Acute Coronary Syndrome Developed in a 17-year-old Boy with Sitosterolemia Comorbid with Takayasu Arteritis: A Rare Case Report and Review of the Literature.
Internal Medicine (Tokyo, Japan)
Iyama, Keita K; Ikeda, Satoshi S; Koga, Seiji S; Yoshimuta, Tsuyoshi T; Kawano, Hiroaki H; Tsuji, Sosuke S; Ando, Koji K; Matsushima, Kayoko K; Tada, Hayato H; Kawashiri, Masa-Aki MA; Kawakami, Atsushi A; Maemura, Koji K
Ser-Phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family With Sequence Similarity 20, Member C) Kinase Enhances Its Ability to Degrade the LDLR (Low-Density Lipoprotein Receptor).
Arteriosclerosis, Thrombosis, And Vascular Biology
Ben Djoudi Ouadda, Ali A; Gauthier, Marie-Soleil MS; Susan-Resiga, Delia D; Girard, Emmanuelle E; Essalmani, Rachid R; Black, Miles M; Marcinkiewicz, Jadwiga J; Forget, Diane D; Hamelin, Josée J; Evagelidis, Alexandra A; Ly, Kevin K; Day, Robert R; Galarneau, Luc L; Corbin, Francois F; Coulombe, Benoit B; Çaku, Artuela A; Tagliabracci, Vincent S VS; Seidah, Nabil G NG
Cyclase-associated protein 1 is a binding partner of proprotein convertase subtilisin/kexin type-9 and is required for the degradation of low-density lipoprotein receptors by proprotein convertase subtilisin/kexin type-9.
European Heart Journal
Jang, Hyun-Duk HD; Lee, Sang Eun SE; Yang, Jimin J; Lee, Hyun-Chae HC; Shin, Dasom D; Lee, Hwan H; Lee, Jaewon J; Jin, Sooryeonhwa S; Kim, Soungchan S; Lee, Seung Ji SJ; You, Jihye J; Park, Hyun-Woo HW; Nam, Ky-Youb KY; Lee, Sang-Hak SH; Park, Sahng Wook SW; Kim, Jin-Soo JS; Kim, Sang-Yeob SY; Kwon, Yoo-Wook YW; Kwak, Soo Heon SH; Yang, Han-Mo HM; Kim, Hyo-Soo HS
Findings of a 1303 Korean whole-exome sequencing study.
Experimental & Molecular Medicine
Kwak, Soo Heon SH; Chae, Jeesoo J; Choi, Seongmin S; Kim, Min Jung MJ; Choi, Murim M; Chae, Jong-Hee JH; Cho, Eun-Hae EH; Hwang, Tai Ju TJ; Jang, Se Song SS; Kim, Jong-Il JI; Park, Kyong Soo KS; Bang, Yung-Jue YJ
Publication Date: 2017-07-14
Variant appearance in text: PCSK9: S668R; rs762298323
Plasma Membrane Tetraspanin CD81 Complexes with Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and Low Density Lipoprotein Receptor (LDLR), and Its Levels Are Reduced by PCSK9.
The Journal Of Biological Chemistry
Le, Quoc-Tuan QT; Blanchet, Matthieu M; Seidah, Nabil G NG; Labonté, Patrick P
The M2 module of the Cys-His-rich domain (CHRD) of PCSK9 protein is needed for the extracellular low-density lipoprotein receptor (LDLR) degradation pathway.
The Journal Of Biological Chemistry
Saavedra, Yascara Grisel Luna YG; Day, Robert R; Seidah, Nabil G NG