Publications:

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PTEN regulates invasiveness in pancreatic neuroendocrine tumors through DUSP19-mediated VEGFR3 dephosphorylation.

Journal Of Biomedical Science

Chang, Tsung-Ming TM; Chu, Pei-Yi PY; Lin, Hui-You HY; Huang, Kuo-Wei KW; Hung, Wen-Chun WC; Shan, Yan-Shen YS; Chen, Li-Tzong LT; Tsai, Hui-Jen HJ

Publication Date: 2022-11-06

Variant appearance in text: PTEN: Y138L

PubMed Link: 36336681

Variant Present in the following documents:

• Main text
• 12929_2022_Article_875.pdf

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PTEN Protein Phosphatase Activity Is Not Required for Tumour Suppression in the Mouse Prostate.

Biomolecules

Wise, Helen M HM; Harris, Adam A; Kriplani, Nisha N; Schofield, Adam A; Caldwell, Helen H; Arends, Mark J MJ; Overton, Ian M IM; Leslie, Nick R NR

Publication Date: 2022-10-19

Variant appearance in text: PTEN: Y138L

PubMed Link: 36291720

Variant Present in the following documents:

• Main text
• biomolecules-12-01511.pdf

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PTEN inhibits AMPK to control collective migration.

Nature Communications

Peglion, Florent F; Capuana, Lavinia L; Perfettini, Isabelle I; Boucontet, Laurent L; Braithwaite, Ben B; Colucci-Guyon, Emma E; Quissac, Emie E; Forsberg-Nilsson, Karin K; Llense, Flora F; Etienne-Manneville, Sandrine S

Publication Date: 2022-08-11

Variant appearance in text: PTEN: Y138L

PubMed Link: 35953476

Variant Present in the following documents:

• Main text
• 41467_2022_Article_31842.pdf

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The Novel Phosphatase Domain Mutations Q171R and Y65S Switch PTEN from Tumor Suppressor to Oncogene.

Cells

Garrido, Jose Antonio Ma G JAMG; Alcantara, Krizelle Mae M KMM; Danac, Joshua Miguel C JMC; Serrano, Fidel Emmanuel C FEC; Cutiongco-de la Paz, Eva Maria EM; Garcia, Reynaldo L RL

Publication Date: 2021-12-05

Variant appearance in text: PTEN: Y138L

PubMed Link: 34943931

Variant Present in the following documents:

• Main text
• cells-10-03423.pdf

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The Novel Phosphatase Domain Mutations Q171R and Y65S Switch PTEN from Tumor Suppressor to Oncogene.

Cells

Garrido, Jose Antonio Ma G JAMG; Alcantara, Krizelle Mae M KMM; Danac, Joshua Miguel C JMC; Serrano, Fidel Emmanuel C FEC; Cutiongco-de la Paz, Eva Maria EM; Garcia, Reynaldo L RL

Publication Date: 2021-12-05

Variant appearance in text: PTEN: Y138L

PubMed Link: 34943931

Variant Present in the following documents:

• Main text
• cells-10-03423.pdf

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A scalable Drosophila assay for clinical interpretation of human PTEN variants in suppression of PI3K/AKT induced cellular proliferation.

Plos Genetics

Ganguly, Payel P; Madonsela, Landiso L; Chao, Jesse T JT; Loewen, Christopher J R CJR; O'Connor, Timothy P TP; Verheyen, Esther M EM; Allan, Douglas W DW

Publication Date: 2021-09

Variant appearance in text: PTEN: Y138L

PubMed Link: 34492006

Variant Present in the following documents:

• Main text

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PTEN suppresses tumorigenesis by directly dephosphorylating Akt.

Signal Transduction And Targeted Therapy

Bu, Lang L; Wang, Huan H; Pan, Ji-An JA; Chen, Lang L; Xing, Fan F; Wu, Junyu J; Li, Shun S; Guo, Deyin D

Publication Date: 2021-07-12

Variant appearance in text: PTEN: Y138L

PubMed Link: 34248141

Variant Present in the following documents:

• Main text
• 41392_2021_571_MOESM2_ESM.pdf
• 41392_2021_Article_571.pdf

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PTEN suppresses tumorigenesis by directly dephosphorylating Akt.

Signal Transduction And Targeted Therapy

Bu, Lang L; Wang, Huan H; Pan, Ji-An JA; Chen, Lang L; Xing, Fan F; Wu, Junyu J; Li, Shun S; Guo, Deyin D

Publication Date: 2021-07-12

Variant appearance in text: PTEN: Y138L

PubMed Link: 34248141

Variant Present in the following documents:

• Main text
• 41392_2021_571_MOESM2_ESM.pdf
• 41392_2021_Article_571.pdf

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Molecular Events Occurring in Lipophagy and Its Regulation in Flaviviridae Infection.

Frontiers In Microbiology

Wu, Keke K; Fan, Shuangqi S; Zou, Linke L; Zhao, Feifan F; Ma, Shengming S; Fan, Jindai J; Li, Xiaowen X; Zhao, Mingqiu M; Yan, Huichao H; Chen, Jinding J

Publication Date: 2021

Variant appearance in text: PTEN: Y138L

PubMed Link: 34093468

Variant Present in the following documents:

• Main text

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PTENε suppresses tumor metastasis through regulation of filopodia formation.

The Embo Journal

Zhang, Qiaoling Q; Liang, Hui H; Zhao, Xuyang X; Zheng, Lin L; Li, Yunqiao Y; Gong, Jingjing J; Zhu, Yizhang Y; Jin, Yan Y; Yin, Yuxin Y

Publication Date: 2021-05-17

Variant appearance in text: PTEN: Y138L

PubMed Link: 33755220

Variant Present in the following documents:

• Main text
• EMBJ-40-e105806-s005.pdf
• EMBJ-40-e105806.pdf

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Recent advances in PTEN signalling axes in cancer.

Faculty Reviews

Chow, Jonathan Tak-Sum JT; Salmena, Leonardo L

Publication Date: 2020

Variant appearance in text: PTEN: Y138L

PubMed Link: 33659963

Variant Present in the following documents:

• Main text
• facrev-09-31.pdf

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PTEN Lipid Phosphatase Activity Enhances Dengue Virus Production through Akt/FoxO1/Maf1 Signaling.

Virologica Sinica

Liu, Bin B; Gao, Ting-Ting TT; Fu, Xiao-Yu XY; Xu, Zhen-Hao ZH; Ren, Hao H; Zhao, Ping P; Qi, Zhong-Tian ZT; Qin, Zhao-Ling ZL

Publication Date: 2021-06

Variant appearance in text: PTEN: Y138L

PubMed Link: 33044659

Variant Present in the following documents:

• Main text

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Role of Ubiquitination in PTEN Cellular Homeostasis and Its Implications in GB Drug Resistance.

Frontiers In Oncology

Xia, Qin Q; Ali, Sakhawat S; Liu, Liqun L; Li, Yang Y; Liu, Xuefeng X; Zhang, Lingqiang L; Dong, Lei L

Publication Date: 2020

Variant appearance in text: PTEN: Y138L

PubMed Link: 32984016

Variant Present in the following documents:

• Main text
• fonc-10-01569.pdf

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The Role of PTEN in Neurodevelopment.

Molecular Neuropsychiatry

Skelton, Patrick D PD; Stan, Radu V RV; Luikart, Bryan W BW

Publication Date: 2020-04

Variant appearance in text: PTEN: Y138L

PubMed Link: 32399470

Variant Present in the following documents:

• Main text

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Multi-model functionalization of disease-associated PTEN missense mutations identifies multiple molecular mechanisms underlying protein dysfunction.

Nature Communications

Post, Kathryn L KL; Belmadani, Manuel M; Ganguly, Payel P; Meili, Fabian F; Dingwall, Riki R; McDiarmid, Troy A TA; Meyers, Warren M WM; Herrington, Caitlin C; Young, Barry P BP; Callaghan, Daniel B DB; Rogic, Sanja S; Edwards, Matthew M; Niciforovic, Ana A; Cau, Alessandro A; Rankin, Catharine H CH; O'Connor, Timothy P TP; Bamji, Shernaz X SX; Loewen, Christopher J R CJR; Allan, Douglas W DW; Pavlidis, Paul P; Haas, Kurt K

Publication Date: 2020-04-29

Variant appearance in text: PTEN: Y138L

PubMed Link: 32350270

Variant Present in the following documents:

• Main text
• 41467_2020_Article_15943.pdf

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Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases.

Scientific Reports

Šimčíková, Daniela D; Heneberg, Petr P

Publication Date: 2019-12-09

Variant appearance in text: PTEN: Y138L

PubMed Link: 31819097

Variant Present in the following documents:

• 41598_2019_54976_MOESM2_ESM.xlsx, sheet 8

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Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers.

Cell Reports

Chatterjee, Nilanjana N; Pazarentzos, Evangelos E; Mayekar, Manasi K MK; Gui, Philippe P; Allegakoen, David V DV; Hrustanovic, Gorjan G; Olivas, Victor V; Lin, Luping L; Verschueren, Erik E; Johnson, Jeffrey R JR; Hofree, Matan M; Yan, Jenny J JJ; Newton, Billy W BW; Dollen, John V JV; Earnshaw, Charles H CH; Flanagan, Jennifer J; Chan, Elton E; Asthana, Saurabh S; Ideker, Trey T; Wu, Wei W; Suzuki, Junji J; Barad, Benjamin A BA; Kirichok, Yuriy Y; Fraser, James S JS; Weiss, William A WA; Krogan, Nevan J NJ; Tulpule, Asmin A; Sabnis, Amit J AJ; Bivona, Trever G TG

Publication Date: 2019-08-27

Variant appearance in text: PTEN: Y138L

PubMed Link: 31461649

Variant Present in the following documents:

• Main text

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Multifaceted Regulation of PTEN Subcellular Distributions and Biological Functions.

Cancers

Liu, Tian T; Wang, Yiwei Y; Wang, Yubing Y; Chan, Andrew M AM

Publication Date: 2019-08-26

Variant appearance in text: PTEN: Y138L

PubMed Link: 31454965

Variant Present in the following documents:

• Main text
• cancers-11-01247.pdf

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The Impact of Genetic Variants on PTEN Molecular Functions and Cellular Phenotypes.

Cold Spring Harbor Perspectives In Medicine

Hasle, Nicholas N; Matreyek, Kenneth A KA; Fowler, Douglas M DM

Publication Date: 2019-11-01

Variant appearance in text: PTEN: Y138L

PubMed Link: 31451538

Variant Present in the following documents:

• Main text

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PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage.

Cancer Discovery

Zhang, Jinfang J; Lee, Yu-Ru YR; Dang, Fabin F; Gan, Wenjian W; Menon, Archita Venugopal AV; Katon, Jesse M JM; Hsu, Chih-Hung CH; Asara, John M JM; Tibarewal, Priyanka P; Leslie, Nicholas R NR; Shi, Yang Y; Pandolfi, Pier Paolo PP; Wei, Wenyi W

Publication Date: 2019-09

Variant appearance in text: PTEN: Y138L

PubMed Link: 31217297

Variant Present in the following documents:

• Main text

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Conformational Dynamics and Allosteric Regulation Landscapes of Germline PTEN Mutations Associated with Autism Compared to Those Associated with Cancer.

American Journal Of Human Genetics

Smith, Iris Nira IN; Thacker, Stetson S; Seyfi, Marilyn M; Cheng, Feixiong F; Eng, Charis C

Publication Date: 2019-05-02

Variant appearance in text: PTEN: Tyr138Leu

PubMed Link: 31006514

Variant Present in the following documents:

• Main text

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The PTEN⁻PI3K Axis in Cancer.

Biomolecules

Papa, Antonella A; Pandolfi, Pier Paolo PP

Publication Date: 2019-04-17

Variant appearance in text: PTEN: Y138L

PubMed Link: 30999672

Variant Present in the following documents:

• Main text
• biomolecules-09-00153.pdf

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LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.

Cell Research

Hu, Qingsong Q; Li, Chunlai C; Wang, Shouyu S; Li, Yajuan Y; Wen, Bo B; Zhang, Yanyan Y; Liang, Ke K; Yao, Jun J; Ye, Youqiong Y; Hsiao, Heidi H; Nguyen, Tina K TK; Park, Peter K PK; Egranov, Sergey D SD; Hawke, David H DH; Marks, Jeffrey R JR; Han, Leng L; Hung, Mien-Chie MC; Zhang, Bing B; Lin, Chunru C; Yang, Liuqing L

Publication Date: 2019-04

Variant appearance in text: PTEN: Y138L

PubMed Link: 30631154

Variant Present in the following documents:

• Main text

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Nuclear Excluded Autism-Associated Phosphatase and Tensin Homolog Mutations Dysregulate Neuronal Growth.

Biological Psychiatry

Fricano-Kugler, Catherine J CJ; Getz, Stephanie A SA; Williams, Michael R MR; Zurawel, Ashley A AA; DeSpenza, Tyrone T; Frazel, Paul W PW; Li, Meijie M; O'Malley, Alistair J AJ; Moen, Erika L EL; Luikart, Bryan W BW

Publication Date: 2018-08-15

Variant appearance in text: PTEN: Y138L

PubMed Link: 29373119

Variant Present in the following documents:

• Main text

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PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer.

Nature Communications

Wozniak, Darren J DJ; Kajdacsy-Balla, Andre A; Macias, Virgilia V; Ball-Kell, Susan S; Zenner, Morgan L ML; Bie, Wenjun W; Tyner, Angela L AL

Publication Date: 2017-11-15

Variant appearance in text: PTEN: Y138L

PubMed Link: 29142193

Variant Present in the following documents:

• Main text
• 41467_2017_1574_MOESM1_ESM.pdf
• 41467_2017_Article_1574.pdf
• 41467_2017_1574_MOESM2_ESM.pdf

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The role of PTEN - HCV core interaction in hepatitis C virus replication.

Scientific Reports

Wu, Qi Q; Li, Zhubing Z; Mellor, Paul P; Zhou, Yan Y; Anderson, Deborah H DH; Liu, Qiang Q

Publication Date: 2017-06-16

Variant appearance in text: PTEN: Y138L

PubMed Link: 28623358

Variant Present in the following documents:

• Main text

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PTENβ is an alternatively translated isoform of PTEN that regulates rDNA transcription.

Nature Communications

Liang, Hui H; Chen, Xi X; Yin, Qi Q; Ruan, Danhui D; Zhao, Xuyang X; Zhang, Cong C; McNutt, Michael A MA; Yin, Yuxin Y

Publication Date: 2017-03-23

Variant appearance in text: PTEN: Y138L

PubMed Link: 28332494

Variant Present in the following documents:

• ncomms14771-s2.pdf
• ncomms14771-s1.pdf

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The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair.

Scientific Reports

Vuono, Elizabeth A EA; Mukherjee, Ananda A; Vierra, David A DA; Adroved, Morganne M MM; Hodson, Charlotte C; Deans, Andrew J AJ; Howlett, Niall G NG

Publication Date: 2016-11-07

Variant appearance in text: PTEN: Y138L

PubMed Link: 27819275

Variant Present in the following documents:

• Main text
• srep36439.pdf
• srep36439-s1.pdf

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Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development.

Plos One

Stumpf, Miriam M; den Hertog, Jeroen J

Publication Date: 2016

Variant appearance in text: PTEN: Y138L

PubMed Link: 26848951

Variant Present in the following documents:

• Main text

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PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype.

Nature Communications

Duan, Shunlei S; Yuan, Guohong G; Liu, Xiaomeng X; Ren, Ruotong R; Li, Jingyi J; Zhang, Weizhou W; Wu, Jun J; Xu, Xiuling X; Fu, Lina L; Li, Ying Y; Yang, Jiping J; Zhang, Weiqi W; Bai, Ruijun R; Yi, Fei F; Suzuki, Keiichiro K; Gao, Hua H; Esteban, Concepcion Rodriguez CR; Zhang, Chuanbao C; Izpisua Belmonte, Juan Carlos JC; Chen, Zhiguo Z; Wang, Xiaomin X; Jiang, Tao T; Qu, Jing J; Tang, Fuchou F; Liu, Guang-Hui GH

Publication Date: 2015-12-03

Variant appearance in text: PTEN: Y138L

PubMed Link: 26632666

Variant Present in the following documents:

• Main text
• ncomms10068-s1.pdf
• ncomms10068.pdf

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PTEN regulates cilia through Dishevelled.

Nature Communications

Shnitsar, Iryna I; Bashkurov, Mikhail M; Masson, Glenn R GR; Ogunjimi, Abiodun A AA; Mosessian, Sherly S; Cabeza, Eduardo Aguiar EA; Hirsch, Calley L CL; Trcka, Daniel D; Gish, Gerald G; Jiao, Jing J; Wu, Hong H; Winklbauer, Rudolf R; Williams, Roger L RL; Pelletier, Laurence L; Wrana, Jeffrey L JL; Barrios-Rodiles, Miriam M

Publication Date: 2015-09-24

Variant appearance in text: PTEN: Y138L

PubMed Link: 26399523

Variant Present in the following documents:

• Main text

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A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity.

Nature Communications

Conde-Perez, Alejandro A; Gros, Gwendoline G; Longvert, Christine C; Pedersen, Malin M; Petit, Valérie V; Aktary, Zackie Z; Viros, Amaya A; Gesbert, Franck F; Delmas, Véronique V; Rambow, Florian F; Bastian, Boris C BC; Campbell, Andrew D AD; Colombo, Sophie S; Puig, Isabel I; Bellacosa, Alfonso A; Sansom, Owen O; Marais, Richard R; Van Kempen, Leon C L T LC; Larue, Lionel L

Publication Date: 2015-08-26

Variant appearance in text: PTEN: Y138L

PubMed Link: 26307673

Variant Present in the following documents:

• Main text

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The protein phosphatase activity of PTEN is essential for regulating neural stem cell differentiation.

Molecular Brain

Lyu, Jingwen J; Yu, Xiuya X; He, Lingjie L; Cheng, Tianlin T; Zhou, Jingjing J; Cheng, Cheng C; Chen, Zhifang Z; Cheng, Guoqiang G; Qiu, Zilong Z; Zhou, Wenhao W

Publication Date: 2015-04-18

Variant appearance in text: PTEN: Y138L

PubMed Link: 25927309

Variant Present in the following documents:

• Main text

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FAK mediates a compensatory survival signal parallel to PI3K-AKT in PTEN-null T-ALL cells.

Cell Reports

You, Dewen D; Xin, Junping J; Volk, Andrew A; Wei, Wei W; Schmidt, Rachel R; Scurti, Gina G; Nand, Sucha S; Breuer, Eun-Kyoung EK; Kuo, Paul C PC; Breslin, Peter P; Kini, Ameet R AR; Nishimura, Michael I MI; Zeleznik-Le, Nancy J NJ; Zhang, Jiwang J

Publication Date: 2015-03-31

Variant appearance in text: PTEN: Y138L

PubMed Link: 25801032

Variant Present in the following documents:

• Main text

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Functionally distinct groups of inherited PTEN mutations in autism and tumour syndromes.

Journal Of Medical Genetics

Spinelli, Laura L; Black, Fiona M FM; Berg, Jonathan N JN; Eickholt, Britta J BJ; Leslie, Nicholas R NR

Publication Date: 2015-02

Variant appearance in text: PTEN: Y138L

PubMed Link: 25527629

Variant Present in the following documents:

• jmedgenet-2014-102803-s1.pdf

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PTEN is a protein tyrosine phosphatase for IRS1.

Nature Structural & Molecular Biology

Shi, Yuji Y; Wang, Junru J; Chandarlapaty, Sarat S; Cross, Justin J; Thompson, Craig C; Rosen, Neal N; Jiang, Xuejun X

Publication Date: 2014-06

Variant appearance in text: PTEN: Y138L

PubMed Link: 24814346

Variant Present in the following documents:

• Main text

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Subcellular targeting and dynamic regulation of PTEN: implications for neuronal cells and neurological disorders.

Frontiers In Molecular Neuroscience

Kreis, Patricia P; Leondaritis, George G; Lieberam, Ivo I; Eickholt, Britta J BJ

Publication Date: 2014

Variant appearance in text: PTEN: Y138L

PubMed Link: 24744697

Variant Present in the following documents:

• Main text
• fnmol-07-00023.pdf

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Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110α/PIK3CA but not by HER2 or mutant AKT1.

Oncogene

Berglund, F M FM; Weerasinghe, N R NR; Davidson, L L; Lim, J C JC; Eickholt, B J BJ; Leslie, N R NR

Publication Date: 2013-09-12

Variant appearance in text: PTEN: Y138L

PubMed Link: 23085752

Variant Present in the following documents:

• Main text

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Functional analysis of the protein phosphatase activity of PTEN.

The Biochemical Journal

Zhang, Xiaoqun Catherine XC; Piccini, Antonella A; Myers, Michael P MP; Van Aelst, Linda L; Tonks, Nicholas K NK

Publication Date: 2012-06-15

Variant appearance in text: PTEN: Y138L

PubMed Link: 22413754

Variant Present in the following documents:

• Main text
• bj4440457.pdf

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Mechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cells.

Molecular And Cellular Biology

Kim, Jung-Sik JS; Xu, Xuehua X; Li, Huifang H; Solomon, David D; Lane, William S WS; Jin, Tian T; Waldman, Todd T

Publication Date: 2011-07

Variant appearance in text: PTEN: Y138L

PubMed Link: 21536651

Variant Present in the following documents:

• Main text

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p53 regulation of podosome formation and cellular invasion in vascular smooth muscle cells.

Cell Adhesion & Migration

Mak, Alan S AS

Publication Date: 2011

Variant appearance in text: PTEN: Y138L

PubMed Link: 21164280

Variant Present in the following documents:

• Main text

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Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN.

Oncogene

Davidson, L L; Maccario, H H; Perera, N M NM; Yang, X X; Spinelli, L L; Tibarewal, P P; Glancy, B B; Gray, A A; Weijer, C J CJ; Downes, C P CP; Leslie, N R NR

Publication Date: 2010-02-04

Variant appearance in text: PTEN: Y138L

PubMed Link: 19915616

Variant Present in the following documents:

• Main text
• NIHMS27910-supplement-1.pdf
• ukmss-27910.pdf

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