Advanced statistics identification of participant and treatment predictors associated with severe adverse effects induced by fluoropyrimidine-based chemotherapy.
Cancer Chemotherapy And Pharmacology
Korver, Samantha K SK; Bowen, Joanne M JM; Gibson, Rachel J RJ; Ball, Imogen A IA; Secombe, Kate R KR; Wain, Taylor J TJ; Logan, Richard M RM; Tuke, Jonathan J; Mead, Kelly R KR; Richards, Alison M AM; Karapetis, Christos S CS; Keefe, Dorothy M DM; Coller, Janet K JK
Influence of Single-Nucleotide Polymorphisms on Clinical Outcomes of Capecitabine-Based Chemotherapy in Colorectal Cancer Patients: A Systematic Review.
Cancers
Cura, Yasmin Y; Pérez-Ramírez, Cristina C; Sánchez-Martín, Almudena A; Membrive-Jimenez, Cristina C; Valverde-Merino, María Isabel MI; González-Flores, Encarnación E; Morales, Alberto Jiménez AJ
Publication Date: 2023-03-17
Variant appearance in text: DPYD: 1601G>A; Ser534Asn; rs1801158
Personalized Medicine in Infant Population with Cancer: Pharmacogenetic Pilot Study of Polymorphisms Related to Toxicity and Response to Chemotherapy.
Cancers
Urtasun, Andrea A; Olivera, Gladys G GG; Sendra, Luis L; Aliño, Salvador F SF; Berlanga, Pablo P; Gargallo, Pablo P; Hervás, David D; Balaguer, Julia J; Juan-Ribelles, Antonio A; Andrés, María Del Mar MDM; Cañete, Adela A; Herrero, María José MJ
Renal impairment and abnormal liver function tests in pre-therapeutic phenotype-based DPD deficiency screening using uracilemia: a comprehensive population-based study in 1138 patients.
Therapeutic Advances In Medical Oncology
Callon, Sidonie S; Brugel, Mathias M; Botsen, Damien D; Royer, Bernard B; Slimano, Florian F; Feliu, Catherine C; Gozalo, Claire C; Konecki, Céline C; Devie, Bruno B; Carlier, Claire C; Daire, Viktor V; Laurés, Nicolas N; Perrier, Marine M; Djerada, Zoubir Z; Bouché, Olivier O
Predicting Dihydropyrimidine Dehydrogenase Deficiency and Related 5-Fluorouracil Toxicity: Opportunities and Challenges of DPYD Exon Sequencing and the Role of Phenotyping Assays.
International Journal Of Molecular Sciences
De Luca, Ottavia O; Salerno, Gerardo G; De Bernardini, Donatella D; Torre, Maria Simona MS; Simmaco, Maurizio M; Lionetto, Luana L; Gentile, Giovanna G; Borro, Marina M
Publication Date: 2022-11-11
Variant appearance in text: DPYD: 1601G>A; S534N; rs1801158
Genome screening, reporting, and genetic counseling for healthy populations.
Human Genetics
Casalino, Selina S; Frangione, Erika E; Chung, Monica M; MacDonald, Georgia G; Chowdhary, Sunakshi S; Mighton, Chloe C; Faghfoury, Hanna H; Bombard, Yvonne Y; Strug, Lisa L; Pugh, Trevor J TJ; Simpson, Jared J; Arnoldo, Saranya S; Aujla, Navneet N; Bearss, Erin E; Binnie, Alexandra A; Borgundvaag, Bjug B; Chertkow, Howard H; Clausen, Marc M; Dagher, Marc M; Devine, Luke L; Di Iorio, David D; Friedman, Steven Marc SM; Fung, Chun Yiu Jordan CYJ; Gingras, Anne-Claude AC; Goneau, Lee W LW; Kaushik, Deepanjali D; Khan, Zeeshan Z; Lapadula, Elisa E; Lu, Tiffany T; Mazzulli, Tony T; McGeer, Allison A; McLeod, Shelley L SL; Morgan, Gregory G; Richardson, David D; Singh, Harpreet H; Stern, Seth S; Taher, Ahmed A; Wong, Iris I; Zarei, Natasha N; Greenfeld, Elena E; Hao, Limin L; Lebo, Matthew M; Lane, William W; Noor, Abdul A; Taher, Jennifer J; Lerner-Ellis, Jordan J
Impact of Guidelines Regarding Dihydropyrimidine Dehydrogenase (DPD) Deficiency Screening Using Uracil-Based Phenotyping on the Reduction of Severe Side Effect of 5-Fluorouracil-Based Chemotherapy: A Propension Score Analysis.
Characterization of ADME Gene Variation in Colombian Population by Exome Sequencing.
Frontiers In Pharmacology
Silgado-Guzmán, Daniel Felipe DF; Angulo-Aguado, Mariana M; Morel, Adrien A; Niño-Orrego, María José MJ; Ruiz-Torres, Daniel-Armando DA; Contreras Bravo, Nora Constanza NC; Restrepo, Carlos Martin CM; Ortega-Recalde, Oscar O; Fonseca-Mendoza, Dora Janeth DJ
Publication Date: 2022
Variant appearance in text: DPYD: 1601G>A; Ser534Asn; rs1801158
Upfront DPYD Genotyping and Toxicity Associated with Fluoropyrimidine-Based Concurrent Chemoradiotherapy for Oropharyngeal Carcinomas: A Work in Progress.
Current Oncology (Toronto, Ont.)
Desilets, Antoine A; McCarvill, William W; Aubin, Francine F; Bahig, Houda H; Ballivy, Olivier O; Charpentier, Danielle D; Filion, Édith É; Jamal, Rahima R; Lambert, Louise L; Nguyen-Tan, Phuc Felix PF; Vadnais, Charles C; Weng, Xiaoduan X; Soulières, Denis D
DPYD Exome, mRNA Expression and Uracil Levels in Early Severe Toxicity to Fluoropyrimidines: An Extreme Phenotype Approach.
Journal Of Personalized Medicine
Villalvazo, Priscila P; Marzal-Alfaro, Belén B; García-Alfonso, Pilar P; Revuelta-Herrero, José Luis JL; Thomas, Fabienne F; López-Tarruella, Sara S; García-González, Xandra X; Calvo, Aitana A; Yakoubi, Malika M; Salvador-Martín, Sara S; López-López, Flora F; Aguilar, Iker I; Sanjurjo-Sáez, María M; Martín, Miguel M; López-Fernández, Luis Andrés LA
Publication Date: 2021-08-13
Variant appearance in text: DPYD: 1601G>A; Ser534Asn; rs1801158
A novel machine learning-based approach for the computational functional assessment of pharmacogenomic variants.
Human Genomics
Pandi, Maria-Theodora MT; Koromina, Maria M; Tsafaridis, Iordanis I; Patsilinakos, Sotirios S; Christoforou, Evangelos E; van der Spek, Peter J PJ; Patrinos, George P GP
Relation between body composition and severe diarrhea in patients treated with preoperative chemoradiation with capecitabine for rectal cancer: a single-centre cohort study.
Bmc Gastroenterology
van Rees, J M JM; Hartman, W W; Nuyttens, J J M E JJME; Oomen-de Hoop, E E; van Vugt, J L A JLA; Rothbarth, J J; Verhoef, C C; van Meerten, E E
Eastern Canadian Gastrointestinal Cancer Consensus Conference 2019.
Current Oncology (Toronto, Ont.)
Gotfrit, Joanna J; Goodwin, Rachel R; Asmis, Timothy T; Hyde, Angela J AJ; Alcindor, Thierry T; Aubin, Francine F; Berry, Scott S; Bossé, Dominick D; Brown, Colin C; Burkes, Ronald R; Burnell, Margot M; Colwell, Bruce B; Corbett, Jessica J; Craswell, Jeff J; Daaboul, Nathalie N; Doherty, Mark M; Fleming, D A Barry DAB; Galvis, Luisa L; Goel, Rakesh R; Harb, Mohammed M; Jeyakumar, Alwin A; Jonker, Derek D; Kennedy, Erin E; Lock, Michael M; Mahmud, Aamer A; McCrea, Patrick H PH; Nair, Vimoj V; Nassabein, Rami R; Nessim, Carolyn C; Ramjeesingh, Ravi R; Raza, Muhammad M; Saliba, Wissam W; Samimi, Satareh S; Singh, Simron S; Snow, Stephanie S; Tehfé, Mustapha M; Thirlwell, Michael M; Valdes, Mario M; Welch, Stephen S; Vickers, Michael M
Implementing Pharmacogenomics Testing: Single Center Experience at Arkansas Children's Hospital.
Journal Of Personalized Medicine
Gill, Pritmohinder S PS; Yu, Feliciano B FB; Porter-Gill, Patricia A PA; Boyanton, Bobby L BL; Allen, Judy C JC; Farrar, Jason E JE; Veerapandiyan, Aravindhan A; Prodhan, Parthak P; Bielamowicz, Kevin J KJ; Sellars, Elizabeth E; Burrow, Andrew A; Kennedy, Joshua L JL; Clothier, Jeffery L JL; Becton, David L DL; Rule, Don D; Schaefer, G Bradley GB
Impact of pretreatment dihydropyrimidine dehydrogenase genotype-guided fluoropyrimidine dosing on chemotherapy associated adverse events.
Clinical And Translational Science
Wigle, Theodore J TJ; Povitz, Brandi L BL; Medwid, Samantha S; Teft, Wendy A WA; Legan, Robin M RM; Lenehan, John J; Nevison, Stephanie S; Panuganty, Veera V; Keller, Denise D; Mailloux, Jaymie J; Siebring, Victoria V; Sarma, Sisira S; Choi, Yun-Hee YH; Welch, Stephen S; Winquist, Eric E; Schwarz, Ute I UI; Kim, Richard B RB
Comparison of 4 Screening Methods for Detecting Fluoropyrimidine Toxicity Risk: Identification of the Most Effective, Cost-Efficient Method to Save Lives.
Dose-Response : A Publication Of International Hormesis Society
Capitain, Olivier O; Seegers, Valérie V; Metges, Jean-Philippe JP; Faroux, Roger R; Stampfli, Claire C; Ferec, Marc M; Budnik, Tamara Matysiak TM; Senellart, Hélène H; Rossi, Valérie V; Blouin, Nadège N; Dauvé, Jonathan J; Campone, Mario M
Population Pharmacokinetic and Pharmacogenetic Analysis of Mitotane in Patients with Adrenocortical Carcinoma: Towards Individualized Dosing.
Clinical Pharmacokinetics
Yin, Anyue A; Ettaieb, Madeleine H T MHT; Swen, Jesse J JJ; van Deun, Liselotte L; Kerkhofs, Thomas M A TMA; van der Straaten, Robert J H M RJHM; Corssmit, Eleonora P M EPM; Gelderblom, Hans H; Kerstens, Michiel N MN; Feelders, Richard A RA; Eekhoff, Marelise M; Timmers, Henri J L M HJLM; D'Avolio, Antonio A; Cusato, Jessica J; Guchelaar, Henk-Jan HJ; Haak, Harm R HR; Moes, Dirk Jan A R DJAR
Publication Date: 2021-01
Variant appearance in text: DPYD: 1601G>A; S534N; rs1801158
Prediction of exposure-driven myelotoxicity of continuous infusion 5-fluorouracil by a semi-physiological pharmacokinetic-pharmacodynamic model in gastrointestinal cancer patients.
Cancer Chemotherapy And Pharmacology
Arshad, Usman U; Ploylearmsaeng, Su-Arpa SA; Karlsson, Mats O MO; Doroshyenko, Oxana O; Langer, Dorothee D; Schömig, Edgar E; Kunze, Sabine S; Güner, Semih A SA; Skripnichenko, Roman R; Ullah, Sami S; Jaehde, Ulrich U; Fuhr, Uwe U; Jetter, Alexander A; Taubert, Max M
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction of DPYD and fluoropyrimidines.
European Journal Of Human Genetics : Ejhg
Lunenburg, Carin A T C CATC; van der Wouden, Cathelijne H CH; Nijenhuis, Marga M; Crommentuijn-van Rhenen, Mandy H MH; de Boer-Veger, Nienke J NJ; Buunk, Anne Marie AM; Houwink, Elisa J F EJF; Mulder, Hans H; Rongen, Gerard A GA; van Schaik, Ron H N RHN; van der Weide, Jan J; Wilffert, Bob B; Deneer, Vera H M VHM; Swen, Jesse J JJ; Guchelaar, Henk-Jan HJ