Association of candidate genetic variants and circulating levels of ApoE/ApoJ with common neuroimaging features of cerebral amyloid angiopathy.
Frontiers In Aging Neuroscience
Bonaterra-Pastra, Anna A; Benítez, Sònia S; Pancorbo, Olalla O; Rodríguez-Luna, David D; Vert, Carla C; Rovira, Alex A; Freijo, M Mar MM; Tur, Silvia S; Martínez-Zabaleta, Maite M; Cardona Portela, Pere P; Vera, Rocío R; Lebrato-Hernández, Lucia L; Arenillas, Juan F JF; Pérez-Sánchez, Soledad S; Domínguez-Mayoral, Ana A; Fàbregas, Joan Martí JM; Mauri, Gerard G; Montaner, Joan J; Sánchez-Quesada, Jose Luis JL; Hernández-Guillamon, Mar M
Systemic inflammation as a predictor of brain aging: Contributions of physical activity, metabolic risk, and genetic risk.
Neuroimage
Corlier, Fabian F; Hafzalla, George G; Faskowitz, Joshua J; Kuller, Lewis H LH; Becker, James T JT; Lopez, Oscar L OL; Thompson, Paul M PM; Braskie, Meredith N MN
Associations of the Top 20 Alzheimer Disease Risk Variants With Brain Amyloidosis.
Jama Neurology
Apostolova, Liana G LG; Risacher, Shannon L SL; Duran, Tugce T; Stage, Eddie C EC; Goukasian, Naira N; West, John D JD; Do, Triet M TM; Grotts, Jonathan J; Wilhalme, Holly H; Nho, Kwangsik K; Phillips, Meredith M; Elashoff, David D; Saykin, Andrew J AJ; ,
iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types.
Stem Cell Reports
Panopoulos, Athanasia D AD; D'Antonio, Matteo M; Benaglio, Paola P; Williams, Roy R; Hashem, Sherin I SI; Schuldt, Bernhard M BM; DeBoever, Christopher C; Arias, Angelo D AD; Garcia, Melvin M; Nelson, Bradley C BC; Harismendy, Olivier O; Jakubosky, David A DA; Donovan, Margaret K R MKR; Greenwald, William W WW; Farnam, KathyJean K; Cook, Megan M; Borja, Victor V; Miller, Carl A CA; Grinstein, Jonathan D JD; Drees, Frauke F; Okubo, Jonathan J; Diffenderfer, Kenneth E KE; Hishida, Yuriko Y; Modesto, Veronica V; Dargitz, Carl T CT; Feiring, Rachel R; Zhao, Chang C; Aguirre, Aitor A; McGarry, Thomas J TJ; Matsui, Hiroko H; Li, He H; Reyna, Joaquin J; Rao, Fangwen F; O'Connor, Daniel T DT; Yeo, Gene W GW; Evans, Sylvia M SM; Chi, Neil C NC; Jepsen, Kristen K; Nariai, Naoki N; Müller, Franz-Josef FJ; Goldstein, Lawrence S B LSB; Izpisua Belmonte, Juan Carlos JC; Adler, Eric E; Loring, Jeanne F JF; Berggren, W Travis WT; D'Antonio-Chronowska, Agnieszka A; Smith, Erin N EN; Frazer, Kelly A KA
Alzheimer risk genes modulate the relationship between plasma apoE and cortical PiB binding.
Neurology. Genetics
Lazaris, Andreas A; Hwang, Kristy S KS; Goukasian, Naira N; Ramirez, Leslie M LM; Eastman, Jennifer J; Blanken, Anna E AE; Teng, Edmond E; Gylys, Karen K; Cole, Greg G; Saykin, Andrew J AJ; Shaw, Leslie M LM; Trojanowski, John Q JQ; Jagust, William J WJ; Weiner, Michael W MW; Apostolova, Liana G LG; ,
Decision tree analysis of genetic risk for clinically heterogeneous Alzheimer's disease.
Bmc Neurology
Yokoyama, Jennifer S JS; Bonham, Luke W LW; Sears, Renee L RL; Klein, Eric E; Karydas, Anna A; Kramer, Joel H JH; Miller, Bruce L BL; Coppola, Giovanni G
Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study.
Jama Neurology
Naj, Adam C AC; Jun, Gyungah G; Reitz, Christiane C; Kunkle, Brian W BW; Perry, William W; Park, Yo Son YS; Beecham, Gary W GW; Rajbhandary, Ruchita A RA; Hamilton-Nelson, Kara L KL; Wang, Li-San LS; Kauwe, John S K JS; Huentelman, Matthew J MJ; Myers, Amanda J AJ; Bird, Thomas D TD; Boeve, Bradley F BF; Baldwin, Clinton T CT; Jarvik, Gail P GP; Crane, Paul K PK; Rogaeva, Ekaterina E; Barmada, M Michael MM; Demirci, F Yesim FY; Cruchaga, Carlos C; Kramer, Patricia L PL; Ertekin-Taner, Nilufer N; Hardy, John J; Graff-Radford, Neill R NR; Green, Robert C RC; Larson, Eric B EB; St George-Hyslop, Peter H PH; Buxbaum, Joseph D JD; Evans, Denis A DA; Schneider, Julie A JA; Lunetta, Kathryn L KL; Kamboh, M Ilyas MI; Saykin, Andrew J AJ; Reiman, Eric M EM; De Jager, Philip L PL; Bennett, David A DA; Morris, John C JC; Montine, Thomas J TJ; Goate, Alison M AM; Blacker, Deborah D; Tsuang, Debby W DW; Hakonarson, Hakon H; Kukull, Walter A WA; Foroud, Tatiana M TM; Martin, Eden R ER; Haines, Jonathan L JL; Mayeux, Richard P RP; Farrer, Lindsay A LA; Schellenberg, Gerard D GD; Pericak-Vance, Margaret A MA; , ; Albert, Marilyn S MS; Albin, Roger L RL; Apostolova, Liana G LG; Arnold, Steven E SE; Barber, Robert R; Barnes, Lisa L LL; Beach, Thomas G TG; Becker, James T JT; Beekly, Duane D; Bigio, Eileen H EH; Bowen, James D JD; Boxer, Adam A; Burke, James R JR; Cairns, Nigel J NJ; Cantwell, Laura B LB; Cao, Chuanhai C; Carlson, Chris S CS; Carney, Regina M RM; Carrasquillo, Minerva M MM; Carroll, Steven L SL; Chui, Helena C HC; Clark, David G DG; Corneveaux, Jason J; Cribbs, David H DH; Crocco, Elizabeth A EA; DeCarli, Charles C; DeKosky, Steven T ST; Dick, Malcolm M; Dickson, Dennis W DW; Duara, Ranjan R; Faber, Kelley M KM; Fallon, Kenneth B KB; Farlow, Martin R MR; Ferris, Steven S; Frosch, Matthew P MP; Galasko, Douglas R DR; Ganguli, Mary M; Gearing, Marla M; Geschwind, Daniel H DH; Ghetti, Bernardino B; Gilbert, John R JR; Glass, Jonathan D JD; Growdon, John H JH; Hamilton, Ronald L RL; Harrell, Lindy E LE; Head, Elizabeth E; Honig, Lawrence S LS; Hulette, Christine M CM; Hyman, Bradley T BT; Jicha, Gregory A GA; Jin, Lee-Way LW; Karydas, Anna A; Kaye, Jeffrey A JA; Kim, Ronald R; Koo, Edward H EH; Kowall, Neil W NW; Kramer, Joel H JH; LaFerla, Frank M FM; Lah, James J JJ; Leverenz, James B JB; Levey, Allan I AI; Li, Ge G; Lieberman, Andrew P AP; Lin, Chiao-Feng CF; Lopez, Oscar L OL; Lyketsos, Constantine G CG; Mack, Wendy J WJ; Martiniuk, Frank F; Mash, Deborah C DC; Masliah, Eliezer E; McCormick, Wayne C WC; McCurry, Susan M SM; McDavid, Andrew N AN; McKee, Ann C AC; Mesulam, Marsel M; Miller, Bruce L BL; Miller, Carol A CA; Miller, Joshua W JW; Murrell, Jill R JR; Olichney, John M JM; Pankratz, Vernon S VS; Parisi, Joseph E JE; Paulson, Henry L HL; Peskind, Elaine E; Petersen, Ronald C RC; Pierce, Aimee A; Poon, Wayne W WW; Potter, Huntington H; Quinn, Joseph F JF; Raj, Ashok A; Raskind, Murray M; Reisberg, Barry B; Ringman, John M JM; Roberson, Erik D ED; Rosen, Howard J HJ; Rosenberg, Roger N RN; Sano, Mary M; Schneider, Lon S LS; Seeley, William W WW; Smith, Amanda G AG; Sonnen, Joshua A JA; Spina, Salvatore S; Stern, Robert A RA; Tanzi, Rudolph E RE; Thornton-Wells, Tricia A TA; Trojanowski, John Q JQ; Troncoso, Juan C JC; Valladares, Otto O; Van Deerlin, Vivianna M VM; Van Eldik, Linda J LJ; Vardarajan, Badri N BN; Vinters, Harry V HV; Vonsattel, Jean Paul JP; Weintraub, Sandra S; Welsh-Bohmer, Kathleen A KA; Williamson, Jennifer J; Wishnek, Sarah S; Woltjer, Randall L RL; Wright, Clinton B CB; Younkin, Steven G SG; Yu, Chang-En CE; Yu, Lei L
eMERGEing progress in genomics-the first seven years.
Frontiers In Genetics
Crawford, Dana C DC; Crosslin, David R DR; Tromp, Gerard G; Kullo, Iftikhar J IJ; Kuivaniemi, Helena H; Hayes, M Geoffrey MG; Denny, Joshua C JC; Bush, William S WS; Haines, Jonathan L JL; Roden, Dan M DM; McCarty, Catherine A CA; Jarvik, Gail P GP; Ritchie, Marylyn D MD
Markers of cholesterol transport are associated with amyloid deposition in the brain.
Neurobiology Of Aging
Hughes, Timothy M TM; Lopez, Oscar L OL; Evans, Rhobert W RW; Kamboh, M Ilyas MI; Williamson, Jeff D JD; Klunk, William E WE; Mathis, Chester A CA; Price, Julie C JC; Cohen, Ann D AD; Snitz, Beth E BE; Dekosky, Steven T ST; Kuller, Lewis H LH
Genetic susceptibility for Alzheimer disease neuritic plaque pathology.
Jama Neurology
Shulman, Joshua M JM; Chen, Kewei K; Keenan, Brendan T BT; Chibnik, Lori B LB; Fleisher, Adam A; Thiyyagura, Pradeep P; Roontiva, Auttawut A; McCabe, Cristin C; Patsopoulos, Nikolaos A NA; Corneveaux, Jason J JJ; Yu, Lei L; Huentelman, Matthew J MJ; Evans, Denis A DA; Schneider, Julie A JA; Reiman, Eric M EM; De Jager, Philip L PL; Bennett, David A DA
Enhancing the power of genetic association studies through the use of silver standard cases derived from electronic medical records.
Plos One
McDavid, Andrew A; Crane, Paul K PK; Newton, Katherine M KM; Crosslin, David R DR; McCormick, Wayne W; Weston, Noah N; Ehrlich, Kelly K; Hart, Eugene E; Harrison, Robert R; Kukull, Walter A WA; Rottscheit, Carla C; Peissig, Peggy P; Stefanski, Elisha E; McCarty, Catherine A CA; Zuvich, Rebecca Lynn RL; Ritchie, Marylyn D MD; Haines, Jonathan L JL; Denny, Joshua C JC; Schellenberg, Gerard D GD; de Andrade, Mariza M; Kullo, Iftikhar I; Li, Rongling R; Mirel, Daniel D; Crenshaw, Andrew A; Bowen, James D JD; Li, Ge G; Tsuang, Debby D; McCurry, Susan S; Teri, Linda L; Larson, Eric B EB; Jarvik, Gail P GP; Carlson, Chris S CS
Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci.
Annals Of Human Genetics
Holton, Patrick P; Ryten, Mina M; Nalls, Michael M; Trabzuni, Daniah D; Weale, Michael E ME; Hernandez, Dena D; Crehan, Helen H; Gibbs, J Raphael JR; Mayeux, Richard R; Haines, Jonathan L JL; Farrer, Lindsay A LA; Pericak-Vance, Margaret A MA; Schellenberg, Gerard D GD; , ; Ramirez-Restrepo, Manuel M; Engel, Anzhelika A; Myers, Amanda J AJ; Corneveaux, Jason J JJ; Huentelman, Matthew J MJ; Dillman, Allissa A; Cookson, Mark R MR; Reiman, Eric M EM; Singleton, Andrew A; Hardy, John J; Guerreiro, Rita R
Alzheimer disease susceptibility loci: evidence for a protein network under natural selection.
American Journal Of Human Genetics
Raj, Towfique T; Shulman, Joshua M JM; Keenan, Brendan T BT; Chibnik, Lori B LB; Evans, Denis A DA; Bennett, David A DA; Stranger, Barbara E BE; De Jager, Philip L PL
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
Nature Genetics
Höglinger, Günter U GU; Melhem, Nadine M NM; Dickson, Dennis W DW; Sleiman, Patrick M A PM; Wang, Li-San LS; Klei, Lambertus L; Rademakers, Rosa R; de Silva, Rohan R; Litvan, Irene I; Riley, David E DE; van Swieten, John C JC; Heutink, Peter P; Wszolek, Zbigniew K ZK; Uitti, Ryan J RJ; Vandrovcova, Jana J; Hurtig, Howard I HI; Gross, Rachel G RG; Maetzler, Walter W; Goldwurm, Stefano S; Tolosa, Eduardo E; Borroni, Barbara B; Pastor, Pau P; , ; Cantwell, Laura B LB; Han, Mi Ryung MR; Dillman, Allissa A; van der Brug, Marcel P MP; Gibbs, J Raphael JR; Cookson, Mark R MR; Hernandez, Dena G DG; Singleton, Andrew B AB; Farrer, Matthew J MJ; Yu, Chang-En CE; Golbe, Lawrence I LI; Revesz, Tamas T; Hardy, John J; Lees, Andrew J AJ; Devlin, Bernie B; Hakonarson, Hakon H; Müller, Ulrich U; Schellenberg, Gerard D GD
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
Nature Genetics
Naj, Adam C AC; Jun, Gyungah G; Beecham, Gary W GW; Wang, Li-San LS; Vardarajan, Badri Narayan BN; Buros, Jacqueline J; Gallins, Paul J PJ; Buxbaum, Joseph D JD; Jarvik, Gail P GP; Crane, Paul K PK; Larson, Eric B EB; Bird, Thomas D TD; Boeve, Bradley F BF; Graff-Radford, Neill R NR; De Jager, Philip L PL; Evans, Denis D; Schneider, Julie A JA; Carrasquillo, Minerva M MM; Ertekin-Taner, Nilufer N; Younkin, Steven G SG; Cruchaga, Carlos C; Kauwe, John S K JS; Nowotny, Petra P; Kramer, Patricia P; Hardy, John J; Huentelman, Matthew J MJ; Myers, Amanda J AJ; Barmada, Michael M MM; Demirci, F Yesim FY; Baldwin, Clinton T CT; Green, Robert C RC; Rogaeva, Ekaterina E; St George-Hyslop, Peter P; Arnold, Steven E SE; Barber, Robert R; Beach, Thomas T; Bigio, Eileen H EH; Bowen, James D JD; Boxer, Adam A; Burke, James R JR; Cairns, Nigel J NJ; Carlson, Chris S CS; Carney, Regina M RM; Carroll, Steven L SL; Chui, Helena C HC; Clark, David G DG; Corneveaux, Jason J; Cotman, Carl W CW; Cummings, Jeffrey L JL; DeCarli, Charles C; DeKosky, Steven T ST; Diaz-Arrastia, Ramon R; Dick, Malcolm M; Dickson, Dennis W DW; Ellis, William G WG; Faber, Kelley M KM; Fallon, Kenneth B KB; Farlow, Martin R MR; Ferris, Steven S; Frosch, Matthew P MP; Galasko, Douglas R DR; Ganguli, Mary M; Gearing, Marla M; Geschwind, Daniel H DH; Ghetti, Bernardino B; Gilbert, John R JR; Gilman, Sid S; Giordani, Bruno B; Glass, Jonathan D JD; Growdon, John H JH; Hamilton, Ronald L RL; Harrell, Lindy E LE; Head, Elizabeth E; Honig, Lawrence S LS; Hulette, Christine M CM; Hyman, Bradley T BT; Jicha, Gregory A GA; Jin, Lee-Way LW; Johnson, Nancy N; Karlawish, Jason J; Karydas, Anna A; Kaye, Jeffrey A JA; Kim, Ronald R; Koo, Edward H EH; Kowall, Neil W NW; Lah, James J JJ; Levey, Allan I AI; Lieberman, Andrew P AP; Lopez, Oscar L OL; Mack, Wendy J WJ; Marson, Daniel C DC; Martiniuk, Frank F; Mash, Deborah C DC; Masliah, Eliezer E; McCormick, Wayne C WC; McCurry, Susan M SM; McDavid, Andrew N AN; McKee, Ann C AC; Mesulam, Marsel M; Miller, Bruce L BL; Miller, Carol A CA; Miller, Joshua W JW; Parisi, Joseph E JE; Perl, Daniel P DP; Peskind, Elaine E; Petersen, Ronald C RC; Poon, Wayne W WW; Quinn, Joseph F JF; Rajbhandary, Ruchita A RA; Raskind, Murray M; Reisberg, Barry B; Ringman, John M JM; Roberson, Erik D ED; Rosenberg, Roger N RN; Sano, Mary M; Schneider, Lon S LS; Seeley, William W; Shelanski, Michael L ML; Slifer, Michael A MA; Smith, Charles D CD; Sonnen, Joshua A JA; Spina, Salvatore S; Stern, Robert A RA; Tanzi, Rudolph E RE; Trojanowski, John Q JQ; Troncoso, Juan C JC; Van Deerlin, Vivianna M VM; Vinters, Harry V HV; Vonsattel, Jean Paul JP; Weintraub, Sandra S; Welsh-Bohmer, Kathleen A KA; Williamson, Jennifer J; Woltjer, Randall L RL; Cantwell, Laura B LB; Dombroski, Beth A BA; Beekly, Duane D; Lunetta, Kathryn L KL; Martin, Eden R ER; Kamboh, M Ilyas MI; Saykin, Andrew J AJ; Reiman, Eric M EM; Bennett, David A DA; Morris, John C JC; Montine, Thomas J TJ; Goate, Alison M AM; Blacker, Deborah D; Tsuang, Debby W DW; Hakonarson, Hakon H; Kukull, Walter A WA; Foroud, Tatiana M TM; Haines, Jonathan L JL; Mayeux, Richard R; Pericak-Vance, Margaret A MA; Farrer, Lindsay A LA; Schellenberg, Gerard D GD
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
Molecular Psychiatry
Furney, S J SJ; Simmons, A A; Breen, G G; Pedroso, I I; Lunnon, K K; Proitsi, P P; Hodges, A A; Powell, J J; Wahlund, L-O LO; Kloszewska, I I; Mecocci, P P; Soininen, H H; Tsolaki, M M; Vellas, B B; Spenger, C C; Lathrop, M M; Shen, L L; Kim, S S; Saykin, A J AJ; Weiner, M W MW; Lovestone, S S; , ; ,
Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes.
Archives Of Neurology
Jun, Gyungah G; Naj, Adam C AC; Beecham, Gary W GW; Wang, Li-San LS; Buros, Jacqueline J; Gallins, Paul J PJ; Buxbaum, Joseph D JD; Ertekin-Taner, Nilufer N; Fallin, M Daniele MD; Friedland, Robert R; Inzelberg, Rivka R; Kramer, Patricia P; Rogaeva, Ekaterina E; St George-Hyslop, Peter P; , ; Cantwell, Laura B LB; Dombroski, Beth A BA; Saykin, Andrew J AJ; Reiman, Eric M EM; Bennett, David A DA; Morris, John C JC; Lunetta, Kathryn L KL; Martin, Eden R ER; Montine, Thomas J TJ; Goate, Alison M AM; Blacker, Deborah D; Tsuang, Debby W DW; Beekly, Duane D; Cupples, L Adrienne LA; Hakonarson, Hakon H; Kukull, Walter W; Foroud, Tatiana M TM; Haines, Jonathan J; Mayeux, Richard R; Farrer, Lindsay A LA; Pericak-Vance, Margaret A MA; Schellenberg, Gerard D GD
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
Nature Genetics
Harold, Denise D; Abraham, Richard R; Hollingworth, Paul P; Sims, Rebecca R; Gerrish, Amy A; Hamshere, Marian L ML; Pahwa, Jaspreet Singh JS; Moskvina, Valentina V; Dowzell, Kimberley K; Williams, Amy A; Jones, Nicola N; Thomas, Charlene C; Stretton, Alexandra A; Morgan, Angharad R AR; Lovestone, Simon S; Powell, John J; Proitsi, Petroula P; Lupton, Michelle K MK; Brayne, Carol C; Rubinsztein, David C DC; Gill, Michael M; Lawlor, Brian B; Lynch, Aoibhinn A; Morgan, Kevin K; Brown, Kristelle S KS; Passmore, Peter A PA; Craig, David D; McGuinness, Bernadette B; Todd, Stephen S; Holmes, Clive C; Mann, David D; Smith, A David AD; Love, Seth S; Kehoe, Patrick G PG; Hardy, John J; Mead, Simon S; Fox, Nick N; Rossor, Martin M; Collinge, John J; Maier, Wolfgang W; Jessen, Frank F; Schürmann, Britta B; Heun, Reinhard R; van den Bussche, Hendrik H; Heuser, Isabella I; Kornhuber, Johannes J; Wiltfang, Jens J; Dichgans, Martin M; Frölich, Lutz L; Hampel, Harald H; Hüll, Michael M; Rujescu, Dan D; Goate, Alison M AM; Kauwe, John S K JS; Cruchaga, Carlos C; Nowotny, Petra P; Morris, John C JC; Mayo, Kevin K; Sleegers, Kristel K; Bettens, Karolien K; Engelborghs, Sebastiaan S; De Deyn, Peter P PP; Van Broeckhoven, Christine C; Livingston, Gill G; Bass, Nicholas J NJ; Gurling, Hugh H; McQuillin, Andrew A; Gwilliam, Rhian R; Deloukas, Panagiotis P; Al-Chalabi, Ammar A; Shaw, Christopher E CE; Tsolaki, Magda M; Singleton, Andrew B AB; Guerreiro, Rita R; Mühleisen, Thomas W TW; Nöthen, Markus M MM; Moebus, Susanne S; Jöckel, Karl-Heinz KH; Klopp, Norman N; Wichmann, H-Erich HE; Carrasquillo, Minerva M MM; Pankratz, V Shane VS; Younkin, Steven G SG; Holmans, Peter A PA; O'Donovan, Michael M; Owen, Michael J MJ; Williams, Julie J