Publications:

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PH domain-mediated autoinhibition and oncogenic activation of Akt.

Elife

Bae, Hwan H; Viennet, Thibault T; Park, Eunyoung E; Chu, Nam N; Salguero, Antonieta A; Eck, Michael J MJ; Arthanari, Haribabu H; Cole, Philip A PA

Publication Date: 2022-08-15

Variant appearance in text: PTEN: R15A

PubMed Link: 35968932

Variant Present in the following documents:

• Main text
• elife-80148.pdf

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Expression of Human PTEN-L in a Yeast Heterologous Model Unveils Specific N-Terminal Motifs Controlling PTEN-L Subcellular Localization and Function.

Cells

Fernández-Acero, Teresa T; Bertalmio, Eleonora E; Luna, Sandra S; Mingo, Janire J; Bravo-Plaza, Ignacio I; Rodríguez-Escudero, Isabel I; Molina, María M; Pulido, Rafael R; Cid, Víctor J VJ

Publication Date: 2019-11-26

Variant appearance in text: PTEN: R15A

PubMed Link: 31779149

Variant Present in the following documents:

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The Impact of Genetic Variants on PTEN Molecular Functions and Cellular Phenotypes.

Cold Spring Harbor Perspectives In Medicine

Hasle, Nicholas N; Matreyek, Kenneth A KA; Fowler, Douglas M DM

Publication Date: 2019-11-01

Variant appearance in text: PTEN: R15A

PubMed Link: 31451538

Variant Present in the following documents:

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Conformational Dynamics and Allosteric Regulation Landscapes of Germline PTEN Mutations Associated with Autism Compared to Those Associated with Cancer.

American Journal Of Human Genetics

Smith, Iris Nira IN; Thacker, Stetson S; Seyfi, Marilyn M; Cheng, Feixiong F; Eng, Charis C

Publication Date: 2019-05-02

Variant appearance in text: PTEN: Arg15Ala

PubMed Link: 31006514

Variant Present in the following documents:

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A functional dissection of PTEN N-terminus: implications in PTEN subcellular targeting and tumor suppressor activity.

Plos One

Gil, Anabel A; Rodríguez-Escudero, Isabel I; Stumpf, Miriam M; Molina, María M; Cid, Víctor J VJ; Pulido, Rafael R

Publication Date: 2015

Variant appearance in text: PTEN: R15A

PubMed Link: 25875300

Variant Present in the following documents:

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Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Nguyen, Hoai-Nghia HN; Yang, Jr-Ming JM; Afkari, Yashar Y; Park, Ben Ho BH; Sesaki, Hiromi H; Devreotes, Peter N PN; Iijima, Miho M

Publication Date: 2014-07-01

Variant appearance in text: PTEN: R15A

PubMed Link: 24979808

Variant Present in the following documents:

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Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis.

Elife

Bolduc, David D; Rahdar, Meghdad M; Tu-Sekine, Becky B; Sivakumaren, Sindhu Carmen SC; Raben, Daniel D; Amzel, L Mario LM; Devreotes, Peter P; Gabelli, Sandra B SB; Cole, Philip P

Publication Date: 2013-07-09

Variant appearance in text: PTEN: R15A

PubMed Link: 23853711

Variant Present in the following documents:

• Main text
• elife00691.pdf

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Phosphatidylinositol 3-kinase-dependent activation of mammalian protein kinase B/Akt in Saccharomyces cerevisiae, an in vivo model for the functional study of Akt mutations.

The Journal Of Biological Chemistry

Rodríguez-Escudero, Isabel I; Andrés-Pons, Amparo A; Pulido, Rafael R; Molina, María M; Cid, Víctor J VJ

Publication Date: 2009-05-15

Variant appearance in text: PTEN: R15A

PubMed Link: 19307184

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Phosphorylation keeps PTEN phosphatase closed for business.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Ross, Alonzo H AH; Gericke, Arne A

Publication Date: 2009-02-03

Variant appearance in text: PTEN: R15A

PubMed Link: 19174524

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A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Rahdar, Meghdad M; Inoue, Takanari T; Meyer, Tobias T; Zhang, Jin J; Vazquez, Francisca F; Devreotes, Peter N PN

Publication Date: 2009-01-13

Variant appearance in text: PTEN: R15A

PubMed Link: 19114656

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Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs.

Molecular Biology Of The Cell

Gil, Anabel A; Andrés-Pons, Amparo A; Fernández, Elena E; Valiente, Miguel M; Torres, Josema J; Cervera, Javier J; Pulido, Rafael R

Publication Date: 2006-09

Variant appearance in text: PTEN: R15A

PubMed Link: 16807353

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