FinnGen provides genetic insights from a well-phenotyped isolated population.
Nature
Kurki, Mitja I MI; Karjalainen, Juha J; Palta, Priit P; Sipilä, Timo P TP; Kristiansson, Kati K; Donner, Kati M KM; Reeve, Mary P MP; Laivuori, Hannele H; Aavikko, Mervi M; Kaunisto, Mari A MA; Loukola, Anu A; Lahtela, Elisa E; Mattsson, Hannele H; Laiho, Päivi P; Della Briotta Parolo, Pietro P; Lehisto, Arto A AA; Kanai, Masahiro M; Mars, Nina N; Rämö, Joel J; Kiiskinen, Tuomo T; Heyne, Henrike O HO; Veerapen, Kumar K; Rüeger, Sina S; Lemmelä, Susanna S; Zhou, Wei W; Ruotsalainen, Sanni S; Pärn, Kalle K; Hiekkalinna, Tero T; Koskelainen, Sami S; Paajanen, Teemu T; Llorens, Vincent V; Gracia-Tabuenca, Javier J; Siirtola, Harri H; Reis, Kadri K; Elnahas, Abdelrahman G AG; Sun, Benjamin B; Foley, Christopher N CN; Aalto-Setälä, Katriina K; Alasoo, Kaur K; Arvas, Mikko M; Auro, Kirsi K; Biswas, Shameek S; Bizaki-Vallaskangas, Argyro A; Carpen, Olli O; Chen, Chia-Yen CY; Dada, Oluwaseun A OA; Ding, Zhihao Z; Ehm, Margaret G MG; Eklund, Kari K; Färkkilä, Martti M; Finucane, Hilary H; Ganna, Andrea A; Ghazal, Awaisa A; Graham, Robert R RR; Green, Eric M EM; Hakanen, Antti A; Hautalahti, Marco M; Hedman, Åsa K ÅK; Hiltunen, Mikko M; Hinttala, Reetta R; Hovatta, Iiris I; Hu, Xinli X; Huertas-Vazquez, Adriana A; Huilaja, Laura L; Hunkapiller, Julie J; Jacob, Howard H; Jensen, Jan-Nygaard JN; Joensuu, Heikki H; John, Sally S; Julkunen, Valtteri V; Jung, Marc M; Junttila, Juhani J; Kaarniranta, Kai K; Kähönen, Mika M; Kajanne, Risto R; Kallio, Lila L; Kälviäinen, Reetta R; Kaprio, Jaakko J; , ; Kerimov, Nurlan N; Kettunen, Johannes J; Kilpeläinen, Elina E; Kilpi, Terhi T; Klinger, Katherine K; Kosma, Veli-Matti VM; Kuopio, Teijo T; Kurra, Venla V; Laisk, Triin T; Laukkanen, Jari J; Lawless, Nathan N; Liu, Aoxing A; Longerich, Simonne S; Mägi, Reedik R; Mäkelä, Johanna J; Mäkitie, Antti A; Malarstig, Anders A; Mannermaa, Arto A; Maranville, Joseph J; Matakidou, Athena A; Meretoja, Tuomo T; Mozaffari, Sahar V SV; Niemi, Mari E K MEK; Niemi, Marianna M; Niiranen, Teemu T; O Donnell, Christopher J CJ; Obeidat, Ma En ME; Okafo, George G; Ollila, Hanna M HM; Palomäki, Antti A; Palotie, Tuula T; Partanen, Jukka J; Paul, Dirk S DS; Pelkonen, Margit M; Pendergrass, Rion K RK; Petrovski, Slavé S; Pitkäranta, Anne A; Platt, Adam A; Pulford, David D; Punkka, Eero E; Pussinen, Pirkko P; Raghavan, Neha N; Rahimov, Fedik F; Rajpal, Deepak D; Renaud, Nicole A NA; Riley-Gillis, Bridget B; Rodosthenous, Rodosthenis R; Saarentaus, Elmo E; Salminen, Aino A; Salminen, Eveliina E; Salomaa, Veikko V; Schleutker, Johanna J; Serpi, Raisa R; Shen, Huei-Yi HY; Siegel, Richard R; Silander, Kaisa K; Siltanen, Sanna S; Soini, Sirpa S; Soininen, Hilkka H; Sul, Jae Hoon JH; Tachmazidou, Ioanna I; Tasanen, Kaisa K; Tienari, Pentti P; Toppila-Salmi, Sanna S; Tukiainen, Taru T; Tuomi, Tiinamaija T; Turunen, Joni A JA; Ulirsch, Jacob C JC; Vaura, Felix F; Virolainen, Petri P; Waring, Jeffrey J; Waterworth, Dawn D; Yang, Robert R; Nelis, Mari M; Reigo, Anu A; Metspalu, Andres A; Milani, Lili L; Esko, Tõnu T; Fox, Caroline C; Havulinna, Aki S AS; Perola, Markus M; Ripatti, Samuli S; Jalanko, Anu A; Laitinen, Tarja T; Mäkelä, Tomi P TP; Plenge, Robert R; McCarthy, Mark M; Runz, Heiko H; Daly, Mark J MJ; Palotie, Aarno A
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.
Nature Genetics
Robertson, Catherine C CC; Inshaw, Jamie R J JRJ; Onengut-Gumuscu, Suna S; Chen, Wei-Min WM; Santa Cruz, David Flores DF; Yang, Hanzhi H; Cutler, Antony J AJ; Crouch, Daniel J M DJM; Farber, Emily E; Bridges, S Louis SL; Edberg, Jeffrey C JC; Kimberly, Robert P RP; Buckner, Jane H JH; Deloukas, Panos P; Divers, Jasmin J; Dabelea, Dana D; Lawrence, Jean M JM; Marcovina, Santica S; Shah, Amy S AS; Greenbaum, Carla J CJ; Atkinson, Mark A MA; Gregersen, Peter K PK; Oksenberg, Jorge R JR; Pociot, Flemming F; Rewers, Marian J MJ; Steck, Andrea K AK; Dunger, David B DB; , ; Wicker, Linda S LS; Concannon, Patrick P; Todd, John A JA; Rich, Stephen S SS
Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.
Nature Genetics
Robertson, Catherine C CC; Inshaw, Jamie R J JRJ; Onengut-Gumuscu, Suna S; Chen, Wei-Min WM; Santa Cruz, David Flores DF; Yang, Hanzhi H; Cutler, Antony J AJ; Crouch, Daniel J M DJM; Farber, Emily E; Bridges, S Louis SL; Edberg, Jeffrey C JC; Kimberly, Robert P RP; Buckner, Jane H JH; Deloukas, Panos P; Divers, Jasmin J; Dabelea, Dana D; Lawrence, Jean M JM; Marcovina, Santica S; Shah, Amy S AS; Greenbaum, Carla J CJ; Atkinson, Mark A MA; Gregersen, Peter K PK; Oksenberg, Jorge R JR; Pociot, Flemming F; Rewers, Marian J MJ; Steck, Andrea K AK; Dunger, David B DB; , ; Wicker, Linda S LS; Concannon, Patrick P; Todd, John A JA; Rich, Stephen S SS
Germline Variation in PDCD1 Is Associated with Overall Survival in Patients with Metastatic Melanoma Treated with Anti-PD-1 Monotherapy.
Cancers
de With, Mirjam M; Hurkmans, Daan P DP; Oomen-de Hoop, Esther E; Lalouti, Ayoub A; Bins, Sander S; El Bouazzaoui, Samira S; van Brakel, Mandy M; Debets, Reno R; Aerts, Joachim G J V JGJV; van Schaik, Ron H N RHN; Mathijssen, Ron H J RHJ; van der Veldt, Astrid A M AAM
Granzyme B is correlated with clinical outcome after PD-1 blockade in patients with stage IV non-small-cell lung cancer.
Journal For Immunotherapy Of Cancer
Hurkmans, Daan P DP; Basak, Edwin A EA; Schepers, Nina N; Oomen-De Hoop, Esther E; Van der Leest, Cor H CH; El Bouazzaoui, Samira S; Bins, Sander S; Koolen, Stijn L W SLW; Sleijfer, Stefan S; Van der Veldt, Astrid A M AAM; Debets, Reno R; Van Schaik, Ron H N RHN; Aerts, Joachim G J V JGJV; Mathijssen, Ron H J RHJ
The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes.
Nature Genetics
Ramos-Rodríguez, Mireia M; Raurell-Vila, Helena H; Colli, Maikel L ML; Alvelos, Maria Inês MI; Subirana-Granés, Marc M; Juan-Mateu, Jonàs J; Norris, Richard R; Turatsinze, Jean-Valery JV; Nakayasu, Ernesto S ES; Webb-Robertson, Bobbie-Jo M BM; Inshaw, Jamie R J JRJ; Marchetti, Piero P; Piemonti, Lorenzo L; Esteller, Manel M; Todd, John A JA; Metz, Thomas O TO; Eizirik, Décio L DL; Pasquali, Lorenzo L
Association of Epstein-Barr virus serological reactivation with transitioning to systemic lupus erythematosus in at-risk individuals.
Annals Of The Rheumatic Diseases
Jog, Neelakshi R NR; Young, Kendra A KA; Munroe, Melissa E ME; Harmon, Michael T MT; Guthridge, Joel M JM; Kelly, Jennifer A JA; Kamen, Diane L DL; Gilkeson, Gary S GS; Weisman, Michael H MH; Karp, David R DR; Gaffney, Patrick M PM; Harley, John B JB; Wallace, Daniel J DJ; Norris, Jill M JM; James, Judith A JA
Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes.
Nature Genetics
Westra, Harm-Jan HJ; Martínez-Bonet, Marta M; Onengut-Gumuscu, Suna S; Lee, Annette A; Luo, Yang Y; Teslovich, Nikola N; Worthington, Jane J; Martin, Javier J; Huizinga, Tom T; Klareskog, Lars L; Rantapaa-Dahlqvist, Solbritt S; Chen, Wei-Min WM; Quinlan, Aaron A; Todd, John A JA; Eyre, Steve S; Nigrovic, Peter A PA; Gregersen, Peter K PK; Rich, Stephen S SS; Raychaudhuri, Soumya S
Fine-mapping inflammatory bowel disease loci to single-variant resolution.
Nature
Huang, Hailiang H; Fang, Ming M; Jostins, Luke L; Umićević Mirkov, Maša M; Boucher, Gabrielle G; Anderson, Carl A CA; Andersen, Vibeke V; Cleynen, Isabelle I; Cortes, Adrian A; Crins, François F; D'Amato, Mauro M; Deffontaine, Valérie V; Dmitrieva, Julia J; Docampo, Elisa E; Elansary, Mahmoud M; Farh, Kyle Kai-How KK; Franke, Andre A; Gori, Ann-Stephan AS; Goyette, Philippe P; Halfvarson, Jonas J; Haritunians, Talin T; Knight, Jo J; Lawrance, Ian C IC; Lees, Charlie W CW; Louis, Edouard E; Mariman, Rob R; Meuwissen, Theo T; Mni, Myriam M; Momozawa, Yukihide Y; Parkes, Miles M; Spain, Sarah L SL; Théâtre, Emilie E; Trynka, Gosia G; Satsangi, Jack J; van Sommeren, Suzanne S; Vermeire, Severine S; Xavier, Ramnik J RJ; , ; Weersma, Rinse K RK; Duerr, Richard H RH; Mathew, Christopher G CG; Rioux, John D JD; McGovern, Dermot P B DPB; Cho, Judy H JH; Georges, Michel M; Daly, Mark J MJ; Barrett, Jeffrey C JC
Inflammatory pathway genes associated with inter-individual variability in the trajectories of morning and evening fatigue in patients receiving chemotherapy.
Cytokine
Wright, Fay F; Hammer, Marilyn M; Paul, Steven M SM; Aouizerat, Bradley E BE; Kober, Kord M KM; Conley, Yvette P YP; Cooper, Bruce A BA; Dunn, Laura B LB; Levine, Jon D JD; DEramo Melkus, Gail G; Miaskowski, Christine C
Genetic dissection of host immune response in pneumonia development and progression.
Scientific Reports
Smelaya, Tamara V TV; Belopolskaya, Olesya B OB; Smirnova, Svetlana V SV; Kuzovlev, Artem N AN; Moroz, Viktor V VV; Golubev, Arkadiy M AM; Pabalan, Noel A NA; Salnikova, Lyubov E LE
Distinct Gene Regulatory Pathways for Human Innate versus Adaptive Lymphoid Cells.
Cell
Koues, Olivia I OI; Collins, Patrick L PL; Cella, Marina M; Robinette, Michelle L ML; Porter, Sofia I SI; Pyfrom, Sarah C SC; Payton, Jacqueline E JE; Colonna, Marco M; Oltz, Eugene M EM
The Expression Quantitative Trait Loci in Immune Pathways and their Effect on Cutaneous Melanoma Prognosis.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Vogelsang, Matjaz M; Martinez, Carlos N CN; Rendleman, Justin J; Bapodra, Anuj A; Malecek, Karolina K; Romanchuk, Artur A; Kazlow, Esther E; Shapiro, Richard L RL; Berman, Russell S RS; Krogsgaard, Michelle M; Osman, Iman I; Kirchhoff, Tomas T
Identification of a Novel Pathogenic Germline KDR Variant in Melanoma.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Silva, Ines P IP; Salhi, Amel A; Giles, Keith M KM; Vogelsang, Matjaz M; Han, Sung W SW; Ismaili, Naima N; Lui, Kevin P KP; Robinson, Eric M EM; Wilson, Melissa A MA; Shapiro, Richard L RL; Pavlick, Anna A; Zhong, Judy J; Kirchhoff, Tomas T; Osman, Iman I
Somatic and germline analyses of a long term melanoma survivor with a recurrent brain metastasis.
Bmc Cancer
Weiss, Sarah S; Darvishian, Farbod F; Tadepalli, Jyothi J; Shapiro, Richard R; Golfinos, John J; Pavlick, Anna A; Polsky, David D; Kirchhoff, Tomas T; Osman, Iman I
Immunogenetic influences on acquisition of HIV-1 infection: consensus findings from two African cohorts point to an enhancer element in IL19 (1q32.2).
Genes And Immunity
Li, X X; Zhang, K K; Pajewski, N M NM; Brill, I I; Prentice, H A HA; Shrestha, S S; Kilembe, W W; Karita, E E; Allen, S S; Hunter, E E; Kaslow, R A RA; Tang, J J
Genetic associations of the interleukin locus at 1q32.1 with clinical outcomes of cutaneous melanoma.
Journal Of Medical Genetics
Rendleman, Justin J; Vogelsang, Matjaz M; Bapodra, Anuj A; Adaniel, Christina C; Silva, Ines I; Moogk, Duane D; Martinez, Carlos N CN; Fleming, Nathaniel N; Shields, Jerry J; Shapiro, Richard R; Berman, Russell R; Pavlick, Anna A; Polsky, David D; Shao, Yongzhao Y; Osman, Iman I; Krogsgaard, Michelle M; Kirchhoff, Tomas T
A study of genes encoding cytokines (IL6, IL10, TNF), cytokine receptors (IL6R, IL6ST), and glucocorticoid receptor (NR3C1) and susceptibility to bronchopulmonary dysplasia.
Bmc Medical Genetics
Huusko, Johanna M JM; Karjalainen, Minna K MK; Mahlman, Mari M; Haataja, Ritva R; Kari, M Anneli MA; Andersson, Sture S; Toldi, Gergely G; Tammela, Outi O; Rämet, Mika M; Lavoie, Pascal M PM; Hallman, Mikko M; ,
Genetic variants in interleukin genes are associated with breast cancer risk and survival in a genetically admixed population: the Breast Cancer Health Disparities Study.
Carcinogenesis
Slattery, Martha L ML; Herrick, Jennifer S JS; Torres-Mejia, Gabriella G; John, Esther M EM; Giuliano, Anna R AR; Hines, Lisa M LM; Stern, Mariana C MC; Baumgartner, Kathy B KB; Presson, Angela P AP; Wolff, Roger K RK
Association of rheumatoid arthritis susceptibility gene with lipid profiles in patients with rheumatoid arthritis.
Rheumatology (Oxford, England)
Davis, Lisa A LA; Whitfield, Emily E; Cannon, Grant W GW; Wolff, Roger K RK; Johnson, Dannette S DS; Reimold, Andreas M AM; Kerr, Gail S GS; Richards, J Steuart JS; Mikuls, Ted R TR; Caplan, Liron L
Preferential binding to Elk-1 by SLE-associated IL10 risk allele upregulates IL10 expression.
Plos Genetics
Sakurai, Daisuke D; Zhao, Jian J; Deng, Yun Y; Kelly, Jennifer A JA; Brown, Elizabeth E EE; Harley, John B JB; Bae, Sang-Cheol SC; Alarcόn-Riquelme, Marta E ME; , ; Edberg, Jeffrey C JC; Kimberly, Robert P RP; Ramsey-Goldman, Rosalind R; Petri, Michelle A MA; Reveille, John D JD; Vilá, Luis M LM; Alarcón, Graciela S GS; Kaufman, Kenneth M KM; Vyse, Timothy J TJ; Jacob, Chaim O CO; Gaffney, Patrick M PM; Sivils, Kathy Moser KM; James, Judith A JA; Kamen, Diane L DL; Gilkeson, Gary S GS; Niewold, Timothy B TB; Merrill, Joan T JT; Scofield, R Hal RH; Criswell, Lindsey A LA; Stevens, Anne M AM; Boackle, Susan A SA; Kim, Jae-Hoon JH; Choi, Jiyoung J; Pons-Estel, Bernardo A BA; , ; Freedman, Barry I BI; Anaya, Juan-Manuel JM; Martin, Javier J; Yu, C Yung CY; Chang, Deh-Ming DM; Song, Yeong Wook YW; Langefeld, Carl D CD; Chen, Weiling W; Grossman, Jennifer M JM; Cantor, Rita M RM; Hahn, Bevra H BH; Tsao, Betty P BP
Nucleotide variation in IL-10 and IL-12 and their receptors and cervical and vulvar cancer risk: a hybrid case-parent triad and case-control study.
International Journal Of Cancer
Hussain, Shehnaz K SK; Madeleine, Margaret M MM; Johnson, Lisa G LG; Du, Qin Q; Galloway, Denise A DA; Daling, Janet R JR; Malkki, Mari M; Petersdorf, Effie W EW; Schwartz, Stephen M SM
A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap.
Plos Genetics
Ramos, Paula S PS; Criswell, Lindsey A LA; Moser, Kathy L KL; Comeau, Mary E ME; Williams, Adrienne H AH; Pajewski, Nicholas M NM; Chung, Sharon A SA; Graham, Robert R RR; Zidovetzki, Raphael R; Kelly, Jennifer A JA; Kaufman, Kenneth M KM; Jacob, Chaim O CO; Vyse, Timothy J TJ; Tsao, Betty P BP; Kimberly, Robert P RP; Gaffney, Patrick M PM; Alarcón-Riquelme, Marta E ME; Harley, John B JB; Langefeld, Carl D CD; ,
The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study.
Bmc Medical Genetics
Andersen, Vibeke V; Ernst, Anja A; Christensen, Jane J; Østergaard, Mette M; Jacobsen, Bent A BA; Tjønneland, Anne A; Krarup, Henrik B HB; Vogel, Ulla U
Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis.
American Journal Of Respiratory And Critical Care Medicine
Wurfel, Mark M MM; Gordon, Anthony C AC; Holden, Tarah D TD; Radella, Frank F; Strout, Jeanna J; Kajikawa, Osamu O; Ruzinski, John T JT; Rona, Gail G; Black, R Anthony RA; Stratton, Seth S; Jarvik, Gail P GP; Hajjar, Adeline M AM; Nickerson, Deborah A DA; Rieder, Mark M; Sevransky, Jonathan J; Maloney, James P JP; Moss, Marc M; Martin, Greg G; Shanholtz, Carl C; Garcia, Joe G N JG; Gao, Li L; Brower, Roy R; Barnes, Kathleen C KC; Walley, Keith R KR; Russell, James A JA; Martin, Thomas R TR