PTEN c.499A>G ;(p.T167A)

Variant ID: 10-89711881-A-G

NM_000314.4(PTEN):c.499A>G;(p.T167A)

This variant was identified in 33 publications

View GRCh38 version.




Publications:


Significance of logistic regression scoring model based on natural killer cell-mediated cytotoxic pathway in the diagnosis of colon cancer.

Frontiers In Immunology
Ye, Zhen Z; Zhang, Huanhuan H; Liang, Jianwei J; Yi, Shuying S; Zhan, Xianquan X
Publication Date: 2023

Variant appearance in text: PTEN: T167A
PubMed Link: 36742322
Variant Present in the following documents:
  • Table_8.xlsx, sheet 1
View BVdb publication page



Analysis of single-nucleotide polymorphisms in genes associated with triple-negative breast cancer.

Frontiers In Genetics
G, Vigneshwaran V; Hasan, Qurratulain Annie QA; Kumar, Rahul R; Eranki, Avinash A
Publication Date: 2022

Variant appearance in text: PTEN: T167A
PubMed Link: 36561320
Variant Present in the following documents:
  • Table3.xlsx, sheet 1
  • Table2.xlsx, sheet 6
View BVdb publication page



Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications
Boström, Martin M; Larsson, Erik E
Publication Date: 2022-11-17

Variant appearance in text: PTEN: T167A
PubMed Link: 36396655
Variant Present in the following documents:
  • 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1
View BVdb publication page



Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer.

Nature Cancer
Westcott, Peter M K PMK; Sacks, Nathan J NJ; Schenkel, Jason M JM; Ely, Zackery A ZA; Smith, Olivia O; Hauck, Haley H; Jaeger, Alex M AM; Zhang, Daniel D; Backlund, Coralie M CM; Beytagh, Mary C MC; Patten, J J JJ; Elbashir, Ryan R; Eng, George G; Irvine, Darrell J DJ; Yilmaz, Omer H OH; Jacks, Tyler T
Publication Date: 2021-10

Variant appearance in text: PTEN: 499A>G; Thr167Ala
PubMed Link: 34738089
Variant Present in the following documents:
  • NIHMS1725490-supplement-Source_Data_Figure_1.xlsx, sheet 1
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: PTEN: T167A
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



Improvement of Neoantigen Identification Through Convolution Neural Network.

Frontiers In Immunology
Hao, Qing Q; Wei, Ping P; Shu, Yang Y; Zhang, Yi-Guan YG; Xu, Heng H; Zhao, Jun-Ning JN
Publication Date: 2021

Variant appearance in text: PTEN: T167A
PubMed Link: 34113354
Variant Present in the following documents:
  • Table_1.xlsx, sheet 6
View BVdb publication page



Anticancer Activity of Two Novel Hydroxylated Biphenyl Compounds toward Malignant Melanoma Cells.

International Journal Of Molecular Sciences
Pisano, Marina M; Dettori, Maria Antonietta MA; Fabbri, Davide D; Delogu, Giovanna G; Palmieri, Giuseppe G; Rozzo, Carla C
Publication Date: 2021-05-26

Variant appearance in text: PTEN: T167A
PubMed Link: 34073232
Variant Present in the following documents:
  • Main text
View BVdb publication page



Melanoma subpopulations that rapidly escape MAPK pathway inhibition incur DNA damage and rely on stress signalling.

Nature Communications
Yang, Chen C; Tian, Chengzhe C; Hoffman, Timothy E TE; Jacobsen, Nicole K NK; Spencer, Sabrina L SL
Publication Date: 2021-03-19

Variant appearance in text: PTEN: T167A
PubMed Link: 33741929
Variant Present in the following documents:
  • 41467_2021_21549_MOESM1_ESM.pdf
View BVdb publication page



Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer
Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA
Publication Date: 2021-05

Variant appearance in text: PTEN: 499A>G; T167A
PubMed Link: 33704917
Variant Present in the following documents:
  • TCA-12-1271-s003.xls, sheet 1
View BVdb publication page



Horizontal Combination of MEK and PI3K/mTOR Inhibition in BRAF Mutant Tumor Cells with or without Concomitant PI3K Pathway Mutations.

International Journal Of Molecular Sciences
Rittler, Dominika D; Molnár, Eszter E; Baranyi, Marcell M; Garay, Tamás T; Hegedűs, Luca L; Aigner, Clemens C; Tóvári, József J; Tímár, József J; Hegedűs, Balázs B
Publication Date: 2020-10-16

Variant appearance in text: PTEN: T167A
PubMed Link: 33081092
Variant Present in the following documents:
  • Main text
  • ijms-21-07649.pdf
View BVdb publication page



Clinical advantage of targeted sequencing for unbiased tumor mutational burden estimation in samples with low tumor purity.

Journal For Immunotherapy Of Cancer
Hong, Tae Hee TH; Cha, Hongui H; Shim, Joon Ho JH; Lee, Boram B; Chung, Jongsuk J; Lee, Chung C; Kim, Nayoung K D NKD; Choi, Yoon-La YL; Hwang, Soohyun S; Lee, Yoomi Y; Park, Sehhoon S; Jung, Hyun Ae HA; Kim, Ji-Yeon JY; Park, Yeon Hee YH; Sun, Jong-Mu JM; Ahn, Jin Seok JS; Ahn, Myung-Ju MJ; Park, Keunchil K; Lee, Se-Hoon SH; Park, Woong-Yang WY
Publication Date: 2020-10

Variant appearance in text: PTEN: T167A
PubMed Link: 33077514
Variant Present in the following documents:
  • jitc-2020-001199supp002.pdf
View BVdb publication page



mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis.

Cell Reports
Triki, Mouna M; Rinaldi, Gianmarco G; Planque, Melanie M; Broekaert, Dorien D; Winkelkotte, Alina M AM; Maier, Carina R CR; Janaki Raman, Sudha S; Vandekeere, Anke A; Van Elsen, Joke J; Orth, Martin F MF; Grünewald, Thomas G P TGP; Schulze, Almut A; Fendt, Sarah-Maria SM
Publication Date: 2020-06-23

Variant appearance in text: PTEN: T167A
PubMed Link: 32579932
Variant Present in the following documents:
  • mmc5.xlsx, sheet 3
View BVdb publication page



Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: PTEN: T167A
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
View BVdb publication page



Diversity spectrum analysis identifies mutation-specific effects of cancer driver genes.

Communications Biology
Dong, Xiaobao X; Huang, Dandan D; Yi, Xianfu X; Zhang, Shijie S; Wang, Zhao Z; Yan, Bin B; Chung Sham, Pak P; Chen, Kexin K; Jun Li, Mulin M
Publication Date: 2020-01-07

Variant appearance in text: PTEN: 499A>G; T167A
PubMed Link: 31925297
Variant Present in the following documents:
  • 42003_2019_736_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Targeted mutation detection in breast cancer using MammaSeq™.

Breast Cancer Research : Bcr
Smith, Nicholas G NG; Gyanchandani, Rekha R; Shah, Osama S OS; Gurda, Grzegorz T GT; Lucas, Peter C PC; Hartmaier, Ryan J RJ; Brufsky, Adam M AM; Puhalla, Shannon S; Bahreini, Amir A; Kota, Karthik K; Wald, Abigail I AI; Nikiforov, Yuri E YE; Nikiforova, Marina N MN; Oesterreich, Steffi S; Lee, Adrian V AV
Publication Date: 2019-02-08

Variant appearance in text: PTEN: T167A
PubMed Link: 30736836
Variant Present in the following documents:
  • 13058_2019_1102_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Publication Date: 2018

Variant appearance in text: PTEN: T167A
PubMed Link: 29698444
Variant Present in the following documents:
  • pone.0196434.s001.xlsx, sheet 3
  • pone.0196434.s001.xlsx, sheet 1
  • pone.0196434.s001.xlsx, sheet 2
View BVdb publication page



Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.

The Journal Of Pathology
Temko, Daniel D; Van Gool, Inge C IC; Rayner, Emily E; Glaire, Mark M; Makino, Seiko S; Brown, Matthew M; Chegwidden, Laura L; Palles, Claire C; Depreeuw, Jeroen J; Beggs, Andrew A; Stathopoulou, Chaido C; Mason, John J; Baker, Ann-Marie AM; Williams, Marc M; Cerundolo, Vincenzo V; Rei, Margarida M; Taylor, Jenny C JC; Schuh, Anna A; Ahmed, Ahmed A; Amant, Frédéric F; Lambrechts, Diether D; Smit, Vincent Thbm VT; Bosse, Tjalling T; Graham, Trevor A TA; Church, David N DN; Tomlinson, Ian I
Publication Date: 2018-07

Variant appearance in text: PTEN: 499A>G; T167A
PubMed Link: 29604063
Variant Present in the following documents:
  • PATH-245-283-s022.xlsx, sheet 1
View BVdb publication page



Cell Dispersal Influences Tumor Heterogeneity and Introduces a Bias in NGS Data Interpretation.

Scientific Reports
Pongor, Lőrinc L; Harami-Papp, Hajnalka H; Méhes, Előd E; Czirók, András A; Győrffy, Balázs B
Publication Date: 2017-08-04

Variant appearance in text: PTEN: 499A>G
PubMed Link: 28779157
Variant Present in the following documents:
  • 41598_2017_7487_MOESM5_ESM.xls, sheet 5
  • 41598_2017_7487_MOESM6_ESM.xls, sheet 1
  • 41598_2017_7487_MOESM5_ESM.xls, sheet 3
  • 41598_2017_7487_MOESM5_ESM.xls, sheet 4
  • 41598_2017_7487_MOESM5_ESM.xls, sheet 2
  • 41598_2017_7487_MOESM6_ESM.xls, sheet 2
  • 41598_2017_7487_MOESM5_ESM.xls, sheet 1
View BVdb publication page



Pan-urologic cancer genomic subtypes that transcend tissue of origin.

Nature Communications
Chen, Fengju F; Zhang, Yiqun Y; Bossé, Dominick D; Lalani, Aly-Khan A AA; Hakimi, A Ari AA; Hsieh, James J JJ; Choueiri, Toni K TK; Gibbons, Don L DL; Ittmann, Michael M; Creighton, Chad J CJ
Publication Date: 2017-08-04

Variant appearance in text: PTEN: 499A>G; T167A
PubMed Link: 28775315
Variant Present in the following documents:
  • 41467_2017_289_MOESM7_ESM.xlsx, sheet 1
View BVdb publication page



Next-generation Sequencing (NGS) Analysis on Single Circulating Tumor Cells (CTCs) with No Need of Whole-genome Amplification (WGA).

Cancer Genomics & Proteomics
Palmirotta, Raffaele R; Lovero, Domenica D; Silvestris, Erica E; Felici, Claudia C; Quaresmini, Davide D; Cafforio, Paola P; Silvestris, Franco F
Publication Date: 2017

Variant appearance in text: PTEN: T167A
PubMed Link: 28446532
Variant Present in the following documents:
  • Main text
View BVdb publication page



Sorafenib inhibits cell growth but fails to enhance radio- and chemosensitivity of glioblastoma cell lines.

Oncotarget
Riedel, Matthias M; Struve, Nina N; Müller-Goebel, Justus J; Köcher, Sabrina S; Petersen, Cordula C; Dikomey, Ekkehard E; Rothkamm, Kai K; Kriegs, Malte M
Publication Date: 2016-09-20

Variant appearance in text: PTEN: T167A
PubMed Link: 27542273
Variant Present in the following documents:
  • oncotarget-07-61988-s001.pdf
View BVdb publication page



A Landscape of Pharmacogenomic Interactions in Cancer.

Cell
Iorio, Francesco F; Knijnenburg, Theo A TA; Vis, Daniel J DJ; Bignell, Graham R GR; Menden, Michael P MP; Schubert, Michael M; Aben, Nanne N; Gonçalves, Emanuel E; Barthorpe, Syd S; Lightfoot, Howard H; Cokelaer, Thomas T; Greninger, Patricia P; van Dyk, Ewald E; Chang, Han H; de Silva, Heshani H; Heyn, Holger H; Deng, Xianming X; Egan, Regina K RK; Liu, Qingsong Q; Mironenko, Tatiana T; Mitropoulos, Xeni X; Richardson, Laura L; Wang, Jinhua J; Zhang, Tinghu T; Moran, Sebastian S; Sayols, Sergi S; Soleimani, Maryam M; Tamborero, David D; Lopez-Bigas, Nuria N; Ross-Macdonald, Petra P; Esteller, Manel M; Gray, Nathanael S NS; Haber, Daniel A DA; Stratton, Michael R MR; Benes, Cyril H CH; Wessels, Lodewyk F A LFA; Saez-Rodriguez, Julio J; McDermott, Ultan U; Garnett, Mathew J MJ
Publication Date: 2016-07-28

Variant appearance in text: PTEN: 499A>G; T167A
PubMed Link: 27397505
Variant Present in the following documents:
  • mmc3.xlsx, sheet 3
View BVdb publication page



SNPase-ARMS qPCR: Ultrasensitive Mutation-Based Detection of Cell-Free Tumor DNA in Melanoma Patients.

Plos One
Stadler, Julia J; Eder, Johanna J; Pratscher, Barbara B; Brandt, Sabine S; Schneller, Doris D; Müllegger, Robert R; Vogl, Claus C; Trautinger, Franz F; Brem, Gottfried G; Burgstaller, Joerg P JP
Publication Date: 2015

Variant appearance in text: PTEN: T167A
PubMed Link: 26562020
Variant Present in the following documents:
  • Main text
  • pone.0142273.pdf
View BVdb publication page



EGFRvIII does not affect radiosensitivity with or without gefitinib treatment in glioblastoma cells.

Oncotarget
Struve, Nina N; Riedel, Matthias M; Schulte, Alexander A; Rieckmann, Thorsten T; Grob, Tobias J TJ; Gal, Andreas A; Rothkamm, Kai K; Lamszus, Katrin K; Petersen, Cordula C; Dikomey, Ekkehard E; Kriegs, Malte M
Publication Date: 2015-10-20

Variant appearance in text: PTEN: T167A
PubMed Link: 26418954
Variant Present in the following documents:
  • Main text
View BVdb publication page



Individualized strategies to target specific mechanisms of disease in malignant melanoma patients displaying unique mutational signatures.

Oncotarget
Curiel-Olmo, Soraya S; García-Castaño, Almudena A; Vidal, Rebeca R; Pisonero, Helena H; Varela, Ignacio I; León-Castillo, Alicia A; Trillo, Eugenio E; González-Vela, Carmen C; García-Diaz, Nuria N; Almaraz, Carmen C; Moreno, Thaidy T; Cereceda, Laura L; Madureira, Rebeca R; Martinez, Nerea N; Ortiz-Romero, Pablo P; Valdizán, Elsa E; Piris, Miguel A MA; Vaqué, José P JP; Piris, Miguel M; Vaqué, José J
Publication Date: 2015-09-22

Variant appearance in text: PTEN: T167A
PubMed Link: 26327537
Variant Present in the following documents:
  • oncotarget-06-25452-s003.xlsx, sheet 1
View BVdb publication page



Using CellMiner 1.6 for Systems Pharmacology and Genomic Analysis of the NCI-60.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Reinhold, William C WC; Sunshine, Margot M; Varma, Sudhir S; Doroshow, James H JH; Pommier, Yves Y
Publication Date: 2015-09-01

Variant appearance in text: PTEN: T167A
PubMed Link: 26048278
Variant Present in the following documents:
  • Main text
View BVdb publication page



Voltage sensitive phosphatases: emerging kinship to protein tyrosine phosphatases from structure-function research.

Frontiers In Pharmacology
Hobiger, Kirstin K; Friedrich, Thomas T
Publication Date: 2015

Variant appearance in text: PTEN: T167A
PubMed Link: 25713537
Variant Present in the following documents:
  • Main text
  • fphar-06-00020.pdf
View BVdb publication page



NCI-60 whole exome sequencing and pharmacological CellMiner analyses.

Plos One
Reinhold, William C WC; Varma, Sudhir S; Sousa, Fabricio F; Sunshine, Margot M; Abaan, Ogan D OD; Davis, Sean R SR; Reinhold, Spencer W SW; Kohn, Kurt W KW; Morris, Joel J; Meltzer, Paul S PS; Doroshow, James H JH; Pommier, Yves Y
Publication Date: 2014

Variant appearance in text: PTEN: T167A
PubMed Link: 25032700
Variant Present in the following documents:
  • pone.0101670.s004.xlsx, sheet 1
  • pone.0101670.s001.xlsx, sheet 1
View BVdb publication page



Targeted-capture massively-parallel sequencing enables robust detection of clinically informative mutations from formalin-fixed tumours.

Scientific Reports
Wong, Stephen Q SQ; Li, Jason J; Salemi, Renato R; Sheppard, Karen E KE; Do, Hongdo H; Tothill, Richard W RW; McArthur, Grant A GA; Dobrovic, Alexander A
Publication Date: 2013-12-13

Variant appearance in text: PTEN: T167A
PubMed Link: 24336498
Variant Present in the following documents:
  • Main text
  • srep03494.pdf
View BVdb publication page



Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research
Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C
Publication Date: 2011-09-01

Variant appearance in text: PTEN: T167A
PubMed Link: 21727090
Variant Present in the following documents:
  • supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1
View BVdb publication page



Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts.

The American Journal Of Pathology
Fernandez, Karen K; Serinagaoglu, Yelda Y; Hammond, Sue S; Martin, Laura T LT; Martin, Paul T PT
Publication Date: 2010-01

Variant appearance in text: PTEN: T167A
PubMed Link: 20019182
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genetic diversity in melanoma metastases from a patient with xeroderma pigmentosum.

The Journal Of Investigative Dermatology
Wang, Yun Y; Tan, Xiao Hui XH; DiGiovanna, John J JJ; Lee, Chyi-Chia Richard CC; Stern, Jere B JB; Raffeld, Mark M; Jaffe, Elaine S ES; Kraemer, Kenneth H KH
Publication Date: 2010-04

Variant appearance in text: PTEN: Thr167Ala
PubMed Link: 19956187
Variant Present in the following documents:
  • Main text
View BVdb publication page