Publications:

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The Impact of Genetic Variants on PTEN Molecular Functions and Cellular Phenotypes.

Cold Spring Harbor Perspectives In Medicine

Hasle, Nicholas N; Matreyek, Kenneth A KA; Fowler, Douglas M DM

Publication Date: 2019-11-01

Variant appearance in text: PTEN: Y315F

PubMed Link: 31451538

Variant Present in the following documents:

• Main text

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Stromal PTEN Regulates Extracellular Matrix Organization in the Mammary Gland.

Neoplasia (New York, N.Y.)

Jones, Caitlin E CE; Hammer, Anisha M AM; Cho, YouJin Y; Sizemore, Gina M GM; Cukierman, Edna E; Yee, Lisa D LD; Ghadiali, Samir N SN; Ostrowski, Michael C MC; Leight, Jennifer L JL

Publication Date: 2019-01

Variant appearance in text: PTEN: Y315F

PubMed Link: 30550871

Variant Present in the following documents:

• Main text
• main.pdf

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A Transformation-Defective Polyomavirus Middle T Antigen with a Novel Defect in PI3 Kinase Signaling.

Journal Of Virology

Denis, Deborah D; Rouleau, Cecile C; Schaffhausen, Brian S BS

Publication Date: 2017-01-15

Variant appearance in text: PTEN: Y315F

PubMed Link: 27852846

Variant Present in the following documents:

• Main text

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Amplicon sequencing of colorectal cancer: variant calling in frozen and formalin-fixed samples.

Plos One

Betge, Johannes J; Kerr, Grainne G; Miersch, Thilo T; Leible, Svenja S; Erdmann, Gerrit G; Galata, Christian L CL; Zhan, Tianzuo T; Gaiser, Timo T; Post, Stefan S; Ebert, Matthias P MP; Horisberger, Karoline K; Boutros, Michael M

Publication Date: 2015

Variant appearance in text: PTEN: Y315F

PubMed Link: 26010451

Variant Present in the following documents:

• pone.0127146.s014.xlsx, sheet 3

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The phosphatidylinositol 3-kinase (PI3K) isoform dependence of tumor formation is determined by the genetic mode of PI3K pathway activation rather than by tissue type.

Journal Of Virology

Utermark, Tamara T; Schmit, Fabienne F; Lee, Sang Hyun SH; Gao, Xueliang X; Schaffhausen, Brian S BS; Roberts, Thomas M TM

Publication Date: 2014-09

Variant appearance in text: PTEN: Y315F

PubMed Link: 24991009

Variant Present in the following documents:

• Main text

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Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Fenton, Tim R TR; Nathanson, David D; Ponte de Albuquerque, Claudio C; Kuga, Daisuke D; Iwanami, Akio A; Dang, Julie J; Yang, Huijun H; Tanaka, Kazuhiro K; Oba-Shinjo, Sueli Mieko SM; Uno, Miyuki M; Inda, Maria del Mar MM; Wykosky, Jill J; Bachoo, Robert M RM; James, C David CD; DePinho, Ronald A RA; Vandenberg, Scott R SR; Zhou, Huilin H; Marie, Suely K N SK; Mischel, Paul S PS; Cavenee, Webster K WK; Furnari, Frank B FB

Publication Date: 2012-08-28

Variant appearance in text: PTEN: Y315F

PubMed Link: 22891331

Variant Present in the following documents:

• Main text

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Rak functions as a tumor suppressor by regulating PTEN protein stability and function.

Cancer Cell

Yim, Eun-Kyoung EK; Peng, Guang G; Dai, Hui H; Hu, Ruozhen R; Li, Kaiyi K; Lu, Yiling Y; Mills, Gordon B GB; Meric-Bernstam, Funda F; Hennessy, Bryan T BT; Craven, Rolf J RJ; Lin, Shiaw-Yih SY

Publication Date: 2009-04-07

Variant appearance in text: PTEN: Y315F

PubMed Link: 19345329

Variant Present in the following documents:

• Main text

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