Publications:

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N-of-1 Trials in Cancer Drug Development.

Cancer Discovery

Gouda, Mohamed A MA; Buschhorn, Lars L; Schneeweiss, Andreas A; Wahida, Adam A; Subbiah, Vivek V

Publication Date: 2023-04-18

Variant appearance in text: RET: G810S

PubMed Link: 37070849

Variant Present in the following documents:

• Main text

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RET signaling in breast cancer therapeutic resistance and metastasis.

Breast Cancer Research : Bcr

Pecar, Geoffrey G; Liu, Simeng S; Hooda, Jagmohan J; Atkinson, Jennifer M JM; Oesterreich, Steffi S; Lee, Adrian V AV

Publication Date: 2023-03-14

Variant appearance in text: RET: G810S

PubMed Link: 36918928

Variant Present in the following documents:

• Main text
• 13058_2023_Article_1622.pdf

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A comprehensive overview of the relationship between RET gene and tumor occurrence.

Frontiers In Oncology

Zhao, Lu L; Wang, Na N; Zhang, Dou D; Jia, Yingjie Y; Kong, Fanming F

Publication Date: 2023

Variant appearance in text: RET: G810S

PubMed Link: 36865807

Variant Present in the following documents:

• Main text
• fonc-13-1090757.pdf

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Precious Gene: The Application of RET-Altered Inhibitors.

Molecules (Basel, Switzerland)

Gou, Qitao Q; Gan, Xiaochuan X; Li, Longhao L; Gou, Qiheng Q; Zhang, Tao T

Publication Date: 2022-12-13

Variant appearance in text: RET: G810S

PubMed Link: 36557971

Variant Present in the following documents:

• Main text
• molecules-27-08839.pdf

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Design of new drugs for medullary thyroid carcinoma.

Frontiers In Oncology

Li, Yanqing Y; Luo, Ziyu Z; Wang, Xinxing X; Zhang, Songtao S; Hei, Hu H; Qin, Jianwu J

Publication Date: 2022

Variant appearance in text: RET: G810S

PubMed Link: 36544713

Variant Present in the following documents:

• Main text
• fonc-12-993725.pdf

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Calibration of computational tools for missense variant pathogenicity classification and ClinGen recommendations for PP3/BP4 criteria.

American Journal Of Human Genetics

Pejaver, Vikas V; Byrne, Alicia B AB; Feng, Bing-Jian BJ; Pagel, Kymberleigh A KA; Mooney, Sean D SD; Karchin, Rachel R; O'Donnell-Luria, Anne A; Harrison, Steven M SM; Tavtigian, Sean V SV; Greenblatt, Marc S MS; Biesecker, Leslie G LG; Radivojac, Predrag P; Brenner, Steven E SE; ,

Publication Date: 2022-12-01

Variant appearance in text: RET: G810S; rs764784013

PubMed Link: 36413997

Variant Present in the following documents:

• mmc3.xlsx, sheet 1

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Small molecule inhibitors targeting the cancers.

Medcomm

Liu, Gui-Hong GH; Chen, Tao T; Zhang, Xin X; Ma, Xue-Lei XL; Shi, Hua-Shan HS

Publication Date: 2022-12

Variant appearance in text: RET: G810S

PubMed Link: 36254250

Variant Present in the following documents:

• MCO2-3-e181-s003.xlsx, sheet 1

View BVdb publication page

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Genomic and biological study of fusion genes as resistance mechanisms to EGFR inhibitors.

Nature Communications

Kobayashi, Yoshihisa Y; Oxnard, Geoffrey R GR; Cohen, Elizabeth F EF; Mahadevan, Navin R NR; Alessi, Joao V JV; Hung, Yin P YP; Bertram, Arrien A AA; Heppner, David E DE; Ribeiro, Mauricio F MF; Sacardo, Karina P KP; Saddi, Rodrigo R; Macedo, Mariana P MP; Blasco, Rafael B RB; Li, Jiaqi J; Kurppa, Kari J KJ; Nguyen, Tom T; Voligny, Emma E; Ananda, Guruprasad G; Chiarle, Roberto R; Katz, Artur A; Tolstorukov, Michael Y MY; Sholl, Lynette M LM; Jänne, Pasi A PA

Publication Date: 2022-09-24

Variant appearance in text: RET: G810S

PubMed Link: 36153311

Variant Present in the following documents:

• Main text
• 41467_2022_Article_33210.pdf
• 41467_2022_33210_MOESM1_ESM.pdf

View BVdb publication page

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Protein tyrosine kinase inhibitor resistance in malignant tumors: molecular mechanisms and future perspective.

Signal Transduction And Targeted Therapy

Yang, Yang Y; Li, Shuo S; Wang, Yujiao Y; Zhao, Yi Y; Li, Qiu Q

Publication Date: 2022-09-17

Variant appearance in text: RET: G810S

PubMed Link: 36115852

Variant Present in the following documents:

• Main text
• 41392_2022_Article_1168.pdf

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[Research Progress of Acquired Resistance Mediated by MET Amplification 
in Advanced Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer

Pan, Sisi S; Wang, Na N; Song, Xia X

Publication Date: 2022-08-20

Variant appearance in text: RET: G810S

PubMed Link: 36002199

Variant Present in the following documents:

• zgfazz-25-8-615.pdf

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RET signaling pathway and RET inhibitors in human cancer.

Frontiers In Oncology

Regua, Angelina T AT; Najjar, Mariana M; Lo, Hui-Wen HW

Publication Date: 2022

Variant appearance in text: RET: G810S

PubMed Link: 35957881

Variant Present in the following documents:

• Main text
• fonc-12-932353.pdf

View BVdb publication page

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Applications of Liquid Biopsies in Non-Small-Cell Lung Cancer.

Diagnostics (Basel, Switzerland)

Pesta, Martin M; Shetti, Dattatrya D; Kulda, Vlastimil V; Knizkova, Tereza T; Houfkova, Katerina K; Bagheri, Mahyar Sharif MS; Svaton, Martin M; Polivka, Jiri J

Publication Date: 2022-07-25

Variant appearance in text: RET: G810S

PubMed Link: 35892510

Variant Present in the following documents:

• Main text
• diagnostics-12-01799.pdf

View BVdb publication page

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AACR Project GENIE: 100,000 Cases and Beyond.

Cancer Discovery

Pugh, Trevor J TJ; Bell, Jonathan L JL; Bruce, Jeff P JP; Doherty, Gary J GJ; Galvin, Matthew M; Green, Michelle F MF; Hunter-Zinck, Haley H; Kumari, Priti P; Lenoue-Newton, Michele L ML; Li, Marilyn M MM; Lindsay, James J; Mazor, Tali T; Ovalle, Andrea A; Sammut, Stephen-John SJ; Schultz, Nikolaus N; Yu, Thomas V TV; Sweeney, Shawn M SM; Bernard, Brady B; ,

Publication Date: 2022-09-02

Variant appearance in text: RET: G810S

PubMed Link: 35819403

Variant Present in the following documents:

• cd-21-1547_supplementary_table_1_suppst1.xlsx, sheet 1

View BVdb publication page

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RET kinase inhibitors for RET-altered thyroid cancers.

Therapeutic Advances In Medical Oncology

Vodopivec, Danica M DM; Hu, Mimi I MI

Publication Date: 2022

Variant appearance in text: RET: G810S

PubMed Link: 35756966

Variant Present in the following documents:

• 10.1177_17588359221101691.pdf

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Morphologic-Molecular Transformation of Oncogene Addicted Non-Small Cell Lung Cancer.

International Journal Of Molecular Sciences

Calabrese, Fiorella F; Pezzuto, Federica F; Lunardi, Francesca F; Fortarezza, Francesco F; Tzorakoleftheraki, Sofia-Eleni SE; Resi, Maria Vittoria MV; Tiné, Mariaenrica M; Pasello, Giulia G; Hofman, Paul P

Publication Date: 2022-04-09

Variant appearance in text: RET: G810S

PubMed Link: 35456982

Variant Present in the following documents:

• Main text
• ijms-23-04164.pdf

View BVdb publication page

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Sporadic Medullary Thyroid Carcinoma: Towards a Precision Medicine.

Frontiers In Endocrinology

Matrone, Antonio A; Gambale, Carla C; Prete, Alessandro A; Elisei, Rossella R

Publication Date: 2022

Variant appearance in text: RET: G810S

PubMed Link: 35422765

Variant Present in the following documents:

• Main text
• fendo-13-864253.pdf

View BVdb publication page

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Designing Novel Compounds for the Treatment and Management of RET-Positive Non-Small Cell Lung Cancer-Fragment Based Drug Design Strategy.

Molecules (Basel, Switzerland)

Ramesh, Priyanka P; Veerappapillai, Shanthi S

Publication Date: 2022-02-28

Variant appearance in text: RET: G810S

PubMed Link: 35268691

Variant Present in the following documents:

• molecules-27-01590.pdf

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Utility of the Ba/F3 cell system for exploring on-target mechanisms of resistance to targeted therapies for lung cancer.

Cancer Science

Koga, Takamasa T; Suda, Kenichi K; Mitsudomi, Tetsuya T

Publication Date: 2022-03

Variant appearance in text: RET: G810S

PubMed Link: 34997674

Variant Present in the following documents:

• Main text
• CAS-113-815.pdf

View BVdb publication page

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RET Fusion: Joining the Ranks of Targetable Molecular Drivers in NSCLC.

Jto Clinical And Research Reports

Osta, Badi El BE; Ramalingam, Suresh S SS

Publication Date: 2020-09

Variant appearance in text: RET: G810S

PubMed Link: 34589946

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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RET Inhibitors in Non-Small-Cell Lung Cancer.

Cancers

Cascetta, Priscilla P; Sforza, Vincenzo V; Manzo, Anna A; Carillio, Guido G; Palumbo, Giuliano G; Esposito, Giovanna G; Montanino, Agnese A; Costanzo, Raffaele R; Sandomenico, Claudia C; De Cecio, Rossella R; Piccirillo, Maria Carmela MC; La Manna, Carmine C; Totaro, Giuseppe G; Muto, Paolo P; Picone, Carmine C; Bianco, Roberto R; Normanno, Nicola N; Morabito, Alessandro A

Publication Date: 2021-09-01

Variant appearance in text: RET: G810S

PubMed Link: 34503226

Variant Present in the following documents:

• Main text
• cancers-13-04415.pdf

View BVdb publication page

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Hallmarks of RET and Co-occuring Genomic Alterations in RET-aberrant Cancers.

Molecular Cancer Therapeutics

Adashek, Jacob J JJ; Desai, Aakash P AP; Andreev-Drakhlin, Alexander Y AY; Roszik, Jason J; Cote, Gilbert J GJ; Subbiah, Vivek V

Publication Date: 2021-10

Variant appearance in text: RET: G810S

PubMed Link: 34493590

Variant Present in the following documents:

• Main text
• 1769.pdf

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Precision therapy for RET-altered cancers with RET inhibitors.

Trends In Cancer

Thein, Kyaw Z KZ; Velcheti, Vamsidhar V; Mooers, Blaine H M BHM; Wu, Jie J; Subbiah, Vivek V

Publication Date: 2021-12

Variant appearance in text: RET: G810S

PubMed Link: 34391699

Variant Present in the following documents:

• Main text

View BVdb publication page

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Targeted activity of the small molecule kinase inhibitor Pz-1 towards RET and TRK kinases.

Scientific Reports

Moccia, Marialuisa M; Yang, Donglin D; Lakkaniga, Naga Rajiv NR; Frett, Brendan B; McConnell, Nicholas N; Zhang, Lingtian L; Brescia, Annalisa A; Federico, Giorgia G; Zhang, Lingzhi L; Salerno, Paolo P; Santoro, Massimo M; Li, Hong-Yu HY; Carlomagno, Francesca F

Publication Date: 2021-08-09

Variant appearance in text: RET: G810S

PubMed Link: 34373541

Variant Present in the following documents:

• Main text
• 41598_2021_Article_95612.pdf

View BVdb publication page

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[Research Progress of Fusion Genes RET in Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer

Zheng, Yujun Y; Jiang, Wei W; Chen, Dongyan D; Li, Yanjun Y; Dai, Lulu L; Huang, Lei L; Wang, Mingji M

Publication Date: 2021-08-20

Variant appearance in text: RET: G810S

PubMed Link: 34120433

Variant Present in the following documents:

• Main text

View BVdb publication page

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The L730V/I RET roof mutations display different activities toward pralsetinib and selpercatinib.

Npj Precision Oncology

Shen, Tao T; Hu, Xueqing X; Liu, Xuan X; Subbiah, Vivek V; Mooers, Blaine H M BHM; Wu, Jie J

Publication Date: 2021-06-07

Variant appearance in text: RET: G810S

PubMed Link: 34099825

Variant Present in the following documents:

• Main text
• 41698_2021_Article_188.pdf

View BVdb publication page

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Chasing the Target: New Phenomena of Resistance to Novel Selective RET Inhibitors in Lung Cancer. Updated Evidence and Future Perspectives.

Cancers

Fancelli, Sara S; Caliman, Enrico E; Mazzoni, Francesca F; Brugia, Marco M; Castiglione, Francesca F; Voltolini, Luca L; Pillozzi, Serena S; Antonuzzo, Lorenzo L

Publication Date: 2021-03-04

Variant appearance in text: RET: G810S

PubMed Link: 33806299

Variant Present in the following documents:

• Main text

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Therapeutic strategies in RET gene rearranged non-small cell lung cancer.

Journal Of Hematology & Oncology

Drusbosky, Leylah M LM; Rodriguez, Estelamari E; Dawar, Richa R; Ikpeazu, Chukwuemeka V CV

Publication Date: 2021-03-26

Variant appearance in text: RET: G810S

PubMed Link: 33771190

Variant Present in the following documents:

• Main text
• 13045_2021_Article_1063.pdf

View BVdb publication page

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Structural basis of acquired resistance to selpercatinib and pralsetinib mediated by non-gatekeeper RET mutations.

Annals Of Oncology : Official Journal Of The European Society For Medical Oncology

Subbiah, V V; Shen, T T; Terzyan, S S SS; Liu, X X; Hu, X X; Patel, K P KP; Hu, M M; Cabanillas, M M; Behrang, A A; Meric-Bernstam, F F; Vo, P T T PTT; Mooers, B H M BHM; Wu, J J

Publication Date: 2021-02

Variant appearance in text: RET: G810S

PubMed Link: 33161056

Variant Present in the following documents:

• Main text

View BVdb publication page

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Systemic and CNS Activity of Selective RET Inhibition With Selpercatinib (LOXO-292) in a Patient With RET-Mutant Medullary Thyroid Cancer With Extensive CNS Metastases.

Jco Precision Oncology

Andreev-Drakhlin, Alexander A; Cabanillas, Maria M; Amini, Behrang B; Subbiah, Vivek V

Publication Date: 2020

Variant appearance in text: RET: G810S

PubMed Link: 33154983

Variant Present in the following documents:

• Main text
• PO.20.00096.pdf

View BVdb publication page

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New Horizons: Emerging Therapies and Targets in Thyroid Cancer.

The Journal Of Clinical Endocrinology And Metabolism

Ringel, Matthew D MD

Publication Date: 2021-01-01

Variant appearance in text: RET: G810S

PubMed Link: 32977343

Variant Present in the following documents:

• Main text

View BVdb publication page

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Clinicopathologic features of kinase fusion-related thyroid carcinomas: an integrative analysis with molecular characterization.

Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc

Chu, Ying-Hsia YH; Wirth, Lori J LJ; Farahani, Alexander A AA; Nosé, Vânia V; Faquin, William C WC; Dias-Santagata, Dora D; Sadow, Peter M PM

Publication Date: 2020-12

Variant appearance in text: RET: G810S

PubMed Link: 32737449

Variant Present in the following documents:

• Main text
• nihms-1613364.pdf

View BVdb publication page

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RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies.

Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer

Solomon, Benjamin J BJ; Tan, Lavinia L; Lin, Jessica J JJ; Wong, Stephen Q SQ; Hollizeck, Sebastian S; Ebata, Kevin K; Tuch, Brian B BB; Yoda, Satoshi S; Gainor, Justin F JF; Sequist, Lecia V LV; Oxnard, Geoffrey R GR; Gautschi, Oliver O; Drilon, Alexander A; Subbiah, Vivek V; Khoo, Christine C; Zhu, Edward Y EY; Nguyen, Michele M; Henry, Dahlia D; Condroski, Kevin R KR; Kolakowski, Gabrielle R GR; Gomez, Eliana E; Ballard, Joshua J; Metcalf, Andrew T AT; Blake, James F JF; Dawson, Sarah-Jane SJ; Blosser, Wayne W; Stancato, Louis F LF; Brandhuber, Barbara J BJ; Andrews, Steve S; Robinson, Bruce G BG; Rothenberg, S Michael SM

Publication Date: 2020-04

Variant appearance in text: RET: G810S

PubMed Link: 31988000

Variant Present in the following documents:

• Main text
• nihms-1616172.pdf

View BVdb publication page

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Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases.

Scientific Reports

Šimčíková, Daniela D; Heneberg, Petr P

Publication Date: 2019-12-09

Variant appearance in text: RET: G810S

PubMed Link: 31819097

Variant Present in the following documents:

• 41598_2019_54976_MOESM2_ESM.xlsx, sheet 8

View BVdb publication page

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Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib.

The Journal Of Biological Chemistry

Terzyan, Simon S SS; Shen, Tao T; Liu, Xuan X; Huang, Qingling Q; Teng, Peng P; Zhou, Mi M; Hilberg, Frank F; Cai, Jianfeng J; Mooers, Blaine H M BHM; Wu, Jie J

Publication Date: 2019-07-05

Variant appearance in text: RET: G810S

PubMed Link: 31118272

Variant Present in the following documents:

• Main text

View BVdb publication page

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Drug resistance profiles of mutations in the RET kinase domain.

British Journal Of Pharmacology

Liu, Xuan X; Shen, Tao T; Mooers, Blaine H M BHM; Hilberg, Frank F; Wu, Jie J

Publication Date: 2018-09

Variant appearance in text: RET: G810S

PubMed Link: 29908090

Variant Present in the following documents:

• Main text

View BVdb publication page

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Sequencing of Lynch syndrome tumors reveals the importance of epigenetic alterations.

Oncotarget

Porkka, Noora N; Valo, Satu S; Nieminen, Taina T TT; Olkinuora, Alisa A; Mäki-Nevala, Satu S; Eldfors, Samuli S; Peltomäki, Päivi P

Publication Date: 2017-12-08

Variant appearance in text: RET: G810S

PubMed Link: 29296220

Variant Present in the following documents:

• oncotarget-08-108020-s006.xlsx, sheet 1

View BVdb publication page

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Intratumoral heterogeneity in a minority of ovarian low-grade serous carcinomas.

Bmc Cancer

Tone, Alicia A AA; McConechy, Melissa K MK; Yang, Winnie W; Ding, Jiarui J; Yip, Stephen S; Kong, Esther E; Wong, Kwong-Kwok KK; Gershenson, David M DM; Mackay, Helen H; Shah, Sohrab S; Gilks, Blake B; Tinker, Anna V AV; Clarke, Blaise B; McAlpine, Jessica N JN; Huntsman, David D

Publication Date: 2014-12-18

Variant appearance in text: RET: G810S

PubMed Link: 25523272

Variant Present in the following documents:

• 12885_2014_5198_MOESM14_ESM.xlsx, sheet 1

View BVdb publication page

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