CYP2C9 c.322_324delinsCAT ;(p.R108H)

Variant ID: 10-96701768-AGA-CAT

NM_000771.3(CYP2C9):c.322_324delinsCAT;(p.R108H)

This variant was identified in 6 publications

View GRCh38 version.



Variant-Specific Resource Links:
gnomAD v2.1.1
Mutalizer Name Checker
Google
UCSC Genome Browser
ClinVar
dbSNP

Publications:

Induced fit for cytochrome P450 3A4 based on molecular dynamics.

Admet & Dmpk
Quiroga, Israel I; Scior, Thomas T
Publication Date: 2019

Variant appearance in text: CYP2C9: R108H
PubMed Link: 35359616
Variant Present in the following documents:
  • Main text
  • Admet-7-729.pdf
View BVdb publication page


Insights into molecular mechanisms of drug metabolism dysfunction of human CYP2C9*30.

Plos One
Louet, Maxime M; Labbé, Céline M CM; Fagnen, Charline C; Aono, Cassiano M CM; Homem-de-Mello, Paula P; Villoutreix, Bruno O BO; Miteva, Maria A MA
Publication Date: 2018

Variant appearance in text: CYP2C9: R108H
PubMed Link: 29746595
Variant Present in the following documents:
  • pone.0197249.pdf
View BVdb publication page


Pharmacogenomics of CYP2C9: Functional and Clinical Considerations.

Journal Of Personalized Medicine
Daly, Ann K AK; Rettie, Allan E AE; Fowler, Douglas M DM; Miners, John O JO
Publication Date: 2017-12-28

Variant appearance in text: CYP2C9: R108H
PubMed Link: 29283396
Variant Present in the following documents:
  • Main text
  • jpm-08-00001.pdf
View BVdb publication page


Physical Studies of P450-P450 Interactions: Predicting Quaternary Structures of P450 Complexes in Membranes from Their X-ray Crystal Structures.

Frontiers In Pharmacology
Reed, James R JR; Backes, Wayne L WL
Publication Date: 2017

Variant appearance in text: CYP2C9: R108H
PubMed Link: 28194112
Variant Present in the following documents:
  • fphar-08-00028.pdf
View BVdb publication page


Structure and dynamics of the membrane-bound cytochrome P450 2C9.

Plos Computational Biology
Cojocaru, Vlad V; Balali-Mood, Kia K; Sansom, Mark S P MS; Wade, Rebecca C RC
Publication Date: 2011-08

Variant appearance in text: CYP2C9: R108H
PubMed Link: 21852944
Variant Present in the following documents:
  • pcbi.1002152.pdf
View BVdb publication page


Intramolecular heme ligation of the cytochrome P450 2C9 R108H mutant demonstrates pronounced conformational flexibility of the B-C loop region: implications for substrate binding.

Biochemistry
Roberts, Arthur G AG; Cheesman, Matthew J MJ; Primak, Andrew A; Bowman, Michael K MK; Atkins, William M WM; Rettie, Allan E AE
Publication Date: 2010-10-12

Variant appearance in text: CYP2C9: R108H
PubMed Link: 20815369
Variant Present in the following documents:
  • Main text
View BVdb publication page