Tunable-combinatorial mechanisms of acquired resistance limit the efficacy of BRAF/MEK cotargeting but result in melanoma drug addiction.
Cancer Cell
Moriceau, Gatien G; Hugo, Willy W; Hong, Aayoung A; Shi, Hubing H; Kong, Xiangju X; Yu, Clarissa C CC; Koya, Richard C RC; Samatar, Ahmed A AA; Khanlou, Negar N; Braun, Jonathan J; Ruchalski, Kathleen K; Seifert, Heike H; Larkin, James J; Dahlman, Kimberly B KB; Johnson, Douglas B DB; Algazi, Alain A; Sosman, Jeffrey A JA; Ribas, Antoni A; Lo, Roger S RS