Discovering Synergistic Compounds with BYL-719 in PI3K Overactivated Basal-like PDXs.
Cancers
Boyd, David C DC; Zboril, Emily K EK; Olex, Amy L AL; Leftwich, Tess J TJ; Hairr, Nicole S NS; Byers, Holly A HA; Valentine, Aaron D AD; Altman, Julia E JE; Alzubi, Mohammad A MA; Grible, Jacqueline M JM; Turner, Scott A SA; Ferreira-Gonzalez, Andrea A; Dozmorov, Mikhail G MG; Harrell, J Chuck JC
Blocking Y-Box Binding Protein-1 through Simultaneous Targeting of PI3K and MAPK in Triple Negative Breast Cancers.
Cancers
Tiwari, Aadhya A; Iida, Mari M; Kosnopfel, Corinna C; Abbariki, Mahyar M; Menegakis, Apostolos A; Fehrenbacher, Birgit B; Maier, Julia J; Schaller, Martin M; Brucker, Sara Y SY; Wheeler, Deric L DL; Harari, Paul M PM; Rothbauer, Ulrich U; Schittek, Birgit B; Zips, Daniel D; Toulany, Mahmoud M
Genetic and transcriptional evolution alters cancer cell line drug response.
Nature
Ben-David, Uri U; Siranosian, Benjamin B; Ha, Gavin G; Tang, Helen H; Oren, Yaara Y; Hinohara, Kunihiko K; Strathdee, Craig A CA; Dempster, Joshua J; Lyons, Nicholas J NJ; Burns, Robert R; Nag, Anwesha A; Kugener, Guillaume G; Cimini, Beth B; Tsvetkov, Peter P; Maruvka, Yosef E YE; O'Rourke, Ryan R; Garrity, Anthony A; Tubelli, Andrew A AA; Bandopadhayay, Pratiti P; Tsherniak, Aviad A; Vazquez, Francisca F; Wong, Bang B; Birger, Chet C; Ghandi, Mahmoud M; Thorner, Aaron R AR; Bittker, Joshua A JA; Meyerson, Matthew M; Getz, Gad G; Beroukhim, Rameen R; Golub, Todd R TR
Molecular characterization of breast cancer cell lines through multiple omic approaches.
Breast Cancer Research : Bcr
Smith, Shari E SE; Mellor, Paul P; Ward, Alison K AK; Kendall, Stephanie S; McDonald, Megan M; Vizeacoumar, Frederick S FS; Vizeacoumar, Franco J FJ; Napper, Scott S; Anderson, Deborah H DH
Heregulin-expressing HER2-positive breast and gastric cancer exhibited heterogeneous susceptibility to the anti-HER2 agents lapatinib, trastuzumab and T-DM1.
A Landscape of Pharmacogenomic Interactions in Cancer.
Cell
Iorio, Francesco F; Knijnenburg, Theo A TA; Vis, Daniel J DJ; Bignell, Graham R GR; Menden, Michael P MP; Schubert, Michael M; Aben, Nanne N; Gonçalves, Emanuel E; Barthorpe, Syd S; Lightfoot, Howard H; Cokelaer, Thomas T; Greninger, Patricia P; van Dyk, Ewald E; Chang, Han H; de Silva, Heshani H; Heyn, Holger H; Deng, Xianming X; Egan, Regina K RK; Liu, Qingsong Q; Mironenko, Tatiana T; Mitropoulos, Xeni X; Richardson, Laura L; Wang, Jinhua J; Zhang, Tinghu T; Moran, Sebastian S; Sayols, Sergi S; Soleimani, Maryam M; Tamborero, David D; Lopez-Bigas, Nuria N; Ross-Macdonald, Petra P; Esteller, Manel M; Gray, Nathanael S NS; Haber, Daniel A DA; Stratton, Michael R MR; Benes, Cyril H CH; Wessels, Lodewyk F A LFA; Saez-Rodriguez, Julio J; McDermott, Ultan U; Garnett, Mathew J MJ
A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.
Molecular Systems Biology
Vizeacoumar, Franco J FJ; Arnold, Roland R; Vizeacoumar, Frederick S FS; Chandrashekhar, Megha M; Buzina, Alla A; Young, Jordan T F JT; Kwan, Julian H M JH; Sayad, Azin A; Mero, Patricia P; Lawo, Steffen S; Tanaka, Hiromasa H; Brown, Kevin R KR; Baryshnikova, Anastasia A; Mak, Anthony B AB; Fedyshyn, Yaroslav Y; Wang, Yadong Y; Brito, Glauber C GC; Kasimer, Dahlia D; Makhnevych, Taras T; Ketela, Troy T; Datti, Alessandro A; Babu, Mohan M; Emili, Andrew A; Pelletier, Laurence L; Wrana, Jeff J; Wainberg, Zev Z; Kim, Philip M PM; Rottapel, Robert R; O'Brien, Catherine A CA; Andrews, Brenda B; Boone, Charles C; Moffat, Jason J
Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.
Nature Genetics
Saal, Lao H LH; Gruvberger-Saal, Sofia K SK; Persson, Camilla C; Lövgren, Kristina K; Jumppanen, Mervi M; Staaf, Johan J; Jönsson, Göran G; Pires, Maira M MM; Maurer, Matthew M; Holm, Karolina K; Koujak, Susan S; Subramaniyam, Shivakumar S; Vallon-Christersson, Johan J; Olsson, Håkan H; Su, Tao T; Memeo, Lorenzo L; Ludwig, Thomas T; Ethier, Stephen P SP; Krogh, Morten M; Szabolcs, Matthias M; Murty, Vundavalli V V S VV; Isola, Jorma J; Hibshoosh, Hanina H; Parsons, Ramon R; Borg, Ake A