Publications:

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The Loss of Nuclear PTEN Increases Tumorigenesis in a Preclinical Mouse Model for Hepatocellular Carcinoma.

Iscience

Kato, Takashi T; Yamada, Tatsuya T; Nakamura, Hideki H; Igarashi, Atsushi A; Anders, Robert A RA; Sesaki, Hiromi H; Iijima, Miho M

Publication Date: 2020-10-23

Variant appearance in text: PTEN: T366A

PubMed Link: 33083717

Variant Present in the following documents:

• Main text
• mmc1.pdf
• main.pdf

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The Impact of Genetic Variants on PTEN Molecular Functions and Cellular Phenotypes.

Cold Spring Harbor Perspectives In Medicine

Hasle, Nicholas N; Matreyek, Kenneth A KA; Fowler, Douglas M DM

Publication Date: 2019-11-01

Variant appearance in text: PTEN: T366A

PubMed Link: 31451538

Variant Present in the following documents:

• Main text

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Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization.

Oncogene

Yang, Jr-M JM; Schiapparelli, P P; Nguyen, H-N HN; Igarashi, A A; Zhang, Q Q; Abbadi, S S; Amzel, L M LM; Sesaki, H H; Quiñones-Hinojosa, A A; Iijima, M M

Publication Date: 2017-06-29

Variant appearance in text: PTEN: T366A

PubMed Link: 28263967

Variant Present in the following documents:

• onc2016493a.pdf

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Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development.

Plos One

Stumpf, Miriam M; den Hertog, Jeroen J

Publication Date: 2016

Variant appearance in text: PTEN: T366A

PubMed Link: 26848951

Variant Present in the following documents:

• Main text
• pone.0148508.pdf

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The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity.

The Biochemical Journal

Masson, Glenn R GR; Perisic, Olga O; Burke, John E JE; Williams, Roger L RL

Publication Date: 2016-01-15

Variant appearance in text: PTEN: T366A

PubMed Link: 26527737

Variant Present in the following documents:

• Main text
• bj4730135.pdf

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A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation.

Plos Genetics

Esteve-Puig, Rosaura R; Gil, Rosa R; González-Sánchez, Elena E; Bech-Serra, Joan Josep JJ; Grueso, Judit J; Hernández-Losa, Javier J; Moliné, Teresa T; Canals, Francesc F; Ferrer, Berta B; Cortés, Javier J; Bastian, Boris B; Ramón Y Cajal, Santiago S; Martín-Caballero, Juan J; Flores, Juana Maria JM; Vivancos, Ana A; García-Patos, Vicenç V; Recio, Juan Ángel JÁ

Publication Date: 2014-10

Variant appearance in text: PTEN: T366A

PubMed Link: 25329316

Variant Present in the following documents:

• Main text

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Cdh1, a substrate-recruiting component of anaphase-promoting complex/cyclosome (APC/C) ubiquitin E3 ligase, specifically interacts with phosphatase and tensin homolog (PTEN) and promotes its removal from chromatin.

The Journal Of Biological Chemistry

Choi, Byeong Hyeok BH; Pagano, Michele M; Huang, Chaunshu C; Dai, Wei W

Publication Date: 2014-06-20

Variant appearance in text: PTEN: T366A

PubMed Link: 24811168

Variant Present in the following documents:

• Main text

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Plk1 protein phosphorylates phosphatase and tensin homolog (PTEN) and regulates its mitotic activity during the cell cycle.

The Journal Of Biological Chemistry

Choi, Byeong Hyeok BH; Pagano, Michele M; Dai, Wei W

Publication Date: 2014-05-16

Variant appearance in text: PTEN: T366A

PubMed Link: 24706748

Variant Present in the following documents:

• Main text

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Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis.

Elife

Bolduc, David D; Rahdar, Meghdad M; Tu-Sekine, Becky B; Sivakumaren, Sindhu Carmen SC; Raben, Daniel D; Amzel, L Mario LM; Devreotes, Peter P; Gabelli, Sandra B SB; Cole, Philip P

Publication Date: 2013-07-09

Variant appearance in text: PTEN: T366A

PubMed Link: 23853711

Variant Present in the following documents:

• Main text
• elife00691.pdf

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Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110α/PIK3CA but not by HER2 or mutant AKT1.

Oncogene

Berglund, F M FM; Weerasinghe, N R NR; Davidson, L L; Lim, J C JC; Eickholt, B J BJ; Leslie, N R NR

Publication Date: 2013-09-12

Variant appearance in text: PTEN: Thr366Ala

PubMed Link: 23085752

Variant Present in the following documents:

• Main text

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What Are the bona fide GSK3 Substrates?

International Journal Of Alzheimer'S Disease

Sutherland, Calum C

Publication Date: 2011

Variant appearance in text: PTEN: T366A

PubMed Link: 21629754

Variant Present in the following documents:

• Main text
• IJAD2011-505607.pdf

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Regulation of PTEN stability and activity by Plk3.

The Journal Of Biological Chemistry

Xu, Dazhong D; Yao, Yixin Y; Jiang, Xuejun X; Lu, Luo L; Dai, Wei W

Publication Date: 2010-12-17

Variant appearance in text: PTEN: T366A

PubMed Link: 20940307

Variant Present in the following documents:

• Main text

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AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling.

Molecular Cell

Sherman, Mara H MH; Kuraishy, Ali I AI; Deshpande, Chetan C; Hong, Jason S JS; Cacalano, Nicholas A NA; Gatti, Richard A RA; Manis, John P JP; Damore, Michael A MA; Pellegrini, Matteo M; Teitell, Michael A MA

Publication Date: 2010-09-24

Variant appearance in text: PTEN: T366A

PubMed Link: 20864035

Variant Present in the following documents:

• Main text

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Leptin-dependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels.

The Journal Of Biological Chemistry

Ning, Ke K; Miller, Lisa C LC; Laidlaw, Hilary A HA; Watterson, Kenneth R KR; Gallagher, Jennifer J; Sutherland, Calum C; Ashford, Michael L J ML

Publication Date: 2009-04-03

Variant appearance in text: PTEN: T366A

PubMed Link: 19208634

Variant Present in the following documents:

• Main text
• 9331.pdf

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PTEN is destabilized by phosphorylation on Thr366.

The Biochemical Journal

Maccario, Helene H; Perera, Nevin M NM; Davidson, Lindsay L; Downes, C Peter CP; Leslie, Nick R NR

Publication Date: 2007-08-01

Variant appearance in text: PTEN: T366A

PubMed Link: 17444818

Variant Present in the following documents:

• Main text

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Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Okumura, Koichi K; Zhao, Mujun M; Depinho, Ronald A RA; Furnari, Frank B FB; Cavenee, Webster K WK

Publication Date: 2005-02-22

Variant appearance in text: PTEN: T366A

PubMed Link: 15659546

Variant Present in the following documents:

• Main text

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