Publications:

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Assessing variants of uncertain significance implicated in hearing loss using a comprehensive deafness proteome.

Human Genetics

Tollefson, Mallory R MR; Gogal, Rose A RA; Weaver, A Monique AM; Schaefer, Amanda M AM; Marini, Robert J RJ; Azaiez, Hela H; Kolbe, Diana L DL; Wang, Donghong D; Weaver, Amy E AE; Casavant, Thomas L TL; Braun, Terry A TA; Smith, Richard J H RJH; Schnieders, Michael J MJ

Publication Date: 2023-04-22

Variant appearance in text: FGFR2: 1647T>A; Asn549Lys

PubMed Link: 37086329

Variant Present in the following documents:

• 439_2023_2559_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Integrative pan-cancer genomic and transcriptomic analyses of refractory metastatic cancer.

Cancer Discovery

Pradat, Yoann Y; Viot, Julien J; Yurchenko, Andrey A AA; Gunbin, Konstantin K; Cerbone, Luigi L; Deloger, Marc M; Grisay, Guillaume G; Verlingue, Loic L; Scott, Veronique V; Padioleau, Ismael I; Panunzi, Leonardo L; Michiels, Stefan S; Hollebecque, Antoine A; Jules-Clement, Gerome G; Mezquita, Laura L; Laine, Antoine A; Loriot, Yohann Y; Besse, Benjamin B; Friboulet, Luc L; Andre, Fabrice F; Cournede, Paul-Henry PH; Gautheret, Daniel D; Nikolaev, Sergey I SI

Publication Date: 2023-03-02

Variant appearance in text: FGFR2: Asn549Lys; rs121913476

PubMed Link: 36862804

Variant Present in the following documents:

• cd-22-0966_supplementary_tables_s1-s11_suppst1.xlsx, sheet 6

View BVdb publication page

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Characterization of the cholangiocarcinoma drug pemigatinib against FGFR gatekeeper mutants.

Communications Chemistry

Lin, Qianmeng Q; Chen, Xiaojuan X; Qu, Lingzhi L; Guo, Ming M; Wei, Hudie H; Dai, Shuyan S; Jiang, Longying L; Chen, Yongheng Y

Publication Date: 2022-08-22

Variant appearance in text: FGFR2: N549K

PubMed Link: 36698015

Variant Present in the following documents:

• Main text
• 42004_2022_Article_718.pdf

View BVdb publication page

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Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer.

Nature Communications

Sivakumar, Smruthy S; Jin, Dexter X DX; Tukachinsky, Hanna H; Murugesan, Karthikeyan K; McGregor, Kimberly K; Danziger, Natalie N; Pavlick, Dean D; Gjoerup, Ole O; Ross, Jeffrey S JS; Harmon, Robert R; Chung, Jon J; Decker, Brennan B; Dennis, Lucas L; Frampton, Garrett M GM; Molinero, Luciana L; Oesterreich, Steffi S; Venstrom, Jeffrey M JM; Oxnard, Geoffrey R GR; Hegde, Priti S PS; Sokol, Ethan S ES

Publication Date: 2022-12-05

Variant appearance in text: FGFR2: N549K

PubMed Link: 36470901

Variant Present in the following documents:

• 41467_2022_35245_MOESM4_ESM.xlsx, sheet 17

View BVdb publication page

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Targeting the FGF/FGFR axis and its co-alteration allies.

Esmo Open

Uehara, Y Y; Ikeda, S S; Kim, K H KH; Lim, H J HJ; Adashek, J J JJ; Persha, H E HE; Okamura, R R; Lee, S S; Sicklick, J K JK; Kato, S S; Kurzrock, R R

Publication Date: 2022-11-28

Variant appearance in text: FGFR2: N549K

PubMed Link: 36455506

Variant Present in the following documents:

• Main text
• mmc1.pdf

View BVdb publication page

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Molecular diagnosis of pancreatobiliary tract cancer by detecting mutations and methylation changes in bile samples.

Eclinicalmedicine

He, Shun S; Zeng, Fanxin F; Yin, Huihui H; Wang, Pei P; Bai, Yinlei Y; Song, Qianqian Q; Chu, Jiangtao J; Huang, Zhen Z; Liu, Yumeng Y; Liu, Hong H; Chen, Qichen Q; Liu, Li L; Zhou, Jun J; Hu, Hanjie H; Li, Xingchen X; Li, Tengyan T; Wang, Guiqi G; Cai, Jianqiang J; Jiao, Yuchen Y; Zhao, Hong H

Publication Date: 2023-01

Variant appearance in text: FGFR2: 1647T>A; Asn549Lys

PubMed Link: 36425869

Variant Present in the following documents:

• mmc1.xlsx, sheet 4

View BVdb publication page

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Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications

Boström, Martin M; Larsson, Erik E

Publication Date: 2022-11-17

Variant appearance in text: FGFR2: N549K

PubMed Link: 36396655

Variant Present in the following documents:

• 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1

View BVdb publication page

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Predictive mutation signature of immunotherapy benefits in NSCLC based on machine learning algorithms.

Frontiers In Immunology

Liu, Zhichao Z; Lin, Guo G; Yan, Zeping Z; Li, Linduo L; Wu, Xingchen X; Shi, Jingrong J; He, Jianxing J; Zhao, Lei L; Liang, Hengrui H; Wang, Wei W

Publication Date: 2022

Variant appearance in text: FGFR2: 1647T>A; N549K

PubMed Link: 36238300

Variant Present in the following documents:

• Table_1.xlsx, sheet 4

View BVdb publication page

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Targeting FGFR2 Positive Gastroesophageal Cancer: Current and Clinical Developments.

Oncotargets And Therapy

Gordon, Anderley A; Johnston, Edwina E; Lau, David K DK; Starling, Naureen N

Publication Date: 2022

Variant appearance in text: FGFR2: N549K

PubMed Link: 36238135

Variant Present in the following documents:

• Main text
• ott-15-1183.pdf

View BVdb publication page

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Human papillomavirus integration perspective in small cell cervical carcinoma.

Nature Communications

Wang, Xiaoli X; Jia, Wenlong W; Wang, Mengyao M; Liu, Jihong J; Zhou, Xianrong X; Liang, Zhiqing Z; Zhang, Qinghua Q; Long, Sixiang S; Quzhen, Suolang S; Li, Xiangchun X; Tian, Qiang Q; Li, Xiong X; Sun, Haiying H; Zhao, Caili C; Meng, Silu S; Ning, Ruoqi R; Xi, Ling L; Wang, Lin L; Zhou, Shasha S; Zhang, Jianwei J; Wu, Li L; Chen, Yile Y; Liu, Aijun A; Ma, Yaqi Y; Zhao, Xia X; Cheng, Xiaodong X; Zhang, Qing Q; Han, Xiaobing X; Pan, Huaxiong H; Zhang, Yuan Y; Cao, Lili L; Wang, Yiqin Y; Ling, Shaoping S; Cao, Lihua L; Xing, Hui H; Xu, Chang C; Sui, Long L; Wang, Shixuan S; Zhou, Jianfeng J; Kong, Beihua B; Xie, Xing X; Chen, Gang G; Li, Shuaicheng S; Ma, Ding D; Li, Shuang S

Publication Date: 2022-10-10

Variant appearance in text: rs121913476

PubMed Link: 36216793

Variant Present in the following documents:

• 41467_2022_33359_MOESM21_ESM.xlsx, sheet 1

View BVdb publication page

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Small-molecule inhibitors, immune checkpoint inhibitors, and more: FDA-approved novel therapeutic drugs for solid tumors from 1991 to 2021.

Journal Of Hematology & Oncology

Wu, Qing Q; Qian, Wei W; Sun, Xiaoli X; Jiang, Shaojie S

Publication Date: 2022-10-08

Variant appearance in text: FGFR2: N549K

PubMed Link: 36209184

Variant Present in the following documents:

• Main text
• 13045_2022_Article_1362.pdf

View BVdb publication page

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Comparative kinase and cancer cell panel profiling of kinase inhibitors approved for clinical use from 2018 to 2020.

Frontiers In Oncology

Kooijman, Jeffrey J JJ; van Riel, Wilhelmina E WE; Dylus, Jelle J; Prinsen, Martine B W MBW; Grobben, Yvonne Y; de Bitter, Tessa J J TJJ; van Doornmalen, Antoon M AM; Melis, Janneke J T M JJTM; Uitdehaag, Joost C M JCM; Narumi, Yugo Y; Kawase, Yusuke Y; de Roos, Jeroen A D M JADM; Willemsen-Seegers, Nicole N; Zaman, Guido J R GJR

Publication Date: 2022

Variant appearance in text: FGFR2: N549K

PubMed Link: 36185300

Variant Present in the following documents:

• Main text
• fonc-12-953013.pdf

View BVdb publication page

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EPHA5 mutation was associated with adverse outcome of atezolizumab treatment in late-stage non-small cell lung cancers.

Bmc Pulmonary Medicine

Li, Zhenxiang Z; Zhou, Qing Q; Wang, Qi Q; Wang, Haiyong H; Yue, Weiming W

Publication Date: 2022-09-19

Variant appearance in text: FGFR2: 1647T>A; N549K

PubMed Link: 36123678

Variant Present in the following documents:

• 12890_2022_2161_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Protein tyrosine kinase inhibitor resistance in malignant tumors: molecular mechanisms and future perspective.

Signal Transduction And Targeted Therapy

Yang, Yang Y; Li, Shuo S; Wang, Yujiao Y; Zhao, Yi Y; Li, Qiu Q

Publication Date: 2022-09-17

Variant appearance in text: FGFR2: N549K

PubMed Link: 36115852

Variant Present in the following documents:

• Main text
• 41392_2022_Article_1168.pdf

View BVdb publication page

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Prognostic value of baseline genetic features and newly identified TP53 mutations in advanced breast cancer.

Molecular Oncology

Zhang, Lanxin L; Sun, Siwen S; Zhao, Xiaotian X; Liu, Jingwen J; Xu, Yang Y; Xu, Lingzhi L; Song, Chen C; Li, Na N; Yu, Jing J; Zhao, Shanshan S; Yu, Peiyao P; Fang, Fengqi F; Xie, Jiping J; Ji, Xuening X; Yu, Ruoying R; Ou, Qiuxiang Q; Zhao, Zuowei Z; Li, Man M

Publication Date: 2022-10

Variant appearance in text: FGFR2: 1647T>A; N549K

PubMed Link: 35971249

Variant Present in the following documents:

• MOL2-16-3689-s005.xlsx, sheet 1

View BVdb publication page

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Truncated FGFR2 is a clinically actionable oncogene in multiple cancers.

Nature

Zingg, Daniel D; Bhin, Jinhyuk J; Yemelyanenko, Julia J; Kas, Sjors M SM; Rolfs, Frank F; Lutz, Catrin C; Lee, Jessica K JK; Klarenbeek, Sjoerd S; Silverman, Ian M IM; Annunziato, Stefano S; Chan, Chang S CS; Piersma, Sander R SR; Eijkman, Timo T; Badoux, Madelon M; Gogola, Ewa E; Siteur, Bjørn B; Sprengers, Justin J; de Klein, Bim B; de Goeij-de Haas, Richard R RR; Riedlinger, Gregory M GM; Ke, Hua H; Madison, Russell R; Drenth, Anne Paulien AP; van der Burg, Eline E; Schut, Eva E; Henneman, Linda L; van Miltenburg, Martine H MH; Proost, Natalie N; Zhen, Huiling H; Wientjens, Ellen E; de Bruijn, Roebi R; de Ruiter, Julian R JR; Boon, Ute U; de Korte-Grimmerink, Renske R; van Gerwen, Bastiaan B; Féliz, Luis L; Abou-Alfa, Ghassan K GK; Ross, Jeffrey S JS; van de Ven, Marieke M; Rottenberg, Sven S; Cuppen, Edwin E; Chessex, Anne Vaslin AV; Ali, Siraj M SM; Burn, Timothy C TC; Jimenez, Connie R CR; Ganesan, Shridar S; Wessels, Lodewyk F A LFA; Jonkers, Jos J

Publication Date: 2022-08

Variant appearance in text: FGFR2: N549K

PubMed Link: 35948633

Variant Present in the following documents:

• Main text

View BVdb publication page

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A multicenter investigator-initiated Phase 2 trial of E7090 in patients with advanced or recurrent solid tumor with fibroblast growth factor receptor (FGFR) gene alteration: FORTUNE trial.

Bmc Cancer

Chiba, Yohei Y; Sudo, Kazuki K; Kojima, Yuki Y; Okuma, Hitomi H; Kohsaka, Shinji S; Machida, Ryunosuke R; Ichimura, Masahiko M; Anjo, Kenta K; Kurishita, Kazumi K; Okita, Natsuko N; Nakamura, Kenichi K; Kinoshita, Ichiro I; Takahashi, Masanobu M; Matsubara, Junichi J; Kusaba, Hitoshi H; Yonemori, Kan K; Takahashi, Masamichi M

Publication Date: 2022-08-09

Variant appearance in text: FGFR2: N549K

PubMed Link: 35945547

Variant Present in the following documents:

• Main text
• 12885_2022_Article_9949.pdf

View BVdb publication page

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Genomic Landscape of RTK/RAS Pathway and Tumor Immune Infiltration as Prognostic Indicator of Lung Adenocarcinoma.

Frontiers In Oncology

Yin, Xiang-Qian XQ; Yin, Xue-Hui XH; Yu, Ya-Qin YQ; Xu, Lang L; Zhang, Mao M

Publication Date: 2022

Variant appearance in text: N/A

PubMed Link: 35936718

Variant Present in the following documents:

View BVdb publication page

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Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.

Nature Communications

Havugimana, Pierre C PC; Goel, Raghuveera Kumar RK; Phanse, Sadhna S; Youssef, Ahmed A; Padhorny, Dzmitry D; Kotelnikov, Sergei S; Kozakov, Dima D; Emili, Andrew A

Publication Date: 2022-07-13

Variant appearance in text: FGFR2: 1647T>A; N549K; rs121913476

PubMed Link: 35831314

Variant Present in the following documents:

• 41467_2022_31809_MOESM8_ESM.xlsx, sheet 3

View BVdb publication page

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Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.

Nature Communications

Gounder, Mrinal M MM; Agaram, Narasimhan P NP; Trabucco, Sally E SE; Robinson, Victoria V; Ferraro, Richard A RA; Millis, Sherri Z SZ; Krishnan, Anita A; Lee, Jessica J; Attia, Steven S; Abida, Wassim W; Drilon, Alexander A; Chi, Ping P; Angelo, Sandra P D' SP; Dickson, Mark A MA; Keohan, Mary Lou ML; Kelly, Ciara M CM; Agulnik, Mark M; Chawla, Sant P SP; Choy, Edwin E; Chugh, Rashmi R; Meyer, Christian F CF; Myer, Parvathi A PA; Moore, Jessica L JL; Okimoto, Ross A RA; Pollock, Raphael E RE; Ravi, Vinod V; Singh, Arun S AS; Somaiah, Neeta N; Wagner, Andrew J AJ; Healey, John H JH; Frampton, Garrett M GM; Venstrom, Jeffrey M JM; Ross, Jeffrey S JS; Ladanyi, Marc M; Singer, Samuel S; Brennan, Murray F MF; Schwartz, Gary K GK; Lazar, Alexander J AJ; Thomas, David M DM; Maki, Robert G RG; Tap, William D WD; Ali, Siraj M SM; Jin, Dexter X DX

Publication Date: 2022-06-15

Variant appearance in text: FGFR2: N549K

PubMed Link: 35705558

Variant Present in the following documents:

• 41467_2022_30496_MOESM2_ESM.xls, sheet 1

View BVdb publication page

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Combined exome and transcriptome sequencing of non-muscle-invasive bladder cancer: associations between genomic changes, expression subtypes, and clinical outcomes.

Genome Medicine

Goel, Anshita A; Ward, Douglas G DG; Noyvert, Boris B; Yu, Minghao M; Gordon, Naheema S NS; Abbotts, Ben B; Colbourne, John K JK; Kissane, Stephen S; James, Nicholas D ND; Zeegers, Maurice P MP; Cheng, Kar Keung KK; Cazier, Jean-Baptiste JB; Whalley, Celina M CM; Beggs, Andrew D AD; Palles, Claire C; Arnold, Roland R; Bryan, Richard T RT

Publication Date: 2022-06-03

Variant appearance in text: rs121913476

PubMed Link: 35655252

Variant Present in the following documents:

• 13073_2022_1056_MOESM1_ESM.xlsx, sheet 3

View BVdb publication page

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Precision Medicine Targeting FGFR2 Genomic Alterations in Advanced Cholangiocarcinoma: Current State and Future Perspectives.

Frontiers In Oncology

Zugman, Miguel M; Botrus, Gehan G; Pestana, Roberto Carmagnani RC; Uson Junior, Pedro Luiz Serrano PLS

Publication Date: 2022

Variant appearance in text: FGFR2: N549K

PubMed Link: 35444941

Variant Present in the following documents:

• Main text
• fonc-12-860453.pdf

View BVdb publication page

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Molecular landscape of TP53 mutations in breast cancer and their utility for predicting the response to HER-targeted therapy in HER2 amplification-positive and HER2 mutation-positive amplification-negative patients.

Cancer Medicine

Liu, Binliang B; Yi, Zongbi Z; Guan, Yanfang Y; Ouyang, Quchang Q; Li, Chunxiao C; Guan, Xiuwen X; Lv, Dan D; Li, Lixi L; Zhai, Jingtong J; Qian, Haili H; Xu, Binghe B; Ma, Fei F; Zeng, Yixin Y

Publication Date: 2022-07

Variant appearance in text: FGFR2: 1647T>A; N549K

PubMed Link: 35393784

Variant Present in the following documents:

• CAM4-11-2767-s001.xlsx, sheet 1

View BVdb publication page

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FGFR2/3 genomic alterations and response to Enfortumab Vedotin in metastatic urothelial carcinoma.

Bjui Compass

Adib, Elio E; El Zarif, Talal T; Jain, Rohit K RK; Skelton, William P WP; Freeman, Dory D; Curran, Catherine C; Akl, Elie E; Nassar, Amin H AH; Ravi, Praful P; Mantia, Charlene C; Kwiatkowski, David J DJ; Choueiri, Toni K TK; Sonpavde, Guru G

Publication Date: 2022-03

Variant appearance in text: FGFR2: N549K

PubMed Link: 35224552

Variant Present in the following documents:

• Main text
• BCO2-3-169.pdf

View BVdb publication page

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The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer

Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J

Publication Date: 2022-02

Variant appearance in text: FGFR2: Asn549Lys

PubMed Link: 35221333

Variant Present in the following documents:

• 43018_2022_332_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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Fibroblast growth factor receptor signalling dysregulation and targeting in breast cancer.

Open Biology

Francavilla, Chiara C; O'Brien, Ciara S CS

Publication Date: 2022-02

Variant appearance in text: FGFR2: N549K

PubMed Link: 35193394

Variant Present in the following documents:

• Main text
• rsob.210373.pdf

View BVdb publication page

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Genomic landscape of advanced endometrial cancer analyzed by targeted next-generation sequencing and the cancer genome atlas (TCGA) dataset.

Journal Of Gynecologic Oncology

Hong, Jin Hwa JH; Cho, Hyun Woong HW; Ouh, Yung-Taek YT; Lee, Jae Kwan JK; Chun, Yikyeong Y; Gim, Jeong-An JA

Publication Date: 2022-05

Variant appearance in text: FGFR2: 1647T>A; N549K

PubMed Link: 35128859

Variant Present in the following documents:

• jgo-33-e29-s002.xls, sheet 1

View BVdb publication page

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Investigation of PALB2 Mutation and Correlation With Immunotherapy Biomarker in Chinese Non-Small Cell Lung Cancer Patients.

Frontiers In Oncology

Zhang, Jiexia J; Tang, Shuangfeng S; Zhang, Chunning C; Li, Mingyao M; Zheng, Yating Y; Hu, Xue X; Huang, Mengli M; Cheng, Xiangyang X

Publication Date: 2021

Variant appearance in text: FGFR2: 1647T>A; N549K

PubMed Link: 35087742

Variant Present in the following documents:

• Table_1.xlsx, sheet 1
• Table_2.xlsx, sheet 1

View BVdb publication page

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KLF3 and PAX6 are candidate driver genes in late-stage, MSI-hypermutated endometrioid endometrial carcinomas.

Plos One

Rudd, Meghan L ML; Hansen, Nancy F NF; Zhang, Xiaolu X; Urick, Mary Ellen ME; Zhang, Suiyuan S; Merino, Maria J MJ; , ; Mullikin, James C JC; Brody, Lawrence C LC; Bell, Daphne W DW

Publication Date: 2022

Variant appearance in text: rs121913476

PubMed Link: 35081118

Variant Present in the following documents:

• pone.0251286.s005.xlsx, sheet 6
• pone.0251286.s005.xlsx, sheet 8

View BVdb publication page

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KLF3 and PAX6 are candidate driver genes in late-stage, MSI-hypermutated endometrioid endometrial carcinomas.

Plos One

Rudd, Meghan L ML; Hansen, Nancy F NF; Zhang, Xiaolu X; Urick, Mary Ellen ME; Zhang, Suiyuan S; Merino, Maria J MJ; , ; Mullikin, James C JC; Brody, Lawrence C LC; Bell, Daphne W DW

Publication Date: 2022

Variant appearance in text: rs121913476

PubMed Link: 35081118

Variant Present in the following documents:

• pone.0251286.s005.xlsx, sheet 6
• pone.0251286.s005.xlsx, sheet 8

View BVdb publication page

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Genetic Profile of Adenomatoid Odontogenic Tumor and Ameloblastoma. A Systematic Review.

Frontiers In Oral Health

Marín, Constanza C; Niklander, Sven E SE; Martínez-Flores, René R

Publication Date: 2021

Variant appearance in text: FGFR2: N549K

PubMed Link: 35048068

Variant Present in the following documents:

• Main text

View BVdb publication page

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The Molecular Pathology of Odontogenic Tumors: Expanding the Spectrum of MAPK Pathway Driven Tumors.

Frontiers In Oral Health

Guimarães, Letícia Martins LM; Coura, Bruna Pizziolo BP; Gomez, Ricardo Santiago RS; Gomes, Carolina Cavalieri CC

Publication Date: 2021

Variant appearance in text: FGFR2: N549K

PubMed Link: 35048058

Variant Present in the following documents:

• Main text
• froh-02-740788.pdf

View BVdb publication page

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Identification of Immune-Related Gene Signatures in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma.

Frontiers In Immunology

Li, Na N; Wang, Jiahong J; Zhan, Xianquan X

Publication Date: 2021

Variant appearance in text: FGFR2: 1647T>A; Asn549Lys

PubMed Link: 34887858

Variant Present in the following documents:

• Table_3.xlsx, sheet 1

View BVdb publication page

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Serial monitoring of genomic alterations in circulating tumor cells of ER-positive/HER2-negative advanced breast cancer: feasibility of precision oncology biomarker detection.

Molecular Oncology

Cani, Andi K AK; Dolce, Emily M EM; Darga, Elizabeth P EP; Hu, Kevin K; Liu, Chia-Jen CJ; Pierce, Jackie J; Bradbury, Kieran K; Kilgour, Elaine E; Aung, Kimberly K; Schiavon, Gaia G; Carroll, Danielle D; Carr, T Hedley TH; Klinowska, Teresa T; Lindemann, Justin J; Marshall, Gayle G; Rowlands, Vicky V; Harrington, Elizabeth A EA; Barrett, J Carl JC; Sathiyayogan, Nitharsan N; Morrow, Christopher C; Sero, Valeria V; Armstrong, Anne C AC; Baird, Richard R; Hamilton, Erika E; Im, Seock-Ah SA; Jhaveri, Komal K; Patel, Manish R MR; Dive, Caroline C; Tomlins, Scott A SA; Udager, Aaron M AM; Hayes, Daniel F DF; Paoletti, Costanza C

Publication Date: 2022-05

Variant appearance in text: FGFR2: N549K

PubMed Link: 34866317

Variant Present in the following documents:

• MOL2-16-1969.pdf
• MOL2-16-1969-s001.pdf

View BVdb publication page

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Anti-cancer effects of 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one derivatives on hepatocellular carcinoma harboring FGFR4 activation.

Neoplasia (New York, N.Y.)

Nam, Yunju Y; Shin, Injae I; Kim, Younghoon Y; Ryu, SeongShick S; Kim, Namdoo N; Ju, Eunhye E; Sim, Taebo T

Publication Date: 2022-01

Variant appearance in text: FGFR2: N549K

PubMed Link: 34864570

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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Anti-cancer effects of 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one derivatives on hepatocellular carcinoma harboring FGFR4 activation.

Neoplasia (New York, N.Y.)

Nam, Yunju Y; Shin, Injae I; Kim, Younghoon Y; Ryu, SeongShick S; Kim, Namdoo N; Ju, Eunhye E; Sim, Taebo T

Publication Date: 2021-12-02

Variant appearance in text: FGFR2: N549K

PubMed Link: 34864570

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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Redefine Hyperprogressive Disease During Treatment With Immune-Checkpoint Inhibitors in Patients With Gastrointestinal Cancer.

Frontiers In Oncology

Wang, Zhenghang Z; Liu, Chang C; Bai, Yuezong Y; Zhao, Xiaochen X; Cui, Longgang L; Peng, Zhi Z; Zhang, Xiaotian X; Wang, Xicheng X; Zhao, Zhengyi Z; Li, Jian J; Shen, Lin L

Publication Date: 2021

Variant appearance in text: FGFR2: 1647T>A; N549K

PubMed Link: 34858840

Variant Present in the following documents:

• Table_2.xlsx, sheet 1

View BVdb publication page

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Rearrangement-mediated cis-regulatory alterations in advanced patient tumors reveal interactions with therapy.

Cell Reports

Zhang, Yiqun Y; Chen, Fengju F; Pleasance, Erin E; Williamson, Laura L; Grisdale, Cameron J CJ; Titmuss, Emma E; Laskin, Janessa J; Jones, Steven J M SJM; Cortes-Ciriano, Isidro I; Marra, Marco A MA; Creighton, Chad J CJ

Publication Date: 2021-11-16

Variant appearance in text: FGFR2: 1647T>A; Asn549Lys

PubMed Link: 34788622

Variant Present in the following documents:

• NIHMS1757901-supplement-2.xlsx, sheet 3

View BVdb publication page

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: FGFR2: N549K

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

View BVdb publication page

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Comprehensive identification of FGFR1-4 alterations in 5 557 Chinese patients with solid tumors by next-generation sequencing.

American Journal Of Cancer Research

Gu, Weiquan W; Yang, Jie J; Wang, Yong Y; Xu, Jun J; Wang, Xiaoxuan X; Du, Furong F; Hu, Xiangjing X; Guo, Hao H; Song, Chao C; Tao, Rongjie R; Zhang, Xuchao X

Publication Date: 2021

Variant appearance in text: FGFR2: N549K

PubMed Link: 34522456

Variant Present in the following documents:

• Main text

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Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer.

Npj Precision Oncology

Nakamura, Ikuko Takeda IT; Kohsaka, Shinji S; Ikegami, Masachika M; Ikeuchi, Hiroshi H; Ueno, Toshihide T; Li, Kunhua K; Beyett, Tyler S TS; Koyama, Takafumi T; Shimizu, Toshio T; Yamamoto, Noboru N; Takahashi, Fumiyuki F; Takahashi, Kazuhisa K; Eck, Michael J MJ; Mano, Hiroyuki H

Publication Date: 2021-07-16

Variant appearance in text: FGFR2: N549K

PubMed Link: 34272467

Variant Present in the following documents:

• Main text
• 41698_2021_Article_204.pdf
• 41698_2021_204_MOESM5_ESM.xlsx, sheet 1

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Novel Pharmacological Options in the Treatment of Cholangiocarcinoma: Mechanisms of Resistance.

Cancers

Marin, Jose J G JJG; Sanchon-Sanchez, Paula P; Cives-Losada, Candela C; Del Carmen, Sofía S; González-Santiago, Jesús M JM; Monte, Maria J MJ; Macias, Rocio I R RIR

Publication Date: 2021-05-13

Variant appearance in text: FGFR2: N549K

PubMed Link: 34068398

Variant Present in the following documents:

• Main text

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Cell-free DNA captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer.

Nature Communications

Pereira, Bernard B; Chen, Christopher T CT; Goyal, Lipika L; Walmsley, Charlotte C; Pinto, Christopher J CJ; Baiev, Islam I; Allen, Read R; Henderson, Laura L; Saha, Supriya S; Reyes, Stephanie S; Taylor, Martin S MS; Fitzgerald, Donna M DM; Broudo, Maida Williams MW; Sahu, Avinash A; Gao, Xin X; Winckler, Wendy W; Brannon, A Rose AR; Engelman, Jeffrey A JA; Leary, Rebecca R; Stone, James R JR; Campbell, Catarina D CD; Juric, Dejan D

Publication Date: 2021-05-27

Variant appearance in text: FGFR2: N549K

PubMed Link: 34045463

Variant Present in the following documents:

• Main text
• 41467_2021_Article_23394.pdf
• 41467_2021_23394_MOESM4_ESM.xlsx, sheet 1

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Sensitivity, specificity, and accuracy of a liquid biopsy approach utilizing molecular amplification pools.

Scientific Reports

Garcia, Jessica J; Kamps-Hughes, Nick N; Geiguer, Florence F; Couraud, Sébastien S; Sarver, Brice B; Payen, Léa L; Ionescu-Zanetti, Cristian C

Publication Date: 2021-05-24

Variant appearance in text: FGFR2: 1647T>A; N549K

PubMed Link: 34031447

Variant Present in the following documents:

• 41598_2021_89592_MOESM1_ESM.xlsx, sheet 3

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A Pancancer Analysis of the Expression Landscape and Clinical Relevance of Fibroblast Growth Factor Receptor 2 in Human Cancers.

Frontiers In Oncology

Li, Juanni J; Hu, Kuan K; Huang, Jinzhou J; Zhou, Lei L; Yan, Yuanliang Y; Xu, Zhijie Z

Publication Date: 2021

Variant appearance in text: FGFR2: N549K

PubMed Link: 33968743

Variant Present in the following documents:

• Main text

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Comprehensive omic characterization of breast cancer in Mexican-Hispanic women.

Nature Communications

Romero-Cordoba, Sandra L SL; Salido-Guadarrama, Ivan I; Rebollar-Vega, Rosa R; Bautista-Piña, Veronica V; Dominguez-Reyes, Carlos C; Tenorio-Torres, Alberto A; Villegas-Carlos, Felipe F; Fernández-López, Juan C JC; Uribe-Figueroa, Laura L; Alfaro-Ruiz, Luis L; Hidalgo-Miranda, Alfredo A

Publication Date: 2021-04-14

Variant appearance in text: FGFR2: N549K

PubMed Link: 33854067

Variant Present in the following documents:

• 41467_2021_22478_MOESM8_ESM.xlsx, sheet 7

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Molecular characterization of lung squamous cell carcinoma tumors reveals therapeutically relevant alterations.

Oncotarget

Joshi, Asim A; Mishra, Rohit R; Desai, Sanket S; Chandrani, Pratik P; Kore, Hitesh H; Sunder, Roma R; Hait, Supriya S; Iyer, Prajish P; Trivedi, Vaishakhi V; Choughule, Anuradha A; Noronha, Vanita V; Joshi, Amit A; Patil, Vijay V; Menon, Nandini N; Kumar, Rajiv R; Prabhash, Kumar K; Dutt, Amit A

Publication Date: 2021-03-16

Variant appearance in text: FGFR2: N549K

PubMed Link: 33796225

Variant Present in the following documents:

• oncotarget-12-578-s003.xlsx, sheet 1

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Targeting FGFR in non-small cell lung cancer: implications from the landscape of clinically actionable aberrations of FGFR kinases.

Cancer Biology & Medicine

Zhou, Zhen Z; Liu, Zichuan Z; Ou, Qiuxiang Q; Wu, Xue X; Wang, Xiaonan X; Shao, Yang Y; Liu, Hongyan H; Yang, Yu Y

Publication Date: 2021-03-12

Variant appearance in text: FGFR2: N549K

PubMed Link: 33710807

Variant Present in the following documents:

• cbm-18-490-s001.pdf

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Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer

Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA

Publication Date: 2021-05

Variant appearance in text: FGFR2: 1647T>A; N549K

PubMed Link: 33704917

Variant Present in the following documents:

• TCA-12-1271-s003.xls, sheet 1

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Inhibition of FGF-FGFR and VEGF-VEGFR signalling in cancer treatment.

Cell Proliferation

Liu, Guihong G; Chen, Tao T; Ding, Zhenyu Z; Wang, Yang Y; Wei, Yuquan Y; Wei, Xiawei X

Publication Date: 2021-04

Variant appearance in text: FGFR2: N549K

PubMed Link: 33655556

Variant Present in the following documents:

• Main text

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Assessment of Clinical Benefit of Integrative Genomic Profiling in Advanced Solid Tumors.

Jama Oncology

Cobain, Erin F EF; Wu, Yi-Mi YM; Vats, Pankaj P; Chugh, Rashmi R; Worden, Francis F; Smith, David C DC; Schuetze, Scott M SM; Zalupski, Mark M MM; Sahai, Vaibhav V; Alva, Ajjai A; Schott, Anne F AF; Caram, Megan E V MEV; Hayes, Daniel F DF; Stoffel, Elena M EM; Jacobs, Michelle F MF; Kumar-Sinha, Chandan C; Cao, Xuhong X; Wang, Rui R; Lucas, David D; Ning, Yu Y; Rabban, Erica E; Bell, Janice J; Camelo-Piragua, Sandra S; Udager, Aaron M AM; Cieslik, Marcin M; Lonigro, Robert J RJ; Kunju, Lakshmi P LP; Robinson, Dan R DR; Talpaz, Moshe M; Chinnaiyan, Arul M AM

Publication Date: 2021-04-01

Variant appearance in text: FGFR2: N549K

PubMed Link: 33630025

Variant Present in the following documents:

• jamaoncol-e207987-s004.xlsx, sheet 2

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Genomic profiling of Chinese patients with urothelial carcinoma.

Bmc Cancer

Yang, Bo B; Zhao, Xiao X; Wan, Chong C; Ma, Xin X; Niu, Shaoxi S; Guo, Aitao A; Wang, Jieli J; Wang, Jinliang J; Sun, Decong D; Jiao, Shunchang S

Publication Date: 2021-02-15

Variant appearance in text: FGFR2: Asn549Lys

PubMed Link: 33588785

Variant Present in the following documents:

• Main text
• 12885_2021_Article_7829.pdf

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Targeting Aberrant FGFR Signaling to Overcome CDK4/6 Inhibitor Resistance in Breast Cancer.

Cells

Sobhani, Navid N; Fassl, Anne A; Mondani, Giuseppina G; Generali, Daniele D; Otto, Tobias T

Publication Date: 2021-02-01

Variant appearance in text: FGFR2: N549K

PubMed Link: 33535617

Variant Present in the following documents:

• Main text
• cells-10-00293.pdf

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Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications

Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q

Publication Date: 2021-01-04

Variant appearance in text: FGFR2: 1647T>A; N549K

PubMed Link: 33397889

Variant Present in the following documents:

• 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1

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Predictive Biomarkers for Immune Checkpoint Inhibitors in Metastatic Breast Cancer.

Cancer Medicine

Sivapiragasam, Abirami A; Ashok Kumar, Prashanth P; Sokol, Ethan S ES; Albacker, Lee A LA; Killian, Jonathan K JK; Ramkissoon, Shakti H SH; Huang, Richard S P RSP; Severson, Eric A EA; Brown, Charlotte A CA; Danziger, Natalie N; McGregor, Kimberly K; Ross, Jeffrey S JS

Publication Date: 2021-01

Variant appearance in text: FGFR2: N549K

PubMed Link: 33314633

Variant Present in the following documents:

• CAM4-10-53-s003.xlsx, sheet 1
• CAM4-10-53-s004.xlsx, sheet 1
• CAM4-10-53-s002.xlsx, sheet 1

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Fibroblast growth factor receptors in cancer: genetic alterations, diagnostics, therapeutic targets and mechanisms of resistance.

British Journal Of Cancer

Krook, Melanie A MA; Reeser, Julie W JW; Ernst, Gabrielle G; Barker, Hannah H; Wilberding, Max M; Li, Gary G; Chen, Hui-Zi HZ; Roychowdhury, Sameek S

Publication Date: 2021-03

Variant appearance in text: FGFR2: N549K

PubMed Link: 33268819

Variant Present in the following documents:

• Main text

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