Publications:

---

A strategy for the treatment of gastrointestinal cancer: Targeting tumor senescent cells.

Frontiers In Molecular Biosciences

Liu, Yujing Y; Zhang, Qiang Q; Ni, Wenjing W; Ji, Guang G; Xu, Hanchen H

Publication Date: 2023

Variant appearance in text: ATM: R270H

PubMed Link: 36950520

Variant Present in the following documents:

• Main text
• fmolb-10-1139840.pdf

View BVdb publication page

---

Clinical and Molecular Features in Medulloblastomas Subtypes in Children in a Cohort in Taiwan.

Cancers

Wu, Kuo-Sheng KS; Sung, Shian-Ying SY; Huang, Man-Hsu MH; Lin, Yu-Ling YL; Chang, Che-Chang CC; Fang, Chia-Lang CL; Wong, Tai-Tong TT; Chen, Hsin-Hung HH; Tsai, Min-Lan ML

Publication Date: 2022-11-03

Variant appearance in text: ATM: R270H

PubMed Link: 36358838

Variant Present in the following documents:

• cancers-14-05419.pdf

View BVdb publication page

---

Advanced Strategies for Therapeutic Targeting of Wild-Type and Mutant p53 in Cancer.

Biomolecules

Zhang, Shengliang S; Carlsen, Lindsey L; Hernandez Borrero, Liz L; Seyhan, Attila A AA; Tian, Xiaobing X; El-Deiry, Wafik S WS

Publication Date: 2022-04-06

Variant appearance in text: ATM: R270H

PubMed Link: 35454137

Variant Present in the following documents:

• Main text
• biomolecules-12-00548.pdf

View BVdb publication page

---

Cross-Talk between p53 and Wnt Signaling in Cancer.

Biomolecules

Xiao, Qiyun Q; Werner, Johannes J; Venkatachalam, Nachiyappan N; Boonekamp, Kim E KE; Ebert, Matthias P MP; Zhan, Tianzuo T

Publication Date: 2022-03-15

Variant appearance in text: ATM: R270H

PubMed Link: 35327645

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Targeting Post-Translational Regulation of p53 in Colorectal Cancer by Exploiting Vulnerabilities in the p53-MDM2 Axis.

Cancers

Lai, Chunwei W CW; Xie, Cindy C; Raufman, Jean-Pierre JP; Xie, Guofeng G

Publication Date: 2022-01-03

Variant appearance in text: ATM: R270H

PubMed Link: 35008383

Variant Present in the following documents:

• Main text
• cancers-14-00219.pdf

View BVdb publication page

---

Targeting Post-Translational Regulation of p53 in Colorectal Cancer by Exploiting Vulnerabilities in the p53-MDM2 Axis.

Cancers

Lai, Chunwei W CW; Xie, Cindy C; Raufman, Jean-Pierre JP; Xie, Guofeng G

Publication Date: 2022-01-03

Variant appearance in text: ATM: R270H

PubMed Link: 35008383

Variant Present in the following documents:

• Main text
• cancers-14-00219.pdf

View BVdb publication page

---

The Function of the Mutant p53-R175H in Cancer.

Cancers

Chiang, Yen-Ting YT; Chien, Yi-Chung YC; Lin, Yu-Heng YH; Wu, Hui-Hsuan HH; Lee, Dung-Fang DF; Yu, Yung-Luen YL

Publication Date: 2021-08-13

Variant appearance in text: ATM: R270H

PubMed Link: 34439241

Variant Present in the following documents:

• Main text
• cancers-13-04088.pdf

View BVdb publication page

---

Chaperones and Ubiquitin Ligases Balance Mutant p53 Protein Stability in Esophageal and Other Digestive Cancers.

Cellular And Molecular Gastroenterology And Hepatology

Martinho, May San MS; Nancarrow, Derek J DJ; Lawrence, Theodore S TS; Beer, David G DG; Ray, Dipankar D

Publication Date: 2021

Variant appearance in text: ATM: R270H

PubMed Link: 33130332

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Gain-of-function mutant p53 in cancer progression and therapy.

Journal Of Molecular Cell Biology

Zhang, Cen C; Liu, Juan J; Xu, Dandan D; Zhang, Tianliang T; Hu, Wenwei W; Feng, Zhaohui Z

Publication Date: 2020-09-01

Variant appearance in text: ATM: R270H

PubMed Link: 32722796

Variant Present in the following documents:

• Main text
• mjaa040.pdf

View BVdb publication page

---

The Janus Face of p53-Targeting Ubiquitin Ligases.

Cells

Hao, Qian Q; Chen, Yajie Y; Zhou, Xiang X

Publication Date: 2020-07-09

Variant appearance in text: ATM: R270H

PubMed Link: 32660118

Variant Present in the following documents:

• Main text
• cells-09-01656.pdf

View BVdb publication page

---

Pancreatic Cancer and Its Microenvironment-Recent Advances and Current Controversies.

International Journal Of Molecular Sciences

Stopa, Kinga B KB; Kusiak, Agnieszka A AA; Szopa, Mateusz D MD; Ferdek, Pawel E PE; Jakubowska, Monika A MA

Publication Date: 2020-05-01

Variant appearance in text: ATM: R270H

PubMed Link: 32370075

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model.

Nature Genetics

Sethi, Nilay S NS; Kikuchi, Osamu O; Duronio, Gina N GN; Stachler, Matthew D MD; McFarland, James M JM; Ferrer-Luna, Ruben R; Zhang, Yanxi Y; Bao, Chunyang C; Bronson, Roderick R; Patil, Deepa D; Sanchez-Vega, Francisco F; Liu, Jie-Bin JB; Sicinska, Ewa E; Lazaro, Jean-Bernard JB; Ligon, Keith L KL; Beroukhim, Rameen R; Bass, Adam J AJ

Publication Date: 2020-02

Variant appearance in text: ATM: R270H

PubMed Link: 32025000

Variant Present in the following documents:

• Main text
• nihms-1546989.pdf

View BVdb publication page

---

Murine models for familial pancreatic cancer: Histopathology, latency and drug sensitivity among cancers of Palb2, Brca1 and Brca2 mutant mouse strains.

Plos One

Park, Dongju D; Shakya, Reena R; Koivisto, Christopher C; Pitarresi, Jason R JR; Szabolcs, Matthias M; Kladney, Raleigh R; Hadjis, Ashley A; Mace, Thomas A TA; Ludwig, Thomas T

Publication Date: 2019

Variant appearance in text: ATM: R270H

PubMed Link: 31877165

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Emerging treatment options for patients with p53-pathway-deficient CLL.

Therapeutic Advances In Hematology

Aitken, Marisa J L MJL; Lee, Hun J HJ; Post, Sean M SM

Publication Date: 2019

Variant appearance in text: ATM: R270H

PubMed Link: 31839919

Variant Present in the following documents:

• Main text
• 10.1177_2040620719891356.pdf

View BVdb publication page

---

Salvation of the fallen angel: Reactivating mutant p53.

British Journal Of Pharmacology

Li, Yang Y; Wang, Zhuoyi Z; Chen, Yuchen Y; Petersen, Robert B RB; Zheng, Ling L; Huang, Kun K

Publication Date: 2019-04

Variant appearance in text: ATM: R270H

PubMed Link: 30632144

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Lung Cancers: Molecular Characterization, Clonal Heterogeneity and Evolution, and Cancer Stem Cells.

Cancers

Testa, Ugo U; Castelli, Germana G; Pelosi, Elvira E

Publication Date: 2018-07-27

Variant appearance in text: ATM: R270H

PubMed Link: 30060526

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Zinc Metallochaperones as Mutant p53 Reactivators: A New Paradigm in Cancer Therapeutics.

Cancers

Kogan, Samuel S; Carpizo, Darren R DR

Publication Date: 2018-05-29

Variant appearance in text: ATM: R270H

PubMed Link: 29843463

Variant Present in the following documents:

• cancers-10-00166.pdf

View BVdb publication page

---

Genetically Engineered Mouse Models of Prostate Cancer in the Postgenomic Era.

Cold Spring Harbor Perspectives In Medicine

Arriaga, Juan M JM; Abate-Shen, Cory C

Publication Date: 2019-02-01

Variant appearance in text: ATM: R270H

PubMed Link: 29661807

Variant Present in the following documents:

• Main text

View BVdb publication page

---

TP53 Modulates Oxidative Stress in Gata1+ Erythroid Cells.

Stem Cell Reports

Kramer, Ashley C AC; Weber, Jenna J; Zhang, Ying Y; Tolar, Jakub J; Gibbens, Ying Y YY; Shevik, Margaret M; Lund, Troy C TC

Publication Date: 2017-02-14

Variant appearance in text: ATM: R270H

PubMed Link: 28132886

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Molecular genetics of osteosarcoma.

Bone

Rickel, Kirby K; Fang, Fang F; Tao, Jianning J

Publication Date: 2017-09

Variant appearance in text: ATM: R270H

PubMed Link: 27760307

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Aspirin inhibits epithelial-to-mesenchymal transition and migration of oncogenic K-ras-expressing non-small cell lung carcinoma cells by down-regulating E-cadherin repressor Slug.

Bmc Cancer

Khan, Poulami P; Manna, Argha A; Saha, Shilpi S; Mohanty, Suchismita S; Mukherjee, Shravanti S; Mazumdar, Minakshi M; Guha, Deblina D; Das, Tanya T

Publication Date: 2016-01-26

Variant appearance in text: ATM: R270H

PubMed Link: 26810856

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Mutant p53 protein expression and antioxidant status deficiency in breast cancer.

Excli Journal

Milicevic, Zorka Z; Kasapovic, Jelena J; Gavrilovic, Ljubica L; Milovanovic, Zorka Z; Bajic, Vladan V; Spremo-Potparevic, Biljana B

Publication Date: 2014

Variant appearance in text: ATM: R270H

PubMed Link: 26417293

Variant Present in the following documents:

• EXCLI-13-691.pdf

View BVdb publication page

---

Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.

Cell

Creixell, Pau P; Schoof, Erwin M EM; Simpson, Craig D CD; Longden, James J; Miller, Chad J CJ; Lou, Hua Jane HJ; Perryman, Lara L; Cox, Thomas R TR; Zivanovic, Nevena N; Palmeri, Antonio A; Wesolowska-Andersen, Agata A; Helmer-Citterich, Manuela M; Ferkinghoff-Borg, Jesper J; Itamochi, Hiroaki H; Bodenmiller, Bernd B; Erler, Janine T JT; Turk, Benjamin E BE; Linding, Rune R

Publication Date: 2015-09-24

Variant appearance in text: ATM: R270H

PubMed Link: 26388441

Variant Present in the following documents:

• mmc4.xlsx, sheet 1

View BVdb publication page

---

Antitumor mechanisms when pRb and p53 are genetically inactivated.

Oncogene

Zhu, L L; Lu, Z Z; Zhao, H H

Publication Date: 2015-08-27

Variant appearance in text: ATM: R270H

PubMed Link: 25486431

Variant Present in the following documents:

• Main text

View BVdb publication page

---

The role of tumor suppressor p53 in the antioxidant defense and metabolism.

Sub-Cellular Biochemistry

Budanov, Andrei V AV

Publication Date: 2014

Variant appearance in text: ATM: R270H

PubMed Link: 25201203

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Mutant TP53 posttranslational modifications: challenges and opportunities.

Human Mutation

Nguyen, Thuy-Ai TA; Menendez, Daniel D; Resnick, Michael A MA; Anderson, Carl W CW

Publication Date: 2014-06

Variant appearance in text: ATM: R270H

PubMed Link: 24395704

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Illuminating p53 function in cancer with genetically engineered mouse models.

Seminars In Cell & Developmental Biology

Garcia, Patty B PB; Attardi, Laura D LD

Publication Date: 2014-03

Variant appearance in text: ATM: R270H

PubMed Link: 24394915

Variant Present in the following documents:

• Main text

View BVdb publication page

---

The regulation of MDM2 oncogene and its impact on human cancers.

Acta Biochimica Et Biophysica Sinica

Zhao, Yuhan Y; Yu, Haiyang H; Hu, Wenwei W

Publication Date: 2014-03

Variant appearance in text: ATM: R270H

PubMed Link: 24389645

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis.

Nature Communications

Zheng, Tongsen T; Wang, Jiabei J; Zhao, Yuhan Y; Zhang, Cen C; Lin, Meihua M; Wang, Xiaowen X; Yu, Haiyang H; Liu, Lianxin L; Feng, Zhaohui Z; Hu, Wenwei W

Publication Date: 2013

Variant appearance in text: ATM: R270H

PubMed Link: 24356649

Variant Present in the following documents:

• nihms-543897.pdf

View BVdb publication page

---

Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models.

Cancer Cell

Perets, Ruth R; Wyant, Gregory A GA; Muto, Katherine W KW; Bijron, Jonathan G JG; Poole, Barish B BB; Chin, Kenneth T KT; Chen, Jin Yun H JY; Ohman, Anders W AW; Stepule, Corey D CD; Kwak, Soongu S; Karst, Alison M AM; Hirsch, Michelle S MS; Setlur, Sunita R SR; Crum, Christopher P CP; Dinulescu, Daniela M DM; Drapkin, Ronny R

Publication Date: 2013-12-09

Variant appearance in text: ATM: R270H

PubMed Link: 24332043

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Using genetically engineered mice for radiation research.

Radiation Research

Kirsch, David G DG

Publication Date: 2011-09

Variant appearance in text: ATM: R270H

PubMed Link: 21867429

Variant Present in the following documents:

• Main text

View BVdb publication page

---

BRCA1 deficient mouse models to study pathogenesis and therapy of triple negative breast cancer.

Breast Disease

Diaz-Cruz, Edgar S ES; Cabrera, Marina C MC; Nakles, Rebecca R; Rutstein, Beth H BH; Furth, Priscilla A PA

Publication Date: 2010

Variant appearance in text: ATM: R270H

PubMed Link: 21778574

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Pathways contributing to development of spontaneous mammary tumors in BALB/c-Trp53+/- mice.

The American Journal Of Pathology

Yan, Haoheng H; Blackburn, Anneke C AC; McLary, S Christine SC; Tao, Luwei L; Roberts, Amy L AL; Xavier, Elizabeth A EA; Dickinson, Ellen S ES; Seo, Jae Hong JH; Arenas, Richard B RB; Otis, Christopher N CN; Cao, Qing J QJ; Lawlor, Rebecca G RG; Osborne, Barbara A BA; Kittrell, Frances S FS; Medina, Daniel D; Jerry, D Joseph DJ

Publication Date: 2010-03

Variant appearance in text: ATM: R270H

PubMed Link: 20110418

Variant Present in the following documents:

• Main text

View BVdb publication page

---