CDA c.208G>A ;(p.A70T)

Variant ID: 1-20931474-G-A

NM_001785.2(CDA):c.208G>A;(p.A70T)

This variant was identified in 35 publications

View GRCh38 version.




Publications:


An EGFR L858R mutation identified in 1862 Chinese NSCLC patients can be a promising neoantigen vaccine therapeutic strategy.

Frontiers In Immunology
Lin, Jing J; Liu, Jun J; Hao, Shi-Guang SG; Lan, Bin B; Zheng, Xiao-Bin XB; Xiong, Jia-Ni JN; Zhang, Ying-Qian YQ; Gao, Xuan X; Chen, Chuan-Ben CB; Chen, Ling L; Huang, Yu-Fang YF; Luo, Hong H; Yi, Yu-Ting YT; Yi, Xin X; Lu, Jian-Ping JP; Zheng, Xiong-Wei XW; Chen, Gang G; Wang, Xue-Feng XF; Chen, Yu Y
Publication Date: 2022

Variant appearance in text: CDA: 208G>A; A70T
PubMed Link: 36505399
Variant Present in the following documents:
  • Table_2.xlsx, sheet 2
View BVdb publication page



Comparison of genetic susceptibility to lung adenocarcinoma and squamous cell carcinoma in Japanese patients using a novel panel for cancer-related drug-metabolizing enzyme genes.

Scientific Reports
Ohnami, Sumiko S; Naruoka, Akane A; Isaka, Mitsuhiro M; Mizuguchi, Maki M; Nakatani, Sou S; Kamada, Fukumi F; Shimoda, Yuji Y; Sakai, Ai A; Ohshima, Keiichi K; Hatakeyama, Keiichi K; Maruyama, Kouji K; Ohde, Yasuhisa Y; Kenmotsu, Hirotsugu H; Takahashi, Toshiaki T; Akiyama, Yasuto Y; Nagashima, Takeshi T; Urakami, Kenichi K; Ohnami, Shumpei S; Yamaguchi, Ken K
Publication Date: 2022-10-26

Variant appearance in text: CDA: Ala70Thr; rs60369023
PubMed Link: 36289279
Variant Present in the following documents:
  • Main text
  • 41598_2022_Article_22914.pdf
View BVdb publication page



Pharmacogenetics of hepatocellular carcinoma and cholangiocarcinoma.

Cancer Drug Resistance (Alhambra, Calif.)
Alonso-Peña, Marta M; Sanchez-Martin, Anabel A; Sanchon-Sanchez, Paula P; Soto-Muñiz, Meraris M; Espinosa-Escudero, Ricardo R; Marin, Jose J G JJG
Publication Date: 2019

Variant appearance in text: CDA: 208G>A; Ala70Thr
PubMed Link: 35582588
Variant Present in the following documents:
  • Main text
  • cdr-2-680.pdf
View BVdb publication page



Role of Pharmacogenetics in the Treatment of Acute Myeloid Leukemia: Systematic Review and Future Perspectives.

Pharmaceutics
Pinto-Merino, Álvaro Á; Labrador, Jorge J; Zubiaur, Pablo P; Alcaraz, Raquel R; Herrero, María José MJ; Montesinos, Pau P; Abad-Santos, Francisco F; Saiz-Rodríguez, Miriam M
Publication Date: 2022-03-03

Variant appearance in text: CDA: 208G>A; rs60369023
PubMed Link: 35335935
Variant Present in the following documents:
  • Main text
  • pharmaceutics-14-00559.pdf
View BVdb publication page



The Extent and Impact of Variation in ADME Genes in Sub-Saharan African Populations.

Frontiers In Pharmacology
da Rocha, Jorge E B JEB; Othman, Houcemeddine H; Botha, Gerrit G; Cottino, Laura L; Twesigomwe, David D; Ahmed, Samah S; Drögemöller, Britt I BI; Fadlelmola, Faisal M FM; Machanick, Philip P; Mbiyavanga, Mamana M; Panji, Sumir S; Wright, Galen E B GEB; Adebamowo, Clement C; Matshaba, Mogomotsi M; Ramsay, Michéle M; Simo, Gustave G; Simuunza, Martin C MC; Tiemessen, Caroline T CT; Baldwin, Sandra S; Chiano, Mathias M; Cox, Charles C; Gross, Annette S AS; Thomas, Pamela P; Gamo, Francisco-Javier FJ; Hazelhurst, Scott S
Publication Date: 2021

Variant appearance in text: rs60369023
PubMed Link: 34721006
Variant Present in the following documents:
  • datasheet1.pdf
View BVdb publication page



Comprehensive analysis of important pharmacogenes in Koreans using the DMET™ platform.

Translational And Clinical Pharmacology
Kim, Byungwook B; Yoon, Deok Yong DY; Lee, SeungHwan S; Jang, In-Jin IJ; Yu, Kyung-Sang KS; Cho, Joo-Youn JY; Oh, Jaeseong J
Publication Date: 2021-09

Variant appearance in text: CDA: 208G>A; A70T; rs60369023
PubMed Link: 34621706
Variant Present in the following documents:
  • tcp-29-135-s001.xls, sheet 1
View BVdb publication page



Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications
Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q
Publication Date: 2021-01-04

Variant appearance in text: CDA: 208G>A
PubMed Link: 33397889
Variant Present in the following documents:
  • 41467_2020_20162_MOESM9_ESM.xlsx, sheet 1
  • 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1
View BVdb publication page



Population Pharmacokinetic and Pharmacogenetic Analysis of Mitotane in Patients with Adrenocortical Carcinoma: Towards Individualized Dosing.

Clinical Pharmacokinetics
Yin, Anyue A; Ettaieb, Madeleine H T MHT; Swen, Jesse J JJ; van Deun, Liselotte L; Kerkhofs, Thomas M A TMA; van der Straaten, Robert J H M RJHM; Corssmit, Eleonora P M EPM; Gelderblom, Hans H; Kerstens, Michiel N MN; Feelders, Richard A RA; Eekhoff, Marelise M; Timmers, Henri J L M HJLM; D'Avolio, Antonio A; Cusato, Jessica J; Guchelaar, Henk-Jan HJ; Haak, Harm R HR; Moes, Dirk Jan A R DJAR
Publication Date: 2021-01

Variant appearance in text: CDA: 208G>A; A70T; rs60369023
PubMed Link: 32607875
Variant Present in the following documents:
  • 40262_2020_913_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



The Emerging Role of Cytidine Deaminase in Human Diseases: A New Opportunity for Therapy?

Molecular Therapy : The Journal Of The American Society Of Gene Therapy
Frances, Audrey A; Cordelier, Pierre P
Publication Date: 2020-02-05

Variant appearance in text: CDA: A70T
PubMed Link: 31870623
Variant Present in the following documents:
  • Main text
View BVdb publication page



Evolving neoantigen profiles in colorectal cancers with DNA repair defects.

Genome Medicine
Rospo, Giuseppe G; Lorenzato, Annalisa A; Amirouchene-Angelozzi, Nabil N; Magrì, Alessandro A; Cancelliere, Carlotta C; Corti, Giorgio G; Negrino, Carola C; Amodio, Vito V; Montone, Monica M; Bartolini, Alice A; Barault, Ludovic L; Novara, Luca L; Isella, Claudio C; Medico, Enzo E; Bertotti, Andrea A; Trusolino, Livio L; Germano, Giovanni G; Di Nicolantonio, Federica F; Bardelli, Alberto A
Publication Date: 2019-06-28

Variant appearance in text: CDA: A70T
PubMed Link: 31253177
Variant Present in the following documents:
  • 13073_2019_654_MOESM2_ESM.xlsx, sheet 43
View BVdb publication page



Determinants of the interindividual variability in serum cytidine deaminase activity of patients with solid tumours.

British Journal Of Clinical Pharmacology
Cohen, R R; Preta, L H LH; Joste, V V; Curis, E E; Huillard, O O; Jouinot, A A; Narjoz, C C; Thomas-Schoemann, A A; Bellesoeur, A A; Tiako Meyo, M M; Quilichini, J J; Desaulle, D D; Nicolis, I I; Cessot, A A; Vidal, M M; Goldwasser, F F; Alexandre, J J; Blanchet, B B
Publication Date: 2019-06

Variant appearance in text: rs60369023
PubMed Link: 30701582
Variant Present in the following documents:
  • Main text
View BVdb publication page



Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target.

Nature Communications
Dufva, Olli O; Kankainen, Matti M; Kelkka, Tiina T; Sekiguchi, Nodoka N; Awad, Shady Adnan SA; Eldfors, Samuli S; Yadav, Bhagwan B; Kuusanmäki, Heikki H; Malani, Disha D; Andersson, Emma I EI; Pietarinen, Paavo P; Saikko, Leena L; Kovanen, Panu E PE; Ojala, Teija T; Lee, Dean A DA; Loughran, Thomas P TP; Nakazawa, Hideyuki H; Suzumiya, Junji J; Suzuki, Ritsuro R; Ko, Young Hyeh YH; Kim, Won Seog WS; Chuang, Shih-Sung SS; Aittokallio, Tero T; Chan, Wing C WC; Ohshima, Koichi K; Ishida, Fumihiro F; Mustjoki, Satu S
Publication Date: 2018-04-19

Variant appearance in text: CDA: A70T; rs60369023
PubMed Link: 29674644
Variant Present in the following documents:
  • 41467_2018_3987_MOESM5_ESM.xlsx, sheet 4
View BVdb publication page



Severe acute toxicity following gemcitabine administration: A report of four cases with cytidine deaminase polymorphisms evaluation.

Oncology Letters
Hryciuk, Beata B; Szymanowski, Bartosz B; Romanowska, Anna A; Salt, Ewa E; Wasąg, Bartosz B; Grala, Bartłomiej B; Jassem, Jacek J; Duchnowska, Renata R
Publication Date: 2018-02

Variant appearance in text: CDA: 208G>A; rs60369023
PubMed Link: 29434889
Variant Present in the following documents:
  • Main text
View BVdb publication page



Overcoming tumor cell chemoresistance using nanoparticles: lysosomes are beneficial for (stearoyl) gemcitabine-incorporated solid lipid nanoparticles.

International Journal Of Nanomedicine
Chen, Zhe Z; Zheng, Yuanqiang Y; Shi, Yanchun Y; Cui, Zhengrong Z
Publication Date: 2018

Variant appearance in text: rs60369023
PubMed Link: 29391792
Variant Present in the following documents:
  • Main text
  • ijn-13-319.pdf
View BVdb publication page



Genotypes Affecting the Pharmacokinetics of Anticancer Drugs.

Clinical Pharmacokinetics
Bertholee, Daphne D; Maring, Jan Gerard JG; van Kuilenburg, André B P AB
Publication Date: 2017-04

Variant appearance in text: CDA: 208G>A; rs60369023
PubMed Link: 27641154
Variant Present in the following documents:
  • Main text
  • 40262_2016_Article_450.pdf
View BVdb publication page



Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes.

Nature Communications
Cereda, Matteo M; Gambardella, Gennaro G; Benedetti, Lorena L; Iannelli, Fabio F; Patel, Dominic D; Basso, Gianluca G; Guerra, Rosalinda F RF; Mourikis, Thanos P TP; Puccio, Ignazio I; Sinha, Shruti S; Laghi, Luigi L; Spencer, Jo J; Rodriguez-Justo, Manuel M; Ciccarelli, Francesca D FD
Publication Date: 2016-07-05

Variant appearance in text: CDA: A70T
PubMed Link: 27377421
Variant Present in the following documents:
  • ncomms12072-s6.xlsx, sheet 1
View BVdb publication page



Pharmacogenomics of platinum-based chemotherapy response in NSCLC: a genotyping study and a pooled analysis.

Oncotarget
Chen, Juan J; Wang, Zhan Z; Zou, Ting T; Cui, Jiajia J; Yin, Jiye J; Zheng, Wei W; Jiang, Wuzhong W; Zhou, Honghao H; Liu, Zhaoqian Z
Publication Date: 2016-08-23

Variant appearance in text: CDA: Ala70Thr
PubMed Link: 27248474
Variant Present in the following documents:
  • oncotarget-07-55741.pdf
View BVdb publication page



Pharmacokinetics and pharmacogenetics of Gemcitabine as a mainstay in adult and pediatric oncology: an EORTC-PAMM perspective.

Cancer Chemotherapy And Pharmacology
Ciccolini, Joseph J; Serdjebi, Cindy C; Peters, Godefridus J GJ; Giovannetti, Elisa E
Publication Date: 2016-07

Variant appearance in text: CDA: Ala70Thr; rs60369023
PubMed Link: 27007129
Variant Present in the following documents:
  • Main text
  • 280_2016_Article_3003.pdf
View BVdb publication page



Impact of Polymorphic Variations of Gemcitabine Metabolism, DNA Damage Repair, and Drug-Resistance Genes on the Effect of High-Dose Chemotherapy for Relapsed or Refractory Lymphoid Malignancies.

Biology Of Blood And Marrow Transplantation : Journal Of The American Society For Blood And Marrow Transplantation
Shinozuka, Keiji K; Tang, Hongwei H; Jones, Roy B RB; Li, Donghui D; Nieto, Yago Y
Publication Date: 2016-05

Variant appearance in text: CDA: A70T
PubMed Link: 26743341
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genomic profiling guides the choice of molecular targeted therapy of pancreatic cancer.

Cancer Letters
Frank, Thomas S TS; Sun, Xiaotian X; Zhang, Yuqing Y; Yang, Jingxuan J; Fisher, William E WE; Gingras, Marie-Claude MC; Li, Min M
Publication Date: 2015-07-10

Variant appearance in text: CDA: Ala70Thr
PubMed Link: 25890222
Variant Present in the following documents:
  • Main text
View BVdb publication page



The Affymetrix DMET Plus platform reveals unique distribution of ADME-related variants in ethnic Arabs.

Disease Markers
Wakil, Salma M SM; Nguyen, Cao C; Muiya, Nzioka P NP; Andres, Editha E; Lykowska-Tarnowska, Agnieszka A; Baz, Batoul B; Tahir, Asma I AI; Meyer, Brian F BF; Morahan, Grant G; Dzimiri, Nduna N
Publication Date: 2015

Variant appearance in text: rs60369023
PubMed Link: 25802476
Variant Present in the following documents:
  • 542543.f1.xlsx, sheet 1
View BVdb publication page



Novel SNP improves differential survivability and mortality in non-small cell lung cancer patients.

Bmc Genomics
Mah, Tzia Liang TL; Yap, Xin Ning Adeline XN; Limviphuvadh, Vachiranee V; Li, Nanpu N; Sridharan, Srinath S; Kuralmani, Vellaisemy V; Feng, Mengling M; Liem, Natalia N; Adhikari, Sharmila S; Yong, Wei Peng WP; Soo, Ross A RA; Maurer-Stroh, Sebastian S; Eisenhaber, Frank F; Tong, Joo Chuan JC
Publication Date: 2014

Variant appearance in text: rs60369023
PubMed Link: 25521664
Variant Present in the following documents:
  • Main text
  • 1471-2164-15-S9-S20.pdf
View BVdb publication page



SLC29A1 single nucleotide polymorphisms as independent prognostic predictors for survival of patients with acute myeloid leukemia: an in vitro study.

Journal Of Experimental & Clinical Cancer Research : Cr
Wan, Haixia H; Zhu, Jianyi J; Chen, Fangyuan F; Xiao, Fei F; Huang, Honghui H; Han, Xiaofeng X; Zhong, Lu L; Zhong, Hua H; Xu, Lan L; Ni, Beiwen B; Zhong, Jihua J
Publication Date: 2014-11-15

Variant appearance in text: CDA: 208G>A; rs60369023
PubMed Link: 25398670
Variant Present in the following documents:
  • Main text
  • 13046_2014_Article_90.pdf
View BVdb publication page



PharmGKB summary: gemcitabine pathway.

Pharmacogenetics And Genomics
Alvarellos, Maria L ML; Lamba, Jatinder J; Sangkuhl, Katrin K; Thorn, Caroline F CF; Wang, Liewei L; Klein, Daniel J DJ; Altman, Russ B RB; Klein, Teri E TE
Publication Date: 2014-11

Variant appearance in text: CDA: Ala70Thr; rs60369023
PubMed Link: 25162786
Variant Present in the following documents:
  • Main text
View BVdb publication page



The RPTEC/TERT1 cell line models key renal cell responses to the environmental toxicants, benzo[a]pyrene and cadmium.

Toxicology Reports
Simon, B R BR; Wilson, M J MJ; Wickliffe, J K JK
Publication Date: 2014

Variant appearance in text: rs60369023
PubMed Link: 25126521
Variant Present in the following documents:
  • mmc1.xls, sheet 1
View BVdb publication page



Screening for 392 polymorphisms in 141 pharmacogenes.

Biomedical Reports
Kim, Jason Yongha JY; Cheong, Hyun Sub HS; Park, Tae-Joon TJ; Shin, Hee Jung HJ; Seo, Doo Won DW; Na, Han Sung HS; Chung, Myeon Woo MW; Shin, Hyoung Doo HD
Publication Date: 2014-07

Variant appearance in text: CDA: 208G>A; Ala70Thr; rs60369023
PubMed Link: 24944790
Variant Present in the following documents:
  • Main text
View BVdb publication page



Human cytidine deaminase: a biochemical characterization of its naturally occurring variants.

International Journal Of Biological Macromolecules
Micozzi, Daniela D; Carpi, Francesco Martino FM; Pucciarelli, Stefania S; Polzonetti, Valeria V; Polidori, Paolo P; Vilar, Santiago S; Williams, Brian B; Costanzi, Stefano S; Vincenzetti, Silvia S
Publication Date: 2014-02

Variant appearance in text: CDA: A70T
PubMed Link: 24183806
Variant Present in the following documents:
  • Main text
View BVdb publication page



Higher capecitabine AUC in elderly patients with advanced colorectal cancer (SWOGS0030).

British Journal Of Cancer
Louie, S G SG; Ely, B B; Lenz, H-J HJ; Albain, K S KS; Gotay, C C; Coleman, D D; Raghavan, D D; Shields, A F AF; Gold, P J PJ; Blanke, C D CD
Publication Date: 2013-10-01

Variant appearance in text: CDA: Ala70Thr
PubMed Link: 24022189
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenetics in breast cancer: steps toward personalized medicine in breast cancer management.

Pharmacogenomics And Personalized Medicine
Rofaiel, Sarah S; Muo, Esther N EN; Mousa, Shaker A SA
Publication Date: 2010

Variant appearance in text: CDA: A70T
PubMed Link: 23226048
Variant Present in the following documents:
  • Main text
  • pgpm-3-129.pdf
View BVdb publication page



Genetic polymorphisms of XPD and CDA and lung cancer risk.

Oncology Letters
Zhou, Min M; Wan, Huan-Ying HY; Gao, Bei-Li BL; Ding, Yong-Jie YJ; Jun, Rong-Xia RX
Publication Date: 2012-08

Variant appearance in text: CDA: Ala70Thr
PubMed Link: 22844363
Variant Present in the following documents:
  • Main text
View BVdb publication page



Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer.

Cancer
Tanaka, Motofumi M; Javle, Milind M; Dong, Xiaoqun X; Eng, Cathy C; Abbruzzese, James L JL; Li, Donghui D
Publication Date: 2010-11-15

Variant appearance in text: CDA: A70T
PubMed Link: 20665488
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacokinetics of gemcitabine in non-small-cell lung cancer patients: impact of the 79A>C cytidine deaminase polymorphism.

European Journal Of Clinical Pharmacology
Maring, Jan Gerard JG; Wachters, Floris M FM; Slijfer, Monique M; Maurer, J Marina JM; Boezen, H Marike HM; Uges, Donald R A DR; de Vries, Elisabeth G E EG; Groen, Harry J M HJ
Publication Date: 2010-06

Variant appearance in text: CDA: Ala70Thr
PubMed Link: 20213492
Variant Present in the following documents:
  • Main text
View BVdb publication page



Homozygous CDA*3 is a major cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients.

British Journal Of Cancer
Ueno, H H; Kaniwa, N N; Okusaka, T T; Ikeda, M M; Morizane, C C; Kondo, S S; Sugiyama, E E; Kim, S R SR; Hasegawa, R R; Saito, Y Y; Yoshida, T T; Saijo, N N; Sawada, J J
Publication Date: 2009-03-24

Variant appearance in text: CDA: Ala70Thr; rs60369023
PubMed Link: 19293806
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genotyping panel for assessing response to cancer chemotherapy.

Bmc Medical Genomics
Dai, Zunyan Z; Papp, Audrey C AC; Wang, Danxin D; Hampel, Heather H; Sadee, Wolfgang W
Publication Date: 2008-06-11

Variant appearance in text: CDA: A70T
PubMed Link: 18547414
Variant Present in the following documents:
  • Main text
  • 1755-8794-1-24-S1.xls, sheet 1
View BVdb publication page



Pharmacogenomics of gemcitabine: can genetic studies lead to tailor-made therapy?

British Journal Of Cancer
Ueno, H H; Kiyosawa, K K; Kaniwa, N N
Publication Date: 2007-07-16

Variant appearance in text: CDA: Ala70Thr
PubMed Link: 17595663
Variant Present in the following documents:
  • Main text
  • 6603860a.pdf
View BVdb publication page