Effects of Pre-Pregnancy Overweight/Obesity on the Pattern of Association of Hypertension Susceptibility Genes with Preeclampsia.
Life (Basel, Switzerland)
Abramova, Maria M; Churnosova, Maria M; Efremova, Olesya O; Aristova, Inna I; Reshetnikov, Evgeny E; Polonikov, Alexey A; Churnosov, Mikhail M; Ponomarenko, Irina I
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants.
Nature Genetics
Aragam, Krishna G KG; Jiang, Tao T; Goel, Anuj A; Kanoni, Stavroula S; Wolford, Brooke N BN; Atri, Deepak S DS; Weeks, Elle M EM; Wang, Minxian M; Hindy, George G; Zhou, Wei W; Grace, Christopher C; Roselli, Carolina C; Marston, Nicholas A NA; Kamanu, Frederick K FK; Surakka, Ida I; Venegas, Loreto Muñoz LM; Sherliker, Paul P; Koyama, Satoshi S; Ishigaki, Kazuyoshi K; Åsvold, Bjørn O BO; Brown, Michael R MR; Brumpton, Ben B; de Vries, Paul S PS; Giannakopoulou, Olga O; Giardoglou, Panagiota P; Gudbjartsson, Daniel F DF; Güldener, Ulrich U; Haider, Syed M Ijlal SMI; Helgadottir, Anna A; Ibrahim, Maysson M; Kastrati, Adnan A; Kessler, Thorsten T; Kyriakou, Theodosios T; Konopka, Tomasz T; Li, Ling L; Ma, Lijiang L; Meitinger, Thomas T; Mucha, Sören S; Munz, Matthias M; Murgia, Federico F; Nielsen, Jonas B JB; Nöthen, Markus M MM; Pang, Shichao S; Reinberger, Tobias T; Schnitzler, Gavin G; Smedley, Damian D; Thorleifsson, Gudmar G; von Scheidt, Moritz M; Ulirsch, Jacob C JC; , ; , ; Arnar, David O DO; Burtt, Noël P NP; Costanzo, Maria C MC; Flannick, Jason J; Ito, Kaoru K; Jang, Dong-Keun DK; Kamatani, Yoichiro Y; Khera, Amit V AV; Komuro, Issei I; Kullo, Iftikhar J IJ; Lotta, Luca A LA; Nelson, Christopher P CP; Roberts, Robert R; Thorgeirsson, Gudmundur G; Thorsteinsdottir, Unnur U; Webb, Thomas R TR; Baras, Aris A; Björkegren, Johan L M JLM; Boerwinkle, Eric E; Dedoussis, George G; Holm, Hilma H; Hveem, Kristian K; Melander, Olle O; Morrison, Alanna C AC; Orho-Melander, Marju M; Rallidis, Loukianos S LS; Ruusalepp, Arno A; Sabatine, Marc S MS; Stefansson, Kari K; Zalloua, Pierre P; Ellinor, Patrick T PT; Farrall, Martin M; Danesh, John J; Ruff, Christian T CT; Finucane, Hilary K HK; Hopewell, Jemma C JC; Clarke, Robert R; Gupta, Rajat M RM; Erdmann, Jeanette J; Samani, Nilesh J NJ; Schunkert, Heribert H; Watkins, Hugh H; Willer, Cristen J CJ; Deloukas, Panos P; Kathiresan, Sekar S; Butterworth, Adam S AS; ,
A homozygous stop-gain variant in ARHGAP42 is associated with childhood interstitial lung disease, systemic hypertension, and immunological findings.
Plos Genetics
Li, Qifei Q; Dibus, Michal M; Casey, Alicia A; Yee, Christina S K CSK; Vargas, Sara O SO; Luo, Shiyu S; Rosen, Samantha M SM; Madden, Jill A JA; Genetti, Casie A CA; Brabek, Jan J; Brownstein, Catherine A CA; Kazerounian, Shideh S; Raby, Benjamin A BA; Schmitz-Abe, Klaus K; Kennedy, John C JC; Fishman, Martha P MP; Mullen, Mary P MP; Taylor, Joan M JM; Rosel, Daniel D; Agrawal, Pankaj B PB
Polygenic risk scores predict diabetes complications and their response to intensive blood pressure and glucose control.
Diabetologia
Tremblay, Johanne J; Haloui, Mounsif M; Attaoua, Redha R; Tahir, Ramzan R; Hishmih, Camil C; Harvey, François F; Marois-Blanchet, François-Christophe FC; Long, Carole C; Simon, Paul P; Santucci, Lara L; Hizel, Candan C; Chalmers, John J; Marre, Michel M; Harrap, Stephen S; Cífková, Renata R; Krajčoviechová, Alena A; Matthews, David R DR; Williams, Bryan B; Poulter, Neil N; Zoungas, Sophia S; Colagiuri, Stephen S; Mancia, Giuseppe G; Grobbee, Diederick E DE; Rodgers, Anthony A; Liu, Liusheng L; Agbessi, Mawussé M; Bruat, Vanessa V; Favé, Marie-Julie MJ; Harwood, Michelle P MP; Awadalla, Philip P; Woodward, Mark M; Hussin, Julie G JG; Hamet, Pavel P
Exploring the Role of Contactins across Psychological, Psychiatric and Cardiometabolic Traits within UK Biobank.
Genes
Morris, Julia J; Leung, Soddy Sau Yu SSY; Bailey, Mark E S MES; Cullen, Breda B; Ferguson, Amy A; Graham, Nicholas N; Johnston, Keira J A KJA; Lyall, Donald M DM; Lyall, Laura M LM; Ward, Joey J; Smith, Daniel J DJ; Strawbridge, Rona J RJ
Maternal Hypertension-Related Genotypes and Congenital Heart Defects.
American Journal Of Hypertension
Lei, Yunping Y; Ludorf, Katherine L KL; Yu, Xiao X; Benjamin, Renata H RH; Gu, Xue X; Lin, Ying Y; Finnell, Richard H RH; Mitchell, Laura E LE; Musfee, Fadi I FI; Malik, Sadia S; Canfield, Mark A MA; Morrison, Alanna C AC; Hobbs, Charlotte A CA; Van Zutphen, Alissa R AR; Fisher, Sarah S; Agopian, A J AJ
A genome-wide association and replication study of blood pressure in Ugandan early adolescents.
Molecular Genetics & Genomic Medicine
Lule, Swaib A SA; Mentzer, Alexander J AJ; Namara, Benigna B; Muwenzi, Allan G AG; Nassanga, Beatrice B; Kizito, Dennison D; Akurut, Helen H; Lubyayi, Lawrence L; Tumusiime, Josephine J; Zziwa, Christopher C; Akello, Florence F; Gurdasani, Deept D; Sandhu, Manjinder M; Smeeth, Liam L; Elliott, Alison M AM; Webb, Emily L EL
The association of elevated maternal genetic risk scores for hypertension, type 2 diabetes and obesity and having a child with a congenital heart defect.
Plos One
Kaplinski, Michelle M; Taylor, Deanne D; Mitchell, Laura E LE; Hammond, Dorothy A DA; Goldmuntz, Elizabeth E; Agopian, A J AJ; ,
Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies.
Nature Genetics
Zhou, Wei W; Nielsen, Jonas B JB; Fritsche, Lars G LG; Dey, Rounak R; Gabrielsen, Maiken E ME; Wolford, Brooke N BN; LeFaive, Jonathon J; VandeHaar, Peter P; Gagliano, Sarah A SA; Gifford, Aliya A; Bastarache, Lisa A LA; Wei, Wei-Qi WQ; Denny, Joshua C JC; Lin, Maoxuan M; Hveem, Kristian K; Kang, Hyun Min HM; Abecasis, Goncalo R GR; Willer, Cristen J CJ; Lee, Seunggeun S
Human longevity: 25 genetic loci associated in 389,166 UK biobank participants.
Aging
Pilling, Luke C LC; Kuo, Chia-Ling CL; Sicinski, Kamil K; Tamosauskaite, Jone J; Kuchel, George A GA; Harries, Lorna W LW; Herd, Pamela P; Wallace, Robert R; Ferrucci, Luigi L; Melzer, David D
Towards Precision Medicine for Hypertension: A Review of Genomic, Epigenomic, and Microbiomic Effects on Blood Pressure in Experimental Rat Models and Humans.
Genome-Wide Association Study of Blood Pressure Traits by Hispanic/Latino Background: the Hispanic Community Health Study/Study of Latinos.
Scientific Reports
Sofer, Tamar T; Wong, Quenna Q; Hartwig, Fernando P FP; Taylor, Kent K; Warren, Helen R HR; Evangelou, Evangelos E; Cabrera, Claudia P CP; Levy, Daniel D; Kramer, Holly H; Lange, Leslie A LA; Horta, Bernardo L BL; , ; Kerr, Kathleen F KF; Reiner, Alex P AP; Franceschini, Nora N
Hypertension Susceptibility Loci are Associated with Anthracycline-related Cardiotoxicity in Long-term Childhood Cancer Survivors.
Scientific Reports
Hildebrandt, Michelle A T MAT; Reyes, Monica M; Wu, Xifeng X; Pu, Xia X; Thompson, Kara A KA; Ma, Jianzhong J; Landstrom, Andrew P AP; Morrison, Alanna C AC; Ater, Joann L JL
Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding.
The Journal Of Clinical Investigation
Bai, Xue X; Mangum, Kevin D KD; Dee, Rachel A RA; Stouffer, George A GA; Lee, Craig R CR; Oni-Orisan, Akinyemi A; Patterson, Cam C; Schisler, Jonathan C JC; Viera, Anthony J AJ; Taylor, Joan M JM; Mack, Christopher P CP
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.
Nature Genetics
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Utility of blood pressure genetic risk score in admixed Hispanic samples.
Journal Of Human Hypertension
Beecham, A H AH; Wang, L L; Vasudeva, N N; Liu, Z Z; Dong, C C; Goldschmidt-Clermont, P J PJ; Pericak-Vance, M A MA; Rundek, T T; Seo, D D; Blanton, S H SH; Sacco, R L RL; Beecham, G W GW
Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypes.
Hypertension (Dallas, Tex. : 1979)
Andreassen, Ole A OA; McEvoy, Linda K LK; Thompson, Wesley K WK; Wang, Yunpeng Y; Reppe, Sjur S; Schork, Andrew J AJ; Zuber, Verena V; Barrett-Connor, Elizabeth E; Gautvik, Kaare K; Aukrust, Pål P; Karlsen, Tom H TH; Djurovic, Srdjan S; Desikan, Rahul S RS; Dale, Anders M AM; ,
The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension.
Nature Communications
Bai, Xue X; Lenhart, Kaitlin C KC; Bird, Kim E KE; Suen, Alisa A AA; Rojas, Mauricio M; Kakoki, Masao M; Li, Feng F; Smithies, Oliver O; Mack, Christopher P CP; Taylor, Joan M JM
Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.
Plos One
Bhatnagar, Pallav P; Barron-Casella, Emily E; Bean, Christopher J CJ; Milton, Jacqueline N JN; Baldwin, Clinton T CT; Steinberg, Martin H MH; Debaun, Michael M; Casella, James F JF; Arking, Dan E DE
Overlap between common genetic polymorphisms underpinning kidney traits and cardiovascular disease phenotypes: the CKDGen consortium.
American Journal Of Kidney Diseases : The Official Journal Of The National Kidney Foundation
Olden, Matthias M; Teumer, Alexander A; Bochud, Murielle M; Pattaro, Cristian C; Köttgen, Anna A; Turner, Stephen T ST; Rettig, Rainer R; Chen, Ming-Huei MH; Dehghan, Abbas A; Bastardot, Francois F; Schmidt, Reinhold R; Vollenweider, Peter P; Schunkert, Heribert H; Reilly, Muredach P MP; Fornage, Myriam M; Launer, Lenore J LJ; Verwoert, Germaine C GC; Mitchell, Gary F GF; Bis, Joshua C JC; O'Donnell, Christopher J CJ; Cheng, Ching-Yu CY; Sim, Xueling X; Siscovick, David S DS; Coresh, Josef J; Kao, W H Linda WH; Fox, Caroline S CS; O'Seaghdha, Conall M CM; ,
Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study.
Plos One
Spencer, Kylee L KL; Malinowski, Jennifer J; Carty, Cara L CL; Franceschini, Nora N; Fernández-Rhodes, Lindsay L; Young, Alicia A; Cheng, Iona I; Ritchie, Marylyn D MD; Haiman, Christopher A CA; Wilkens, Lynne L; Chunyuanwu, ; Matise, Tara C TC; Carlson, Christopher S CS; Brennan, Kathleen K; Park, Amy A; Rajkovic, Aleksandar A; Hindorff, Lucia A LA; Buyske, Steven S; Crawford, Dana C DC
Hypothesis-based analysis of gene-gene interactions and risk of myocardial infarction.
Plos One
Lucas, Gavin G; Lluís-Ganella, Carla C; Subirana, Isaac I; Musameh, Muntaser D MD; Gonzalez, Juan Ramon JR; Nelson, Christopher P CP; Sentí, Mariano M; , ; , ; Schwartz, Stephen M SM; Siscovick, David D; O'Donnell, Christopher J CJ; Melander, Olle O; Salomaa, Veikko V; Purcell, Shaun S; Altshuler, David D; Samani, Nilesh J NJ; Kathiresan, Sekar S; Elosua, Roberto R
Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium.
European Heart Journal
Fedorowski, Artur A; Franceschini, Nora N; Brody, Jennifer J; Liu, Chunyu C; Verwoert, Germaine C GC; Boerwinkle, Eric E; Couper, David D; Rice, Kenneth M KM; Rotter, Jerome I JI; Mattace-Raso, Francesco F; Uitterlinden, Andre A; Hofman, Albert A; Almgren, Peter P; Sjögren, Marketa M; Hedblad, Bo B; Larson, Martin G MG; Newton-Cheh, Christopher C; Wang, Thomas J TJ; Rose, Kathryn M KM; Psaty, Bruce M BM; Levy, Daniel D; Witteman, Jacqueline J; Melander, Olle O
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
Nature
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Schwartz, Stephen M SM; Ikram, M Arfan MA; Longstreth, W T WT; Mosley, Thomas H TH; Seshadri, Sudha S; Shrine, Nick R G NR; Wain, Louise V LV; Morken, Mario A MA; Swift, Amy J AJ; Laitinen, Jaana J; Prokopenko, Inga I; Zitting, Paavo P; Cooper, Jackie A JA; Humphries, Steve E SE; Danesh, John J; Rasheed, Asif A; Goel, Anuj A; Hamsten, Anders A; Watkins, Hugh H; Bakker, Stephan J L SJ; van Gilst, Wiek H WH; Janipalli, Charles S CS; Mani, K Radha KR; Yajnik, Chittaranjan S CS; Hofman, Albert A; Mattace-Raso, Francesco U S FU; Oostra, Ben A BA; Demirkan, Ayse A; Isaacs, Aaron A; Rivadeneira, Fernando F; Lakatta, Edward G EG; Orru, Marco M; Scuteri, Angelo A; Ala-Korpela, Mika M; Kangas, Antti J AJ; Lyytikäinen, Leo-Pekka LP; Soininen, Pasi P; Tukiainen, Taru T; Würtz, Peter P; Ong, Rick Twee-Hee RT; Dörr, Marcus M; Kroemer, Heyo K HK; Völker, Uwe U; Völzke, Henry H; Galan, Pilar P; Hercberg, Serge S; Lathrop, Mark M; Zelenika, Diana D; Deloukas, Panos P; Mangino, Massimo M; Spector, Tim D TD; Zhai, Guangju G; Meschia, James F JF; Nalls, Michael A MA; Sharma, Pankaj P; Terzic, Janos J; Kumar, M V Kranthi MV; Denniff, Matthew M; Zukowska-Szczechowska, Ewa E; Wagenknecht, Lynne E LE; Fowkes, F Gerald R FG; Charchar, Fadi J FJ; Schwarz, Peter E H PE; Hayward, Caroline C; Guo, Xiuqing X; Rotimi, Charles C; Bots, Michiel L ML; Brand, Eva E; Samani, Nilesh J NJ; Polasek, Ozren O; Talmud, Philippa J PJ; Nyberg, Fredrik F; Kuh, Diana D; Laan, Maris M; Hveem, Kristian K; Palmer, Lyle J LJ; van der Schouw, Yvonne T YT; Casas, Juan P JP; Mohlke, Karen L KL; Vineis, Paolo P; Raitakari, Olli O; Ganesh, Santhi K SK; Wong, Tien Y TY; Tai, E Shyong ES; Cooper, Richard S RS; Laakso, Markku M; Rao, Dabeeru C DC; Harris, Tamara B TB; Morris, Richard W RW; Dominiczak, Anna F AF; Kivimaki, Mika M; Marmot, Michael G MG; Miki, Tetsuro T; Saleheen, Danish D; Chandak, Giriraj R GR; Coresh, Josef J; Navis, Gerjan G; Salomaa, Veikko V; Han, Bok-Ghee BG; Zhu, Xiaofeng X; Kooner, Jaspal S JS; Melander, Olle O; Ridker, Paul M PM; Bandinelli, Stefania S; Gyllensten, Ulf B UB; Wright, Alan F AF; Wilson, James F JF; Ferrucci, Luigi L; Farrall, Martin M; Tuomilehto, Jaakko J; Pramstaller, Peter P PP; Elosua, Roberto R; Soranzo, Nicole N; Sijbrands, Eric J G EJ; Altshuler, David D; Loos, Ruth J F RJ; Shuldiner, Alan R AR; Gieger, Christian C; Meneton, Pierre P; Uitterlinden, Andre G AG; Wareham, Nicholas J NJ; Gudnason, Vilmundur V; Rotter, Jerome I JI; Rettig, Rainer R; Uda, Manuela M; Strachan, David P DP; Witteman, Jacqueline C M JC; Hartikainen, Anna-Liisa AL; Beckmann, Jacques S JS; Boerwinkle, Eric E; Vasan, Ramachandran S RS; Boehnke, Michael M; Larson, Martin G MG; Järvelin, Marjo-Riitta MR; Psaty, Bruce M BM; Abecasis, Gonçalo R GR; Chakravarti, Aravinda A; Elliott, Paul P; van Duijn, Cornelia M CM; Newton-Cheh, Christopher C; Levy, Daniel D; Caulfield, Mark J MJ; Johnson, Toby T