Publications:

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ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage.

Nature Communications

Liu, Mingdong M; Zeng, Taoling T; Zhang, Xin X; Liu, Chunyan C; Wu, Zhihui Z; Yao, Luming L; Xie, Changchuan C; Xia, Hui H; Lin, Qi Q; Xie, Liping L; Zhou, Dawang D; Deng, Xianming X; Chan, Hong-Lin HL; Zhao, Tong-Jin TJ; Wang, Hong-Rui HR

Publication Date: 2018-10-08

Variant appearance in text: ATM: D130A

PubMed Link: 30297842

Variant Present in the following documents:

• Main text
• 41467_2018_Article_6556.pdf
• 41467_2018_6556_MOESM1_ESM.pdf

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Cryo-EM structure of human ATR-ATRIP complex.

Cell Research

Rao, Qinhui Q; Liu, Mengjie M; Tian, Yuan Y; Wu, Zihan Z; Hao, Yuhan Y; Song, Lei L; Qin, Zhaoyu Z; Ding, Chen C; Wang, Hong-Wei HW; Wang, Jiawei J; Xu, Yanhui Y

Publication Date: 2018-02

Variant appearance in text: ATM: D130A

PubMed Link: 29271416

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The novel Chk1 inhibitor MK-8776 sensitizes human leukemia cells to HDAC inhibitors by targeting the intra-S checkpoint and DNA replication and repair.

Molecular Cancer Therapeutics

Dai, Yun Y; Chen, Shuang S; Kmieciak, Maciej M; Zhou, Liang L; Lin, Hui H; Pei, Xin-Yan XY; Grant, Steven S

Publication Date: 2013-06

Variant appearance in text: ATM: D130A

PubMed Link: 23536721

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p50 (NF-κB1) is an effector protein in the cytotoxic response to DNA methylation damage.

Molecular Cell

Schmitt, Adam M AM; Crawley, Clayton D CD; Kang, Shijune S; Raleigh, David R DR; Yu, Xiaohong X; Wahlstrom, Joshua S JS; Voce, David J DJ; Darga, Thomas E TE; Weichselbaum, Ralph R RR; Yamini, Bakhtiar B

Publication Date: 2011-12-09

Variant appearance in text: ATM: D130A

PubMed Link: 22152481

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Chk1-dependent constitutive phosphorylation of BLM helicase at serine 646 decreases after DNA damage.

Molecular Cancer Research : Mcr

Kaur, Sarabpreet S; Modi, Priyanka P; Srivastava, Vivek V; Mudgal, Richa R; Tikoo, Shweta S; Arora, Prateek P; Mohanty, Debasisa D; Sengupta, Sagar S

Publication Date: 2010-09

Variant appearance in text: ATM: D130A

PubMed Link: 20719863

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Mismatch repair system decreases cell survival by stabilizing the tetraploid G1 arrest in response to SN-38.

International Journal Of Cancer

Bhonde, Mandar Ramesh MR; Hanski, Marie-Luise ML; Stehr, Jenny J; Jebautzke, Britta B; Peiró-Jordán, Roser R; Fechner, Henry H; Yokoyama, Kazunari Kazushige KK; Lin, Weei-Chin WC; Zeitz, Martin M; Hanski, Christoph C

Publication Date: 2010-06-15

Variant appearance in text: ATM: D130A

PubMed Link: 19739070

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DNA damage induces Chk1-dependent centrosome amplification.

Embo Reports

Bourke, Emer E; Dodson, Helen H; Merdes, Andreas A; Cuffe, Lorraine L; Zachos, George G; Walker, Mark M; Gillespie, David D; Morrison, Ciaran G CG

Publication Date: 2007-06

Variant appearance in text: ATM: D130A

PubMed Link: 17468739

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Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit.

Molecular And Cellular Biology

Leung-Pineda, Van V; Ryan, Christine E CE; Piwnica-Worms, Helen H

Publication Date: 2006-10

Variant appearance in text: ATM: D130A

PubMed Link: 17015476

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p73alpha regulation by Chk1 in response to DNA damage.

Molecular And Cellular Biology

Gonzalez, Susana S; Prives, Carol C; Cordon-Cardo, Carlos C

Publication Date: 2003-11

Variant appearance in text: ATM: D130A

PubMed Link: 14585975

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Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Peters, Malte M; DeLuca, Carmela C; Hirao, Atsushi A; Stambolic, Vuk V; Potter, Julia J; Zhou, Lily L; Liepa, Jennifer J; Snow, Bryan B; Arya, Sudha S; Wong, Jorge J; Bouchard, Denis D; Binari, Richard R; Manoukian, Armen S AS; Mak, Tak W TW

Publication Date: 2002-08-20

Variant appearance in text: ATM: D130A

PubMed Link: 12172011

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Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing.

The Journal Of Cell Biology

Feijoo, C C; Hall-Jackson, C C; Wu, R R; Jenkins, D D; Leitch, J J; Gilbert, D M DM; Smythe, C C

Publication Date: 2001-09-03

Variant appearance in text: ATM: D130A

PubMed Link: 11535615

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• Main text
• 0104099.pdf

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ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1.

Molecular And Cellular Biology

Zhao, H H; Piwnica-Worms, H H

Publication Date: 2001-07

Variant appearance in text: ATM: D130A

PubMed Link: 11390642

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