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Breast Cancer Research : Bcr
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The molecular and functional landscape of resistance to immune checkpoint blockade in melanoma.
Nature Communications
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Uterine lavage identifies cancer mutations and increased TP53 somatic mutation burden in individuals with ovarian cancer.
Cancer Research Communications
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Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.
Nature Communications
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Construction and validation of an immunoediting-based optimized neoantigen load (ioTNL) model to predict the response and prognosis of immune checkpoint therapy in various cancers.
Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies.
Oncogene
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Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies.
Oncogene
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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Utility of a custom designed next generation DNA sequencing gene panel to molecularly classify endometrial cancers according to The Cancer Genome Atlas subgroups.
Bmc Medical Genomics
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Alterations in PTEN and ESR1 promote clinical resistance to alpelisib plus aromatase inhibitors.
Nature Cancer
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Phase and context shape the function of composite oncogenic mutations.
Nature
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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.
Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
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Whole-exon sequencing of human myeloma cell lines shows mutations related to myeloma patients at relapse with major hits in the DNA regulation and repair pathways.
Journal Of Hematology & Oncology
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Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.
The Journal Of Pathology
Temko, Daniel D; Van Gool, Inge C IC; Rayner, Emily E; Glaire, Mark M; Makino, Seiko S; Brown, Matthew M; Chegwidden, Laura L; Palles, Claire C; Depreeuw, Jeroen J; Beggs, Andrew A; Stathopoulou, Chaido C; Mason, John J; Baker, Ann-Marie AM; Williams, Marc M; Cerundolo, Vincenzo V; Rei, Margarida M; Taylor, Jenny C JC; Schuh, Anna A; Ahmed, Ahmed A; Amant, Frédéric F; Lambrechts, Diether D; Smit, Vincent Thbm VT; Bosse, Tjalling T; Graham, Trevor A TA; Church, David N DN; Tomlinson, Ian I
Pan-urologic cancer genomic subtypes that transcend tissue of origin.
Nature Communications
Chen, Fengju F; Zhang, Yiqun Y; Bossé, Dominick D; Lalani, Aly-Khan A AA; Hakimi, A Ari AA; Hsieh, James J JJ; Choueiri, Toni K TK; Gibbons, Don L DL; Ittmann, Michael M; Creighton, Chad J CJ
A Landscape of Pharmacogenomic Interactions in Cancer.
Cell
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PredictSNP2: A Unified Platform for Accurately Evaluating SNP Effects by Exploiting the Different Characteristics of Variants in Distinct Genomic Regions.
Plos Computational Biology
Bendl, Jaroslav J; Musil, Miloš M; Štourač, Jan J; Zendulka, Jaroslav J; Damborský, Jiří J; Brezovský, Jan J
Acquired resistance to combination treatment through loss of synergy with MEK and PI3K inhibitors in colorectal cancer.
Oncotarget
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Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma.
Nature Communications
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Discovery and functional characterization of a neomorphic PTEN mutation.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Costa, Helio A HA; Leitner, Michael G MG; Sos, Martin L ML; Mavrantoni, Angeliki A; Rychkova, Anna A; Johnson, Jeffrey R JR; Newton, Billy W BW; Yee, Muh-Ching MC; De La Vega, Francisco M FM; Ford, James M JM; Krogan, Nevan J NJ; Shokat, Kevan M KM; Oliver, Dominik D; Halaszovich, Christian R CR; Bustamante, Carlos D CD
Age-related mutations associated with clonal hematopoietic expansion and malignancies.
Nature Medicine
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