Publications:

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Advances in the Diagnosis and Treatment of a Driving Target: RET Rearrangements in non-Small-Cell Lung Cancer (NSCLC) Especially in China.

Technology In Cancer Research & Treatment

Li, Tao T; Yang, Wen-Yu WY; Liu, Ting-Ting TT; Li, Yao Y; Liu, Lu L; Zheng, Xuan X; Zhao, Lei L; Zhang, Fan F; Hu, Yi Y

Publication Date: 2023

Variant appearance in text: RET: S904F

PubMed Link: 36628459

Variant Present in the following documents:

• Main text
• 10.1177_15330338221148802.pdf

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Targeted therapy of RET fusion-positive non-small cell lung cancer.

Frontiers In Oncology

Shen, Zixiong Z; Qiu, Binxu B; Li, Lin L; Yang, Bo B; Li, Guanghu G

Publication Date: 2022

Variant appearance in text: RET: S904F

PubMed Link: 36582799

Variant Present in the following documents:

• Main text
• fonc-12-1033484.pdf

View BVdb publication page

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Calibration of computational tools for missense variant pathogenicity classification and ClinGen recommendations for PP3/BP4 criteria.

American Journal Of Human Genetics

Pejaver, Vikas V; Byrne, Alicia B AB; Feng, Bing-Jian BJ; Pagel, Kymberleigh A KA; Mooney, Sean D SD; Karchin, Rachel R; O'Donnell-Luria, Anne A; Harrison, Steven M SM; Tavtigian, Sean V SV; Greenblatt, Marc S MS; Biesecker, Leslie G LG; Radivojac, Predrag P; Brenner, Steven E SE; ,

Publication Date: 2022-12-01

Variant appearance in text: RET: S904F; rs267607011

PubMed Link: 36413997

Variant Present in the following documents:

• mmc2.xlsx, sheet 1

View BVdb publication page

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Mutually exclusive genetic interactions and gene essentiality shape the genomic landscape of primary melanoma.

The Journal Of Pathology

Birkeälv, Sofia S; Harland, Mark M; Matsuyama, Larissa Satiko Alcantara Sekimoto LSAS; Rashid, Mamun M; Mehta, Ishan I; Laye, Jonathan P JP; Haase, Kerstin K; Mell, Tracey T; Iyer, Vivek V; Robles-Espinoza, Carla Daniela CD; McDermott, Ultan U; van Loo, Peter P; Kuijjer, Marieke L ML; Possik, Patricia A PA; Maria Engler, Silvya Stuchi SS; Bishop, D Timothy DT; Newton-Bishop, Julia J; Adams, David J DJ

Publication Date: 2022-10-11

Variant appearance in text: RET: 2711C>T; S904F

PubMed Link: 36219477

Variant Present in the following documents:

• PATH-259-56-s004.xlsx, sheet 2

View BVdb publication page

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Small-molecule inhibitors, immune checkpoint inhibitors, and more: FDA-approved novel therapeutic drugs for solid tumors from 1991 to 2021.

Journal Of Hematology & Oncology

Wu, Qing Q; Qian, Wei W; Sun, Xiaoli X; Jiang, Shaojie S

Publication Date: 2022-10-08

Variant appearance in text: RET: S904F

PubMed Link: 36209184

Variant Present in the following documents:

• Main text
• 13045_2022_Article_1362.pdf

View BVdb publication page

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Precision oncology for RET-related tumors.

Frontiers In Oncology

Verrienti, Antonella A; Grani, Giorgio G; Sponziello, Marialuisa M; Pecce, Valeria V; Damante, Giuseppe G; Durante, Cosimo C; Russo, Diego D; Filetti, Sebastiano S

Publication Date: 2022

Variant appearance in text: RET: S904F

PubMed Link: 36091144

Variant Present in the following documents:

• Main text
• fonc-12-992636.pdf

View BVdb publication page

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RET kinase inhibitors for RET-altered thyroid cancers.

Therapeutic Advances In Medical Oncology

Vodopivec, Danica M DM; Hu, Mimi I MI

Publication Date: 2022

Variant appearance in text: RET: S904F

PubMed Link: 35756966

Variant Present in the following documents:

• 10.1177_17588359221101691.pdf

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Research Progress on RET Fusion in Non-Small-Cell Lung Cancer.

Frontiers In Oncology

Zhao, Lu L; Mei, Qingyun Q; Yu, Yongchao Y; Wang, Na N; Zhang, Dou D; Liao, Dongying D; Zuo, Jinhui J; Xie, Hongxia H; Jia, Yingjie Y; Kong, Fanming F

Publication Date: 2022

Variant appearance in text: RET: S904F

PubMed Link: 35707347

Variant Present in the following documents:

• Main text
• fonc-12-894214.pdf

View BVdb publication page

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Structural and dynamic determinants for highly selective RET kinase inhibition reveal cryptic druggability.

Journal Of Advanced Research

Shehata, Moustafa A MA; Contreras, Julia J; Martín-Hurtado, Ana A; Froux, Aurane A; Mohamed, Hossam Taha HT; El-Sherif, Ahmed A AA; Plaza-Menacho, Iván I

Publication Date: 2022-05-17

Variant appearance in text: RET: S904F

PubMed Link: 35595215

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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Designing Novel Compounds for the Treatment and Management of RET-Positive Non-Small Cell Lung Cancer-Fragment Based Drug Design Strategy.

Molecules (Basel, Switzerland)

Ramesh, Priyanka P; Veerappapillai, Shanthi S

Publication Date: 2022-02-28

Variant appearance in text: RET: S904F

PubMed Link: 35268691

Variant Present in the following documents:

• Main text
• molecules-27-01590.pdf

View BVdb publication page

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New approaches for patients with advanced radioiodine-refractory thyroid cancer.

World Journal Of Clinical Oncology

Pitoia, Fabián F; Jerkovich, Fernando F; Trimboli, Pierpaolo P; Smulever, Anabella A

Publication Date: 2022-01-24

Variant appearance in text: RET: S904F

PubMed Link: 35116229

Variant Present in the following documents:

• Main text
• WJCO-13-9.pdf

View BVdb publication page

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The value of cell-free circulating tumour DNA profiling in advanced non-small cell lung cancer (NSCLC) management.

Cancer Cell International

Fernandes, Maria Gabriela O MGO; Cruz-Martins, Natália N; Machado, José Carlos JC; Costa, José Luís JL; Hespanhol, Venceslau V

Publication Date: 2021-12-16

Variant appearance in text: RET: S904F

PubMed Link: 34915883

Variant Present in the following documents:

• Main text
• 12935_2021_Article_2382.pdf

View BVdb publication page

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The value of cell-free circulating tumour DNA profiling in advanced non-small cell lung cancer (NSCLC) management.

Cancer Cell International

Fernandes, Maria Gabriela O MGO; Cruz-Martins, Natália N; Machado, José Carlos JC; Costa, José Luís JL; Hespanhol, Venceslau V

Publication Date: 2021-12-16

Variant appearance in text: RET: S904F

PubMed Link: 34915883

Variant Present in the following documents:

• Main text
• 12935_2021_Article_2382.pdf

View BVdb publication page

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[Advances in the Treatment of RET Fusion-Positive Advanced Non-Small-Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer

Gao, Qingyun Q; Su, Junwei J; Xiao, Faman F; Lin, Xiaocheng X; Yang, Jinji J

Publication Date: 2021-11-08

Variant appearance in text: RET: S904F

PubMed Link: 34743497

Variant Present in the following documents:

• Main text
• zgfazz-24-12-853.pdf

View BVdb publication page

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[Advances in the Treatment of RET Fusion-positive Advanced Non-small Cell Lung Cancer].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer

Gao, Qingyun Q; Su, Junwei J; Xiao, Faman F; Lin, Xiaocheng X; Yang, Jinji J

Publication Date: 2021-12-20

Variant appearance in text: RET: S904F

PubMed Link: 34743497

Variant Present in the following documents:

• Main text
• zgfazz-24-12-853.pdf

View BVdb publication page

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: RET: S904F

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

View BVdb publication page

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RET Fusion: Joining the Ranks of Targetable Molecular Drivers in NSCLC.

Jto Clinical And Research Reports

Osta, Badi El BE; Ramalingam, Suresh S SS

Publication Date: 2020-09

Variant appearance in text: RET: S904F

PubMed Link: 34589946

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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Precision therapy for RET-altered cancers with RET inhibitors.

Trends In Cancer

Thein, Kyaw Z KZ; Velcheti, Vamsidhar V; Mooers, Blaine H M BHM; Wu, Jie J; Subbiah, Vivek V

Publication Date: 2021-12

Variant appearance in text: RET: S904F

PubMed Link: 34391699

Variant Present in the following documents:

• Main text

View BVdb publication page

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Targeted activity of the small molecule kinase inhibitor Pz-1 towards RET and TRK kinases.

Scientific Reports

Moccia, Marialuisa M; Yang, Donglin D; Lakkaniga, Naga Rajiv NR; Frett, Brendan B; McConnell, Nicholas N; Zhang, Lingtian L; Brescia, Annalisa A; Federico, Giorgia G; Zhang, Lingzhi L; Salerno, Paolo P; Santoro, Massimo M; Li, Hong-Yu HY; Carlomagno, Francesca F

Publication Date: 2021-08-09

Variant appearance in text: RET: S904F

PubMed Link: 34373541

Variant Present in the following documents:

• Main text
• 41598_2021_Article_95612.pdf

View BVdb publication page

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Chasing the Target: New Phenomena of Resistance to Novel Selective RET Inhibitors in Lung Cancer. Updated Evidence and Future Perspectives.

Cancers

Fancelli, Sara S; Caliman, Enrico E; Mazzoni, Francesca F; Brugia, Marco M; Castiglione, Francesca F; Voltolini, Luca L; Pillozzi, Serena S; Antonuzzo, Lorenzo L

Publication Date: 2021-03-04

Variant appearance in text: RET: S904F

PubMed Link: 33806299

Variant Present in the following documents:

• Main text

View BVdb publication page

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Therapeutic strategies in RET gene rearranged non-small cell lung cancer.

Journal Of Hematology & Oncology

Drusbosky, Leylah M LM; Rodriguez, Estelamari E; Dawar, Richa R; Ikpeazu, Chukwuemeka V CV

Publication Date: 2021-03-26

Variant appearance in text: RET: S904F

PubMed Link: 33771190

Variant Present in the following documents:

• Main text
• 13045_2021_Article_1063.pdf

View BVdb publication page

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A Narrative Review of Genetic Alterations in Primary Thyroid Epithelial Cancer.

International Journal Of Molecular Sciences

Romei, Cristina C; Elisei, Rossella R

Publication Date: 2021-02-09

Variant appearance in text: MEN2B: S904F

PubMed Link: 33572167

Variant Present in the following documents:

• Main text
• ijms-22-01726.pdf

View BVdb publication page

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Decade in review: a new era for RET-rearranged lung cancers.

Translational Lung Cancer Research

Choudhury, Noura J NJ; Drilon, Alexander A

Publication Date: 2020-12

Variant appearance in text: RET: S904F

PubMed Link: 33489819

Variant Present in the following documents:

• Main text
• tlcr-09-06-2571.pdf

View BVdb publication page

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Results and Clinical Interpretation of Germline RET Analysis in a Series of Patients with Medullary Thyroid Carcinoma: The Challenge of the Variants of Uncertain Significance.

Cancers

Innella, Giovanni G; Rossi, Cesare C; Romagnoli, Maria M; Repaci, Andrea A; Bianchi, Davide D; Cantarini, Maria Elena ME; Martorana, Davide D; Godino, Lea L; Pession, Andrea A; Percesepe, Antonio A; Pagotto, Uberto U; Turchetti, Daniela D

Publication Date: 2020-11-05

Variant appearance in text: RET: 2711C>T

PubMed Link: 33167350

Variant Present in the following documents:

• Main text
• cancers-12-03268.pdf

View BVdb publication page

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Structural basis of acquired resistance to selpercatinib and pralsetinib mediated by non-gatekeeper RET mutations.

Annals Of Oncology : Official Journal Of The European Society For Medical Oncology

Subbiah, V V; Shen, T T; Terzyan, S S SS; Liu, X X; Hu, X X; Patel, K P KP; Hu, M M; Cabanillas, M M; Behrang, A A; Meric-Bernstam, F F; Vo, P T T PTT; Mooers, B H M BHM; Wu, J J

Publication Date: 2021-02

Variant appearance in text: RET: S904F

PubMed Link: 33161056

Variant Present in the following documents:

• Main text

View BVdb publication page

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5P Strategies for Management of Multiple Endocrine Neoplasia Type 2: A Paradigm of Precision Medicine.

Frontiers In Endocrinology

Li, Shu-Yuan SY; Ding, Yi-Qiang YQ; Si, You-Liang YL; Ye, Mu-Jin MJ; Xu, Chen-Ming CM; Qi, Xiao-Ping XP

Publication Date: 2020

Variant appearance in text: RET: S904F

PubMed Link: 33071967

Variant Present in the following documents:

• Main text

View BVdb publication page

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[Chinese Expert Consensus on Next Generation Sequencing Diagnosis 
for Non-small Cell Lung Cancer (2020 Edition)].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer

,

Publication Date: 2020-09-20

Variant appearance in text: RET: S904F

PubMed Link: 32957170

Variant Present in the following documents:

• Main text

View BVdb publication page

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Emergence and Targeting of Acquired and Hereditary Resistance to Multikinase RET Inhibition in Patients With RET-Altered Cancer.

Jco Precision Oncology

Wirth, Lori J LJ; Kohno, Takashi T; Udagawa, Hibiki H; Matsumoto, Shingo S; Ishii, Genichiro G; Ebata, Kevin K; Tuch, Brian B BB; Zhu, Edward Y EY; Nguyen, Michele M; Smith, Steve S; Hanson, Lauren M LM; Burkard, Michael R MR; Cable, LouAnn L; Blake, James F JF; Condroski, Kevin R KR; Brandhuber, Barbara J BJ; Andrews, Steve S; Rothenberg, S Michael SM; Goto, Koichi K

Publication Date: 2019

Variant appearance in text: RET: S904F

PubMed Link: 32923848

Variant Present in the following documents:

• Main text
• PO.19.00189.pdf

View BVdb publication page

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: RET: S904F

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

View BVdb publication page

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Advances in Targeting RET-Dependent Cancers.

Cancer Discovery

Subbiah, Vivek V; Cote, Gilbert J GJ

Publication Date: 2020-04

Variant appearance in text: RET: S904F

PubMed Link: 32094155

Variant Present in the following documents:

• Main text

View BVdb publication page

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State-of-the-Art Strategies for Targeting RET-Dependent Cancers.

Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology

Subbiah, Vivek V; Yang, Dong D; Velcheti, Vamsidhar V; Drilon, Alexander A; Meric-Bernstam, Funda F

Publication Date: 2020-04-10

Variant appearance in text: RET: S904F

PubMed Link: 32083997

Variant Present in the following documents:

• Main text

View BVdb publication page

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RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies.

Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer

Solomon, Benjamin J BJ; Tan, Lavinia L; Lin, Jessica J JJ; Wong, Stephen Q SQ; Hollizeck, Sebastian S; Ebata, Kevin K; Tuch, Brian B BB; Yoda, Satoshi S; Gainor, Justin F JF; Sequist, Lecia V LV; Oxnard, Geoffrey R GR; Gautschi, Oliver O; Drilon, Alexander A; Subbiah, Vivek V; Khoo, Christine C; Zhu, Edward Y EY; Nguyen, Michele M; Henry, Dahlia D; Condroski, Kevin R KR; Kolakowski, Gabrielle R GR; Gomez, Eliana E; Ballard, Joshua J; Metcalf, Andrew T AT; Blake, James F JF; Dawson, Sarah-Jane SJ; Blosser, Wayne W; Stancato, Louis F LF; Brandhuber, Barbara J BJ; Andrews, Steve S; Robinson, Bruce G BG; Rothenberg, S Michael SM

Publication Date: 2020-04

Variant appearance in text: RET: S904F

PubMed Link: 31988000

Variant Present in the following documents:

• Main text
• nihms-1616172.pdf

View BVdb publication page

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Targeting RET-rearranged non-small-cell lung cancer: future prospects.

Lung Cancer (Auckland, N.Z.)

Bronte, Giuseppe G; Ulivi, Paola P; Verlicchi, Alberto A; Cravero, Paola P; Delmonte, Angelo A; Crinò, Lucio L

Publication Date: 2019

Variant appearance in text: RET: S904F

PubMed Link: 30962732

Variant Present in the following documents:

• Main text
• lctt-10-027.pdf

View BVdb publication page

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A pioneering RET genetic screening study in the State of Ceará, Brazil, evaluating patients with medullary thyroid cancer and at-risk relatives: experience with 247 individuals.

Archives Of Endocrinology And Metabolism

Martins-Costa, Maria Cecília MC; Lindsey, Susan C SC; Cunha, Lucas L LL; Carreiro-Filho, Fernando Porto FP; Cortez, André P AP; Holanda, Marcelo E ME; Farias, J Wilson M de JWM; Lima, Sérgio B SB; Ferreira, Luís A Albano LAA; Maia Filho, Pedro Collares PC; Camacho, Cléber P CP; Furuzawa, Gilberto K GK; Kunii, Ilda S IS; Dias-da-Silva, Magnus R MR; Martins, João R M JRM; Maciel, Rui M B RMB

Publication Date: 2018

Variant appearance in text: RET: S904F

PubMed Link: 30624503

Variant Present in the following documents:

• Main text
• 2359-4292-aem-62-06-0623.pdf

View BVdb publication page

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Current and Future Molecular Testing in NSCLC, What Can We Expect from New Sequencing Technologies?

Journal Of Clinical Medicine

Garinet, Simon S; Laurent-Puig, Pierre P; Blons, Hélène H; Oudart, Jean-Baptiste JB

Publication Date: 2018-06-09

Variant appearance in text: RET: Ser904Phe

PubMed Link: 29890761

Variant Present in the following documents:

• Main text
• jcm-07-00144.pdf

View BVdb publication page

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A secondary RET mutation in the activation loop conferring resistance to vandetanib.

Nature Communications

Nakaoku, Takashi T; Kohno, Takashi T; Araki, Mitsugu M; Niho, Seiji S; Chauhan, Rakhee R; Knowles, Phillip P PP; Tsuchihara, Katsuya K; Matsumoto, Shingo S; Shimada, Yoko Y; Mimaki, Sachiyo S; Ishii, Genichiro G; Ichikawa, Hitoshi H; Nagatoishi, Satoru S; Tsumoto, Kouhei K; Okuno, Yasushi Y; Yoh, Kiyotaka K; McDonald, Neil Q NQ; Goto, Koichi K

Publication Date: 2018-02-12

Variant appearance in text: RET: S904F

PubMed Link: 29434222

Variant Present in the following documents:

• 41467_2018_2994_MOESM1_ESM.pdf
• 41467_2018_2994_MOESM2_ESM.pdf
• 41467_2018_2994_MOESM3_ESM.pdf

View BVdb publication page

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Distribution of RET Mutations in Multiple Endocrine Neoplasia 2 in Denmark 1994-2014: A Nationwide Study.

Thyroid : Official Journal Of The American Thyroid Association

Mathiesen, Jes Sloth JS; Kroustrup, Jens Peter JP; Vestergaard, Peter P; Stochholm, Kirstine K; Poulsen, Per Løgstrup PL; Rasmussen, Åse Krogh ÅK; Feldt-Rasmussen, Ulla U; Gaustadnes, Mette M; Ørntoft, Torben Falck TF; van Overeem Hansen, Thomas T; Nielsen, Finn Cilius FC; Brixen, Kim K; Godballe, Christian C; Frederiksen, Anja Lisbeth AL

Publication Date: 2017-02

Variant appearance in text: RET: S904F

PubMed Link: 27809725

Variant Present in the following documents:

• Main text
• thy.2016.0411.pdf

View BVdb publication page

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Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing.

Molecular Cancer

Kovaleva, Valentina V; Geissler, Anna-Lena AL; Lutz, Lisa L; Fritsch, Ralph R; Makowiec, Frank F; Wiesemann, Sebastian S; Hopt, Ulrich T UT; Passlick, Bernward B; Werner, Martin M; Lassmann, Silke S

Publication Date: 2016-10-18

Variant appearance in text: RET: 2711C>T; Ser904Phe

PubMed Link: 27756406

Variant Present in the following documents:

• 12943_2016_549_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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A Landscape of Pharmacogenomic Interactions in Cancer.

Cell

Iorio, Francesco F; Knijnenburg, Theo A TA; Vis, Daniel J DJ; Bignell, Graham R GR; Menden, Michael P MP; Schubert, Michael M; Aben, Nanne N; Gonçalves, Emanuel E; Barthorpe, Syd S; Lightfoot, Howard H; Cokelaer, Thomas T; Greninger, Patricia P; van Dyk, Ewald E; Chang, Han H; de Silva, Heshani H; Heyn, Holger H; Deng, Xianming X; Egan, Regina K RK; Liu, Qingsong Q; Mironenko, Tatiana T; Mitropoulos, Xeni X; Richardson, Laura L; Wang, Jinhua J; Zhang, Tinghu T; Moran, Sebastian S; Sayols, Sergi S; Soleimani, Maryam M; Tamborero, David D; Lopez-Bigas, Nuria N; Ross-Macdonald, Petra P; Esteller, Manel M; Gray, Nathanael S NS; Haber, Daniel A DA; Stratton, Michael R MR; Benes, Cyril H CH; Wessels, Lodewyk F A LFA; Saez-Rodriguez, Julio J; McDermott, Ultan U; Garnett, Mathew J MJ

Publication Date: 2016-07-28

Variant appearance in text: RET: 2711C>T; S904F

PubMed Link: 27397505

Variant Present in the following documents:

• mmc3.xlsx, sheet 2

View BVdb publication page

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Predicting phenotypic severity of uncertain gene variants in the RET proto-oncogene.

Plos One

Crockett, David K DK; Piccolo, Stephen R SR; Ridge, Perry G PG; Margraf, Rebecca L RL; Lyon, Elaine E; Williams, Marc S MS; Mitchell, Joyce A JA

Publication Date: 2011-03-30

Variant appearance in text: RET: S904F

PubMed Link: 21479187

Variant Present in the following documents:

• pone.0018380.pdf

View BVdb publication page

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