The novel Chk1 inhibitor MK-8776 sensitizes human leukemia cells to HDAC inhibitors by targeting the intra-S checkpoint and DNA replication and repair.
Molecular Cancer Therapeutics
Dai, Yun Y; Chen, Shuang S; Kmieciak, Maciej M; Zhou, Liang L; Lin, Hui H; Pei, Xin-Yan XY; Grant, Steven S
p50 (NF-κB1) is an effector protein in the cytotoxic response to DNA methylation damage.
Molecular Cell
Schmitt, Adam M AM; Crawley, Clayton D CD; Kang, Shijune S; Raleigh, David R DR; Yu, Xiaohong X; Wahlstrom, Joshua S JS; Voce, David J DJ; Darga, Thomas E TE; Weichselbaum, Ralph R RR; Yamini, Bakhtiar B