CYP2C9 c.1429G>A ;(p.A477T)

Variant ID: 10-96748741-G-A

NM_000771.3(CYP2C9):c.1429G>A;(p.A477T)

This variant was identified in 16 publications

View GRCh38 version.




Publications:


PepNN: a deep attention model for the identification of peptide binding sites.

Communications Biology
Abdin, Osama O; Nim, Satra S; Wen, Han H; Kim, Philip M PM
Publication Date: 2022-05-26

Variant appearance in text: CYP2C9: A477T
PubMed Link: 35618814
Variant Present in the following documents:
  • 42003_2022_3445_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Clinical pharmacogenetic analysis in 5,001 individuals with diagnostic Exome Sequencing data.

Npj Genomic Medicine
Lanillos, Javier J; Carcajona, Marta M; Maietta, Paolo P; Alvarez, Sara S; Rodriguez-Antona, Cristina C
Publication Date: 2022-02-18

Variant appearance in text: CYP2C9: A477T
PubMed Link: 35181665
Variant Present in the following documents:
  • 41525_2022_283_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Insights into the Genetic Variations of Human Cytochrome P450 2C9: Structural Analysis, Characterization and Comparison.

International Journal Of Molecular Sciences
Parikh, Sonia J SJ; Kamat, Sumit S; Phillips, Margaret M; Boyson, Samuel P SP; Yarbrough, Thomas T; Davie, Dylan D; Zhang, Qinghai Q; Glass, Karen C KC; Shah, Manish B MB
Publication Date: 2021-09-22

Variant appearance in text: CYP2C9: A477T
PubMed Link: 34638547
Variant Present in the following documents:
  • Main text
  • ijms-22-10206.pdf
View BVdb publication page



Current concepts and molecular mechanisms in pharmacogenetics of essential hypertension.

Indian Journal Of Pharmacology
Rahman, Farhana F; Muthaiah, Nagasundaram N; Kumaramanickavel, Govindasamy G
Publication Date: 2021

Variant appearance in text: CYP2C9: Ala477Thr
PubMed Link: 34414909
Variant Present in the following documents:
  • Main text
View BVdb publication page



Identification and Enzymatic Activity Evaluation of a Novel CYP2C9 Allelic Variant Discovered in a Patient.

Frontiers In Pharmacology
Zhou, Xiao-Yang XY; Lu, Xiang-Ran XR; Li, Ying-Hui YH; Ma, Ya-Qing YQ; Zhao, Shi-Wen SW; Wang, Fang F; Xu, Ren-Ai RA; Hu, Guo-Xin GX; Cai, Jian-Ping JP
Publication Date: 2021

Variant appearance in text: CYP2C9: A477T
PubMed Link: 33643050
Variant Present in the following documents:
  • Main text
  • fphar-12-619339.pdf
View BVdb publication page



Structure of Cytochrome P450 2C9*2 in Complex with Losartan: Insights into the Effect of Genetic Polymorphism.

Molecular Pharmacology
Parikh, Sonia J SJ; Evans, Chiara M CM; Obi, Juliet O JO; Zhang, Qinghai Q; Maekawa, Keiko K; Glass, Karen C KC; Shah, Manish B MB
Publication Date: 2020-11

Variant appearance in text: CYP2C9: Ala477Thr
PubMed Link: 32938720
Variant Present in the following documents:
  • Main text
View BVdb publication page



Computational Simulations to Guide Enzyme-Mediated Prodrug Activation.

International Journal Of Molecular Sciences
Markovic, Milica M; Ben-Shabat, Shimon S; Dahan, Arik A
Publication Date: 2020-05-20

Variant appearance in text: CYP2C9: A477T
PubMed Link: 32443905
Variant Present in the following documents:
  • Main text
  • ijms-21-03621.pdf
View BVdb publication page



CYP2C9 and CYP2C19: Deep Mutational Scanning and Functional Characterization of Genomic Missense Variants.

Clinical And Translational Science
Zhang, Lingxin L; Sarangi, Vivekananda V; Moon, Irene I; Yu, Jia J; Liu, Duan D; Devarajan, Sandhya S; Reid, Joel M JM; Kalari, Krishna R KR; Wang, Liewei L; Weinshilboum, Richard R
Publication Date: 2020-07

Variant appearance in text: CYP2C9: 1429G>A; Ala477Thr
PubMed Link: 32004414
Variant Present in the following documents:
  • Main text
  • CTS-13-727.pdf
View BVdb publication page



Functional Characterization of Pharmcogenetic Variants of Human Cytochrome P450 2C9 in Korean Populations.

Biomolecules & Therapeutics
Cho, Myung-A MA; Yoon, Jihoon G JG; Kim, Vitchan V; Kim, Harim H; Lee, Rowoon R; Lee, Min Goo MG; Kim, Donghak D
Publication Date: 2019-11-01

Variant appearance in text: CYP2C9: A477T
PubMed Link: 31484472
Variant Present in the following documents:
  • bt-27-577.pdf
View BVdb publication page



Pharmacogenomics Clinical Annotation Tool (PharmCAT).

Clinical Pharmacology And Therapeutics
Sangkuhl, Katrin K; Whirl-Carrillo, Michelle M; Whaley, Ryan M RM; Woon, Mark M; Lavertu, Adam A; Altman, Russ B RB; Carter, Lester L; Verma, Anurag A; Ritchie, Marylyn D MD; Klein, Teri E TE
Publication Date: 2020-01

Variant appearance in text: rs781583846
PubMed Link: 31306493
Variant Present in the following documents:
  • CPT-107-203-s004.pdf
View BVdb publication page



Evolving neoantigen profiles in colorectal cancers with DNA repair defects.

Genome Medicine
Rospo, Giuseppe G; Lorenzato, Annalisa A; Amirouchene-Angelozzi, Nabil N; Magrì, Alessandro A; Cancelliere, Carlotta C; Corti, Giorgio G; Negrino, Carola C; Amodio, Vito V; Montone, Monica M; Bartolini, Alice A; Barault, Ludovic L; Novara, Luca L; Isella, Claudio C; Medico, Enzo E; Bertotti, Andrea A; Trusolino, Livio L; Germano, Giovanni G; Di Nicolantonio, Federica F; Bardelli, Alberto A
Publication Date: 2019-06-28

Variant appearance in text: CYP2C9: A477T
PubMed Link: 31253177
Variant Present in the following documents:
  • 13073_2019_654_MOESM2_ESM.xlsx, sheet 46
View BVdb publication page



Automated Metabolic Phenotyping of Cytochrome Polymorphisms Using PubMed Abstract Mining.

Amia ... Annual Symposium Proceedings. Amia Symposium
Chen, Luoxin L; Friedman, Carol C; Finkelstein, Joseph J
Publication Date: 2017

Variant appearance in text: CYP2C9: A477T
PubMed Link: 29854118
Variant Present in the following documents:
  • Main text
View BVdb publication page



Insights into molecular mechanisms of drug metabolism dysfunction of human CYP2C9*30.

Plos One
Louet, Maxime M; Labbé, Céline M CM; Fagnen, Charline C; Aono, Cassiano M CM; Homem-de-Mello, Paula P; Villoutreix, Bruno O BO; Miteva, Maria A MA
Publication Date: 2018

Variant appearance in text: CYP2C9: A477T
PubMed Link: 29746595
Variant Present in the following documents:
  • Main text
  • pone.0197249.s006.pdf
  • pone.0197249.pdf
  • pone.0197249.s009.pdf
  • pone.0197249.s008.pdf
  • pone.0197249.s001.pdf
  • pone.0197249.s002.pdf
View BVdb publication page



Structural Basis of Single-Nucleotide Polymorphisms in Cytochrome P450 2C9.

Biochemistry
Maekawa, Keiko K; Adachi, Motoyasu M; Matsuzawa, Yumiko Y; Zhang, Qinghai Q; Kuroki, Ryota R; Saito, Yoshiro Y; Shah, Manish B MB
Publication Date: 2017-10-17

Variant appearance in text: CYP2C9: A477T
PubMed Link: 28972767
Variant Present in the following documents:
  • Main text
View BVdb publication page



Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects.

Clinical Pharmacology And Therapeutics
Zhou, Y Y; Ingelman-Sundberg, M M; Lauschke, V M VM
Publication Date: 2017-10

Variant appearance in text: CYP2C9: A477T; rs781583846
PubMed Link: 28378927
Variant Present in the following documents:
  • Main text
  • CPT-102-688.pdf
View BVdb publication page



A Landscape of Pharmacogenomic Interactions in Cancer.

Cell
Iorio, Francesco F; Knijnenburg, Theo A TA; Vis, Daniel J DJ; Bignell, Graham R GR; Menden, Michael P MP; Schubert, Michael M; Aben, Nanne N; Gonçalves, Emanuel E; Barthorpe, Syd S; Lightfoot, Howard H; Cokelaer, Thomas T; Greninger, Patricia P; van Dyk, Ewald E; Chang, Han H; de Silva, Heshani H; Heyn, Holger H; Deng, Xianming X; Egan, Regina K RK; Liu, Qingsong Q; Mironenko, Tatiana T; Mitropoulos, Xeni X; Richardson, Laura L; Wang, Jinhua J; Zhang, Tinghu T; Moran, Sebastian S; Sayols, Sergi S; Soleimani, Maryam M; Tamborero, David D; Lopez-Bigas, Nuria N; Ross-Macdonald, Petra P; Esteller, Manel M; Gray, Nathanael S NS; Haber, Daniel A DA; Stratton, Michael R MR; Benes, Cyril H CH; Wessels, Lodewyk F A LFA; Saez-Rodriguez, Julio J; McDermott, Ultan U; Garnett, Mathew J MJ
Publication Date: 2016-07-28

Variant appearance in text: CYP2C9: 1429G>A; A477T
PubMed Link: 27397505
Variant Present in the following documents:
  • mmc3.xlsx, sheet 3
View BVdb publication page