Characterization of Rheumatoid Arthritis Risk-Associated SNPs and Identification of Novel Therapeutic Sites Using an In-Silico Approach.
Biology
Akhtar, Mehran M; Ali, Yasir Y; Islam, Zia-Ul ZU; Arshad, Maria M; Rauf, Mamoona M; Ali, Muhammad M; Maodaa, Saleh N SN; Al-Farraj, Saleh A SA; El-Serehy, Hamed A HA; Jalil, Fazal F
Association analysis in a Latin American population revealed ethnic differences in rheumatoid arthritis-associated SNPs in Caucasian and Asian populations.
Scientific Reports
Castro-Santos, P P; Verdugo, R A RA; Alonso-Arias, R R; Gutiérrez, M A MA; Suazo, J J; Aguillón, J C JC; Olloquequi, J J; Pinochet, C C; Lucia, A A; Quiñones, L A LA; Díaz-Peña, R R
Association of BLK and BANK1 Polymorphisms and Interactions With Rheumatoid Arthritis in a Latin-American Population.
Frontiers In Genetics
Ramírez-Bello, Julian J; Fragoso, José M JM; Alemán-Ávila, Isidro I; Jiménez-Morales, Silvia S; Campos-Parra, Alma D AD; Barbosa-Cobos, Rosa Elda RE; Moreno, José J
Identification of rheumatoid arthritis biomarkers based on single nucleotide polymorphisms and haplotype blocks: A systematic review and meta-analysis.
Journal Of Advanced Research
Saad, Mohamed N MN; Mabrouk, Mai S MS; Eldeib, Ayman M AM; Shaker, Olfat G OG
Replication of GWAS Coding SNPs Implicates MMEL1 as a Potential Susceptibility Locus among Saudi Arabian Celiac Disease Patients.
Disease Markers
Saadah, Omar I OI; Shaik, Noor Ahmad NA; Banaganapalli, Babajan B; Salama, Mohammed A MA; Al-Harthi, Sameer E SE; Wang, Jun J; Shawoosh, Harbi A HA; Alghamdi, Sharifa A SA; Bin-Taleb, Yagoub Y YY; Alhussaini, Bakr H BH; Elango, Ramu R; Al-Aama, Jumana Y JY
Non-HLA genes PTPN22, CDK6 and PADI4 are associated with specific autoantibodies in HLA-defined subgroups of rheumatoid arthritis.
Arthritis Research & Therapy
Snir, Omri O; Gomez-Cabrero, David D; Montes, Ariana A; Perez-Pampin, Eva E; Gómez-Reino, Juan J JJ; Seddighzadeh, Maria M; Klich, Katharina U KU; Israelsson, Lena L; Ding, Bo B; Catrina, Anca I AI; Holmdahl, Rikard R; Alfredsson, Lars L; Klareskog, Lars L; Tegnér, Jesper J; Gonzalez, Antonio A; Malmström, Vivianne V; Padyukov, Leonid L
Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.
Arthritis & Rheumatology (Hoboken, N.J.)
Orozco, Gisela G; Viatte, Sebastien S; Bowes, John J; Martin, Paul P; Wilson, Anthony G AG; Morgan, Ann W AW; Steer, Sophia S; Wordsworth, Paul P; Hocking, Lynne J LJ; , ; , ; , ; Barton, Anne A; Worthington, Jane J; Eyre, Stephen S
Predicting the risk of rheumatoid arthritis and its age of onset through modelling genetic risk variants with smoking.
Plos Genetics
Scott, Ian C IC; Seegobin, Seth D SD; Steer, Sophia S; Tan, Rachael R; Forabosco, Paola P; Hinks, Anne A; Eyre, Stephen S; Morgan, Ann W AW; Wilson, Anthony G AG; Hocking, Lynne J LJ; Wordsworth, Paul P; Barton, Anne A; Worthington, Jane J; Cope, Andrew P AP; Lewis, Cathryn M CM
Seven newly identified loci for autoimmune thyroid disease.
Human Molecular Genetics
Cooper, Jason D JD; Simmonds, Matthew J MJ; Walker, Neil M NM; Burren, Oliver O; Brand, Oliver J OJ; Guo, Hui H; Wallace, Chris C; Stevens, Helen H; Coleman, Gillian G; , ; Franklyn, Jayne A JA; Todd, John A JA; Gough, Stephen C L SC
Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci.
Journal Of Hepatology
Folseraas, Trine T; Melum, Espen E; Rausch, Philipp P; Juran, Brian D BD; Ellinghaus, Eva E; Shiryaev, Alexey A; Laerdahl, Jon K JK; Ellinghaus, David D; Schramm, Christoph C; Weismüller, Tobias J TJ; Gotthardt, Daniel Nils DN; Hov, Johannes Roksund JR; Clausen, Ole Petter OP; Weersma, Rinse K RK; Janse, Marcel M; Boberg, Kirsten Muri KM; Björnsson, Einar E; Marschall, Hanns-Ulrich HU; Cleynen, Isabelle I; Rosenstiel, Philip P; Holm, Kristian K; Teufel, Andreas A; Rust, Christian C; Gieger, Christian C; Wichmann, H-Erich HE; Bergquist, Annika A; Ryu, Euijung E; Ponsioen, Cyriel Y CY; Runz, Heiko H; Sterneck, Martina M; Vermeire, Severine S; Beuers, Ulrich U; Wijmenga, Cisca C; Schrumpf, Erik E; Manns, Michael P MP; Lazaridis, Konstantinos N KN; Schreiber, Stefan S; Baines, John F JF; Franke, Andre A; Karlsen, Tom H TH
Use of a multiethnic approach to identify rheumatoid- arthritis-susceptibility loci, 1p36 and 17q12.
American Journal Of Human Genetics
Kurreeman, Fina A S FA; Stahl, Eli A EA; Okada, Yukinori Y; Liao, Katherine K; Diogo, Dorothée D; Raychaudhuri, Soumya S; Freudenberg, Jan J; Kochi, Yuta Y; Patsopoulos, Nikolaos A NA; Gupta, Namrata N; , ; Sandor, Cynthia C; Bang, So-Young SY; Lee, Hye-Soon HS; Padyukov, Leonid L; Suzuki, Akari A; Siminovitch, Kathy K; Worthington, Jane J; Gregersen, Peter K PK; Hughes, Laura B LB; Reynolds, Richard J RJ; Bridges, S Louis SL; Bae, Sang-Cheol SC; Yamamoto, Kazuhiko K; Plenge, Robert M RM
Evaluation of 19 autoimmune disease-associated loci with rheumatoid arthritis in a Colombian population: evidence for replication and gene-gene interaction.
The Journal Of Rheumatology
Deshmukh, Harshal A HA; Maiti, Amit K AK; Kim-Howard, Xana R XR; Rojas-Villarraga, Adriana A; Guthridge, Joel M JM; Anaya, Juan-Manuel JM; Nath, Swapan K SK
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
Plos Genetics
Zhernakova, Alexandra A; Stahl, Eli A EA; Trynka, Gosia G; Raychaudhuri, Soumya S; Festen, Eleanora A EA; Franke, Lude L; Westra, Harm-Jan HJ; Fehrmann, Rudolf S N RS; Kurreeman, Fina A S FA; Thomson, Brian B; Gupta, Namrata N; Romanos, Jihane J; McManus, Ross R; Ryan, Anthony W AW; Turner, Graham G; Brouwer, Elisabeth E; Posthumus, Marcel D MD; Remmers, Elaine F EF; Tucci, Francesca F; Toes, Rene R; Grandone, Elvira E; Mazzilli, Maria Cristina MC; Rybak, Anna A; Cukrowska, Bozena B; Coenen, Marieke J H MJ; Radstake, Timothy R D J TR; van Riel, Piet L C M PL; Li, Yonghong Y; de Bakker, Paul I W PI; Gregersen, Peter K PK; Worthington, Jane J; Siminovitch, Katherine A KA; Klareskog, Lars L; Huizinga, Tom W J TW; Wijmenga, Cisca C; Plenge, Robert M RM
A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.
Annals Of The Rheumatic Diseases
Padyukov, Leonid L; Seielstad, Mark M; Ong, Rick T H RT; Ding, Bo B; Rönnelid, Johan J; Seddighzadeh, Maria M; Alfredsson, Lars L; Klareskog, Lars L; ,
Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes.
Human Molecular Genetics
Murphy, Amy A; Chu, Jen-Hwa JH; Xu, Mousheng M; Carey, Vincent J VJ; Lazarus, Ross R; Liu, Andy A; Szefler, Stanley J SJ; Strunk, Robert R; Demuth, Karen K; Castro, Mario M; Hansel, Nadia N NN; Diette, Gregory B GB; Vonakis, Becky M BM; Adkinson, N Franklin NF; Klanderman, Barbara J BJ; Senter-Sylvia, Jody J; Ziniti, John J; Lange, Christoph C; Pastinen, Tomi T; Raby, Benjamin A BA
Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis.
Nature Genetics
Hirschfield, Gideon M GM; Liu, Xiangdong X; Han, Younghun Y; Gorlov, Ivan P IP; Lu, Yan Y; Xu, Chun C; Lu, Yue Y; Chen, Wei W; Juran, Brian D BD; Coltescu, Catalina C; Mason, Andrew L AL; Milkiewicz, Piotr P; Myers, Robert P RP; Odin, Joseph A JA; Luketic, Velimir A VA; Speiciene, Danute D; Vincent, Catherine C; Levy, Cynthia C; Gregersen, Peter K PK; Zhang, Jinyi J; Heathcote, E Jenny EJ; Lazaridis, Konstantinos N KN; Amos, Christopher I CI; Siminovitch, Katherine A KA
A non-synonymous SNP within membrane metalloendopeptidase-like 1 (MMEL1) is associated with multiple sclerosis.
Genes And Immunity
Ban, M M; McCauley, J L JL; Zuvich, R R; Baker, A A; Bergamaschi, L L; Cox, M M; Kemppinen, A A; D'Alfonso, S S; Guerini, F R FR; Lechner-Scott, J J; Dudbridge, F F; Wason, J J; Robertson, N P NP; De Jager, P L PL; Hafler, D A DA; Barcellos, L F LF; Ivinson, A J AJ; Sexton, D D; Oksenberg, J R JR; Hauser, S L SL; Pericak-Vance, M A MA; Haines, J J; Compston, A A; Sawcer, S S
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
Nature Genetics
Stahl, Eli A EA; Raychaudhuri, Soumya S; Remmers, Elaine F EF; Xie, Gang G; Eyre, Stephen S; Thomson, Brian P BP; Li, Yonghong Y; Kurreeman, Fina A S FA; Zhernakova, Alexandra A; Hinks, Anne A; Guiducci, Candace C; Chen, Robert R; Alfredsson, Lars L; Amos, Christopher I CI; Ardlie, Kristin G KG; , ; Barton, Anne A; Bowes, John J; Brouwer, Elisabeth E; Burtt, Noel P NP; Catanese, Joseph J JJ; Coblyn, Jonathan J; Coenen, Marieke J H MJ; Costenbader, Karen H KH; Criswell, Lindsey A LA; Crusius, J Bart A JB; Cui, Jing J; de Bakker, Paul I W PI; De Jager, Philip L PL; Ding, Bo B; Emery, Paul P; Flynn, Edward E; Harrison, Pille P; Hocking, Lynne J LJ; Huizinga, Tom W J TW; Kastner, Daniel L DL; Ke, Xiayi X; Lee, Annette T AT; Liu, Xiangdong X; Martin, Paul P; Morgan, Ann W AW; Padyukov, Leonid L; Posthumus, Marcel D MD; Radstake, Timothy R D J TR; Reid, David M DM; Seielstad, Mark M; Seldin, Michael F MF; Shadick, Nancy A NA; Steer, Sophia S; Tak, Paul P PP; Thomson, Wendy W; van der Helm-van Mil, Annette H M AH; van der Horst-Bruinsma, Irene E IE; van der Schoot, C Ellen CE; van Riel, Piet L C M PL; Weinblatt, Michael E ME; Wilson, Anthony G AG; Wolbink, Gert Jan GJ; Wordsworth, B Paul BP; , ; Wijmenga, Cisca C; Karlson, Elizabeth W EW; Toes, Rene E M RE; de Vries, Niek N; Begovich, Ann B AB; Worthington, Jane J; Siminovitch, Katherine A KA; Gregersen, Peter K PK; Klareskog, Lars L; Plenge, Robert M RM
Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy.
Arthritis And Rheumatism
Cui, Jing J; Saevarsdottir, Saedis S; Thomson, Brian B; Padyukov, Leonid L; van der Helm-van Mil, Annette H M AH; Nititham, Joanne J; Hughes, Laura B LB; de Vries, Niek N; Raychaudhuri, Soumya S; Alfredsson, Lars L; Askling, Johan J; Wedrén, Sara S; Ding, Bo B; Guiducci, Candace C; Wolbink, Gert Jan GJ; Crusius, J Bart A JB; van der Horst-Bruinsma, Irene E IE; Herenius, Marieke M; Weinblatt, Michael E ME; Shadick, Nancy A NA; Worthington, Jane J; Batliwalla, Franak F; Kern, Marlena M; Morgan, Ann W AW; Wilson, Anthony G AG; Isaacs, John D JD; Hyrich, Kimme K; Seldin, Michael F MF; Moreland, Larry W LW; Behrens, Timothy W TW; Allaart, Cornelia F CF; Criswell, Lindsey A LA; Huizinga, Tom W J TW; Tak, Paul P PP; Bridges, S Louis SL; Toes, Rene E M RE; Barton, Anne A; Klareskog, Lars L; Gregersen, Peter K PK; Karlson, Elizabeth W EW; Plenge, Robert M RM
Cumulative association of 22 genetic variants with seropositive rheumatoid arthritis risk.
Annals Of The Rheumatic Diseases
Karlson, Elizabeth W EW; Chibnik, Lori B LB; Kraft, Peter P; Cui, Jing J; Keenan, Brendan T BT; Ding, Bo B; Raychaudhuri, Souyma S; Klareskog, Lars L; Alfredsson, Lars L; Plenge, Robert M RM
Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.
Nature Genetics
Raychaudhuri, Soumya S; Thomson, Brian P BP; Remmers, Elaine F EF; Eyre, Stephen S; Hinks, Anne A; Guiducci, Candace C; Catanese, Joseph J JJ; Xie, Gang G; Stahl, Eli A EA; Chen, Robert R; Alfredsson, Lars L; Amos, Christopher I CI; Ardlie, Kristin G KG; , ; Barton, Anne A; Bowes, John J; Burtt, Noel P NP; Chang, Monica M; Coblyn, Jonathan J; Costenbader, Karen H KH; Criswell, Lindsey A LA; Crusius, J Bart A JB; Cui, Jing J; De Jager, Phillip L PL; Ding, Bo B; Emery, Paul P; Flynn, Edward E; Harrison, Pille P; Hocking, Lynne J LJ; Huizinga, Tom W J TW; Kastner, Daniel L DL; Ke, Xiayi X; Kurreeman, Fina A S FA; Lee, Annette T AT; Liu, Xiangdong X; Li, Yonghong Y; Martin, Paul P; Morgan, Ann W AW; Padyukov, Leonid L; Reid, David M DM; Seielstad, Mark M; Seldin, Michael F MF; Shadick, Nancy A NA; Steer, Sophia S; Tak, Paul P PP; Thomson, Wendy W; van der Helm-van Mil, Annette H M AH; van der Horst-Bruinsma, Irene E IE; Weinblatt, Michael E ME; Wilson, Anthony G AG; Wolbink, Gert Jan GJ; Wordsworth, Paul P; , ; Altshuler, David D; Karlson, Elizabeth W EW; Toes, Rene E M RE; de Vries, Niek N; Begovich, Ann B AB; Siminovitch, Katherine A KA; Worthington, Jane J; Klareskog, Lars L; Gregersen, Peter K PK; Daly, Mark J MJ; Plenge, Robert M RM
Association of a single-nucleotide polymorphism in CD40 with the rate of joint destruction in rheumatoid arthritis.
Arthritis And Rheumatism
van der Linden, Michael P M MP; Feitsma, Anouk L AL; le Cessie, Saskia S; Kern, Marlena M; Olsson, Lina M LM; Raychaudhuri, Soumya S; Begovich, Ann B AB; Chang, Monica M; Catanese, Joseph J JJ; Kurreeman, Fina A S FA; van Nies, Jessica J; van der Heijde, Désirée M DM; Gregersen, Peter K PK; Huizinga, Tom W J TW; Toes, René E M RE; van der Helm-Van Mil, Annette H M AH
Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
Nature Genetics
Raychaudhuri, Soumya S; Remmers, Elaine F EF; Lee, Annette T AT; Hackett, Rachel R; Guiducci, Candace C; Burtt, Noël P NP; Gianniny, Lauren L; Korman, Benjamin D BD; Padyukov, Leonid L; Kurreeman, Fina A S FA; Chang, Monica M; Catanese, Joseph J JJ; Ding, Bo B; Wong, Sandra S; van der Helm-van Mil, Annette H M AH; Neale, Benjamin M BM; Coblyn, Jonathan J; Cui, Jing J; Tak, Paul P PP; Wolbink, Gert Jan GJ; Crusius, J Bart A JB; van der Horst-Bruinsma, Irene E IE; Criswell, Lindsey A LA; Amos, Christopher I CI; Seldin, Michael F MF; Kastner, Daniel L DL; Ardlie, Kristin G KG; Alfredsson, Lars L; Costenbader, Karen H KH; Altshuler, David D; Huizinga, Tom W J TW; Shadick, Nancy A NA; Weinblatt, Michael E ME; de Vries, Niek N; Worthington, Jane J; Seielstad, Mark M; Toes, Rene E M RE; Karlson, Elizabeth W EW; Begovich, Ann B AB; Klareskog, Lars L; Gregersen, Peter K PK; Daly, Mark J MJ; Plenge, Robert M RM