Variant ID: 10-96725535-A-T

NM_000771.3(CYP2C9):c.820-6326A>T

This variant was identified in 30 publications




Publications:


Genome-Wide Association Study of VKORC1 and CYP2C9 on acenocoumarol dose, stroke recurrence and intracranial haemorrhage in Spain.

Scientific Reports
N Cullell, C Carrera, E Muiño, NP Torres-Aguila, J Cárcel-Márquez, J González-Sánchez, C Gallego-Fabrega, J Molina, S Besora, J Sotoca, MT Buongiorno, J Jiménez-Conde, E Giralt-Steinhauer, R de Torres-Chacón, J Montaner, F Mancha, JA Cabezas, J Martí-Fàbregas, L Prats-Sánchez, P Camps-Renom, F Purroy, S Cambray, MDM Freijo, C Vives-Bauzá, S Tur, MÀ Font, E López-Cancio, M Hernandez-Perez, V Obach, A Calleja, J Arenillas, M Rodríguez-Yáñez, J Castillo, T Sobrino, I Fernández-Cádenas, J Krupinski
Publication Date: 2020-02-18

Variant appearance in text: rs4917639
PubMed Link: 32071341
Variant Present in the following documents:
  • Main text
View BVdb publication page



Heterogeneity in the distribution of 159 drug-response related SNPs in world populations and their genetic relatedness.

Plos One
T Ahsan, NJ Urmi, AA Sajib
Publication Date: 2020

Variant appearance in text: rs4917639
PubMed Link: 31971968
Variant Present in the following documents:
  • Main text
View BVdb publication page



Introducing the first whole genomes of nationals from the United Arab Emirates.

Scientific Reports
HS AlSafar, M Al-Ali, GD Elbait, MH Al-Maini, D Ruta, B Peramo, A Henschel, GK Tay
Publication Date: 2019-10-11

Variant appearance in text: rs4917639
PubMed Link: 31604968
Variant Present in the following documents:
  • 41598_2019_50876_MOESM1_ESM.xlsx
View BVdb publication page



Establishment of a Han Chinese-specific pharmacogenetic-guided warfarin dosing algorithm.

Medicine
L Pei, X Tian, Y Long, W Nan, M Jia, R Qiao, J Zhang
Publication Date: 2018-09

Variant appearance in text: rs4917639
PubMed Link: 30200121
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenetic studies with oral anticoagulants. Genome-wide association studies in vitamin K antagonist and direct oral anticoagulants.

Oncotarget
N Cullell, C Carrera, E Muiño, N Torres, J Krupinski, I Fernandez-Cadenas
Publication Date: 2018-06-26

Variant appearance in text: rs4917639
PubMed Link: 30018749
Variant Present in the following documents:
  • Main text
  • oncotarget-09-29238-s002.docx
View BVdb publication page



Warfarin-induced life-threatening bleeding associated with a CYP3A4 loss-of-function mutation in an acute limb ischemia patient: Case report and review of the literature.

Experimental And Therapeutic Medicine
XW Ma, CN Hao, ZC Gu, M Ye, M Li, L Zhang
Publication Date: 2017-08

Variant appearance in text: rs4917639
PubMed Link: 28810573
Variant Present in the following documents:
  • Main text
View BVdb publication page



Clinical and genetic factors associated with warfarin maintenance dose in northern Chinese patients with mechanical heart valve replacement.

Medicine
R Liu, J Cao, Q Zhang, XM Shi, XD Pan, R Dong
Publication Date: 2017-01

Variant appearance in text: rs4917639
PubMed Link: 28079798
Variant Present in the following documents:
  • medi-96-e5658-s001.doc
View BVdb publication page



A Prediction Algorithm for Drug Response in Patients with Mesial Temporal Lobe Epilepsy Based on Clinical and Genetic Information.

Plos One
MS Silva-Alves, R Secolin, BS Carvalho, CL Yasuda, E Bilevicius, MK Alvim, RO Santos, CV Maurer-Morelli, F Cendes, I Lopes-Cendes
Publication Date: 2017

Variant appearance in text: rs4917639
PubMed Link: 28052106
Variant Present in the following documents:
  • pone.0169214.s003.doc
View BVdb publication page



Genetic determinants of warfarin maintenance dose and time in therapeutic treatment range: a RE-LY genomics substudy.

Pharmacogenomics
N Eriksson, L Wallentin, L Berglund, T Axelsson, S Connolly, J Eikelboom, M Ezekowitz, J Oldgren, G Paré, P Reilly, A Siegbahn, AC Syvanen, C Wadelius, S Yusuf, M Wadelius
Publication Date: 2016-08

Variant appearance in text: rs4917639
PubMed Link: 27488176
Variant Present in the following documents:
  • Supplemental file
  • Main text
View BVdb publication page



A multi-factorial analysis of response to warfarin in a UK prospective cohort.

Genome Medicine
S Bourgeois, A Jorgensen, EJ Zhang, A Hanson, MS Gillman, S Bumpstead, CH Toh, P Williamson, AK Daly, F Kamali, P Deloukas, M Pirmohamed
Publication Date: 2016-01-06

Variant appearance in text: rs4917639
PubMed Link: 26739746
Variant Present in the following documents:
  • 13073_2015_255_MOESM1_ESM.xlsx
  • Main text
View BVdb publication page



Genome-wide association study of warfarin maintenance dose in a Brazilian sample.

Pharmacogenomics
EJ Parra, MR Botton, JA Perini, S Krithika, S Bourgeois, TA Johnson, T Tsunoda, M Pirmohamed, M Wadelius, NA Limdi, LH Cavallari, JK Burmester, AE Rettie, TE Klein, JA Johnson, MH Hutz, G Suarez-Kurtz
Publication Date: 2015

Variant appearance in text: rs4917639
PubMed Link: 26265036
Variant Present in the following documents:
  • NIHMS715170-supplement-Table_1.xlsx
  • Main text
View BVdb publication page



Evidence for Clinical Implementation of Pharmacogenomics in Cardiac Drugs.

Mayo Clinic Proceedings
AL Kaufman, J Spitz, M Jacobs, M Sorrentino, S Yuen, K Danahey, D Saner, TE Klein, RB Altman, MJ Ratain, PH O'Donnell
Publication Date: 2015-06

Variant appearance in text: rs4917639
PubMed Link: 26046407
Variant Present in the following documents:
  • NIHMS676556-supplement-4.pdf
View BVdb publication page



A pharmacogenetics-based warfarin maintenance dosing algorithm from Northern Chinese patients.

Plos One
J Chen, L Shao, L Gong, F Luo, J Wang, Y Shi, Y Tan, Q Chen, Y Zhang, R Hui, Y Wang
Publication Date: 2014

Variant appearance in text: rs4917639
PubMed Link: 25126975
Variant Present in the following documents:
  • Main text
View BVdb publication page



Role of pharmacogenomic biomarkers in predicting and improving drug response: part 1: the clinical significance of pharmacogenetic variants.

P & T : A Peer-Reviewed Journal For Formulary Management
CL Ventola
Publication Date: 2013-09

Variant appearance in text: rs4917639
PubMed Link: 24273401
Variant Present in the following documents:
  • Main text
View BVdb publication page



Pharmacogenomics discovery and implementation in genome-wide association studies era.

Wiley Interdisciplinary Reviews. Systems Biology And Medicine
X Ni, W Zhang, RS Huang
Publication Date: 2013

Variant appearance in text: rs4917639
PubMed Link: 23188748
Variant Present in the following documents:
  • Main text
View BVdb publication page



Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs.

Pharmacogenetics And Genomics
TJ Urban, Y Shen, A Stolz, N Chalasani, RJ Fontana, J Rochon, D Ge, KV Shianna, AK Daly, MI Lucena, MR Nelson, M Molokhia, GP Aithal, A Floratos, I Pe'er, J Serrano, H Bonkovsky, TJ Davern, WM Lee, VJ Navarro, JA Talwalkar, DB Goldstein, PB Watkins, , , , ,
Publication Date: 2012-11

Variant appearance in text: rs4917639
PubMed Link: 22968431
Variant Present in the following documents:
  • NIHMS446262-supplement-Supplement.docx
View BVdb publication page



Prioritizing genetic variants for causality on the basis of preferential linkage disequilibrium.

American Journal Of Human Genetics
Q Zhu, D Ge, EL Heinzen, SP Dickson, TJ Urban, M Zhu, JM Maia, M He, Q Zhao, KV Shianna, DB Goldstein
Publication Date: 2012-09-07

Variant appearance in text: rs4917639
PubMed Link: 22939045
Variant Present in the following documents:
  • mmc1.pdf
  • Main text
View BVdb publication page



Genome-wide association study of antidepressant treatment-emergent suicidal ideation.

Neuropsychopharmacology : Official Publication Of The American College Of Neuropsychopharmacology
A Menke, K Domschke, D Czamara, T Klengel, J Hennings, S Lucae, BT Baune, V Arolt, B Müller-Myhsok, F Holsboer, EB Binder
Publication Date: 2012-02

Variant appearance in text: rs4917639
PubMed Link: 22030708
Variant Present in the following documents:
  • npp2011257x2.doc
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Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin.

Journal Of The American Medical Informatics Association : Jamia
H Xu, M Jiang, M Oetjens, EA Bowton, AH Ramirez, JM Jeff, MA Basford, JM Pulley, JD Cowan, X Wang, MD Ritchie, DR Masys, DM Roden, DC Crawford, JC Denny
Publication Date: 2011

Variant appearance in text: rs4917639
PubMed Link: 21672908
Variant Present in the following documents:
  • Main text
View BVdb publication page



Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.

Plos Genetics
G Zhai, A Teumer, L Stolk, JR Perry, L Vandenput, AD Coviello, A Koster, JT Bell, S Bhasin, J Eriksson, A Eriksson, F Ernst, L Ferrucci, TM Frayling, D Glass, E Grundberg, R Haring, AK Hedman, A Hofman, DP Kiel, HK Kroemer, Y Liu, KL Lunetta, M Maggio, M Lorentzon, M Mangino, D Melzer, I Miljkovic, , A Nica, BW Penninx, RS Vasan, F Rivadeneira, KS Small, N Soranzo, AG Uitterlinden, H Völzke, SG Wilson, L Xi, WV Zhuang, TB Harris, JM Murabito, C Ohlsson, A Murray, FH de Jong, TD Spector, H Wallaschofski
Publication Date: 2011-04

Variant appearance in text: rs4917639
PubMed Link: 21533175
Variant Present in the following documents:
  • Main text
View BVdb publication page



Detection of common single nucleotide polymorphisms synthesizing quantitative trait association of rarer causal variants.

Genome Research
F Takeuchi, S Kobayashi, T Ogihara, A Fujioka, N Kato
Publication Date: 2011-07

Variant appearance in text: rs4917639
PubMed Link: 21441355
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genomics and drug response.

The New England Journal Of Medicine
L Wang, HL McLeod, RM Weinshilboum
Publication Date: 2011-03-24

Variant appearance in text: rs4917639
PubMed Link: 21428770
Variant Present in the following documents:
  • Main text
View BVdb publication page



An integrative method for scoring candidate genes from association studies: application to warfarin dosing.

Bmc Bioinformatics
NP Tatonetti, JT Dudley, H Sagreiya, AJ Butte, RB Altman
Publication Date: 2010-10-28

Variant appearance in text: rs4917639
PubMed Link: 21044367
Variant Present in the following documents:
  • Main text
View BVdb publication page



Mapping genes that predict treatment outcome in admixed populations.

The Pharmacogenomics Journal
TM Baye, RA Wilke
Publication Date: 2010-12

Variant appearance in text: rs4917639
PubMed Link: 20921971
Variant Present in the following documents:
  • Main text
View BVdb publication page



The genetics of ischaemic stroke.

Journal Of Internal Medicine
M Matarin, A Singleton, J Hardy, J Meschia
Publication Date: 2010-02

Variant appearance in text: rs4917639
PubMed Link: 20175863
Variant Present in the following documents:
  • Main text
View BVdb publication page



A genome-wide association study of acenocoumarol maintenance dosage.

Human Molecular Genetics
M Teichert, M Eijgelsheim, F Rivadeneira, AG Uitterlinden, RH van Schaik, A Hofman, PA De Smet, T van Gelder, LE Visser, BH Stricker
Publication Date: 2009-10-01

Variant appearance in text: rs4917639
PubMed Link: 19578179
Variant Present in the following documents:
  • Supplemental file
  • Main text
View BVdb publication page



A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.

Plos Genetics
F Takeuchi, R McGinnis, S Bourgeois, C Barnes, N Eriksson, N Soranzo, P Whittaker, V Ranganath, V Kumanduri, W McLaren, L Holm, J Lindh, A Rane, M Wadelius, P Deloukas
Publication Date: 2009-03

Variant appearance in text: rs4917639
PubMed Link: 19300499
Variant Present in the following documents:
  • Main text
View BVdb publication page



The largest prospective warfarin-treated cohort supports genetic forecasting.

Blood
M Wadelius, LY Chen, JD Lindh, N Eriksson, MJ Ghori, S Bumpstead, L Holm, R McGinnis, A Rane, P Deloukas
Publication Date: 2009-01-22

Variant appearance in text: rs4917639
PubMed Link: 18574025
Variant Present in the following documents:
  • Main text
View BVdb publication page



A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose.

Blood
GM Cooper, JA Johnson, TY Langaee, H Feng, IB Stanaway, UI Schwarz, MD Ritchie, CM Stein, DM Roden, JD Smith, DL Veenstra, AE Rettie, MJ Rieder
Publication Date: 2008-08-15

Variant appearance in text: rs4917639
PubMed Link: 18535201
Variant Present in the following documents:
  • Main text
View BVdb publication page



Association of warfarin dose with genes involved in its action and metabolism.

Human Genetics
M Wadelius, LY Chen, N Eriksson, S Bumpstead, J Ghori, C Wadelius, D Bentley, R McGinnis, P Deloukas
Publication Date: 2007-03

Variant appearance in text: rs4917639
PubMed Link: 17048007
Variant Present in the following documents:
  • Main text
  • 439_2006_260_MOESM1_ESM.doc
View BVdb publication page



Alternative transcript annotations:

Transcript cDNA Protein Consequence Exon Intron
ENST00000260682.6 c.820-6326A>T - intron_variant - 5/8
NM_000771.4 c.820-6326A>T - intron_variant - 5/8