Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding.
Molecular Metabolism
Alghamdi, Tamadher A TA; Krentz, Nicole A J NAJ; Smith, Nancy N; Spigelman, Aliya F AF; Rajesh, Varsha V; Jha, Alokkumar A; Ferdaoussi, Mourad M; Suzuki, Kunimasa K; Yang, Jing J; Manning Fox, Jocelyn E JE; Sun, Han H; Sun, Zijie Z; Gloyn, Anna L AL; MacDonald, Patrick E PE
Pharmacogenetic association of diabetes-associated genetic risk score with rapid progression of coronary artery calcification following treatment with HMG-CoA-reductase inhibitors -results of the Heinz Nixdorf Recall Study.
Naunyn-Schmiedeberg'S Archives Of Pharmacology
Pechlivanis, Sonali S; Jung, Dominik D; Moebus, Susanne S; Lehmann, Nils N; Mahabadi, Amir A AA; Hoffmann, Per P; Erbel, Raimund R; Nöthen, Markus M MM; Bachmann, Hagen S HS
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D.
Nature Communications
Viñuela, Ana A; Varshney, Arushi A; van de Bunt, Martijn M; Prasad, Rashmi B RB; Asplund, Olof O; Bennett, Amanda A; Boehnke, Michael M; Brown, Andrew A AA; Erdos, Michael R MR; Fadista, João J; Hansson, Ola O; Hatem, Gad G; Howald, Cédric C; Iyengar, Apoorva K AK; Johnson, Paul P; Krus, Ulrika U; MacDonald, Patrick E PE; Mahajan, Anubha A; Manning Fox, Jocelyn E JE; Narisu, Narisu N; Nylander, Vibe V; Orchard, Peter P; Oskolkov, Nikolay N; Panousis, Nikolaos I NI; Payne, Anthony A; Stitzel, Michael L ML; Vadlamudi, Swarooparani S; Welch, Ryan R; Collins, Francis S FS; Mohlke, Karen L KL; Gloyn, Anna L AL; Scott, Laura J LJ; Dermitzakis, Emmanouil T ET; Groop, Leif L; Parker, Stephen C J SCJ; McCarthy, Mark I MI
Quality of dietary fat and genetic risk of type 2 diabetes: individual participant data meta-analysis.
Bmj (Clinical Research Ed.)
Merino, Jordi J; Guasch-Ferré, Marta M; Ellervik, Christina C; Dashti, Hassan S HS; Sharp, Stephen J SJ; Wu, Peitao P; Overvad, Kim K; Sarnowski, Chloé C; Kuokkanen, Mikko M; Lemaitre, Rozenn N RN; Justice, Anne E AE; Ericson, Ulrika U; Braun, Kim V E KVE; Mahendran, Yuvaraj Y; Frazier-Wood, Alexis C AC; Sun, Dianjianyi D; Chu, Audrey Y AY; Tanaka, Toshiko T; Luan, Jian'an J; Hong, Jaeyoung J; Tjønneland, Anne A; Ding, Ming M; Lundqvist, Annamari A; Mukamal, Kenneth K; Rohde, Rebecca R; Schulz, Christina-Alexandra CA; Franco, Oscar H OH; Grarup, Niels N; Chen, Yii-Der Ida YI; Bazzano, Lydia L; Franks, Paul W PW; Buring, Julie E JE; Langenberg, Claudia C; Liu, Ching-Ti CT; Hansen, Torben T; Jensen, Majken K MK; Sääksjärvi, Katri K; Psaty, Bruce M BM; Young, Kristin L KL; Hindy, George G; Sandholt, Camilla Helene CH; Ridker, Paul M PM; Ordovas, Jose M JM; Meigs, James B JB; Pedersen, Oluf O; Kraft, Peter P; Perola, Markus M; North, Kari E KE; Orho-Melander, Marju M; Voortman, Trudy T; Toft, Ulla U; Rotter, Jerome I JI; Qi, Lu L; Forouhi, Nita G NG; Mozaffarian, Dariush D; Sørensen, Thorkild I A TIA; Stampfer, Meir J MJ; Männistö, Satu S; Selvin, Elizabeth E; Imamura, Fumiaki F; Salomaa, Veikko V; Hu, Frank B FB; Wareham, Nick J NJ; Dupuis, Josée J; Smith, Caren E CE; Kilpeläinen, Tuomas O TO; Chasman, Daniel I DI; Florez, Jose C JC
Genome-wide association meta-analysis of individuals of European ancestry identifies new loci explaining a substantial fraction of hair color variation and heritability.
Nature Genetics
Hysi, Pirro G PG; Valdes, Ana M AM; Liu, Fan F; Furlotte, Nicholas A NA; Evans, David M DM; Bataille, Veronique V; Visconti, Alessia A; Hemani, Gibran G; McMahon, George G; Ring, Susan M SM; Smith, George Davey GD; Duffy, David L DL; Zhu, Gu G; Gordon, Scott D SD; Medland, Sarah E SE; Lin, Bochao D BD; Willemsen, Gonneke G; Jan Hottenga, Jouke J; Vuckovic, Dragana D; Girotto, Giorgia G; Gandin, Ilaria I; Sala, Cinzia C; Concas, Maria Pina MP; Brumat, Marco M; Gasparini, Paolo P; Toniolo, Daniela D; Cocca, Massimiliano M; Robino, Antonietta A; Yazar, Seyhan S; Hewitt, Alex W AW; Chen, Yan Y; Zeng, Changqing C; Uitterlinden, Andre G AG; Ikram, M Arfan MA; Hamer, Merel A MA; van Duijn, Cornelia M CM; Nijsten, Tamar T; Mackey, David A DA; Falchi, Mario M; Boomsma, Dorret I DI; Martin, Nicholas G NG; , ; Hinds, David A DA; Kayser, Manfred M; Spector, Timothy D TD
Influence of genetic ancestry and socioeconomic status on type 2 diabetes in the diverse Colombian populations of Chocó and Antioquia.
Scientific Reports
Chande, Aroon T AT; Rowell, Jessica J; Rishishwar, Lavanya L; Conley, Andrew B AB; Norris, Emily T ET; Valderrama-Aguirre, Augusto A; Medina-Rivas, Miguel A MA; Jordan, I King IK
CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes.
Scientific Reports
Peng, Danfeng D; Wang, Jie J; Zhang, Rong R; Jiang, Feng F; Tam, Claudia H T CHT; Jiang, Guozhi G; Wang, Tao T; Chen, Miao M; Yan, Jing J; Wang, Shiyun S; Yan, Dandan D; He, Zhen Z; Ma, Ronald C W RCW; Bao, Yuqian Y; Hu, Cheng C; Jia, Weiping W
Genetics of Type 2 Diabetes in U.S. Hispanic/Latino Individuals: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).
Diabetes
Qi, Qibin Q; Stilp, Adrienne M AM; Sofer, Tamar T; Moon, Jee-Young JY; Hidalgo, Bertha B; Szpiro, Adam A AA; Wang, Tao T; Ng, Maggie C Y MCY; Guo, Xiuqing X; , ; Chen, Yii-Der Ida YI; Taylor, Kent D KD; Aviles-Santa, M Larissa ML; Papanicolaou, George G; Pankow, James S JS; Schneiderman, Neil N; Laurie, Cathy C CC; Rotter, Jerome I JI; Kaplan, Robert C RC
Several type 2 diabetes-associated variants in genes annotated to WNT signaling interact with dietary fiber in relation to incidence of type 2 diabetes.
Genes & Nutrition
Hindy, George G; Mollet, Inês G IG; Rukh, Gull G; Ericson, Ulrika U; Orho-Melander, Marju M
Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors.
Plos Genetics
van de Bunt, Martijn M; Manning Fox, Jocelyn E JE; Dai, Xiaoqing X; Barrett, Amy A; Grey, Caleb C; Li, Lei L; Bennett, Amanda J AJ; Johnson, Paul R PR; Rajotte, Raymond V RV; Gaulton, Kyle J KJ; Dermitzakis, Emmanouil T ET; MacDonald, Patrick E PE; McCarthy, Mark I MI; Gloyn, Anna L AL
A Mendelian randomization study of the effect of type-2 diabetes on coronary heart disease.
Nature Communications
Ahmad, Omar S OS; Morris, John A JA; Mujammami, Muhammad M; Forgetta, Vincenzo V; Leong, Aaron A; Li, Rui R; Turgeon, Maxime M; Greenwood, Celia M T CM; Thanassoulis, George G; Meigs, James B JB; Sladek, Robert R; Richards, J Brent JB
Replication Study in a Japanese Population to Evaluate the Association between 10 SNP Loci, Identified in European Genome-Wide Association Studies, and Type 2 Diabetes.
Sixty-five common genetic variants and prediction of type 2 diabetes.
Diabetes
Talmud, Philippa J PJ; Cooper, Jackie A JA; Morris, Richard W RW; Dudbridge, Frank F; Shah, Tina T; Engmann, Jorgen J; Dale, Caroline C; White, Jon J; McLachlan, Stela S; Zabaneh, Delilah D; Wong, Andrew A; Ong, Ken K KK; Gaunt, Tom T; Holmes, Michael V MV; Lawlor, Debbie A DA; Richards, Marcus M; Hardy, Rebecca R; Kuh, Diana D; Wareham, Nicholas N; Langenberg, Claudia C; Ben-Shlomo, Yoav Y; Wannamethee, S Goya SG; Strachan, Mark W J MW; Kumari, Meena M; Whittaker, John C JC; Drenos, Fotios F; Kivimaki, Mika M; Hingorani, Aroon D AD; Price, Jacqueline F JF; Humphries, Steve E SE; ,
A comparison of type 2 diabetes risk allele load between African Americans and European Americans.
Human Genetics
Keaton, Jacob M JM; Cooke Bailey, Jessica N JN; Palmer, Nicholette D ND; Freedman, Barry I BI; Langefeld, Carl D CD; Ng, Maggie C Y MC; Bowden, Donald W DW
Gene-lifestyle interaction and type 2 diabetes: the EPIC interact case-cohort study.
Plos Medicine
Langenberg, Claudia C; Sharp, Stephen J SJ; Franks, Paul W PW; Scott, Robert A RA; Deloukas, Panos P; Forouhi, Nita G NG; Froguel, Philippe P; Groop, Leif C LC; Hansen, Torben T; Palla, Luigi L; Pedersen, Oluf O; Schulze, Matthias B MB; Tormo, Maria-Jose MJ; Wheeler, Eleanor E; Agnoli, Claudia C; Arriola, Larraitz L; Barricarte, Aurelio A; Boeing, Heiner H; Clarke, Geraldine M GM; Clavel-Chapelon, Françoise F; Duell, Eric J EJ; Fagherazzi, Guy G; Kaaks, Rudolf R; Kerrison, Nicola D ND; Key, Timothy J TJ; Khaw, Kay Tee KT; Kröger, Janine J; Lajous, Martin M; Morris, Andrew P AP; Navarro, Carmen C; Nilsson, Peter M PM; Overvad, Kim K; Palli, Domenico D; Panico, Salvatore S; Quirós, J Ramón JR; Rolandsson, Olov O; Sacerdote, Carlotta C; Sánchez, María-José MJ; Slimani, Nadia N; Spijkerman, Annemieke M W AM; Tumino, Rosario R; van der A, Daphne L DL; van der Schouw, Yvonne T YT; Barroso, Inês I; McCarthy, Mark I MI; Riboli, Elio E; Wareham, Nicholas J NJ
Polygenic type 2 diabetes prediction at the limit of common variant detection.
Diabetes
Vassy, Jason L JL; Hivert, Marie-France MF; Porneala, Bianca B; Dauriz, Marco M; Florez, Jose C JC; Dupuis, Josée J; Siscovick, David S DS; Fornage, Myriam M; Rasmussen-Torvik, Laura J LJ; Bouchard, Claude C; Meigs, James B JB
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
Nature Genetics
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