PTEN c.481_482delinsGC ;(p.R161A)

Variant ID: 10-89692997-AG-GC

NM_000314.4(PTEN):c.481_482delinsGC;(p.R161A)

This variant was identified in 4 publications

View GRCh38 version.




Publications:


Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis.

Elife
Bolduc, David D; Rahdar, Meghdad M; Tu-Sekine, Becky B; Sivakumaren, Sindhu Carmen SC; Raben, Daniel D; Amzel, L Mario LM; Devreotes, Peter P; Gabelli, Sandra B SB; Cole, Philip P
Publication Date: 2013-07-09

Variant appearance in text: PTEN: R161A
PubMed Link: 23853711
Variant Present in the following documents:
  • Main text
  • elife00691.pdf
View BVdb publication page



A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Rahdar, Meghdad M; Inoue, Takanari T; Meyer, Tobias T; Zhang, Jin J; Vazquez, Francisca F; Devreotes, Peter N PN
Publication Date: 2009-01-13

Variant appearance in text: PTEN: R161A
PubMed Link: 19114656
Variant Present in the following documents:
  • Main text
View BVdb publication page



Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs.

Molecular Biology Of The Cell
Gil, Anabel A; Andrés-Pons, Amparo A; Fernández, Elena E; Valiente, Miguel M; Torres, Josema J; Cervera, Javier J; Pulido, Rafael R
Publication Date: 2006-09

Variant appearance in text: PTEN: R161A
PubMed Link: 16807353
Variant Present in the following documents:
  • Main text
View BVdb publication page



Membrane-binding and activation mechanism of PTEN.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Das, Sudipto S; Dixon, Jack E JE; Cho, Wonhwa W
Publication Date: 2003-06-24

Variant appearance in text: PTEN: R161A
PubMed Link: 12808147
Variant Present in the following documents:
  • Main text
View BVdb publication page