Rare penetrant mutations confer severe risk of common diseases.
Medrxiv : The Preprint Server For Health Sciences
Fiziev, Petko P; McRae, Jeremy J; Ulirsch, Jacob C JC; Dron, Jacqueline S JS; Hamp, Tobias T; Yang, Yanshen Y; Wainschtein, Pierrick P; Ni, Zijian Z; Schraiber, Joshua G JG; Gao, Hong H; Cable, Dylan D; Field, Yair Y; Aguet, Francois F; Fasnacht, Marc M; Metwally, Ahmed A; Rogers, Jeffrey J; Marques-Bonet, Tomas T; Rehm, Heidi L HL; O'Donnell-Luria, Anne A; Khera, Amit V AV; Farh, Kyle Kai-How KK
Follicular Helper T-Cell-Based Classification of Endometrial Cancer Promotes Precise Checkpoint Immunotherapy and Provides Prognostic Stratification.
Frontiers In Immunology
Chen, Yi Y; You, Shuwen S; Li, Jie J; Zhang, Yifan Y; Kokaraki, Georgia G; Epstein, Elisabeth E; Carlson, Joseph J; Huang, Wen-Kuan WK; Haglund, Felix F
Mortality among Care Home Residents in England during the first and second waves of the COVID-19 pandemic: an observational study of 4.3 million adults over the age of 65.
The Lancet Regional Health. Europe
Schultze, Anna A; Nightingale, Emily E; Evans, David D; Hulme, William W; Rosello, Alicia A; Bates, Chris C; Cockburn, Jonathan J; MacKenna, Brian B; Curtis, Helen J HJ; Morton, Caroline E CE; Croker, Richard R; Bacon, Seb S; McDonald, Helen I HI; Rentsch, Christopher T CT; Bhaskaran, Krishnan K; Mathur, Rohini R; Tomlinson, Laurie A LA; Williamson, Elizabeth J EJ; Forbes, Harriet H; Tazare, John J; Grint, Daniel D; Walker, Alex J AJ; Inglesby, Peter P; DeVito, Nicholas J NJ; Mehrkar, Amir A; Hickman, George G; Davy, Simon S; Ward, Tom T; Fisher, Louis L; Green, Amelia Ca AC; Wing, Kevin K; Wong, Angel Ys AY; McManus, Robert R; Parry, John J; Hester, Frank F; Harper, Sam S; Evans, Stephen Jw SJ; Douglas, Ian J IJ; Smeeth, Liam L; Eggo, Rosalind M RM; Goldacre, Ben B; Leon, David A DA
Phospholipid nanoparticles: Therapeutic potentials against atherosclerosis via reducing cholesterol crystals and inhibiting inflammation.
Ebiomedicine
Luo, Yonghong Y; Guo, Yanhong Y; Wang, Huilun H; Yu, Minzhi M; Hong, Kristen K; Li, Dan D; Li, Ruiting R; Wen, Bo B; Hu, Die D; Chang, Lin L; Zhang, Jifeng J; Yang, Bo B; Sun, Duxin D; Schwendeman, Anna S AS; Eugene Chen, Y Y
Phospholipid nanoparticles: Therapeutic potentials against atherosclerosis via reducing cholesterol crystals and inhibiting inflammation.
Ebiomedicine
Luo, Yonghong Y; Guo, Yanhong Y; Wang, Huilun H; Yu, Minzhi M; Hong, Kristen K; Li, Dan D; Li, Ruiting R; Wen, Bo B; Hu, Die D; Chang, Lin L; Zhang, Jifeng J; Yang, Bo B; Sun, Duxin D; Schwendeman, Anna S AS; Eugene Chen, Y Y
Collado, Aida A; Domingo, Elena E; Marques, Patrice P; Perello, Eva E; Martínez-Hervás, Sergio S; Piqueras, Laura L; Ascaso, Juan F JF; Real, José T JT; Sanz, Maria-Jesus MJ
Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase-deficient renal cancer.
Science Signaling
Crooks, Daniel R DR; Maio, Nunziata N; Lang, Martin M; Ricketts, Christopher J CJ; Vocke, Cathy D CD; Gurram, Sandeep S; Turan, Sevilay S; Kim, Yun-Young YY; Cawthon, G Mariah GM; Sohelian, Ferri F; De Val, Natalia N; Pfeiffer, Ruth M RM; Jailwala, Parthav P; Tandon, Mayank M; Tran, Bao B; Fan, Teresa W-M TW; Lane, Andrew N AN; Ried, Thomas T; Wangsa, Darawalee D; Malayeri, Ashkan A AA; Merino, Maria J MJ; Yang, Youfeng Y; Meier, Jordan L JL; Ball, Mark W MW; Rouault, Tracey A TA; Srinivasan, Ramaprasad R; Linehan, W Marston WM
The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel-resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe.
Molecular Oncology
Drápela, Stanislav S; Khirsariya, Prashant P; van Weerden, Wytske M WM; Fedr, Radek R; Suchánková, Tereza T; Búzová, Diana D; Červený, Jan J; Hampl, Aleš A; Puhr, Martin M; Watson, William R WR; Culig, Zoran Z; Krejčí, Lumír L; Paruch, Kamil K; Souček, Karel K
Listeria monocytogenes Exploits Host Caveolin for Cell-to-Cell Spreading.
Mbio
Dhanda, Aaron S AS; Yu, Connie C; Lulic, Katarina T KT; Vogl, A Wayne AW; Rausch, Valentina V; Yang, Diana D; Nichols, Benjamin J BJ; Kim, Sung Hyun SH; Polo, Simona S; Hansen, Carsten G CG; Guttman, Julian A JA
Lead-I ECG for detecting atrial fibrillation in patients attending primary care with an irregular pulse using single-time point testing: A systematic review and economic evaluation.
Plos One
Duarte, Rui R; Stainthorpe, Angela A; Mahon, James J; Greenhalgh, Janette J; Richardson, Marty M; Nevitt, Sarah S; Kotas, Eleanor E; Boland, Angela A; Thom, Howard H; Marshall, Tom T; Hall, Mark M; Takwoingi, Yemisi Y
T cell-mediated regulation of the microbiota protects against obesity.
Science (New York, N.Y.)
Petersen, Charisse C; Bell, Rickesha R; Klag, Kendra A KA; Lee, Soh-Hyun SH; Soto, Raymond R; Ghazaryan, Arevik A; Buhrke, Kaitlin K; Ekiz, H Atakan HA; Ost, Kyla S KS; Boudina, Sihem S; O'Connell, Ryan M RM; Cox, James E JE; Villanueva, Claudio J CJ; Stephens, W Zac WZ; Round, June L JL
AIRE expression controls the peripheral selection of autoreactive B cells.
Science Immunology
Sng, Joel J; Ayoglu, Burcu B; Chen, Jeff W JW; Schickel, Jean-Nicolas JN; Ferre, Elise M N EMN; Glauzy, Salomé S; Romberg, Neil N; Hoenig, Manfred M; Cunningham-Rundles, Charlotte C; Utz, Paul J PJ; Lionakis, Michail S MS; Meffre, Eric E
Evidence that regulation of intramembrane proteolysis is mediated by substrate gating during sporulation in Bacillus subtilis.
Plos Genetics
Ramírez-Guadiana, Fernando H FH; Rodrigues, Christopher D A CDA; Marquis, Kathleen A KA; Campo, Nathalie N; Barajas-Ornelas, Rocío Del Carmen RDC; Brock, Kelly K; Marks, Debora S DS; Kruse, Andrew C AC; Rudner, David Z DZ
Quantitative assessment of cell population diversity in single-cell landscapes.
Plos Biology
Liu, Qi Q; Herring, Charles A CA; Sheng, Quanhu Q; Ping, Jie J; Simmons, Alan J AJ; Chen, Bob B; Banerjee, Amrita A; Li, Wei W; Gu, Guoqiang G; Coffey, Robert J RJ; Shyr, Yu Y; Lau, Ken S KS
Crucial role for Nox2 and sleep deprivation in aircraft noise-induced vascular and cerebral oxidative stress, inflammation, and gene regulation.
European Heart Journal
Kröller-Schön, Swenja S; Daiber, Andreas A; Steven, Sebastian S; Oelze, Matthias M; Frenis, Katie K; Kalinovic, Sanela S; Heimann, Axel A; Schmidt, Frank P FP; Pinto, Antonio A; Kvandova, Miroslava M; Vujacic-Mirski, Ksenija K; Filippou, Konstantina K; Dudek, Markus M; Bosmann, Markus M; Klein, Matthias M; Bopp, Tobias T; Hahad, Omar O; Wild, Philipp S PS; Frauenknecht, Katrin K; Methner, Axel A; Schmidt, Erwin R ER; Rapp, Steffen S; Mollnau, Hanke H; Münzel, Thomas T
Signatures of host specialization and a recent transposable element burst in the dynamic one-speed genome of the fungal barley powdery mildew pathogen.
Bmc Genomics
Frantzeskakis, Lamprinos L; Kracher, Barbara B; Kusch, Stefan S; Yoshikawa-Maekawa, Makoto M; Bauer, Saskia S; Pedersen, Carsten C; Spanu, Pietro D PD; Maekawa, Takaki T; Schulze-Lefert, Paul P; Panstruga, Ralph R
Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1).
Oncotarget
Zak, Krzysztof M KM; Grudnik, Przemyslaw P; Guzik, Katarzyna K; Zieba, Bartosz J BJ; Musielak, Bogdan B; Dömling, Alexander A; Dubin, Grzegorz G; Holak, Tad A TA
Non-coding RNA LINC00857 is predictive of poor patient survival and promotes tumor progression via cell cycle regulation in lung cancer.
Oncotarget
Wang, Lihui L; He, Yanli Y; Liu, Weijun W; Bai, Shengbin S; Xiao, Lei L; Zhang, Jie J; Dhanasekaran, Saravana M SM; Wang, Zhuwen Z; Kalyana-Sundaram, Shanker S; Balbin, O Alejandro OA; Shukla, Sudhanshu S; Lu, Yi Y; Lin, Jules J; Reddy, Rishindra M RM; Carrott, Philip W PW; Lynch, William R WR; Chang, Andrew C AC; Chinnaiyan, Arul M AM; Beer, David G DG; Zhang, Jian J; Chen, Guoan G
Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice.
Aging Cell
Hurez, Vincent V; Dao, Vinh V; Liu, Aijie A; Pandeswara, Srilakshmi S; Gelfond, Jonathan J; Sun, Lishi L; Bergman, Molly M; Orihuela, Carlos J CJ; Galvan, Veronica V; Padrón, Álvaro Á; Drerup, Justin J; Liu, Yang Y; Hasty, Paul P; Sharp, Zelton Dave ZD; Curiel, Tyler J TJ
Poly(ADP-ribosyl)ation acts in the DNA demethylation of mouse primordial germ cells also with DNA damage-independent roles.
Plos One
Ciccarone, Fabio F; Klinger, Francesca Gioia FG; Catizone, Angela A; Calabrese, Roberta R; Zampieri, Michele M; Bacalini, Maria Giulia MG; De Felici, Massimo M; Caiafa, Paola P
Valproic acid induces hair regeneration in murine model and activates alkaline phosphatase activity in human dermal papilla cells.
Plos One
Lee, Soung-Hoon SH; Yoon, Juyong J; Shin, Seung Ho SH; Zahoor, Muhamad M; Kim, Hyoung Jun HJ; Park, Phil June PJ; Park, Won-Seok WS; Min, Do Sik do S; Kim, Hyun-Yi HY; Choi, Kang-Yell KY