing monooxygenase.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Alfieri, Andrea A; Malito, Enrico E; Orru, Roberto R; Fraaije, Marco W MW; Mattevi, Andrea A

Publication Date: 2008-05-06

Variant appearance in text: FMO3: Asn61Ser

PubMed Link: 18443301

Variant Present in the following documents:

• Main text

View BVdb publication page

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Functional characterization of genetic variants of human FMO3 associated with trimethylaminuria.

Archives Of Biochemistry And Biophysics

Yeung, Catherine K CK; Adman, Elinor T ET; Rettie, Allan E AE

Publication Date: 2007-08-15

Variant appearance in text: FMO3: N61S

PubMed Link: 17531949

Variant Present in the following documents:

• Main text

View BVdb publication page

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Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism.

Pharmacology & Therapeutics

Krueger, Sharon K SK; Williams, David E DE

Publication Date: 2005-06

Variant appearance in text: FMO3: N61S

PubMed Link: 15922018

Variant Present in the following documents:

• Main text

View BVdb publication page

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