Publications:

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Increased BUB1B/BUBR1 expression contributes to aberrant DNA repair activity leading to resistance to DNA-damaging agents.

Oncogene

Komura, Kazumasa K; Inamoto, Teruo T; Tsujino, Takuya T; Matsui, Yusuke Y; Konuma, Tsuyoshi T; Nishimura, Kazuki K; Uchimoto, Taizo T; Tsutsumi, Takeshi T; Matsunaga, Tomohisa T; Maenosono, Ryoichi R; Yoshikawa, Yuki Y; Taniguchi, Kohei K; Tanaka, Tomohito T; Uehara, Hirofumi H; Hirata, Koichi K; Hirano, Hajime H; Nomi, Hayahito H; Hirose, Yoshinobu Y; Ono, Fumihito F; Azuma, Haruhito H

Publication Date: 2021-10

Variant appearance in text: ATM: S1981A

PubMed Link: 34545188

Variant Present in the following documents:

• Main text
• 41388_2021_Article_2021.pdf

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Increased BUB1B/BUBR1 expression contributes to aberrant DNA repair activity leading to resistance to DNA-damaging agents.

Oncogene

Komura, Kazumasa K; Inamoto, Teruo T; Tsujino, Takuya T; Matsui, Yusuke Y; Konuma, Tsuyoshi T; Nishimura, Kazuki K; Uchimoto, Taizo T; Tsutsumi, Takeshi T; Matsunaga, Tomohisa T; Maenosono, Ryoichi R; Yoshikawa, Yuki Y; Taniguchi, Kohei K; Tanaka, Tomohito T; Uehara, Hirofumi H; Hirata, Koichi K; Hirano, Hajime H; Nomi, Hayahito H; Hirose, Yoshinobu Y; Ono, Fumihito F; Azuma, Haruhito H

Publication Date: 2021-10

Variant appearance in text: ATM: S1981A

PubMed Link: 34545188

Variant Present in the following documents:

• Main text
• 41388_2021_Article_2021.pdf

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ATM-associated signalling triggers the unfolded protein response and cell death in response to stress.

Communications Biology

Hotokezaka, Yuka Y; Katayama, Ikuo I; Nakamura, Takashi T

Publication Date: 2020-07-14

Variant appearance in text: ATM: S1981A

PubMed Link: 32665601

Variant Present in the following documents:

• Main text
• 42003_2020_Article_1102.pdf
• 42003_2020_1102_MOESM1_ESM.pdf

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A single synonymous mutation determines the phosphorylation and stability of the nascent protein.

Journal Of Molecular Cell Biology

Karakostis, Konstantinos K; Vadivel Gnanasundram, Sivakumar S; López, Ignacio I; Thermou, Aikaterini A; Wang, Lixiao L; Nylander, Karin K; Olivares-Illana, Vanesa V; Fåhraeus, Robin R

Publication Date: 2019-03-01

Variant appearance in text: ATM: S1981A

PubMed Link: 30252118

Variant Present in the following documents:

• Main text

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Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria.

Elife

Qian, Minxian M; Liu, Zuojun Z; Peng, Linyuan L; Tang, Xiaolong X; Meng, Fanbiao F; Ao, Ying Y; Zhou, Mingyan M; Wang, Ming M; Cao, Xinyue X; Qin, Baoming B; Wang, Zimei Z; Zhou, Zhongjun Z; Wang, Guangming G; Gao, Zhengliang Z; Xu, Jun J; Liu, Baohua B

Publication Date: 2018-05-02

Variant appearance in text: ATM: S1981A

PubMed Link: 29717979

Variant Present in the following documents:

• elife-34836.pdf

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Breaking up with ATM.

Journal Of Immunological Sciences

Adamowicz, Marek M

Publication Date: 2018-01

Variant appearance in text: ATM: S1981A

PubMed Link: 29652413

Variant Present in the following documents:

• Main text
• emss-76340.pdf

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Insufficiency of DNA repair enzyme ATM promotes naive CD4 T-cell loss in chronic hepatitis C virus infection.

Cell Discovery

Zhao, Juan J; Dang, Xindi X; Zhang, Peixin P; Nguyen, Lam Nhat LN; Cao, Dechao D; Wang, Lin L; Wu, Xiaoyuan X; Morrison, Zheng D ZD; Zhang, Ying Y; Jia, Zhansheng Z; Xie, Qian Q; Wang, Ling L; Ning, Shunbin S; El Gazzar, Mohamed M; Moorman, Jonathan P JP; Yao, Zhi Q ZQ

Publication Date: 2018

Variant appearance in text: ATM: S1981A

PubMed Link: 29644094

Variant Present in the following documents:

• Main text

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Structures of closed and open conformations of dimeric human ATM.

Science Advances

Baretić, Domagoj D; Pollard, Hannah K HK; Fisher, David I DI; Johnson, Christopher M CM; Santhanam, Balaji B; Truman, Caroline M CM; Kouba, Tomas T; Fersht, Alan R AR; Phillips, Christopher C; Williams, Roger L RL

Publication Date: 2017-05

Variant appearance in text: ATM: S1981A

PubMed Link: 28508083

Variant Present in the following documents:

• Main text
• 1700933.pdf

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Imaging of Fluorescently Tagged ATM Kinase at the Sites of DNA Double Strand Breaks.

Methods In Molecular Biology (Clifton, N.J.)

Davis, Anthony J AJ; Wang, Shih-Ya SY; Chen, David J DJ; Chen, Benjamin P C BPC

Publication Date: 2017

Variant appearance in text: ATM: S1981A

PubMed Link: 28477126

Variant Present in the following documents:

• Main text

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Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenance.

Biomed Research International

Di Domenico, Enea Gino EG; Romano, Elena E; Del Porto, Paola P; Ascenzioni, Fiorentina F

Publication Date: 2014

Variant appearance in text: ATM: S1981A

PubMed Link: 25247188

Variant Present in the following documents:

• Main text

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Dimer monomer transition and dimer re-formation play important role for ATM cellular function during DNA repair.

Biochemical And Biophysical Research Communications

Du, Fengxia F; Zhang, Minjie M; Li, Xiaohua X; Yang, Caiyun C; Meng, Hao H; Wang, Dong D; Chang, Shuang S; Xu, Ye Y; Price, Brendan B; Sun, Yingli Y

Publication Date: 2014-10-03

Variant appearance in text: ATM: S1981A

PubMed Link: 25240135

Variant Present in the following documents:

• Main text

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ATM mediates pRB function to control DNMT1 protein stability and DNA methylation.

Molecular And Cellular Biology

Shamma, Awad A; Suzuki, Misa M; Hayashi, Naoyuki N; Kobayashi, Masahiko M; Sasaki, Nobunari N; Nishiuchi, Takumi T; Doki, Yuichiro Y; Okamoto, Takahiro T; Kohno, Susumu S; Muranaka, Hayato H; Kitajima, Shunsuke S; Yamamoto, Ken-Ichi K; Takahashi, Chiaki C

Publication Date: 2013-08

Variant appearance in text: ATM: S1981A

PubMed Link: 23754744

Variant Present in the following documents:

• Main text

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The ATM signaling network in development and disease.

Frontiers In Genetics

Stracker, Travis H TH; Roig, Ignasi I; Knobel, Philip A PA; Marjanović, Marko M

Publication Date: 2013

Variant appearance in text: ATM: S1981A

PubMed Link: 23532176

Variant Present in the following documents:

• Main text

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Activation of the ATM-Snail pathway promotes breast cancer metastasis.

Journal Of Molecular Cell Biology

Sun, Mianen M; Guo, Xiaojing X; Qian, Xiaolong X; Wang, Haibo H; Yang, Chunying C; Brinkman, Kathryn L KL; Serrano-Gonzalez, Monica M; Jope, Richard S RS; Zhou, Binhua B; Engler, David A DA; Zhan, Ming M; Wong, Stephen T C ST; Fu, Li L; Xu, Bo B

Publication Date: 2012-10

Variant appearance in text: ATM: S1981A

PubMed Link: 22923499

Variant Present in the following documents:

• Main text

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Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice.

The Journal Of Cell Biology

Yamamoto, Kenta K; Wang, Yunyue Y; Jiang, Wenxia W; Liu, Xiangyu X; Dubois, Richard L RL; Lin, Chyuan-Sheng CS; Ludwig, Thomas T; Bakkenist, Christopher J CJ; Zha, Shan S

Publication Date: 2012-08-06

Variant appearance in text: ATM: S1981A

PubMed Link: 22869596

Variant Present in the following documents:

• Main text
• JCB_201204098.pdf

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Aurora-B mediated ATM serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpoint.

Molecular Cell

Yang, Chunying C; Tang, Xi X; Guo, Xiaojing X; Niikura, Yohei Y; Kitagawa, Katsumi K; Cui, Kemi K; Wong, Stephen T C ST; Fu, Li L; Xu, Bo B

Publication Date: 2011-11-18

Variant appearance in text: ATM: S1981A

PubMed Link: 22099307

Variant Present in the following documents:

• Main text

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Analysis of mutations that dissociate G(2) and essential S phase functions of human ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase.

The Journal Of Biological Chemistry

Nam, Edward A EA; Zhao, Runxiang R; Cortez, David D

Publication Date: 2011-10-28

Variant appearance in text: ATM: S1981A

PubMed Link: 21908846

Variant Present in the following documents:

• Main text

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Autophosphorylation and ATM activation: additional sites add to the complexity.

The Journal Of Biological Chemistry

Kozlov, Sergei V SV; Graham, Mark E ME; Jakob, Burkhard B; Tobias, Frank F; Kijas, Amanda W AW; Tanuji, Marcel M; Chen, Philip P; Robinson, Phillip J PJ; Taucher-Scholz, Gisela G; Suzuki, Keiji K; So, Sairai S; Chen, David D; Lavin, Martin F MF

Publication Date: 2011-03-18

Variant appearance in text: ATM: S1981A

PubMed Link: 21149446

Variant Present in the following documents:

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The MRN complex in double-strand break repair and telomere maintenance.

Febs Letters

Lamarche, Brandon J BJ; Orazio, Nicole I NI; Weitzman, Matthew D MD

Publication Date: 2010-09-10

Variant appearance in text: ATM: S1981A

PubMed Link: 20655309

Variant Present in the following documents:

• Main text

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c-Abl mediates high NaCl-induced phosphorylation and activation of the transcription factor TonEBP/OREBP.

Faseb Journal : Official Publication Of The Federation Of American Societies For Experimental Biology

Gallazzini, Morgan M; Yu, Ming-Jiun MJ; Gunaratne, Ruwan R; Burg, Maurice B MB; Ferraris, Joan D JD

Publication Date: 2010-11

Variant appearance in text: ATM: S1981A

PubMed Link: 20585028

Variant Present in the following documents:

• Main text

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Multiple roles of ATM in monitoring and maintaining DNA integrity.

Febs Letters

Derheimer, Frederick A FA; Kastan, Michael B MB

Publication Date: 2010-09-10

Variant appearance in text: ATM: S1981A

PubMed Link: 20580718

Variant Present in the following documents:

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Dynamics of the PI3K-like protein kinase members ATM and DNA-PKcs at DNA double strand breaks.

Cell Cycle (Georgetown, Tex.)

Davis, Anthony J AJ; So, Sairei S; Chen, David J DJ

Publication Date: 2010-07-01

Variant appearance in text: ATM: S1981A

PubMed Link: 20543558

Variant Present in the following documents:

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Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.

The Journal Of Cell Biology

So, Sairei S; Davis, Anthony J AJ; Chen, David J DJ

Publication Date: 2009-12-28

Variant appearance in text: ATM: S1981A

PubMed Link: 20026654

Variant Present in the following documents:

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Common mechanisms of PIKK regulation.

Dna Repair

Lovejoy, Courtney A CA; Cortez, David D

Publication Date: 2009-09-02

Variant appearance in text: ATM: S1981A

PubMed Link: 19464237

Variant Present in the following documents:

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Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death.

Nature Cell Biology

Tian, Bo B; Yang, Qian Q; Mao, Zixu Z

Publication Date: 2009-02

Variant appearance in text: ATM: S1981A

PubMed Link: 19151707

Variant Present in the following documents:

• Main text
• NIHMS100613-supplement-supp_files.pdf
• nihms100613.pdf

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Involvement of novel autophosphorylation sites in ATM activation.

The Embo Journal

Kozlov, Sergei V SV; Graham, Mark E ME; Peng, Cheng C; Chen, Philip P; Robinson, Phillip J PJ; Lavin, Martin F MF

Publication Date: 2006-08-09

Variant appearance in text: ATM: S1981A

PubMed Link: 16858402

Variant Present in the following documents:

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ATM, a DNA damage-inducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Irarrazabal, Carlos E CE; Liu, Jennifer C JC; Burg, Maurice B MB; Ferraris, Joan D JD

Publication Date: 2004-06-08

Variant appearance in text: ATM: S1981A

PubMed Link: 15173573

Variant Present in the following documents:

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