Publications:

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PCSK9 regulates the NODAL signaling pathway and cellular proliferation in hiPSCs.

Stem Cell Reports

Roudaut, Meryl M; Idriss, Salam S; Caillaud, Amandine A; Girardeau, Aurore A; Rimbert, Antoine A; Champon, Benoite B; David, Amandine A; Lévêque, Antoine A; Arnaud, Lucie L; Pichelin, Matthieu M; Prieur, Xavier X; Prat, Annik A; Seidah, Nabil G NG; Zibara, Kazem K; Le May, Cedric C; Cariou, Bertrand B; Si-Tayeb, Karim K

Publication Date: 2021-12-14

Variant appearance in text: PCSK9: L455X

PubMed Link: 34739847

Variant Present in the following documents:

• mmc1.pdf

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PCSK9 regulates the NODAL signaling pathway and cellular proliferation in hiPSCs.

Stem Cell Reports

Roudaut, Meryl M; Idriss, Salam S; Caillaud, Amandine A; Girardeau, Aurore A; Rimbert, Antoine A; Champon, Benoite B; David, Amandine A; Lévêque, Antoine A; Arnaud, Lucie L; Pichelin, Matthieu M; Prieur, Xavier X; Prat, Annik A; Seidah, Nabil G NG; Zibara, Kazem K; Le May, Cedric C; Cariou, Bertrand B; Si-Tayeb, Karim K

Publication Date: 2021-10-26

Variant appearance in text: PCSK9: L455X

PubMed Link: 34739847

Variant Present in the following documents:

• mmc1.pdf

View BVdb publication page

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Roles of the low density lipoprotein receptor and related receptors in inhibition of lipoprotein(a) internalization by proprotein convertase subtilisin/kexin type 9.

Plos One

Romagnuolo, Rocco R; Scipione, Corey A CA; Marcovina, Santica M SM; Gemin, Matthew M; Seidah, Nabil G NG; Boffa, Michael B MB; Koschinsky, Marlys L ML

Publication Date: 2017

Variant appearance in text: PCSK9: L455X

PubMed Link: 28750079

Variant Present in the following documents:

• Main text
• pone.0180869.pdf

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Studies of the autoinhibitory segment comprising residues 31-60 of the prodomain of PCSK9: Possible implications for the mechanism underlying gain-of-function mutations.

Molecular Genetics And Metabolism Reports

Wierød, Lene L; Cameron, Jamie J; Strøm, Thea Bismo TB; Leren, Trond P TP

Publication Date: 2016-12

Variant appearance in text: PCSK9: L455X

PubMed Link: 27896130

Variant Present in the following documents:

• Main text
• main.pdf

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Annexin A2 reduces PCSK9 protein levels via a translational mechanism and interacts with the M1 and M2 domains of PCSK9.

The Journal Of Biological Chemistry

Ly, Kévin K; Saavedra, Yascara Grisel Luna YG; Canuel, Maryssa M; Routhier, Sophie S; Desjardins, Roxane R; Hamelin, Josée J; Mayne, Janice J; Lazure, Claude C; Seidah, Nabil G NG; Day, Robert R

Publication Date: 2014-06-20

Variant appearance in text: PCSK9: L455X

PubMed Link: 24808179

Variant Present in the following documents:

• Main text

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The M2 module of the Cys-His-rich domain (CHRD) of PCSK9 protein is needed for the extracellular low-density lipoprotein receptor (LDLR) degradation pathway.

The Journal Of Biological Chemistry

Saavedra, Yascara Grisel Luna YG; Day, Robert R; Seidah, Nabil G NG

Publication Date: 2012-12-21

Variant appearance in text: PCSK9: L455X

PubMed Link: 23105118

Variant Present in the following documents:

• Main text

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Role of the C-terminal domain of PCSK9 in degradation of the LDL receptors.

Journal Of Lipid Research

Holla, Øystein L ØL; Cameron, Jamie J; Tveten, Kristian K; Strøm, Thea Bismo TB; Berge, Knut Erik KE; Laerdahl, Jon K JK; Leren, Trond P TP

Publication Date: 2011-10

Variant appearance in text: PCSK9: L455X

PubMed Link: 21771976

Variant Present in the following documents:

• Main text

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