Publications:

---

Establishment and characterization of a new mantle cell lymphoma cell line with a NOTCH2 mutation, Arbo.

Ejhaem

Safa, Firas F; Rasmussen, Terri T; Lobelle-Rich, Patricia P; Collier, Stephanie S; Milligan, Nicholas N; Schmeig, John J; Schmid, Janet J; Wiewiorowski, Carol C; Totaro, Denise D; Brown, Theresa C TC; Satyavarapu, Ishwarya I; Badoo, Melody M; Ungerleider, Nathan N; Flemington, Erik K EK; Safah, Hana H; Saba, Nakhle S NS

Publication Date: 2022-11

Variant appearance in text: rs10888897

PubMed Link: 36467812

Variant Present in the following documents:

• JHA2-3-1326-s001.xlsx, sheet 1

View BVdb publication page

---

Association of PCSK9 levels and genetic polymorphisms with stroke recurrence and functional outcome after acute ischemic stroke.

Annals Of Translational Medicine

Chen, Weiqi W; Wang, Yicong Y; Meng, Xia X; Pan, Yuesong Y; Wang, Mengxing M; Li, Hao H; Wang, Yilong Y; Wang, Yongjun Y

Publication Date: 2022-07

Variant appearance in text: rs10888897

PubMed Link: 35957726

Variant Present in the following documents:

• Main text
• atm-10-13-729.pdf

View BVdb publication page

---

Association of Common and Rare Genetic Variation in the 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Gene and Cataract Risk.

Journal Of The American Heart Association

Ghouse, Jonas J; Ahlberg, Gustav G; Skov, Anne Guldhammer AG; Bundgaard, Henning H; Olesen, Morten S MS

Publication Date: 2022-06-21

Variant appearance in text: rs10888897

PubMed Link: 35703387

Variant Present in the following documents:

• JAH3-11-e025361-s001.pdf
• JAH3-11-e025361.pdf

View BVdb publication page

---

Genetic analysis of the PCSK9 locus in psychological, psychiatric, metabolic and cardiovascular traits in UK Biobank.

European Journal Of Human Genetics : Ejhg

Hay, Rachel R; Cullen, Breda B; Graham, Nicholas N; Lyall, Donald M DM; Aman, Alisha A; Pell, Jill P JP; Ward, Joey J; Smith, Daniel J DJ; Strawbridge, Rona J RJ

Publication Date: 2022-12

Variant appearance in text: rs10888897

PubMed Link: 35501368

Variant Present in the following documents:

• Main text
• 41431_2022_Article_1107.pdf

View BVdb publication page

---

Investigating the effects of statins on ischemic heart disease allowing for effects on body mass index: a Mendelian randomization study.

Scientific Reports

Li, Shun S; Schooling, C M CM

Publication Date: 2022-03-03

Variant appearance in text: rs10888897

PubMed Link: 35241713

Variant Present in the following documents:

• Main text
• 41598_2022_Article_7344.pdf

View BVdb publication page

---

Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease.

Nature Communications

Schmidt, Amand F AF; Hunt, Nicholas B NB; Gordillo-Marañón, Maria M; Charoen, Pimphen P; Drenos, Fotios F; Kivimaki, Mika M; Lawlor, Deborah A DA; Giambartolomei, Claudia C; Papacosta, Olia O; Chaturvedi, Nishi N; Bis, Joshua C JC; O'Donnell, Christopher J CJ; Wannamethee, Goya G; Wong, Andrew A; Price, Jackie F JF; Hughes, Alun D AD; Gaunt, Tom R TR; Franceschini, Nora N; Mook-Kanamori, Dennis O DO; Zwierzyna, Magdalena M; Sofat, Reecha R; Hingorani, Aroon D AD; Finan, Chris C

Publication Date: 2021-09-24

Variant appearance in text: rs10888897

PubMed Link: 34561430

Variant Present in the following documents:

• 41467_2021_25703_MOESM1_ESM.pdf

View BVdb publication page

---

Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization study.

Plos Genetics

Gormley, Mark M; Yarmolinsky, James J; Dudding, Tom T; Burrows, Kimberley K; Martin, Richard M RM; Thomas, Steven S; Tyrrell, Jessica J; Brennan, Paul P; Pring, Miranda M; Boccia, Stefania S; Olshan, Andrew F AF; Diergaarde, Brenda B; Hung, Rayjean J RJ; Liu, Geoffrey G; Legge, Danny D; Tajara, Eloiza H EH; Severino, Patricia P; Lacko, Martin M; Ness, Andrew R AR; Davey Smith, George G; Vincent, Emma E EE; Richmond, Rebecca C RC

Publication Date: 2021-04

Variant appearance in text: rs10888897

PubMed Link: 33886544

Variant Present in the following documents:

• Main text

View BVdb publication page

---

PCSK9 genetic variants and cognitive abilities: a large-scale Mendelian randomization study.

Archives Of Medical Science : Ams

Lyall, Donald M DM; Ward, Joey J; Banach, Maciej M; Smith, George Davey GD; Gill, Jason G JG; Pell, Jill P JP; Holmes, Michael V MV; Sattar, Naveed N

Publication Date: 2021

Variant appearance in text: rs10888897

PubMed Link: 33488877

Variant Present in the following documents:

• Main text
• AMS-17-1-127226.pdf

View BVdb publication page

---

Investigating pleiotropic effects of statins on ischemic heart disease in the UK Biobank using Mendelian randomisation.

Elife

Schooling, C M CM; Zhao, J V JV; Au Yeung, S L SL; Leung, G M GM

Publication Date: 2020-08-25

Variant appearance in text: rs10888897

PubMed Link: 32838838

Variant Present in the following documents:

• Main text
• elife-58567.pdf

View BVdb publication page

---

Genetic drug target validation using Mendelian randomisation.

Nature Communications

Schmidt, Amand F AF; Finan, Chris C; Gordillo-Marañón, Maria M; Asselbergs, Folkert W FW; Freitag, Daniel F DF; Patel, Riyaz S RS; Tyl, Benoît B; Chopade, Sandesh S; Faraway, Rupert R; Zwierzyna, Magdalena M; Hingorani, Aroon D AD

Publication Date: 2020-06-26

Variant appearance in text: rs10888897

PubMed Link: 32591531

Variant Present in the following documents:

• 41467_2020_16969_MOESM1_ESM.pdf

View BVdb publication page

---

Genetic Determinants of Lipids and Cardiovascular Disease Outcomes: A Wide-Angled Mendelian Randomization Investigation.

Circulation. Genomic And Precision Medicine

Allara, Elias E; Morani, Gabriele G; Carter, Paul P; Gkatzionis, Apostolos A; Zuber, Verena V; Foley, Christopher N CN; Rees, Jessica M B JMB; Mason, Amy M AM; Bell, Steven S; Gill, Dipender D; Lindström, Sara S; Butterworth, Adam S AS; Di Angelantonio, Emanuele E; Peters, James J; Burgess, Stephen S; ,

Publication Date: 2019-12

Variant appearance in text: rs10888897

PubMed Link: 31756303

Variant Present in the following documents:

• hcg-12-e002711-s001.pdf

View BVdb publication page

---

A Genetic Approach to the Association Between PCSK9 and Sepsis.

Jama Network Open

Feng, QiPing Q; Wei, Wei-Qi WQ; Chaugai, Sandip S; Carranza Leon, Barbara G BG; Kawai, Vivian V; Carranza Leon, Daniel A DA; Jiang, Lan L; Zhong, Xue X; Liu, Ge G; Ihegword, Andrea A; Shaffer, Christian M CM; Linton, MacRae F MF; Chung, Cecilia P CP; Stein, C Michael CM

Publication Date: 2019-09-04

Variant appearance in text: rs10888897

PubMed Link: 31509211

Variant Present in the following documents:

• Main text
• jamanetwopen-2-e1911130-s001.pdf

View BVdb publication page

---

Variation in Serum PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9), Cardiovascular Disease Risk, and an Investigation of Potential Unanticipated Effects of PCSK9 Inhibition.

Circulation. Genomic And Precision Medicine

Brumpton, Ben M BM; Fritsche, Lars G LG; Zheng, Jie J; Nielsen, Jonas Bille JB; Mannila, Maria M; Surakka, Ida I; Rasheed, Humaira H; Vie, Gunnhild Åberge GÅ; Graham, Sarah E SE; Gabrielsen, Maiken Elvestad ME; Laugsand, Lars Erik LE; Aukrust, Pål P; Vatten, Lars Johan LJ; Damås, Jan Kristian JK; Ueland, Thor T; Janszky, Imre I; Zwart, John-Anker JA; Van't Hooft, Ferdinand M FM; Seidah, Nabil Georges NG; Hveem, Kristian K; Willer, Cristen C; Smith, George Davey GD; Åsvold, Bjørn Olav BO; ,

Publication Date: 2019-01

Variant appearance in text: rs10888897

PubMed Link: 30645169

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Association of Genetically Enhanced Lipoprotein Lipase-Mediated Lipolysis and Low-Density Lipoprotein Cholesterol-Lowering Alleles With Risk of Coronary Disease and Type 2 Diabetes.

Jama Cardiology

Lotta, Luca A LA; Stewart, Isobel D ID; Sharp, Stephen J SJ; Day, Felix R FR; Burgess, Stephen S; Luan, Jian'an J; Bowker, Nicholas N; Cai, Lina L; Li, Chen C; Wittemans, Laura B L LBL; Kerrison, Nicola D ND; Khaw, Kay-Tee KT; McCarthy, Mark I MI; O'Rahilly, Stephen S; Scott, Robert A RA; Savage, David B DB; Perry, John R B JRB; Langenberg, Claudia C; Wareham, Nicholas J NJ

Publication Date: 2018-10-01

Variant appearance in text: rs10888897

PubMed Link: 30326043

Variant Present in the following documents:

• jamacardiol-3-957-s001.pdf

View BVdb publication page

---

Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer's disease and Parkinson's disease: Mendelian randomisation study.

Bmj (Clinical Research Ed.)

Benn, Marianne M; Nordestgaard, Børge G BG; Frikke-Schmidt, Ruth R; Tybjærg-Hansen, Anne A

Publication Date: 2017-04-24

Variant appearance in text: rs10888897

PubMed Link: 28438747

Variant Present in the following documents:

• benm033277.ww1.pdf

View BVdb publication page

---

PCSK9 SNP rs11591147 is associated with low cholesterol levels but not with cognitive performance or noncardiovascular clinical events in an elderly population.

Journal Of Lipid Research

Postmus, Iris I; Trompet, Stella S; de Craen, Anton J M AJ; Buckley, Brendan M BM; Ford, Ian I; Stott, David J DJ; Sattar, Naveed N; Slagboom, P Eline PE; Westendorp, Rudi G J RG; Jukema, J Wouter JW

Publication Date: 2013-02

Variant appearance in text: rs10888897

PubMed Link: 23300213

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Effects of PCSK9 genetic variants on plasma LDL cholesterol levels and risk of premature myocardial infarction in the Italian population.

Journal Of Lipid Research

Guella, Ilaria I; Asselta, Rosanna R; Ardissino, Diego D; Merlini, Pier Angelica PA; Peyvandi, Flora F; Kathiresan, Sekar S; Mannucci, Pier Mannuccio PM; Tubaro, Marco M; Duga, Stefano S

Publication Date: 2010-11

Variant appearance in text: rs10888897

PubMed Link: 20699424

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Molecular population genetics of PCSK9: a signature of recent positive selection.

Pharmacogenetics And Genomics

Ding, Keyue K; Kullo, Iftikhar J IJ

Publication Date: 2008-03

Variant appearance in text: rs10888897

PubMed Link: 18300938

Variant Present in the following documents:

• Main text

View BVdb publication page

---