Publications:

Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases.

Scientific Reports

Šimčíková, Daniela D; Heneberg, Petr P

Publication Date: 2019-12-09

Variant appearance in text: RET: Y900F

PubMed Link: 31819097

Variant Present in the following documents:

• 41598_2019_54976_MOESM2_ESM.xlsx, sheet 8

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RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements.

Cell Reports

Plaza-Menacho, Iván I; Barnouin, Karin K; Barry, Rachael R; Borg, Annabel A; Orme, Mariam M; Chauhan, Rakhee R; Mouilleron, Stephane S; Martínez-Torres, Rubén J RJ; Meier, Pascal P; McDonald, Neil Q NQ

Publication Date: 2016-12-20

Variant appearance in text: RET: Y900F

PubMed Link: 28009299

Variant Present in the following documents:

• Main text
• mmc2.pdf
• main.pdf

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Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans.

Molecular Cell

Plaza-Menacho, Iván I; Barnouin, Karin K; Goodman, Kerry K; Martínez-Torres, Rubén J RJ; Borg, Annabel A; Murray-Rust, Judith J; Mouilleron, Stephane S; Knowles, Phillip P; McDonald, Neil Q NQ

Publication Date: 2014-03-06

Variant appearance in text: RET: Y900F

PubMed Link: 24560924

Variant Present in the following documents:

• Main text

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Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism.

The Journal Of Biological Chemistry

Plaza-Menacho, Iván I; Morandi, Andrea A; Mologni, Luca L; Boender, Piet P; Gambacorti-Passerini, Carlo C; Magee, Anthony I AI; Hofstra, Robert M W RM; Knowles, Phillip P; McDonald, Neil Q NQ; Isacke, Clare M CM

Publication Date: 2011-05-13

Variant appearance in text: RET: Y900F

PubMed Link: 21454698

Variant Present in the following documents:

• Main text

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