Publications:

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The Loss of Nuclear PTEN Increases Tumorigenesis in a Preclinical Mouse Model for Hepatocellular Carcinoma.

Iscience

Kato, Takashi T; Yamada, Tatsuya T; Nakamura, Hideki H; Igarashi, Atsushi A; Anders, Robert A RA; Sesaki, Hiromi H; Iijima, Miho M

Publication Date: 2020-10-23

Variant appearance in text: PTEN: K289R

PubMed Link: 33083717

Variant Present in the following documents:

• mmc1.pdf
• main.pdf

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PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage.

Cancer Discovery

Zhang, Jinfang J; Lee, Yu-Ru YR; Dang, Fabin F; Gan, Wenjian W; Menon, Archita Venugopal AV; Katon, Jesse M JM; Hsu, Chih-Hung CH; Asara, John M JM; Tibarewal, Priyanka P; Leslie, Nicholas R NR; Shi, Yang Y; Pandolfi, Pier Paolo PP; Wei, Wenyi W

Publication Date: 2019-09

Variant appearance in text: PTEN: K289R

PubMed Link: 31217297

Variant Present in the following documents:

• Main text

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Controlling PTEN (Phosphatase and Tensin Homolog) Stability: A DOMINANT ROLE FOR LYSINE 66.

The Journal Of Biological Chemistry

Gupta, Amit A; Leslie, Nicholas R NR

Publication Date: 2016-08-26

Variant appearance in text: PTEN: K289R

PubMed Link: 27405757

Variant Present in the following documents:

• Main text

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PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis.

Nature Communications

Lee, Min-Sik MS; Jeong, Man-Hyung MH; Lee, Hyun-Woo HW; Han, Hyun-Ji HJ; Ko, Aram A; Hewitt, Stephen M SM; Kim, Jae-Hoon JH; Chun, Kyung-Hee KH; Chung, Joon-Yong JY; Lee, Cheolju C; Cho, Hanbyoul H; Song, Jaewhan J

Publication Date: 2015-07-17

Variant appearance in text: PTEN: K289R

PubMed Link: 26183061

Variant Present in the following documents:

• Main text
• ncomms8769.pdf
• ncomms8769-s1.pdf

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Critical role of increased PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience

Zhang, Shu S; Taghibiglou, Changiz C; Girling, Kimberly K; Dong, Zhifang Z; Lin, Shinn-Zong SZ; Lee, Wei W; Shyu, Woei-cherng WC; Wang, Yu Tian YT

Publication Date: 2013-05-01

Variant appearance in text: PTEN: K289R

PubMed Link: 23637190

Variant Present in the following documents:

• Main text

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WWP2 is an E3 ubiquitin ligase for PTEN.

Nature Cell Biology

Maddika, Subbareddy S; Kavela, Sridhar S; Rani, Neelam N; Palicharla, Vivek Reddy VR; Pokorny, Jenny L JL; Sarkaria, Jann N JN; Chen, Junjie J

Publication Date: 2011-06

Variant appearance in text: PTEN: K289R

PubMed Link: 21532586

Variant Present in the following documents:

• Main text

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Ubiquitination regulates PTEN nuclear import and tumor suppression.

Cell

Trotman, Lloyd C LC; Wang, Xinjiang X; Alimonti, Andrea A; Chen, Zhenbang Z; Teruya-Feldstein, Julie J; Yang, Haijuan H; Pavletich, Nikola P NP; Carver, Brett S BS; Cordon-Cardo, Carlos C; Erdjument-Bromage, Hediye H; Tempst, Paul P; Chi, Sung-Gil SG; Kim, Hyo-Jong HJ; Misteli, Tom T; Jiang, Xuejun X; Pandolfi, Pier Paolo PP

Publication Date: 2007-01-12

Variant appearance in text: PTEN: K289R

PubMed Link: 17218261

Variant Present in the following documents:

• Main text

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