CYP2C19 c.1003C>T ;(p.R335W)

Variant ID: 10-96602635-C-T

NM_000769.1(CYP2C19):c.1003C>T;(p.R335W)

This variant was identified in 9 publications

View GRCh38 version.




Publications:


Comprehensive in vitro and in silico assessments of metabolic capabilities of 24 genomic variants of CYP2C19 using two different substrates.

Frontiers In Pharmacology
Seo, Myung-Eui ME; Min, Byung-Joo BJ; Heo, Nayoon N; Lee, Kye Hwa KH; Kim, Ju Han JH
Publication Date: 2023

Variant appearance in text: CYP2C19: 1003C>T; Arg335Trp; rs368758960
PubMed Link: 36713839
Variant Present in the following documents:
  • Main text
  • fphar-14-1055991.pdf
View BVdb publication page



The genetic landscape of major drug metabolizing cytochrome P450 genes-an updated analysis of population-scale sequencing data.

The Pharmacogenomics Journal
Zhou, Yitian Y; Lauschke, Volker M VM
Publication Date: 2022-12

Variant appearance in text: CYP2C19: 1003C>T; Arg335Trp; rs368758960
PubMed Link: 36068297
Variant Present in the following documents:
  • 41397_2022_288_MOESM4_ESM.xlsx, sheet 1
View BVdb publication page



Characterization of ADME Gene Variation in Colombian Population by Exome Sequencing.

Frontiers In Pharmacology
Silgado-Guzmán, Daniel Felipe DF; Angulo-Aguado, Mariana M; Morel, Adrien A; Niño-Orrego, María José MJ; Ruiz-Torres, Daniel-Armando DA; Contreras Bravo, Nora Constanza NC; Restrepo, Carlos Martin CM; Ortega-Recalde, Oscar O; Fonseca-Mendoza, Dora Janeth DJ
Publication Date: 2022

Variant appearance in text: CYP2C19: 1003C>T; Arg335Trp; rs368758960
PubMed Link: 35846994
Variant Present in the following documents:
  • Table3.xlsx, sheet 1
View BVdb publication page



Pharmacogenetics of Breast Cancer Treatments: A Sub-Saharan Africa Perspective.

Pharmacogenomics And Personalized Medicine
Nthontho, Keneuoe Cecilia KC; Ndlovu, Andrew Khulekani AK; Sharma, Kirthana K; Kasvosve, Ishmael I; Hertz, Daniel Louis DL; Paganotti, Giacomo Maria GM
Publication Date: 2022

Variant appearance in text: CYP2C19: R335W
PubMed Link: 35761855
Variant Present in the following documents:
  • pgpm-15-613.pdf
View BVdb publication page



Precision Medicine into Clinical Practice: A Web-Based Tool Enables Real-Time Pharmacogenetic Assessment of Tailored Treatments in Psychiatric Disorders.

Journal Of Personalized Medicine
Zampatti, Stefania S; Fabrizio, Carlo C; Ragazzo, Michele M; Campoli, Giulia G; Caputo, Valerio V; Strafella, Claudia C; Pellicano, Clelia C; Cascella, Raffaella R; Spalletta, Gianfranco G; Petrosini, Laura L; Caltagirone, Carlo C; Termine, Andrea A; Giardina, Emiliano E
Publication Date: 2021-08-27

Variant appearance in text: CYP2C19: 1003C>T; Arg335Trp
PubMed Link: 34575628
Variant Present in the following documents:
  • jpm-11-00851.pdf
View BVdb publication page



CYP2C9 and CYP2C19: Deep Mutational Scanning and Functional Characterization of Genomic Missense Variants.

Clinical And Translational Science
Zhang, Lingxin L; Sarangi, Vivekananda V; Moon, Irene I; Yu, Jia J; Liu, Duan D; Devarajan, Sandhya S; Reid, Joel M JM; Kalari, Krishna R KR; Wang, Liewei L; Weinshilboum, Richard R
Publication Date: 2020-07

Variant appearance in text: CYP2C19: 1003C>T; R335W; rs368758960
PubMed Link: 32004414
Variant Present in the following documents:
  • Main text
  • CTS-13-727.pdf
View BVdb publication page



Genomic and Transcriptomic Characterization Links Cell Lines with Aggressive Head and Neck Cancers.

Cell Reports
Cheng, Hui H; Yang, Xinping X; Si, Han H; Saleh, Anthony D AD; Xiao, Wenming W; Coupar, Jamie J; Gollin, Susanne M SM; Ferris, Robert L RL; Issaeva, Natalia N; Yarbrough, Wendell G WG; Prince, Mark E ME; Carey, Thomas E TE; Van Waes, Carter C; Chen, Zhong Z
Publication Date: 2018-10-30

Variant appearance in text: CYP2C19: R335W
PubMed Link: 30380422
Variant Present in the following documents:
  • NIHMS1511993-supplement-6.xlsx, sheet 1
View BVdb publication page



Genetic variation in human drug-related genes.

Genome Medicine
Schärfe, Charlotta Pauline Irmgard CPI; Tremmel, Roman R; Schwab, Matthias M; Kohlbacher, Oliver O; Marks, Debora Susan DS
Publication Date: 2017-12-22

Variant appearance in text: rs368758960
PubMed Link: 29273096
Variant Present in the following documents:
  • 13073_2017_502_MOESM2_ESM.xlsx, sheet 2
View BVdb publication page



Polymorphic cytochrome P450 enzymes (CYPs) and their role in personalized therapy.

Plos One
Preissner, Sarah C SC; Hoffmann, Michael F MF; Preissner, Robert R; Dunkel, Mathias M; Gewiess, Andreas A; Preissner, Saskia S
Publication Date: 2013

Variant appearance in text: CYP2C19: R335W
PubMed Link: 24340040
Variant Present in the following documents:
  • Main text
  • pone.0082562.pdf
View BVdb publication page